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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Riset Industri Hasil Hutan Pharmascience Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) Borneo Journal Of Pharmascientech Sasambo Journal of Pharmacy J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat) Jurnal Pengabdian Masyarakat Panacea Borneo Journal of Pharmacy Pharmacon: Jurnal Farmasi Indonesia
Mia Fitriana
Program Studi Farmasi FMIPA Universitas Lambung Mangkurat Banjarbaru
Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Pharmascience

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Aktivitas Antibakteri Ekstrak Metanol Bunga Teratai (Nymphaea pubescens Willd) Amalia Khairunnisa; Nashrul Wathan; Mia Fitriana; Fadlilaturrahmah Fadlilaturrahmah; Nisriyati Fiddina
Jurnal Pharmascience Vol 7, No 2 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i2.8486

Abstract

Nymphaea pubescens Willd telah diketahui mempunyai efek antibakteri, terutama pada biji dan daunnya. Tetapi sampai saat ini bagian bunga dari tanaman tersebut belum dilakukan pengujian aktivitas antibakteri. Tujuan dari penelitian ini untuk melakukan skrining fitokimia, uji aktivitas antibakteri dan penentuan konsentrasi hambat minimum (KHM) dari ekstrak metanol bunga N. pubescens terhadap S. aureus dan E. coli. Proses ekstraksi bunga N. pubescens dimaserasi menggunakan pelarut metanol dengan perbandingan 1: 4 b/v. Metode pengujian yang digunakan ada dua yaitu metode difusi untuk pengujian aktivitas antibakteri dan metode dilusi untuk pengukuran konsentrasi hambat minimum (KHM). Hasil skrining fitokimia didapatkan bahwa ekstrak metanol bunga N. pubescens mengandung senyawa golongan fenolik, saponin dan flavonoid. Hasil pengujian aktivitas antibakteri menunjukkan bahwa ekstrak metanol bunga N.pubescens mampu menghambat S. aureus (diameter hambat 10 ± 0,29 mm) dan E.coli (diameter hambat 10,2 ± 0,50 mm). Konsentrasi hambat minimum dari ekstrak metanol bunga N. pubescens terhadap S.aureus sebesar 12,5% dan terhadap E.coli sebesar 25%. Dapat disimpulkan bahwa ekstrak metanol bunga N. pubescens memiliki aktivitas sebagai antibakteri. Nymphaea pubescens Willd has known to have antibacterial effects, especially on the seeds and leaves. However, until now the flower of the plant has not been tested for antibacterial activity. The purpose of this study was to perform phytochemical screening, antibacterial activity test and determine the minimum inhibitory concentration (MIC) of the methanol extract of N. pubescens flowers against S. aureus and E. coli. The process of extracting N. pubescens flowers is macerated using methanol as a solvent with a ratio of 1: 4 w / v. There are two test methods used, namely the diffusion method for testing antibacterial activity and the dilution method for measuring the minimum inhibitory concentration (MIC). The results of phytochemical screening showed that the methanol extract of N. pubescens flowers contained phenolic compounds, saponins, and flavonoids. The results of the antibacterial activity test showed that the methanol extract of N.pubescens flowers was able to inhibit S. aureus (inhibition diameter 10 ± 0.29 mm) and E. coli (inhibitory diameter 10.2 ± 0.50 mm). The minimum inhibitory concentration of the methanol extract of N. pubescens flowers against S.aureus was 12.5% and against E. coli was 25%. It can be concluded that the methanol extract of N. pubescens flowers has antibacterial activityKeywords: Nymphaea pubescens, lotus flower, methanol extract, antibacterial
Acne Fighter Microemultion Gel mengandung Basil Oil (Ocimum sanctum) Noridafi, Noridafi; Zainah, Alya; Nahdiya, Nahdiya; Rusda, Salsabila Azzahra; Cahyani, Syifa Nur; Fitriana, Mia
Jurnal Pharmascience Vol 12, No 2 (2025): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23773

