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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) CALYPTRA : Jurnal Ilmiah Mahasiswa Universitas Surabaya Jurnal Farmasi Klinik Indonesia MPI (Media Pharmaceutica Indonesiana) Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Surya Medika Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) Journal Community Service Consortium Borneo Journal of Pharmacy Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Anita Purnamayanti
Fakultas Farmasi Universitas Surabaya, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Pengaruh Jenis dan Dosis Vaksin Covid-19 Terhadap Kejadian Ikutan Pasca Imunisasi di Puskesmas Poncokusumo Kabupaten Malang Yuliastuti, Reny; Purnamayanti, Anita; Kirtishanti, Aguslina
Journal of Islamic Pharmacy Vol 8, No 2 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i2.23684

Abstract

Terdapat beberapa jenis vaksin Covid-19 yang telah diberikan untuk mencegah infeksi SARS-CoV-2, namun perlu dilengkapi dengan data keamanan pada subjek Indonesia. Tujuan penelitian ini untuk menganalisis Kejadian Ikutan Pasca Imunisasi (KIPI) vaksin COVID-19 pada subjek yang diimunisasi di Puskesmas Poncokusumo Kabupaten Malang. Jenis vaksin yang digunakan yaitu CoronaVac, Pfizer, Astra Zeneca, dan Moderna. Data diperoleh dari aplikasi P-care, kuisioner, dan wawancara. Desain penelitian adalah potong lintang. Subjek penelitian usia > 15 tahun, yang telah menerima vaksin hingga dosis ketiga (booster). Kriteria eksklusi penelitian adalah wanita hamil dan menyusui. Total sampel penelitian ini adalah 315 orang dengan karakteristik responden adalah laki-laki (34,96%) dan perempuan (65,08%). CoronaVac paling banyak digunakan pada pemberian dosis pertama dan kedua, sedangkan Astra Zeneca paling banyak digunakan sebagai booster. KIPI yang terbanyak terjadi adalah pada dosis ketiga berupa nyeri tempat injeksi dan demam. Hasil uji regresi linear berganda yaitu (a) uji T parsial menunjukkan bahwa terdapat perbedaan bermakna (p=0,004) angka kejadian KIPI pada dosis vaksin pertama, kedua, dan ketiga (booster), namun jenis vaksin tidak berdampak pada angka kejadian KIPI (p=0,492); serta (b) uji F simultan menunjukkan bahwa terdapat pengaruh pemberian jenis dan dosis vaksin secara simultan terhadap angka kejadian KIPI (p=0.013). Dapat disimpulkan bahwa jenis dan dosis vaksin secara bersama-sama mempengaruhi angka kejadian KIPI (p=0.013).
The Potential Application of Clitoria ternatea for Cancer Treatment Purnamayanti, Anita; Budipramana, Krisyanti; Gondokesumo, Marisca Evalina
Pharmaceutical Sciences and Research Vol. 9, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The Clitoria ternatea flower, known as bunga telang in Indonesia, is commonly mixed with food and beverages to provide a natural blue colour. Aside from its popular culinary use, it is a traditional medicine in Indonesia for diseases in the eyes, urinary tract and skin, as well as functioning as an anti-toxin. Furthermore, recent advances in science and technology have revealed that the C. ternatea flower contains a high level of polyphenol compounds that possess anticancer activity, including saponins, tannins, steroids, triterpenoids, kaempferol, and quercetin. This review aims to identify and analyse recent articles regarding the phytochemical activities of C. ternatea flower extract as an anticancer agent. The literature on main databases from 2011 to 2021 was searched systematically using the keywords “Anticancer activity of Clitorea ternatea” and “Phytochemical activities of Clitorea ternatea flower extract against cancer cells”. The various extracts of C. ternatea flower display a moderate cytotoxic, IC50 = 21 µg/mL - 200 µg/mL, for many cancer cell lines, such as MCF-7, MDA-MB-231, CaoV-3, HEp-G2 in aquadest extract and the DLA cell line in petroleum ether extract. The bioactive compounds responsible for the anticancer effect include ternatins, delphinidin, kaempferol, quercetin, sitosterol, and tocopherols. In addition, there have been no reports of any toxic effect on normal cells (Hs27) and oral consumption in mice. According to many studies, the extract is active on multi-molecular targets, with the most conclusive effect on polymerase enzymes, whose inhibition can be an important therapeutic strategy to treat hyperproliferation in cell cancer. Therefore, the findings suggest a potential application of C. ternatea for cancer treatment.
EFEKTIVITAS DAN KEAMANAN TERAPI NATRIUM DIKLOFENAK DAN PIROKSIKAM PADA PASIEN OSTEOARTHRITIS DI PUSKESMAS KOTA SURABAYA: PERBANDINGAN EFEKTIVITAS DAN KEAMANAN NATRIUM DIKLOFENAK DAN PIROKSIKAM PADA PASIEN OSTEOARTHRITIS Selly Septi Fandinata; Anita Purnamayanti; Primanitha Ria Utami
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.392

