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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Gizi Klinik Indonesia Jurnal Kedokteran dan Kesehatan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat International Journal of Basic and Applied Science Jurnal Katalisator Media Penelitian dan Pengembangan Kesehatan
Ismawati ismawati
Universitas Riau
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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ANALISIS INULIN DARI UMBI DAHLIA (dahlia viriabilis) SEBAGAI PREBIOTIK ANTIDIABETIK Veni Dayu Putri; Sri Yanti; Fitri Dyna; Saryono; Ismawati
JURNAL KATALISATOR Vol. 7 No. 2 (2022): jurnal Katalisator Volume 7 No 2, Oktober 2022
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (517.625 KB) | DOI: 10.62769/katalisator.v7i2.1670

Abstract

Diabetes mellitus (DM) merupakan penyakit menahun yang dapat diderita seumur hidup akibat difisiensi insulin, resistensi insulin atau keduanya yang ditandai dengan kenaikan gula darah (hiperglikemia). DM menjadi masalah kesehatan global dan penyebab utama mordibitas di negara berkembang dan negara maju. Dahlia (dahlia variabilis) memiliki kandungan inulin yang bermanfaat bagi kesehatan karena mengandung serat pangan dan bersifat prebiotik. Penelitian ini bertujuan untuk menganalisis kandungan inulin (analisis proksimat) dari umbi dahlia yaitu kadar air, kadar abu, protein kasar, lemak, karbohidrat, dan serat kasar. Pembuatan inulin dilakukan dengan metode ekstraksi dan analisis proksimat inulin mengacu pada metode pengujian SNI 01-2891-1992. Hasil analisis proksimat diperoleh kadar air (6,75%), kadar abu (0,39%), protein kasar (0,95%), lemak (0,49%, karbohidrat (91,41%) dan serat kasar (0,97%). Inulin berfungsi sebagai prebiotik yang termasuk kelompok food ingredient dan dietary fiber yang dapat memperlambat penyerapan glukosa dalam usus, menurunkan kadar gula darah, dan antihiperglikemia yang keseluruhannya memiliki efek sebagai antidiabetik. Kata Kunci: Analisis proksimat, Diabetes Mellitus, Inulin, Prebiotik , Umbi Dahlia ABSTRACT Diabetes mellitus (DM) is a chronic disease that can last a lifetime due to insulin deficiency, insulin resistance or both, which is characterized by an increase in blood sugar (hyperglycemic). DM is a global health problem and a major cause of morbidity in developing and developed countries. Umbi dahlia (dahlia variabilis) contains inulin which is beneficial for health because it contains dietary fiber and is a prebiotic. This study aimed to analyze the inulin content (proximate analysis) of dahlia tubers, namely water content, ash content, crude protein, fat, carbohydrates, and crude fiber. Inulin was made by extraction method and proximate analysis of inulin referring to the testing method of SNI 01-2891-1992. The results of the proximate analysis obtained water content (6.75%), ash content (0.39%), crude protein (0.95%), fat (0.49%, carbohydrates (91.41%) and crude fiber (0 ,97%). Inulin functions as a prebiotic which belongs to the group of food ingredients and dietary fiber which can slow down the absorption of glucose in the intestines, lower blood sugar levels, and is antihyperglycemic, all of which have antidiabetic effects. Keywords: Proximate analysis, Diabetes Mellitus, Inulin, Prebiotics, Dahlia tubers
Efek Inhibitor Proteasom Terhadap Gambaran Histopatologi Jantung pada Tikus yang diinduksi Aterosklerosis Ilhami Romus; Ismawati Ismawati; Indah Putri Arwandi
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.66-70