Abstract

Jerawat adalah masalah kulit yang ditandai inflamasi pada folikel rambut dan kelenjar sebaceous kulit. Infeksi bakteri Propionibacterium acnes (P. acnes) dapat menjadi salah satu penyebab timbulnya jerawat. Basil oil telah terbukti memiliki potensi sebagai obat jerawat yang memiliki kemampuan menghambat pertumbuhan bakteri P. acnes dengan konsentrasi hambat minimum (KHM) sebesar 2% v/v dan konsentrasi bunuh minimum (KBM) sebesar 3,5% v/v. Penelitian ini bertujuan untuk memformulasi mikroemulgel basil oil dan menguji karakteristik fisik sediaan. Mikroemulgel diformulasikan dengan konsentrasi basil oil 2, 3, dan 4%. Karakterisasi yang dilakukan yaitu uji organoleptis, pH, viskositas, transmitan, sentrifugasi, dan uji daya sebar. Hasilnya, semua formulasi menunjukkan karakteristik organoleptis yang baik. pH sediaan sebesar 7,77; 7,60; dan 7,53. Viskositas berada pada rentang 2,5-6,75 cPs serta transmitan mikroemulgel basil oil sebesar 99,80; 99,33; dan 91,60%. Sediaan juga stabil setelah disentrifugasi dan daya sebar 5,50; 5,83 dan 5,83 cm. Kesimpulan penelitian ini yaitu mikroemulgel basil oil menunjukkan karakteristik fisika dan kimia yang baik. Kata Kunci : Basil Oil, P. acnes, Jerawat, Mikroemulgel, Minyak Acne is a skin condition characterized by inflammation of the hair follicles and sebaceous glands of the skin. Infection with the bacterium Propionibacterium acnes (P. acnes) can be one of the causes of acne. Basil oil has been proven to have potential as an acne treatment with the ability to inhibit the growth of P. acnes bacteria at a minimum inhibitory concentration (MIC) of 2% v/v and a minimum bactericidal concentration (MBC) of 3.5% v/v. This study aims to formulate basil oil microemulsions and test the physical characteristics of the preparations. Microemulsions were formulated with basil oil concentrations of 2%, 3%, and 4%. Characterization was performed using organoleptic tests, pH, viscosity, transmittance, centrifugation, and spreadability tests. The results showed that all formulations had good organoleptic characteristics. The pH of the preparations was 7.77, 7.60, and 7.53. The viscosity was in the range of 2.5-6.75 cPs and the transmittance of the basil oil microemulsions was 99.80, 99.33, and 91.60%. The preparations were also stable after centrifugation, with spreading power of 5.50, 5.83, and 5.83 cm. The conclusion of this study is that basil oil microemulsions exhibit good physical and chemical characteristics.
Co-Authors Amalia Khairunnisa Amalina Amalina, Amalina Anna Khumaira Sari Arnida Arnida Beny Rahmanto Cahyani, Syifa Nur Difa Intannia Dina Rahmawanty Dina Rahmawanty Fadlilaturrahmah Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah Helsawati, Helsawati Isnaini, Nazhifah Izma, Hayatun Khoerul Anwar Khoerul Anwar Khoirunnisa Muslimawati Kurniasari, Winda Tri Maharani, Ni Ayu Muhammad Ikhwan Rizki Nahdiya, Nahdiya Nashrul Wathan Nisriyati Fiddina Nita Yulianti Nita Yulianti, Nita Noridafi, Noridafi Normaidah, Normaidah Rahmatullah, Satrio Wibowo Rahmawanty, Dina Ratnapuri, Prima Happy Rusda, Salsabila Azzahra Safarina, Nor Rezky Sandi, Dita Ayulia Dwi Sarwo, Laura Siswadi Siswadi Susy Andriani Sutomo Sutomo Wawan Halwany Yulianti, Nita Yuni Kartika Yusrinie Wasiaturrahmah Zainah, Alya