Abstract

Osteoarthritis (OA) is a disorder affecting the diarthrodial joints that support the skeletal system and the axial causing joint symptoms. The effectiveness of NSAID pain therapy in osteoarthritis often results in inadequate response and prolonged use can cause unexpected side effects. The therapy offered is diclofenac sodium and piroxicam. This research used the design of Quasy Experimental Design type Non Equivalent Control Group Design. The research was conducted at Puskesmas Tenggilis Surabaya. The outcomes measured as the intensity of pre and post treatment pain, Drug Side Effects on pre and post-treatment kidney function, and side effects on pre and post-treatment blood pressure. The study sampled 42 patients consisting of 20 patients (piroxicam group) and 22 patients (sodium diclofenac group). There was a significant difference with the intensity of the pain scale in both post groups (p= 0.001). There were no significant differences in average creatinine and BUN in the post treatment of pyroclacycam group and post treatment group sodium diclofenac (p = 0.772) and (p = 0.801). This study shows that the piroxicam group is more effective in reducing the pain scale than sodium diclofenac and both groups have not been shown to be safety in renal function (Creatinine and BUN)
Upaya Peningkatan Pengetahuan Lansia Tentang Penggunaan Produk Obat Herbal di Kecamatan Kalirungkut, Surabaya, Jawa Timur Gondokesumo, Marisca Evalina; Purnamayanti, Anita
Journal Community Service Consortium Vol 2 No 1 (2021): Journal Community Service Consortium
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/consortium.v2i1.3290

Abstract

Indonesia merupakan negara yang memiliki banyak sumber daya tanaman yang dapat digunakan sebgai sumber bahan obat. Penggunaan obat herbal di Indonesia telah mencapai tahap industri sehingga banyak ditemukan produk obat herbal beredar di masyarakat. Namun. literasi masyarakat mengenai produk obat herbal ini masih tergolong rendah. Oleh karena itu, diperlukan upaya untuk meningkatkan literasi masyarakat akan penggunaan produk obat herbal. Pengabdian pada masyarakat ini bertujuan untuk meningkatkan level pengetahuan dan sikap lansia mengenai penggunaan obat herbal. Pengabdian dilakukan di 3 Posyandu Lansia (POSLA) di daerah Kecamatan Kalirungkut, Surabaya, Jawa Timur. Penyampaian materi juga dibantu dengan inforgrafis dalam bentuk kalender meja. Pelatihan dilakukan melelui tiga tahap yaitu, 1) tahap sosilalisai; 2) tahap pelaksanaan; dan 3) tahap monitoring dan evaluasi. Peningkatan pengetahuan lansia diukur menggunakan metode one group post-test and pre-test. Hasil pengabdian menunjukkan bahwa terdapat peningkatan yang signifikan (wilcoxon test, P>0.05) pada semua aspek penilaian meliputi aspek legal produk herbal, tanggal kadaluarsa dan tanggal pembuatan kroduk herbal, enggolongan dan pelabelan produk obat herbal tradisional, serta nteraksi obat tradisional dengan obat sintetis atau makanan/minuman pasca diberikan pernyuluhan Penyuluhan yang dilakukan juga efektif dalam merubah perilaku masyarakat terkait penggunaan produk obat herbal.
Analisis Efektivitas Pengikat Fosfat Tablet Kalsium Karbonat yang Dikunyah Dibandingkan yang Ditelan Utuh pada Pasien Penyakit Ginjal Kronis Dengan atau Tanpa Gangguan Saluran Cerna Prawesti, Galuh Nawang; Yogiantoro, R. Moh.; Widodo, Gunawan; Purnamayanti, Anita
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 1 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2009

