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Antihyperglycemic Activity of Aqueous Extract of Insulin Leaves (Tithonia diversifolia) on Hyperglycemic Rats (Rattus norvegicus) Sari, Anisa Rachma; Saraswati, Tyas Rini; Yuniwarti, Enny Yusuf Wachidah
Biosaintifika: Journal of Biology & Biology Education Vol 10, No 3 (2018): December 2018
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (283.849 KB) | DOI: 10.15294/biosaintifika.v10i3.15845

Abstract

Insulin leave (Tithonia diversifolia (Hemsl.) A. Gray) empirically used by people as antihyperglycemic drugs. The study was aimed to evaluate antihyperglycemic activity as well as to determine the most optimum dose of T. diversifolia to reduce blood glucose levels. Hyperglycemic condition was induced to male Rattus norvegicus rats by intraperitoneal injection of alloxan at a dose of 150 mg/kg bw (body weight). In this study, completely randomized design was performed with three treatment groups and five times repetition. Group P1 received glibenclamide 10 mg/kg bw, P2 received aqueous extract of T. diversifolia at a dose of 150 mg/kg bw, P3 received aqueous extract of T. diversifolia at a dose of 300 mg/kg bw. Administration of both glibenclamide and aqueous extract of T. diversifolia was conducted orally for 28 days. Data were analyzed using Anova and Duncan’s test with 95% confidence level (α = 0.05). The results showed that the mean percentage of decrease in blood glucose levels, drink intake and body weight of all treatment groups were not significantly different (p>0.05). Data of feed intake showed that P1 was significantly different from P2 (p<0.05), but P2 was not significantly different from P3 (p>0.05). Based on the result of this research, it was found that the low doses of aqueous extract of T. diversifolia has the same ability to decrease blood glucose level compared to glibenclamide. Futhermore, this study provide some information that can be used as preclinical analysis to determine effective doses of aqueous extract of T. diversifolia to decrease blood glucose levels.  
PRODUKSI SELULASE OLEH KAPANG Aspergillus sp. HASIL ISOLASI DARI LIMBAH PENGOLAHAN SAGU (Metroxylon sp.) DENGAN VARIASI KONSENTRASI INOKULUM PADA FERMENTASI TERENDAM STATIS Anisa Rachma Sari; Endang Kusdiyantini; MG Isworo Rukmi
Jurnal Akademika Biologi Vol. 6 No. 1 Januari 2017
Publisher : Departemen Biologi, Fakultas Sains dan Matematika Undip

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.841 KB)

Abstract

Sago processing waste is one of agro-industry waste, which contains cellulose 19,55% and lignin 25%. Genus Aspergillus has been widely known as cellulase-producing fungi. Isolation of Aspergillus from sago processing waste is expected to get a potential isolates indegenous cellulolytic fungi. Cellulase (EC 3.2.1.4) is an enzyme that can break down cellulose into glucose monomer form, with consists of three components that work in synergy are endoglucanase, eksoglucanase and β-glucoside. This study aims to obtain isolates of Aspergillus sp. cellulolitic potential from sago processing waste and cellulase production of the cellulolytic isolates in various concentrations of inoculum. The study was conducted using completely randomized design (CRD) 1 factor of 4 levels of inoculum concentration treatments were 0%, 2,5%; 5%; and 10% with three replications. The observed variables are biomass, CMCase activity and FPase activity. Data were analyzed by ANOVA with a significance level 95%. The result of isolation, two isolates of Aspergillus namely A. flavus and A. paradoxus with cellulolitic index respectively 2,63 and 2,06. Cellulase activity isolate of A. flavus either endoglucanase (CMCase) or total cellulase (FPase) are not affected by the concentration of inoculum.Keywords: cellulase, sago waste, Aspergillus, inoculum
Potensi Ekstrak Daun Insulin (Tithonia diversifolia (Hemsl.) A. Gray) Terhadap Profil Kadar Glukosa Darah, Kadar Malondialdehid dan Histologi Islet Langerhans Pankreas Tikus Putih (Rattus norvegicus L.) Hiperglikemik Anisa Rachma Sari; Tyas Rini Saraswati; Enny Yusuf Wachidah Yuniwarti
Jurnal Teknologi Pangan dan Hasil Pertanian Vol 16, No 1 (2021): Februari
Publisher : Faculty of Agricultural Technology, Universitas Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26623/jtphp.v16i1.4403

