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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Ilmiah Pertanian Jurnal Pengabdian UntukMu NegeRI Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Gizi Klinik Indonesia Jurnal Kedokteran dan Kesehatan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Acta Chimica Asiana Jurnal Katalisator Biomedika Media Penelitian dan Pengembangan Kesehatan
Ismawati ismawati
Universitas Riau
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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ANALISIS INULIN DARI UMBI DAHLIA (dahlia viriabilis) SEBAGAI PREBIOTIK ANTIDIABETIK Veni Dayu Putri; Sri Yanti; Fitri Dyna; Saryono; Ismawati
JURNAL KATALISATOR Vol. 7 No. 2 (2022): jurnal Katalisator Volume 7 No 2, Oktober 2022
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (517.625 KB) | DOI: 10.62769/katalisator.v7i2.1670

Abstract

Diabetes mellitus (DM) merupakan penyakit menahun yang dapat diderita seumur hidup akibat difisiensi insulin, resistensi insulin atau keduanya yang ditandai dengan kenaikan gula darah (hiperglikemia). DM menjadi masalah kesehatan global dan penyebab utama mordibitas di negara berkembang dan negara maju. Dahlia (dahlia variabilis) memiliki kandungan inulin yang bermanfaat bagi kesehatan karena mengandung serat pangan dan bersifat prebiotik. Penelitian ini bertujuan untuk menganalisis kandungan inulin (analisis proksimat) dari umbi dahlia yaitu kadar air, kadar abu, protein kasar, lemak, karbohidrat, dan serat kasar. Pembuatan inulin dilakukan dengan metode ekstraksi dan analisis proksimat inulin mengacu pada metode pengujian SNI 01-2891-1992. Hasil analisis proksimat diperoleh kadar air (6,75%), kadar abu (0,39%), protein kasar (0,95%), lemak (0,49%, karbohidrat (91,41%) dan serat kasar (0,97%). Inulin berfungsi sebagai prebiotik yang termasuk kelompok food ingredient dan dietary fiber yang dapat memperlambat penyerapan glukosa dalam usus, menurunkan kadar gula darah, dan antihiperglikemia yang keseluruhannya memiliki efek sebagai antidiabetik. Kata Kunci: Analisis proksimat, Diabetes Mellitus, Inulin, Prebiotik , Umbi Dahlia ABSTRACT Diabetes mellitus (DM) is a chronic disease that can last a lifetime due to insulin deficiency, insulin resistance or both, which is characterized by an increase in blood sugar (hyperglycemic). DM is a global health problem and a major cause of morbidity in developing and developed countries. Umbi dahlia (dahlia variabilis) contains inulin which is beneficial for health because it contains dietary fiber and is a prebiotic. This study aimed to analyze the inulin content (proximate analysis) of dahlia tubers, namely water content, ash content, crude protein, fat, carbohydrates, and crude fiber. Inulin was made by extraction method and proximate analysis of inulin referring to the testing method of SNI 01-2891-1992. The results of the proximate analysis obtained water content (6.75%), ash content (0.39%), crude protein (0.95%), fat (0.49%, carbohydrates (91.41%) and crude fiber (0 ,97%). Inulin functions as a prebiotic which belongs to the group of food ingredients and dietary fiber which can slow down the absorption of glucose in the intestines, lower blood sugar levels, and is antihyperglycemic, all of which have antidiabetic effects. Keywords: Proximate analysis, Diabetes Mellitus, Inulin, Prebiotics, Dahlia tubers
Efek Inhibitor Proteasom Terhadap Gambaran Histopatologi Jantung pada Tikus yang diinduksi Aterosklerosis Ilhami Romus; Ismawati Ismawati; Indah Putri Arwandi
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.66-70

