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All Journal Jurnal Biologi Tropis Jurnal Pendidikan dan Pengabdian Masyarakat Indonesian Journal of STEM Education Indonesian Journal of Elementary and Childhood Education Indonesian Journal of Applied Science and Technology Indonesian Journal of Health and Medical Education
As Shiddiq, Muhammad Hilmy
Faculty Of Medicine And Health Sciences, University Of Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Pathophysiology of Skin Aging: Role of Oxidative Stress, Inflammation, and Dermal Remodeling Baiq Merna Merta Sari; Imey Pinasty Harianto Putri; Atriska Citra Muliana; Shira Shalsabina Shafitri; Janiya Abdila Ilmiah; Ihza Namira Athalia; Rashieka Salma Aulia; Gantha Narendra Josafat; Muhammad Hilmy As Shiddiq; I Nyoman Yudayana Indratama; Rangga Cahya Prasetya; Nurhidayati Nurhidayati
Indonesian Journal of Health and Medical Education Vol. 1 No. 1 (2026): Edisi Januari-Juni 2026
Publisher : Indonesian Publication Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67434/ijhme.v1i1.1837

Abstract

The skin, as the largest organ of the human body, plays a vital role in protecting the internal systems from external environments. As age increases, the skin undergoes two types of aging: intrinsic, caused by genetic and hormonal factors, and extrinsic, due to environmental factors such as ultraviolet (UV) radiation and pollution. The aging process is characterized by a decrease in fibroblasts, which are responsible for producing collagen and elastin, leading to a reduction in skin strength and elasticity. Oxidative stress resulting from the accumulation of reactive oxygen species (ROS) contributes to DNA damage and triggers inflammatory responses that accelerate aging, manifesting as wrinkles and sagging skin. Chronic inflammation, induced by ROS, further supports premature aging by increasing inflammatory substances that cause redness and irritation of the skin. Additionally, dermal remodeling is a physiological process essential for maintaining healthy skin. Still, it can become pathological if there is an imbalance between synthesis and degradation of the extracellular matrix, thereby hastening signs of aging such as wrinkles and sagging skin. In efforts to combat skin aging, several pharmacological aspects, such as topical therapies using sunscreens, retinoids, and alpha hydroxy acids (AHAs), have proven effective. Furthermore, systemic antioxidant supplementation also contributes to skin condition improvement. This comprehensive review provides valuable insights into the mechanisms of skin aging, the importance of skincare, and therapeutic strategies to counteract premature aging.
Gunstock Deformity of the Elbow: Clinical Features, Biomechanics, and Current Treatment Strategies: A Literature Review Ihza Namira Athalia; Imey Pinasty Harianto Putri; Atriska Citra Muliana; Shira Shalsabina Shafitri; Janiya Abdila Ilmiah; Baiq Merna Merta Sari; Rashieka Salma Aulia; Gantha Narendra Josafat; Muhammad Hilmy As Shiddiq; I Nyoman Yudayana Indratama; Rangga Cahya Prasetya; Nurhidayati Nurhidayati
Indonesian Journal of Health and Medical Education Vol. 1 No. 1 (2026): Edisi Januari-Juni 2026
Publisher : Indonesian Publication Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.67434/ijhme.v1i1.1838

Abstract

Gunstock deformity, also known as cubitus varus, is a common complication that arises after supracondylar humerus fractures in children, primarily due to malunion of the bone. This condition results in an inward deviation of the forearm when the elbow is in full extension, creating a pronounced change in contour that can significantly impact biomechanical function and the quality of life of the patient. Common clinical symptoms include pain on the lateral side of the elbow, limited range of motion, and joint instability, particularly associated with ulnar neuropathy. Diagnosis is established through physical examination and radiological imaging to identify the angle of deviation and malalignment. Management of this deformity varies based on severity, ranging from observation in mild cases to surgical interventions like osteotomy in more severe cases. Common corrective techniques include lateral closing wedge osteotomy and dome osteotomy, aimed at restoring anatomical alignment and preventing long-term complications. Postoperative rehabilitation is crucial for regaining joint function and muscle strength. Long-term prognosis is generally good; however, it requires appropriate management to avoid complications like joint stiffness and ulnar neuropathy. A comprehensive approach encompassing diagnosis, deformity correction, and rehabilitation is essential for achieving optimal functional outcomes.
A Literature Review: Management of Paralysis and Prevention of Acute Respiratory Failure in Guillain-Barré Syndrome Ahmad Sa'Bi Al Qindi; Cantika Brilliant Senna; Muhammad Hilmy As Shiddiq; Moh. Rizky Yolanda B.S; Yasmin Sabrina Zulkifli; Prima Belia
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.12588