Abstract

Chronic Kidney Disease (CKD) patient with Mineral and Bone Disorder complication have to chew calcium carbonate tablet as a phosphate binder, but infact, patient swallow it in a whole. Gastrointestinal (GI) disorders can affect the efficacy of medicine. This study aims to analyze the effectiveness comparation of chewed and whole swallowed calcium carbonate tablet in CKD patients with or without gastrointestinal disorders. This prospective quasi experimental study with non-inferiority design was conducted on May 28th to August 22nd 2012, with 22 sample (stage 3-5 CKD), 14 men, 8 women, divided into 4 groups (1st: patients with GI disorder and whole swallowed calcium carbonate, 2nd: with GI disorders and chewed tablet, 3rd: without GI disorders and whole swallowed tablet, 4th group: without GI disorders and chewed tablet, all tablet are used with meal). Before and after the 6th week research period, calcium and phosphate blood levels measurements had been taken, adherence had been measured every two weeks using the Morisky questionnaire and pill count. The results showed that there was no significant difference in the increased of calcium levels, except for group 1 compared to group 3 (p = 0.027), the decreased phosphate levels (p = 0.724; 0.089; 0.089; 0.414; 0.569; 1.000) and the value of the product calcium-phosphate (p = 1.000; 0.308; 0.186; 0.414; 0.425; 0.728). The conclusion is that the way to use the medicine and the states of gastrointestinal disorders did not significantly influence the effectiveness of calcium carbonate tablet.
Pemantauan Terapi Obat pada Kasus Penyakit Ginjal Kronis dengan Hipertensi: Drug Therapy Monitoring of Cronic Kidney Disease with Hypertension Dewi, Vira Chandra; Kirthisanti, Aguslina; Purnamayanti, Anita
Jurnal Surya Medika (JSM) Vol. 10 No. 1 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i1.6746

Abstract

Gangguan ginjal meningkatkan risiko toksisitas bagi tubuh; oleh karena itu diperlukan pemantauan terapi obat (PTO). Penelitian observasional dengan arah pengambilan data secara retrospektif ini merupakan studi pendahuluan yang bertujuan untuk menganalisis rasionalitas, efektivitas, dan keamanan terapi obat pada penderita gangguan ginjal dengan hipertensi. Parameter penelitian meliputi (i) rasional jika pemilihan obat sesuai dengan formularium nasional dan pustaka; (ii) efektif bila respon terapi membaik, dan (iii) aman apabila tidak timbul efek samping. Usia subjek ≥18 tahun dengan eGFR <90 ml/ menit/ 1.73 m yang dirawat inap >24 jam pada periode 01 Oktober 2022 – 31 Oktober 2023 di RSAL dr. Midiyato Suratani Tanjungpinang. Subjek hamil, kondisi kritis, dan gangguan jiwa dikeluarkan dari penelitian. Dari 40 subjek, 93.7% gangguan ginjal stage 5. Pemilihan terapi sesuai standar 100%. Respon terapi adalah 57,2% eGFR dan klinis membaik, 21,4% memburuk, 7,1 % memburuk lalu membaik, dan 14,3% hanya terdapat eGFR awal, namun klinis membaik. Antihipertensi terbanyak adalah kombinasi Candesartan-Bisoprolol-Amlodipin-Furosemid. Tidak terdapat catatan efek samping obat pada rekam medis seluruh subjek, namun tidak dapat dipastikan karena arah pengambilan data retrospektif. Hasil PTO disimpulkan relatif rasional, efektif dan aman.
Hypoxia-inducible Factor-2α Probably Mediated the Toxicities of Intravenous Beta-Cyclodextrin in Normal and Diabetic Rats’ Kidneys Anita Purnamayanti; Suharjono; Mahardian Rahmadi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.372-381