Abstract

Proteasome inhibitors are compounds that can inhibit the proteasome pathway in carrying out its functions. Proteasome inhibitors have a beneficial effect due to their anti-inflammatory properties. The proteasome inhibitor used in this study was bortezomib. This study aimed to analyze the effect of proteasome inhibitors on cardiac histopathology in atherosclerosis-induced rats. This study used male Rattus novergicus Wistar strain which was divided into 3 groups, namely the control group, the atherosclerosis-induced group and the atherosclerosis-induced group and given bortezomib. The results obtained the mean scores of edema, inflammation and necrosis in the atherosclerosis group were given bortezomib at a dose of 50 g/kgBW were less than the atherosclerosis group. Theese difference were statistically significant  (p<0.05). This study concluded that the administration of bortezomib can reduce the Impact of atherosclerotic lesions on the heart muscle.
ANALISIS FAKTOR RISIKO DISMENORE PRIMER DAN DISMENORE SEKUNDER PADA MAHASISWI Putra, Amrullah Syah; Saputra, Nicko Pisceski Kusika; Noviardi, Noviardi; Ismawati, Ismawati
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 1 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i1.1974

Abstract

While the incidence of dysmenorrhea is relatively high worldwide, the prevalence of dysmenorrhea reported in the literature varies substantially. This study aimed to analyze the risk factors for primary dysmenorrhea and secondary dysmenorrhea. This research is a cross analytical design. The sample in this study was all medical faculty students at Riau University in 2019-2022, namely 410 people. From the research results, it was found that there was a relationship between menstrual blood volume, history of food allergies and stress with the incidence of primary dysmenorrhea. Meanwhile, the incidence of secondary dysmenorrhea was related to age, menstrual cycle, history of the sample's gestational age at birth, history of low birth weight (LBW), history of emotional violence, stress and birth history of samples from preeclamptic mothers at the time of delivery. This research concluded that there were several significant findings regarding factors related to the occurrence of dysmenorrhea in Riau University medical students in 2019 - 2022. The research showed the importance of paying attention to factors such as the length of the menstrual cycle, history of food allergies, history of emotional violence, stress, and history of maternal preeclampsia in efforts to prevent and manage dysmenorrhea in the population. It is recommended that future research further explore the association between the identified risk factors and the incidence of dysmenorrhea, potentially revealing additional insights to guide clinical practice and public health initiatives.
Vitamin D enhances migration but decreases gene expression of vascular endothelial growth factor and tumor necrosis factor-α in Wharton’s jelly mesenchymal stem cells Yuhendri, Vitriyanna Mutiara; Pratiwi, Nurfi; Paulina, Ariza Julia; Ismawati, Ismawati; Saputra, Nicko Pisceski Kusika; Arfianti, Arfianti
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 1 (2025): Advances in biomarkers, therapeutics, and probiotics: Recent updates in medical l
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i1.6698

Abstract

Mesenchymal stem cells (MSCs) have gained significant interest for their potential application in repairing damaged tissues through immunomodulatory functions. Vitamin D has been shown to regulate both the innate and adaptive immune systems. Active forms of Vitamin D, such as 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are known to influence the action of mesenchymal stem cells (MSCs) in several mechanisms, such as stimulating their proliferation and osteogenic differentiation, as well as tissue regeneration. This study aimed to investigate the effects of vitamin D supplementation on the biological properties and expression of cytokines and growth factor genes in MSCs isolated from the human umbilical cord (UC). MSCs were isolated from Wharton’s jelly (WJ-MSC) of UC, cultured, and supplemented with various concentrations of vitamin D3. The Cell Counting Kit-8 (CCK-8) assay was used to measure cell viability, and a scratch wound healing assay was conducted to evaluate the migration capacity of MSCs. The mRNA expression levels of vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were quantified using reverse transcription-polymerase chain reaction (RT-PCR). This study showed that supplementation with 50 nM of vitamin D3 for 48 h significantly increased the viability and migratory capacity of MSCs. Furthermore, vitamin D supplementation significantly decreased the mRNA levels of TNF-α and VEGF but did not affect IL-6 gene expression compared to the control group. These findings suggest that vitamin D supplementation can enhance the biological characteristics and modulate the expression of key immunomodulatory factors in MSCs, potentially improving the effectiveness of MSC-based therapies.
Isolation and antimicrobial activity of lactic acid bacteria from the traditional fermented food cangkuok semaung in Riau, Indonesia Pratiwi, Nova Wahyu; Saryono, Saryono; Ismawati, Ismawati; Devi, Silvera; Suraya, Nabella; Lovenia, Nia; Nurafriza, Widya; Sasmita, Ellen Rosyelina; Ardhi, Aulia
Jurnal Ilmiah Pertanian Vol. 22 No. 2 (2025): Jurnal Ilmiah Pertanian
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/jip.v22i2.27537

