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Sulistyani, S
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Phenytoin Topical as Pain Neuropathic Therapy: A Scoping Review Sulistyani, S; Rosyidah, Devi Usdiana; Rahmawati, Nailena Widya; Nugrahaen, Sarwasri Fajra; Goprani, Lidya; Sulistiyo, Azka Hafiy; Prameswari, Elza; Hutami, Norma Putri; Azwar, Muhammad Thoriq; Amalia, Riza
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5500

Abstract

Background: Neuropathic pain is a type of pain that can cause prolonged pain in patients. Oral treatment takes a long time and can cause side effects, which can further reduce patient compliance with therapy. Topical treatment is a more acceptable alternative because it has minimal systemic side effects. Phenytoin is an anticonvulsant drug that can be used as a therapy for neuropathic pain. The side effects of oral phenytoin are minimized by using topical preparations. Objective: To obtain information on the effectiveness of topical phenytoin in neuropathic pain. Long-term goal, conduct clinical trials in patients and make topical phenytoin preparations in collaboration with one of the PBF (Large Pharmaceutical Companies) in Indonesia. Methods: Three electronic databases were searched on January 13, 2022: Google Scholar. PubMed and ScienceDirect. All relevant literature was included after screening according to the PRISMA statement. Data obtained were synthesized based on PICO (population, interventions, comparisons, and outcomes). Results: This paper examines case reports, case series, and pre-existing research articles in which topical phenytoin significantly reduces neuropathic pain. Conclusion: Topical phenytoin may be an alternative in the selection of neuropathic pain therapy due to its minimal side effects compared to oral therapy. However, further studies need to be conducted to compare with other topical anticonvulsants.
Relationship between Neutrophil to Lymphocyte Ratio (NLR) and Lymphocyte to Monocyte Ratio (LMR) with Severity of Ischemic Stroke Paramadina, Izzati; Kusumaningsih, Dwi; Sulistyani, S; Puspitasari, Metana
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5516

Abstract

Purpose: The purpose of this study was to determine the correlation between Neutrophil to Lymphocyte Ratio (NLR) and Lymphocyte to Monocyte Ratio (LMR) with the severity of ischemic stroke. Methodology: According to the criteria, a cross-sectional sample of ischemic stroke patients at Yarsis Islamic Hospital in Surakarta (January 2023–November 2024) participated in this observational analytical study, which used the National Institutes of Health Stroke Scale (NIHSS) as a severity measure. Results: 44 subjects were obtained with an equal ratio of gender and hypertension was the most common comorbidity. A substantial relationship between the NLR with the NIHSS score (p value = 0.001) and between LMR with the NIHSS score (p value < 0.001) was discovered using bivariate analysis. NLR (OR 4.713; p = 0.044) and LMR (OR 10.780; p = 0.043) had a 42.2% (R square = 0.422) impact on the severity of ischemic stroke, according to the findings of the logistic regression test. Applications: Based on this study, there is a significant relationship between NLR and LMR with the severity of ischemic stroke. As a consequence, NLR and LMR test findings may serve as a substitute indicator of acute ischemic stroke patients' severity.
Correlation between Glasgow Coma Scale (GCS) Score and Lesion Location with Mortality in Patients with Ischemic Stroke Pramesti, Neva Galih; Sulistyani, S; Busyra, B; Risanti, Erika Diana
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5526

Abstract

Purpose: This study evaluated the correlation between GCS scores and lesion locations with mortality in ischemic stroke patients. Methodology: This cross-sectional study analyzed secondary data from 50 ischemic stroke inpatients at RSUD dr. Soeratno Gemolong between August 2022 and August 2024. GCS scores were categorized as severe (≤8), moderate (9–12), and mild (13–15). Lesion locations were classified as supratentorial or infratentorial. The relationship between these variables and mortality was analyzed using the chi-square test. Results: A significant correlation was found between GCS scores and mortality (p = 0.001). Patients with severe GCS scores had a 54% mortality rate compared to 8% in patients with mild scores. No significant association was observed between lesion location and mortality (p = 0.118), although patients with supratentorial lesions showed a higher mortality rate (40%) than those with infratentorial lesions (28%). Applications/Originality/Value: GCS scores are a strong predictor of mortality in ischemic stroke patients, highlighting their importance in early risk stratification. Lesion location, while showing trends, was not significantly associated with mortality. The findings support healthcare policy improvements, personalized care, and future research into comprehensive stroke management. Further research is needed to explore these factors comprehensively and improve patient outcomes.
The Relationship between Leukocytosis and Hyponatremia with Mortality Ischemic Stroke Patients Futana, Ninda Pradani; Sulistyani, S; Setiawan, Iwan; Djatmiko, Safari Wahyu
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5527

