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All Journal Jurnal Teknologi Pertanian Jurnal Abdimas Terapan Jurnal Vokasi Sains dan Teknologi Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Media Farmasi Media Gizi Pangan Jurnal Sains dan Teknologi Pangan Journal of Digital Business & Banking
Hariana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Journal : Media Farmasi

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Eksplorasi Antioksidan dan Anti-Inflamasi Madu Hutan Pulau Buton Secara in-Vitro dan Efek Inhibisi Edema Telinga Secara in-Vivo Hariana; Wahyuni; Idrus, Loly Subhiaty; Malik, Fadhliyah; Purnama, La Ode Muhammad Julian; Fristiohady, Adryan
Media Farmasi Vol 21 No 2 (2025): Media Farmasi Edisi Oktober 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i2.1633

Abstract

Forest honey is a natural product derived from the nectar of wild plants and is known to contain various bioactive compounds, such as flavonoids and phenolics, which contribute to its antioxidant and anti-inflammatory potential. Buton Regency in Southeast Sulawesi is recognized as a producer of forest honey; however, scientific studies on its biological activities remain limited. This study aimed to evaluate the free radical scavenging activity and anti-inflammatory effects of Buton forest honey through both in vitro and in vivo approaches. Antioxidant activity was assessed using DPPH and ABTS assays, while anti-inflammatory evaluation involved inhibition of BSA protein denaturation and a mouse ear edema model induced by xylene. The honey exhibited IC₅₀ values of 71.69 ± 2.73 mg/L (DPPH) and 49.23 ± 4.24 mg/L (ABTS). Its protein denaturation inhibition showed an IC₅₀ of 14.17 ± 3.18 mg/L. In vivo testing demonstrated that high-dose honey significantly reduced ear thickness in mice, with a percentage of inhibition comparable to diclofenac sodium. Statistical analysis revealed significant differences (p < 0.05) across most parameters. These findings indicate that Buton forest honey holds promise as a natural antioxidant and anti-inflammatory agent.
Aktivitas Radical Scavenging Melalui Penghambatan Nitric Oxide Madu Hutan Asal Kolaka Timur Pada Sel Makrofag Raw 264.7 Hariana; Wahyuni; Haruna, Lidya Agriningsih; Purnama, La Ode Muh. Julian; Fristiohady, Adryan
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.2105

Abstract

Forest honey is a natural product rich in bioactive compounds, particularly phenolics and flavonoids, which contribute to its antioxidant and anti-inflammatory properties. East Kolaka, Southeast Sulawesi, is recognized as a potential source of forest honey; however, scientific data regarding its biological activity remain limited. This study aimed to evaluate the antioxidant and anti-inflammatory activities of forest honey from East Kolaka using in vitro and in vivo approaches. Antioxidant activity was assessed using DPPH, ABTS, and β-carotene bleaching assays, while anti-inflammatory activity was evaluated through inhibition of nitric oxide production in LPS-induced RAW 264.7 macrophage cells and a xylene-induced mouse ear edema model. The results demonstrated notable antioxidant activity, with IC₅₀ values of 68.16 ± 1.18 mg/L (DPPH), 56.36 ± 3.72 mg/L (ABTS), and 4.11 ± 0.66 mg/L (BCB). Additionally, the honey significantly suppressed nitric oxide production in vitro and reduced ear edema in vivo, with the highest dose showing comparable effectiveness to sodium diclofenac. These findings indicate that East Kolaka forest honey has promising potential for development as a functional food or nutraceutical derived from local natural resources.
Co-Authors Adriyani Adam Amaliah, Wa Ode Fitri Aulia, Zakia Ayu Wulandari Cicilia, Retno Detumu, Putri Sakina Fadhliyah Malik Fitrawan, La Ode Muhammad Fristiohady, Adryan Haruna, Lidya Agriningsih Hasnawati Hendrix Yulis Setyawan I Wayan Seriyoga Parta Idrus, Loly Subhiaty Igrisa, Dila Ika Atsari Dewi Irnawati Kiayi , Sri Nisanti Koem , Putri Diyah Ulhaq La Ode Muhammad Fitrawan Loly Subhiaty Idrus Mohd Zulkhairi Mohd Yusoff Mokodompit, Nevalia Nadia Rahmawati Taufik Naini , Ulin NASRUDIN Nimas Mayang Sabrina Sunyoto Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian Rahman Turani Rahmawati Rowa, Sitti Sahariah Ruslin Sahidin Sakunda Anggarini Salmatiana Ali Shafa Salsabila Aji Sirajuddin Siti Fawziah Novianty Siti Magfirah Husain Sri Lismawati S.Dai Syukur, Novita Sari Thahir, Musyawarah WAHYUNI Wolinelo, Juwita Yodha, Agung Wibawa Mahatva