Abstract

Guillain-Barré Syndrome (GBS) is an acute immune-mediated disorder of the peripheral nervous system characterized by progressive muscle weakness and paralysis. In severe cases, respiratory muscle involvement may lead to acute respiratory failure, which remains one of the leading causes of morbidity and mortality in patients with GBS. This literature review aims to discuss the pathophysiology, clinical manifestations, diagnostic approaches, management of paralysis, and strategies for preventing acute respiratory failure in Guillain-Barré Syndrome. A literature review was conducted by analyzing scientific journal articles, textbooks, and international clinical guidelines retrieved from electronic databases. The findings indicate that GBS is the most common cause of acute non-traumatic flaccid paralysis worldwide and is frequently preceded by an infectious illness. Diagnosis is primarily established based on clinical features and supported by cerebrospinal fluid analysis and electrodiagnostic studies, with diagnostic certainty commonly assessed using the Brighton Collaboration Criteria and clinical evaluation guided by the National Institute of Neurological Disorders and Stroke (NINDS) criteria. Respiratory complications occur in approximately 20–30% of patients and often require intensive monitoring and mechanical ventilation. Early recognition of respiratory muscle weakness through serial assessment of respiratory function, prompt airway management, and timely ventilatory support are essential to prevent acute respiratory failure and improve clinical outcomes. A multidisciplinary approach involving neurologists, intensivists, pulmonologists, rehabilitation specialists, and nursing teams is crucial for reducing morbidity and mortality associated with GBS.
Co-Authors Ahmad Sa'Bi Al Qindi Ajmala, Indana Eva Arif Zuhan Athalia, Ihza Namira Atriska Citra Muliana Aulia Putri Mussyafa Aulia, Rashieka Salma Baik Nilawati Astini Baiq Merna Merta Sari Bambang Priyanto Cantika Brilliant Senna Fahmi Yahya Fathoroni Fathoroni G. Gunawan Gantha Narendra Josafat Gunawan Gunawan Hamsu Kadriyan I Nyoman Yudayana Indratama Ihza Namira Athalia Ihza Namira Athalia Ilmiah, Janiya Abdila Ima Arum Lestarini Imey Pinasty Harianto Putri Imey Pinasty Harianto Putri Imran Imran Indratama, I Nyoman Yudayana Janiya Abdila Ilmiah Josafat, Gantha Narendra Lalu Hizrian Zikri Hamdi Lovy Herayanti Luthfiya Nur Fadhila Marisa Syavitri Dilaga Mertasari, Baiq Merna Moh. Rizky Yolanda B.S Muhammad Fathir Rahadian Ansary Muhammad Rifki Muliana, Atriska Citra Muthia Cenderadewi Ni Made Yeni Suranti Ni Made Yeni Suranti Novia Andansari Putri Restuningdyah Nurhidayati Nurhidayati Prasetya, Rangga Cahya Prima Belia Putri, Imey Pinasty Harianto Rahmatullah Rahmatullah Rangga Cahya Prasetya Rashieka Salma Aulia Restuningdyah, Novia Andansari Putri Sari, Baiq Merna Merta Shafitri, Shira Shalsabina Shira Shalsabina Shafitri Siti Raodatul Jannah Tunairin Yasmin Sabrina Zulkifli