Abstract

Background: Ischemic stroke is the cause of increased mortality in the world, especially in developing countries. Ischemic stroke is caused by a decrease in blood flow and oxygen supply in the brain. Increased leukocyte count as an inflammatory response, as well as impaired sodium levels in the form of hyponatremia, can worsen the patients condition and increase the risk of death. Leukocytosis after ischemia causes inflammation of neurons and continuous brain injury. Leukocyte infiltration can also increase obstruction causing oxygen levels to decrease. Hyponatremia which associated with cerebral salt wasting (CSWS), Syndrome of inappropriate antidiuretic hormone (SIADH), cerebral edema and increased intracranial pressure also increases the risk of death for ischemic stroke patients. Purpose: The purpose of this study is determine the relationship between leukocytosis and hyponatremia with the morality of ischemic stroke patients. Methodology: The method used in this study is a cross sectional. Sampling was carried out using non-randomized sampling and obtained 61 patients with a diagnosis of ischemic stroke and recorded completely in medical reports from 2022 to 2024 at RSUD dr soeratno Gemolong. Statistical analysis used was chi square for bivariate and logistic regression for multivariate. Results: The results obtained a significant p value in leukocytosis of 0.007 and hyponatremia of 0.008. The results of multivariate analysis obtained significant values in both variables with p< 0.05. Applications: In this research that shows an association between leukocytosis and hyponatremia with ischemic stroke mortality can be used further for researchers and clinicians, especially in the health fields.
Vertigo as A Manifestation of Cervical Rib: Case Report Sulistyani, S; Hutami, Norma Putri; Sulistiyo, Azka Hafiy; Prameswari, Elza; Azwar, Muhammad Thoriq; Setiawan, Iwan
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5528

Abstract

Background: A cervical rib is a congenital anomaly of a cervical spine vertebra, occurring in about 0.5% to 1% of the population. It is most commonly associated with the seventh cervical vertebra. Cervical ribs can lead to localized pain and affect surrounding structures, presenting with a variety of clinical symptoms. Objective: To demonstrate that a cervical rib can cause vertigo, particularly central vertigo. Case: A 55-year-old woman experienced vertigo and nausea for approximately ten years. Physical examination revealed her head tilted to the left, with an inability to maintain a straight position. Positive cerebellar signs were observed. Imaging studies showed a cervical rib on the seventh cervical vertebra in the X-ray and bilateral cerebellar infarctions in a CT scan. Discussion: The patient, a female, had a cervical rib on the right side. The vertigo was linked to a cerebellar stroke caused by the cervical rib. The underlying mechanism likely involved compression of the subclavian artery and poor posture. Conclusion: Vertigo can be a clinical manifestation of cerebellar stroke, resulting from subclavian artery compression due to a cervical rib.
The Relationship Mean Arterial Pressure and Sleep Quality with The Incident of Tension Type Headache Susanto, Syarafina Ayu Putri; Setiawan, Iwan; Sulistyani, S; Herawati, Erna
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5542

Abstract

Background: Headache is one of the most prevalent neurological illnesses seen in emergency departments. Tension Type Headache (TTH) is the most prevalent type of headache, affecting up to 70% of people aged 18 to 65 globally. Risk factor of TTH often discussed include poor sleep quality and vascular control. According to studies, poor sleep quality increases the frequency and intensity of headaches, including TTH. Furthermore, vascular control, particularly Mean Arterial Pressure (MAP), is thought to be associated with TTH. Previous research suggests that high blood pressure may diminish the occurrence of TTH via a mechanism known as hypertension-induced hypoalgesia, while evidence on the link between MAP and TTH are sparse. Purpose: This study aims to evaluate the relationship between mean arterial pressure, sleep quality, and the occurrence of tension-type headache. Methodology: The study was conducted in Surakarta Boarding High School using a cross-sectional design. The sample approach used was simple random sampling. The data was examined using univariate and bivariate statistics. The chi-square and Fisher's exact tests were used to do bivariate analysis. Results: The bivariate analysis revealed that the p-value for the association between mean arterial pressure and the incidence of TTH is 0.694, and the p-value for the relationship between sleep quality and the occurrence of TTH is 0.992. Applications: The study's findings show that Mean Arterial Pressure and sleep quality had no relationship with the incidence of Tension Type Headache. Thus, further research is needed to explore this risk factor more deeply, enabling clinicians to educate about this risk factors.
Co-Authors Amalia, Riza Azwar, Muhammad Thoriq Busyra, B Devi Usdiana Rosyidah Djatmiko, Safari Wahyu Erika Diana Risanti Erna Herawati, Erna Futana, Ninda Pradani Goprani, Lidya Hutami, Norma Putri Iwan Setiawan kusumaningsih, dwi Nugrahaen, Sarwasri Fajra Paramadina, Izzati Pramesti, Neva Galih Prameswari, Elza Puspitasari, Metana Rahmawati, Nailena Widya Sulistiyo, Azka Hafiy Susanto, Syarafina Ayu Putri