Abstract

Diabetes mellitus is a degenerative disease with high risk. This disease can be caused by an increase in free radicals in the body. Free radicals in the body can be detected by testing malondialdehyde levels. The increase in free radicals can cause damage to the pancreatic islet Langerhans so that insulin ability is reduced. The reduced ability of insulin causes hyperglycemic conditions, which are the first symptoms of DM. The use of medicinal plants is widely used by the community as an alternative treatment for this disease. The insulin leaf plant (Tithonia diversifolia) is empirically used by the public as an antihyperglycemic drug. The aim of this study was to examine the ability of insulin and glibenclamide leaf extracts to reduce the level of free radicals in hyperglycemic conditions and to describe their ability to repair Langerhans islets damaged by toxic substances so that the blood glucose levels of hyperglycemic rats could return to normal. Hyperglycemic rats were obtained by injecting alloxan monohydrate at a dose of 150 mg/ BW of rats into male Rattus norvegicus intraperitoneally. This study used a completely randomized design (CRD), with four treatments with five replications each, namely group P1 as control mice, group P2 as hyperglycemic rats given 10 mg/ BW dose of glibenclamide/day, group P3 as hyperglycemic rats. who were given insulin leaf extract at a dose of 150 mg/ BW rats /day and group P4 as hyperglycemic rats who were given insulin leaf extract at a dose of 300 mg/ BW rats /day. The results showed that the administration of insulin leaf extract at a dose of 300 mg/ BW for rats/day was able to make blood glucose levels significantly different, but the malondialdehyde levels were not significantly different than control rats. In addition, administration of insulin leaf extract at a dose of 300 mg/ BW rats/day to hyperglycemic rats was also able to improve the condition of the Langerhans pancreatic islet towards conditions like control rats. The improvement in the condition of Langerhans pancreatic islet is indicated by the cell nucleus that is colored dark blue with more regular shapes.
Karakteristik Fisikokimia Dan Organoleptik Fruit Leather Semangka Kuning (Citrullus Lanatus) Dengan Variasi Konsentrasi CMC Ika Fitriana; Soraya Kusuma Putri; Anisa Rachma Sari
Jurnal Teknologi Pangan dan Hasil Pertanian Vol 16, No 1 (2021): Februari
Publisher : Faculty of Agricultural Technology, Universitas Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26623/jtphp.v16i1.3498

Abstract

Semangka (Citrullus lanatus) merupakan buah yang disukai oleh sebagian masyarakat Indonesia karena rasanya yang manis dan segar serta banyak mengandung air. Fruit  leather  dapat dijadikan alternatif olahan pangan yang memiliki daya simpan tinggi (hingga 12 bulan). Produk ini dibuat dari bahan dasar buah, dengan bentuk hancuran buah (puree) yang sudah dikeringkan dalam oven. Pembuatan fruit  leather  dari semangka perlu dilakukan penambahan zat penstabil karena berguna untuk meningkatkan tingkat viskositas, mencegah terjadinya sineresis serta untuk memberi rasa manis. Carboxyl methyl cellulose (CMC) merupakan zat penstabil yang biasa digunakan dalam produk makanan atau minuman yang berasal dari buah-buahan. Metode penelitian yang digunakan adalah rancangan acak kelompok (RAK) satu faktorial yaitu kadar CMC dengan 5 level (0,5%; 0,75%; 1%; 1,25%; 1,5%). Masing-masing perlakuan dilakukan pengulangan sebanyak 4 kali. Hasil dari penelitian menunjukkan perbedaan konsentrasi CMC akan menghasilkan perbedaan pada beberapa parameter seperti:  Viskositas fruit  leather  yaitu berkisar antara 11461,33-3984,67 Cp, kadar air  yaitu 16,45-21, 23%bb dan tensile   strength  yaitu  1,26-2,76.  Hasil skoring dari analisa sensori menunjukkan warna fruit  leather  semangka adalah kuning, tekstur pada tiga sampel terasa lunak, satu sampel terasa agak lunak serta satu sampel lainnya terasa keras. Penilaian skoring terhadap rasa fruit leather semangka menunjukkan tiga sampel terasa manis dan dua sampel terasa kurang manis. Secara keseluruhan pada hasil tingkat kesukaan menunjukkan panelis suka terhadap 3 sampel yang diujikan, dan merasa kurang suka terhadap 2 sampel yang diujikan. Kesimpulan dari penelitian ini adalah penambahan konsentrasi CMC  dalam pembuatan fruit  leather  dari semangka kuning akan meningkatkan viskositas, kadar air, dan tensile   strength  dari produk, serta pada uji sensori menunjukkan sampel dengan konsentrasi CMC 0,75% memiliki tingkat tekstur, rasa dan kesukaan yang tinggi.
PENINGKATAN KETERAMPILAN TEKNOLOGI PEMBUATAN TELUR ASIN REMPAH BAGI SISWA SMA SULTAN AGUNG 3 SEMARANG Anisa Rachma Sari; C. Hari Wibowo; Ika Fitriana
Jurnal Pasopati : Pengabdian Masyarakat dan Inovasi Pengembangan Teknologi Vol 4, No 1 (2022)
Publisher : Fakultas Teknik Universitas Diponegoro