Abstract

Proteasome inhibitors are compounds that can inhibit the proteasome pathway in carrying out its functions. Proteasome inhibitors have a beneficial effect due to their anti-inflammatory properties. The proteasome inhibitor used in this study was bortezomib. This study aimed to analyze the effect of proteasome inhibitors on cardiac histopathology in atherosclerosis-induced rats. This study used male Rattus novergicus Wistar strain which was divided into 3 groups, namely the control group, the atherosclerosis-induced group and the atherosclerosis-induced group and given bortezomib. The results obtained the mean scores of edema, inflammation and necrosis in the atherosclerosis group were given bortezomib at a dose of 50 g/kgBW were less than the atherosclerosis group. Theese difference were statistically significant  (p<0.05). This study concluded that the administration of bortezomib can reduce the Impact of atherosclerotic lesions on the heart muscle.
α-glucosidase Inhibitory Activity of Probiotic Isolate LBSU9 Isolated from Traditional Food “Trites”: a Preliminary Study Edy Fachrial; Ismawati Ismawati; Titania T Nugroho; Saryono Saryono
International Journal of Basic and Applied Science Vol. 12 No. 4 (2024): March: Basic and Applied Science
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/ijobas.v12i4.293

Abstract

As the prevalence of type 2 diabetes mellitus continues to increase over the years, research into antidiabetic drugs needs to continue. Probiotics are non-pathogenic microorganisms that have potential as α-glucosidase inhibitors. This study aimed to characterize and determine the α-glucosidase inhibitor activity of LBSU9 isolate, a probiotic isolated from "trites," a traditional food of North Sumatra. The results showed that LBSU9 had bacillus morphology, Gram positive, negative catalase test, TSIA (Triple Sugar Iron Agar) A/A test and non-hemolysis. LBSU9 had good tolerance to simulated gastric acid and bile salts, with growth percentages of 66.54% and 64.74%. LBSU9 also has potent antimicrobial activity against S.aureus and E.coli, with 20 mm and 17 mm inhibition zones, respectively. The alpha-glucosidase inhibitor activity of LBSU9 was 98.4% greater than that of acarbose, which was 97%. Based on the results of this study, it is concluded that LBSU9 isolate has the potential to be a complementary therapy to prevent or treat type 2 diabetes mellitus
ANALISIS FAKTOR RISIKO DISMENORE PRIMER DAN DISMENORE SEKUNDER PADA MAHASISWI Putra, Amrullah Syah; Saputra, Nicko Pisceski Kusika; Noviardi, Noviardi; Ismawati, Ismawati
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 1 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i1.1974

Abstract

While the incidence of dysmenorrhea is relatively high worldwide, the prevalence of dysmenorrhea reported in the literature varies substantially. This study aimed to analyze the risk factors for primary dysmenorrhea and secondary dysmenorrhea. This research is a cross analytical design. The sample in this study was all medical faculty students at Riau University in 2019-2022, namely 410 people. From the research results, it was found that there was a relationship between menstrual blood volume, history of food allergies and stress with the incidence of primary dysmenorrhea. Meanwhile, the incidence of secondary dysmenorrhea was related to age, menstrual cycle, history of the sample's gestational age at birth, history of low birth weight (LBW), history of emotional violence, stress and birth history of samples from preeclamptic mothers at the time of delivery. This research concluded that there were several significant findings regarding factors related to the occurrence of dysmenorrhea in Riau University medical students in 2019 - 2022. The research showed the importance of paying attention to factors such as the length of the menstrual cycle, history of food allergies, history of emotional violence, stress, and history of maternal preeclampsia in efforts to prevent and manage dysmenorrhea in the population. It is recommended that future research further explore the association between the identified risk factors and the incidence of dysmenorrhea, potentially revealing additional insights to guide clinical practice and public health initiatives.
Co-Authors Angel Chen Dhea Ayu Kartini Surya Putri Dyna, Fitri Edy Fachrial Elfima Aditya Utami Enikarmila Asni Erwin Christianto Esy Maryanti Ilhami Romus Ilhami Romus Ilhami Romus Ilhami Romus, Ilhami Imelda Tresia Pardede Indah Putri Arwandi Isnani Kurniyanti Ligat Pribadi Sembiring Luthfianty, Elfiah M Derillovyandra Dwi Anugrah Muhammad Fadhillah Arif Mukhyarjon Noviardi Noviardi, Noviardi Permatasari, Nopi Putra, Amrullah Syah Rijalun Arridho Saputra, Nicko Pisceski Kusika Saryono Saryono Saryono Sonia Dinda Paramitha Sri Yanti Titania Tjandrawati Nugroho Veni Dayu Putri Winarto Winarto