Abstract

Background: Intravenous β-cyclodextrin administration poses an increased risk of toxicity. Objective: This study aimed to determine the nephrotoxicity of intravenous beta-cyclodextrin (BCD) and its underlying molecular mechanism. Methods: Sixteen Wistar rats were randomly assigned to the healthy or diabetic test group, which received a daily intravenous injection of water for injection or a 6% beta-cyclodextrin solution, respectively, for 28 days. Histopathology was analyzed semi-quantitatively on a 0-5 score basis, and RT-PCR was used to quantify the mRNA expression of HIF-1, HIF-2, IL-1, IL-6, IL-18, and eNOS. Results: There were no deaths in any of the groups, and renal function declined in the test groups. Histopathological findings revealed abnormalities in vascular integrity, cellular infiltration/damage, and necrosis in the kidney, while the relative expression of mRNA for hypoxia-inducible factors (HIFs), a marker of regional renal hypoxia, was upregulated. Conclusion:  Intravenous administration of beta-cyclodextrin increases the risk of nephrotoxicity, and the molecular mechanisms underlying kidney injury are probably mediated by hypoxia inducible factors-2α (HIF-2α). We strongly suggest that future research should be conducted with an adequate sample size.
Optimization of ADMET Properties Prediction for Remdesivir, Favipiravir, and their Metabolites Elimination Profiles Purnamayanti, Anita; Suharjono, Suharjono; Rahmadi, Mahardian
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.8464

Abstract

In silico methods have become crucial for the rapid preliminary assessment of drug compound absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties, particularly for vital antivirals such as remdesivir and favipiravir, early in the drug development process. This study aimed to predict the pharmacokinetic profiles of remdesivir, favipiravir, and their respective metabolites, explicitly focusing on their interactions within the unique anatomy and physiology of human elimination organs. Compound summaries from PubChem were computationally analyzed using the pkCSM, ProTox-II, and ADMETLab 3.0 platforms. These predictions were then critically evaluated in the context of established hepatic and renal elimination mechanisms. Favipiravir and its metabolites generally exhibited a favorable ADMET profile, characterized by good oral absorption, wide distribution, efficient metabolism, and rapid excretion, albeit with a slight potential for blood-brain barrier penetration. In contrast, remdesivir, its nucleotide metabolite, and favipiravir showed the highest predicted likelihood of inducing hepatotoxicity. Concerning renal toxicity, remdesivir, remdesivir monophosphate, and the active triphosphate forms of both remdesivir and favipiravir presented a notable risk. This elevated renal risk was primarily attributed to their predicted low renal clearances, potentially resulting from insufficient penetration across the negatively charged glomerular filtration barrier. In conclusion, favipiravir and its metabolites demonstrated a more desirable ADMET profile than remdesivir. These preliminary findings suggest a differential safety and pharmacokinetic landscape between the two antiviral agents. Future research should prioritize leveraging advanced AI-based ADMET platforms to simulate complex human organ functions more accurately, refining these predictive models, and guiding subsequent in vivo investigations.
Co-Authors Abdul Rahem Abdul Rahem Abdul Rahem Adria Rusli Agnes Nuniek Winantari Aguslina Kirtishanti Aguslina Kirtishanti Agustina Fitri Ariyani Agustinus Santoso Arlina Fauziah Arlina Fauziah Budi Santoso Budipramana, Krisyanti Burhan Burhan, Hesti Trisnianti Burhan Dewi Santosaningsih Etik Suryanti Farid Zulkarnain Nur Syah Gunawan Widodo Hastutik Cairn Brisbane I Wayan L.D. Purnamahardika Ida Diana Jamilah Jamilah Kirthisanti, Aguslina Laeliyatun Ikrimah Mahardian Rahmadi Marisca Evalina Gondokesumo, Marisca Evalina Memy Aviatin Nani Parfati nurul latifah Prawesti, Galuh Nawang Prawesti, Galuh Nawang Primanitha Ria Utami Rasyidin Rumlus Rella Indah Karunia Rhatna Dewi Riptasari Rika Yulia Rosamarlina Rosamarlina Septi Fandinata, Selly Soufia Ardiani Suharjono Suharjono, Suharjono Suti Aminah Thomas E. C. J. Huwae Tri Setyowati Vina Martasaphira Vira Chandra Dewi, Vira Chandra Widodo, Gunawan Widodo, Gunawan Wijaya Kartanegara Yogiantoro, R. Moh. Yogiantoro, R. Moh. Yuliastuti, Reny