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Abstract

Karakteristik rasa yang lezat dan ketersediannya yang melimpah membuat telur disukai sebagian besar masyarakat, akan tetapi telur mudah rusak saat disimpan. Telur asin merupakan upaya dalam meningkatkan daya simpannya, namun penilaian terhadap telur asin yang ada dianggap kurang variatif dan tidak mengikuti selera konsumen. Oleh karena itu perlu diciptakan produk diversifikasi telur asin. Kegiatan pengabdian masyarakat ini bermitra dengan 11 siswa-siswi kelas XI IPS 2 SMA Sultan Agung 3 Semarang. Tujuan dari kegiatan adalah memberikan informasi dan keterampilan pada siswa-siswi dalam pembuatan telur asin yang lebih bervariasi yaitu telur asin rempah. Metode yang digunakan terdiri dari beberapa tahapan yaitu: pembagian kuisioner, penyuluhan materi, praktik pembuatan telur asin rempah,serta  monitoring dan evaluasi. Dari kegiatan tersebut terjadi peningkatan tingkat pengetahuan siswa sebesar 53% (dari 20% menjadi 73%) dan penurunan tingkat ketidaktahuan siswa sebesar 26% (dari 53% menjadi 27%), siswa mendapatkan keterampilan dalam pembuatan telur asin rempah serta hasil penilaian organoleptik secara umum menunjukkan telur asin rempah yang berasal dari telur bebek lebih disukai daripada yang berasal dari telur ayam .Kata Kunci : organoleptik; pengetahuan; telur ayam, telur bebek
Pengaruh Lama Pencelupan Pada Larutan Ozon Terhadap Sifat Fisik dan Biokimia Daun Cincau Hijau (Cyclea barbata) Selama Penyimpanan Ika Fitriana; Anisa Rachma Sari
Cannarium Vol 19, No 2 (2021)
Publisher : Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (225.828 KB) | DOI: 10.33387/cannarium.v19i2.4224

Abstract

Cincau hijau merupakan salah satu komoditi yang banyak dimanfaatkan daunnya karena mengandung banyak nilai gizi, tetapi mudah mengalami kerusakan. Air yang mengandung gas ozon dapat digunakan untuk memperpanjang umur simpan tanaman karena tidak meninggalkan residu, tidak mengubah warna, aroma serta tidak menguraikan senyawa organik dalam bahan pangan. Tujuan dari penelitian adalah untuk mengetahui pengaruh lama pencelupan larutan ozon terhadap sifat fisik dan biokimia daun cincau hijau selama penyimpanan. Bahan utama dalam penelitian ini adalah daun cincau hijau kultivar arthaloka dan air minum merk BIRU, sedangkan alat yang digunakan adalah mesin ozon tipe DTM Sterilizer tipe KX919. Tahapan penelitan terdiri: persiapan daun cincau dan larutan ozon, pencelupan kedalam larutan ozon dan pengujian sifat fisik (warna dan tekstur) serta sifat biokimiawi (total padatan terlarut dan total asam). Metode penelitian adalah RAL sederhana dengan perlakuan berupa waktu pencelupan pada larutan ozon dengan pengulangan sebanyak 4 kali. Hasil penelitan menunjukkan waktu pencelupan pada larutan ozon selama penyimpanan berpengaruh nyata terhadap sifat fisik warna, akan tetapi tidak berpengaruh nyata terhadap tekstur dari daun cincau hijau. Sifat biokimiawi berupa total padatan terlarut dan total asam dari daun cincau hijau berpengaruh nyata akibat waktu pencelupan pada larutan ozon selama penyimpanan. Keywords: larutan ozon, tekstur, total asam, total padatan terlarut, warna
Strategic Choice Development Using SWOT Analysis: Diversification Strategy of Batik Creative Industry in Blora, Indonesia Widjajanti, Kesi; Sugiyanto, Eviatiwi Kusumaningtyas; Widyaevan, Dea Aulia; Sari, Anisa Rachma
Journal of Economic Education Vol 12 No 1 (2023): June 2023
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jeec.v12i1.76455