Abstract

Fermentation can be an effective step in addressing postharvest handling challenges and enhancing nutritional value through the conversion of perishable crops into more stable products. One of the traditional fermented foods originating from Kuantan Singingi Regency, Riau Province, Indonesia, is cangkuok semaung (CS). This food is prepared by fermenting all fruit components of the semaung (Pangium edule). This research aimed to isolate and identify lactic acid bacteria (LAB) from CS and investigate their antimicrobial properties. The bacteria were isolated from the food, purified using the quadrant streak method on the De Man–Rogosa–Sharpe agar, and continued with morphological analysis and antimicrobial activities evaluation. The findings of this study revealed that 45 isolates were gram-positive bacteria identified as Lactobacillus sp. Among the LAB isolates, the highest antimicrobial activity against Escherichia coli, Staphylococcus aureus, Acinetobacter baumannii, and Klebsiella pneumoniae were shown by isolates of S12, S14, S27, and S24, respectively. These results suggest that LAB from CS, especially isolates S12 and S14, have promising antimicrobial properties and show potential as probiotic candidates that merit further investigation into possible applications in food and health sectors.
EFFECT OF INULIN EXTRACT FROM DAHLIA TUBER (dahlia variabilis) ON CORONARY ARTERY HISTOPATHOLOGY IN RATS WITH TYPE 2 DIABETES MELLITUS (DM) Hopi, Zikrilla mayuli; Ismawati, Ismawati; Saryono, Saryono; Romus, Ilhami; Putri, Veni Dayu; Yanti, Sri; Dyna, Fitri
Biomedika Vol 17, No 1 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.3734

Abstract

Atherosclerosis in diabetes mellitus (DM) patients is prevented by using inulin to increase glucose metabolism and reduce cholesterol synthesis. Therefore, this research aimed to analyze dahlia tuber inulin extract to determine the effect on coronary artery histopathology in type 2 DM rats. A total of 20 male Wistar rats were divided into five groups, namely negative control without treatment, DM, DM + 0.5 mg/gBW/day inulin extract, DM + 1 mg/gBW/day inulin extract, and DM + 1.5 mg/gBW/day inulin extract. Furthermore, DM induction was carried out by administering 60 mg/kgBB streptozotocin and 120 mg/kgBB nicotinamide. The results of coronary artery histopathology readings showed that the highest and lowest scores of atherosclerosis were in Groups II (0,91±0,17) and V (0,08±0,1), respectively. Data analysis using Kruskal Wallis test reported significant results (p<0.05), while Mann-Whitney test showed differences between control and DM, DM, and inulin groups (III, IV, V). In this context, the administration of dahlia tuber inulin extract to rats induced by Type 2 DM prevented atherosclerosis in histopathological image of coronary artery.
Pemberdayaan Masyarakat Melalui Gerakan Anti Jentik Untuk Penanggulangan DBD di Kelurahan Tanjung Palas, Kota Dumai Effendi, Fallgivando; Timotius Agung Soripada; Ismawati; Adinda Aisyah; Afifah Ramadhani; Ariqa Rahma Abdullah; Irfani Dhia Rafif; Lusi Yusrenti; Mifta Zahira; Nazla Hafizah; Qryoga Irsyad Reyen; Raissa Maharani Putik Kusuma; Salsabila Nurul Wildani Hasibuan; Sera Faren
Jurnal Pengabdian UntukMu NegeRI Vol. 9 No. 2 (2025): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v9i2.9790

Abstract

Demam berdarah dengue (DBD) masih menjadi masalah besar bagi kesehatan masyarakat di Indonesia, dengan 114. 435 kasus dan 894 orang meninggal pada tahun 2023. Di provinsi Riau, terutama Kota Dumai, jumlah kasus DBD terus meningkat. Di kota Dumai juga mencatat sejumlah kasus DBD yakni 450 kasus dengan 4 kematian yang dikonfirmasi pada tahun 2024. Program yang berjudul Pemberdayaan Masyarakat Melalui Gerakan Anti Jentik untuk Penanggulangan DBD di Kelurahan Tanjung Palas, Kecamatan Dumai Timur, Kota Dumai, bertujuan untuk meningkatkan pengetahuan masyarakat dan partisipasi dalam upaya pencegahan DBD. Kami melakukan beberapa kegiatan seperti penyuluhan anak -anak di sekolah, penyuluhan masyarakat, memeriksa jentik nyamuk di rumah warga, membantu membasmi nyamuk dewasa dengan berpartisipasi dalam fogging bekerja sama dengan puskesmas setempat, Pada kegiatan ini kami menemukan cukup banyak larva Aedes aegypti di container beberapa rumah. Program ini memberikan gambaran tentang Aedes aegypti di Tanjung Palas dan juga memberdayakan warga untuk selalu turut serta melaksanakan kegiatan preventif untuk menurunkan angka kasus DBD di Tanjung Palas.
The Potential Of Fungi And Bacteria As α-Glucosidase Inhibitors For The Future Treatment Of Type 2 Diabetes Fachrial, Edy; Ismawati; Jati, Afif P; Nugroho, Titania T; Saryono
Jurnal Penelitian Pendidikan IPA Vol 11 No 1 (2025): January
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i1.9457

Abstract

Diabetes, a disorder of hemostasis of carbohydrate and lipid metabolism, is one of today's leading killers. The most prevalent form of diabetes is type 2 diabetes mellitus (T2DM). Rapid hydrolysis of starch by pancreatic α-amylase and α-glucosidase, followed by intestinal absorption of glucose, causes a sudden increase in blood glucose. Available therapies for T2DM are oral insulin secretagogues, sulfonylureas, repaglinide, nateglinide, biguanides, thiazolidinediones, α-glucosidase, inhibitors and insulin. However, several hypoglycemic agents have limitations, such as side effects and increased diabetes complications. α-glucosidase inhibitors are structurally similar to natural oligosaccharides with a higher affinity for α-glucosidases, and they produce a reversible inhibition of membrane-bound intestinal α-glucoside hydrolase enzymes. This causes delayed carbohydrate absorption and digestion and results in a reduction in postprandial hyperglycemia. Natural α-glucosidase inhibitor drugs from natural sources can be used as a therapeutic approach to treat postprandial hyperglycemia for their assumed lower side effect and more affordable price than synthetic drugs. In this article, the author summarizes the potential of α-glucosidase inhibitors from microorganisms, namely fungi and bacteria, along with several active compounds with better activity than commercial α-glucosidase inhibitors.
Pelatihan dan Pemberdayaan Kader Posyandu dalam Pemanfaatan Makanan Fermentasi Tradisional Kuansing untuk Peningkatan Gizi Ibu Hamil dan Balita Ismawati, Ismawati; saryono, saryono; mukhyarjon, mukhyarjon; enikarmila Asni; Devi, Silvera; Anggraini, Suci; Suraya, Nabella; Kesya, Lunari; Salsabila, Dinda; Deanra, Cantika Natswa
Jurnal Pengabdian UntukMu NegeRI Vol. 9 No. 3 (2025): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v9i3.10439