Abstract

Diversification is a strategic choice to improve company competitiveness sustainably. This paper explores strategies and suggests a suitable diversification strategy for micro, small, and medium enterprises (MSME) on a theoretical concentration and resource-based view.. Blora batik creative industry in Central Java, Indonesia, is selected as a case study. We use descriptive analytic derived from quantitative SWOT framework by combining matrix from Internal Factor Analysis (IFAS) and External Factor Analysis (EFAS). We collect data from field surveys and study literature. Respondents are selected purposively based on a result from a focus group discussion (FGD). This paper finds that Blora batik has both positive IFAS and EFAS scores, 0.42 and 0,26, respectively. These indicate Blora Batik has a strong positional value in "quadrant I", which means this industry has suitable strength to exploit opportunities.. Diversification strategy options proposed in this research can help owners and managers of micro, small and medium enterprises to expand the diversity of their markets and products. This study can also be used as a consideration for the government in implementing policies to empower the Batik creative economy through the MSME diversification strategy
How an Effective Strategy For Implementing Ecopreneurship in Batik MSMEs? Analythical Hierarchy Process Approach Widjajanti, Kesi; Sugiyanto, Eviatiwi Kusumaningtyas; Widyaevan, Dea Aulia; Sari, Anisa Rachma
Journal of Economic Education Vol 13 No 1 (2024): June 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jeec.v13i1.73438

Abstract

This study aims to formulate an effective strategy for implementing ecopreneurship in batik MSMEs. The sampling technique used purposive sampling to ensure that the selected samples have a direct relationship with ecopreneurship practices. Key respondents include MSME owners, environmental experts, academics, and policy makers in the MSME sector. Data collection was carried out through structured interviews, questionnaires, and documentation studies. The questionnaire was designed to evaluate the priorities of respondents. The results of the study indicate that the first priority strategy alternative in the strategy for implementing ecopreneurship in batik MSMEs is the substitution of synthetic dyes for natural dyes with a local weight of 0.60 and a global weight of 0.24. This shows the urgency to reduce environmental impacts through the use of environmentally friendly raw materials. The development of recycled raw materials and the processing of liquid waste into new products are ranked second because of the relevance of both in supporting efficiency and sustainability
Phytochemical Characteristics of Microencapsulated Purple Sweet Potato (Ipomoea batatas L.) Antin 3 Variety with Chitosan and Alginate putri, Aldila; Sari, Anisa Rachma; Azkia, Mita Nurul
Journal of Food and Agricultural Product Vol. 5 No. 1 (2025): JFAP
Publisher : Fakultas Pertanian Universitas Veteran Bangun Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32585/jfap.v5i1.6288

Abstract

Microencapsulation is one of the techniques used to protect and increase the stability of bioactive compounds contained in natural materials, such as purple sweet potato. Purple sweet potato variety Antin 3 contains various phytochemical compounds that have potential as a source of antioxidants, but these compounds are easily degraded by external factors. This study aims to evaluate the differences in phytochemical characteristics of microencapsulated purple sweet potato variety Antin 3 with chitosan and alginate dressing materials. Microencapsulation was done using spray drying method and characterization was done by measuring total phenol content, antioxidant activity, and anthocyanin. The research method used is an experimental method with a randomized block design (RBD) consisting of one factor, namely the difference in coating materials: chitosan and alginate. The results showed significant differences in phytochemical characteristics between the two coating materials, where alginate produced microencapsulation with higher levels of anthocyanin and total phenolic phenol compounds. However, results encapsulated with chitosan showed higher antioxidant activity although not significantly different. Alginate microencapsules also had smaller and more uniform particle size. These findings may provide further information regarding the choice of coating materials in the development of more stable and effective purple sweet potato-based products. Keywords: microencapsulation of phytochemicals, bioactive stability, characterization of phenolic compounds
Drying kinetics and thermal energy evaluation of Moringa oleifera leaves drying using dehumidification with zeolite Siqhny, Zulhaq Dahri; Sari, Anisa Rachma; Utari, Febiani Dwi; Djaeni, Mohamad
Journal of Bioresources and Environmental Sciences Vol 3, No 1 (2024): April 2024
Publisher : BIORE Scientia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61435/jbes.2024.19811

Abstract

Moringa Oleifera leaves contain many phytochemical compounds, as the potential source of antioxidants. The leaves must be converted into dried form to extend the shelf life and prevent the nutritional qualities. The lack of a common sun-drying process for Moringa Oleifera leaves is dependent on the weather. But using convective dryers also requires high investment costs and results in very low energy efficiency. One potential option to enhance energy efficiency is lowering the humidity by dehumidification with zeolite. This research aims to evaluate the effect of drying temperature and the weight of adsorbent (zeolite) on drying kinetic and thermal efficiency of Moringa Oleifera leaves drying. Moringa Oleifera leaves were dried under different drying temperatures (30-70℃) and weight of zeolite (0-0.3 kg). The moisture content of Moringa Oleifera leaves and the input-output temperature was recorded to evaluate the moisture reduction and thermal efficiency. Results showed that the Page model can be used to predict the drying time. At the higher drying temperature and higher zeolite weight, moisture reduction and thermal efficiency increased. But the effect of zeolite is only significant in drying at temperatures below 50℃.