Abstract

Stunting in children remains a health problem in Indonesia. One way to improve the nutritional status of the community to prevent stunting is by utilizing nutrient-rich traditional fermented foods. This community service activity aimed to enhance the knowledge and skills of Posyandu cadres in utilizing conventional fermented foods from Kuansing as a nutritional source for pregnant women and toddlers. The training was conducted on August 30, 2025, at the Gunung Toar Sub-district Multipurpose Hall, Kuantan Singingi Regency, attended by 26 Posyandu cadres. The methods included educational video screening, booklet distribution, interactive discussions, and demonstrations of traditional fermented products such as pekasam, sarobuong, and puduong. Evaluation results showed an increase in participants' knowledge scores from an average of 50 to 70 after the training. This activity demonstrates the effectiveness of science-based education in improving community nutrition awareness and preserving local fermented foods.
Bioactive peptides from traditional homemade fermented foods as an alternative for treatment Suraya, Nabella; Tjandrawati Nugroho, Titania; Ismawati, Ismawati; Saryono, Saryono
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.252

Abstract

Bioactive peptides in fermented foods are attracting scientific interest due to their prospective applications as nutraceutical and functional foods. Conventional fermented foods are naturally processed at home through the action of lactic acid bacteria (LAB). These bacteria break down food components and generate lactic acid, various organic acids, hydrogen peroxide, carbon dioxide, and short-chain peptides, which offer numerous health benefits. The bioactive peptides formed during fermentation exhibit diverse biological functions influenced by their structural compositions. Following enzymatic hydrolysis, peptides initially inactive within the native protein matrix are released and exhibit biological activity. This review aims to comprehensively examine the functional properties of bioactive peptides derived from the fermentation of traditional foods, with a particular emphasis on their therapeutic potential, including antidiabetic, antihypertensive, and anticarcinogenic activities. This review examines the health benefits of various bioactive peptides produced by lactic acid bacteria during the fermentation of traditional foods. Microbial bioactivity during the fermentation process can produce hydrolytic enzymes that break down macromolecules in food into smaller compounds, such as bioactive peptides. A wide range of peptides have been identified as improving insulin uptake, decreasing blood glucose concentrations, and inhibiting key enzymes involved in the pathogenesis of diabetes. Specific peptides exert antihypertensive effects by acting as angiotensin-converting enzyme (ACE) inhibitors, thereby preventing the transformation of angiotensin I into angiotensin II. Moreover, some bioactive peptides demonstrate immunomodulatory properties by enhancing immune responses and inducing apoptosis in cancer cells. This article provides a comprehensive overview of the therapeutic and health-promoting potentials of bioactive peptides derived from fermented foods.
Co-Authors Adinda Aisyah Afifah Ramadhani Angel Chen Anggraini, Suci Ardhi, Aulia Arfianti Arfianti Ariqa Rahma Abdullah Ariza Julia Paulina Deanra, Cantika Natswa Dhea Ayu Kartini Surya Putri Dyna, Fitri Dyna, Fitri Edy Fachrial Effendi, Fallgivando Elfima Aditya Utami Enikarmila Asni Enikarmila Asni Erwin Christianto Esy Maryanti Hopi, Zikrilla mayuli Ilhami Romus Ilhami Romus Ilhami Romus Ilhami Romus, Ilhami Imelda Tresia Pardede Indah Putri Arwandi Irfani Dhia Rafif Isnani Kurniyanti Jati, Afif P Kesya, Lunari Ligat Pribadi Sembiring Lovenia, Nia Lusi Yusrenti Luthfianty, Elfiah M Derillovyandra Dwi Anugrah Mifta Zahira Muhammad Fadhillah Arif Mukhyarjon Nazla Hafizah NOVA WAHYU PRATIWI, NOVA WAHYU Noviardi Noviardi, Noviardi Nurafriza, Widya Nurfi Pratiwi, Nurfi Permatasari, Nopi Putra, Amrullah Syah Qryoga Irsyad Reyen Raissa Maharani Putik Kusuma Rijalun Arridho Salsabila Nurul Wildani Hasibuan Salsabila, Dinda Saputra, Nicko Pisceski Kusika Saryono Saryono Saryono Sasmita, Ellen Rosyelina Sera Faren Silvera Devi Sonia Dinda Paramitha Sri Yanti Sri Yanti suraya, nabella Timotius Agung Soripada Titania Tjandrawati Nugroho Tjandrawati Nugroho, Titania Veni Dayu Putri Veni Dayu Putri Winarto Winarto Yuhendri, Vitriyanna Mutiara