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Jurnal Ilmiah Kedokteran Wijaya Kusuma
Published by Universitas Wijaya Kusuma Surabaya
ISSN : 19782071     EISSN : 25805967     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.
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Articles 390 Documents
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Effectiveness of the Combination of Facial Acupressure and Honey on Facial Skin Moisture Ayly Soekanto; Putu Oky Ari Tania; Andra Agnez Al Aska; Hardiyono Hardiyono
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 2 (2024): September 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i2.3783

Abstract

Background: Facial skin is the most sensitive part, so it is important to take care of it. Facial skin care is a treatment to keep facial skin elastic and maintain facial skin moisture. Facial acupressure is a method of treatment that begins with massaging the meridian points so that blood flow becomes smooth and facial muscles feel more relaxed. Using honey is a facial skin care method that is made into a mask. Objective: The research aims to determine the effectiveness of the combination of facial acupressure and honey on facial skin moisture. Methods: This research is an analytical experimental study, with a sample of 30 women aged 40 - 50 years. In the first treatment, a moisture test was carried out, followed by the second treatment, the moisture test was measured for the facial acupressure and after the third treatment, the combination of the facial acupressure with a honey mask was subjected to a moisture test.  The research was carried out twice a week for 4 weeks for a total of 8 times. The research was carried out in April – May 2024 at the Wijaya Surabaya clinic & in a doctor's practice and used a Skin Moisture Analyzer as a measuring tool to measure skin moisture. Using statistical analysis with the Mann-Whitney test (α= 0.05) with a p-value of 0.000. Result: The results of the third treatment showed an increase in facial skin moisture until it reached 93.4%, including moist skin and 6.6%, which was considered normal skin criteria. Conclusion: It has been proven that the combination of facial acupressure and honey is effective on facial skin moisture, experiencing very significant changes in humidity starting from the first, second and third treatments.
The Association Between Knowledge of Hypertension and Compliance with Antihypertensive Medication on Prospective Hajj Pilgrims Riskiyah Riskiyah; Ermin Rachmawati; Amalia Nur Aisa
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 2 (2024): September 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i2.3440

Abstract

Background: Indonesia is the most significant contributor to Hajj pilgrims, with health risks that are still relatively high, one of which is Hypertension. Lack of knowledge about Hypertension is an obstacle to controlling Hypertension. In addition, half of hypertension-related deaths could be prevented by compliance with taking antihypertensive medication. Objective: This study sought to determine the association between prospective Hajj pilgrims' compliance with medication and their knowledge of hypertension in 2023 who suffer from Hypertension in Batu City. Method: The research used quantitative methods with a cross-sectional design. The sample for this research was 39 Prospective Hajj pilgrims, and total sampling was taken. Result: The results of the study on Prospective Hajj pilgrims who suffer from Hypertension in Batu City showed that the majority of their knowledge about Hypertension was in a good category, 23 people (59.0%), the level of compliance with taking medication was in the low sort 24 people (61.5%); There was no correlation between medication adherence and knowledge of hypertension (p-value 0.185). Conclusion: Non-compliance with taking medication prospective Hajj pilgrims in Batu City can be changed by regularly providing education about the importance of taking medication and the risks that can arise if they do not regularly take hypertension medication
Nicotine in Vapor Exposure Decreases Hippocampal Neurons in Rats Indrayani, Tsaniya Ahda; Hamidah Ikhwan, Salma Nur; Handayani, Ety Sari; Kuswati, Kuswati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 2 (2024): September 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i2.3948

Abstract

Background: Recently, many people have considered electronic cigarettes to be a safer alternative to conventional tobacco cigarettes, even though they still contain harmful substances such as nicotine, which is associated with a decrease in hippocampal neurons. Objective: This study aimed to examine the effect of exposure to e-cigarettes on hippocampal neurons in rats. Methods: An experimental study was performed using 26 tissue samples obtained from Wistar rats. The rats were randomly assigned to four groups and treated over an eight-week period as follows: the control group (K) (n=7) had no vapor exposure; the V0 group (n=6) received vapor without nicotine (0 mg/ml); the V6 group (n=7) was exposed to vapor and 6 mg/ml nicotine; and the V12 group (n=6) was exposed to vapor and 12 mg/ml nicotine. Hippocampal neurons were examined using hematoxylin-eosin staining at 400x magnification across 7 fields of view. Data were analyzed using the Kruskal-Wallis test with the Mann-Whitney post-hoc.  Results: The number of hippocampal neurons was significantly reduced in both the V12 and V0 groups compared to that in the control group (p<0.05). The lowest number of hippocampal neurons was observed in the V0 group (0 mg/ml nicotine), followed by the V12 group (12 mg/ml), and then the V6 group (6 mg/ml).Conclusion: The present study showed that the variation of nicotine in vapor exposure decreases hippocampal neurons in rats.
The Effectiveness of 4% Niacinamide in A Case of Cutaneous Lupus Anggun Putri Yuniaswan; Belladikna Brillianty Sugiatno
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 2 (2024): September 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i2.3592

Abstract

Background: Niacinamide, also called nicotinamide, is the active form of niacin (nicotinic acid, vitamin B3). Niacinamide’s role in medicine continues to be studied due to its extensive effects and low toxicity. Various studies also suggest that niacinamide offers anti-inflammatory effects, improves the skin barrier, and acts as an anti-aging, brightening, and anticancer agent. Cutaneous lupus (CL) is a general term for a group of autoimmune connective tissue disorders affecting the skin that may be associated with systemic lupus erythematosus (SLE). There are plenty of treatment modalities for patients with CL, each with varying efficacy. Therapeutic options for CL can range from topical agents, including corticosteroids and calcineurin inhibitors, to systemic therapy, such as antimalarials, immunosuppressants, retinoids, thalidomide, and biological agents. Niacinamide is a topical agent widely used in various cases, one of which is CL. Objective: This case report aims to discuss the effectiveness of niacinamide as an adjuvant therapy in CL. Case Presentation: A 48-year-old woman with SLE and CL received systemic therapy consisting of methylprednisolone, hydroxychloroquine, and 4% niacinamide gel for 8 weeks. Results: Observations showed clinical improvement in CL lesions without any significant side effects. Conclusion: Therefore, 4% niacinamide gel therapy can be used as an adjuvant therapy.
Terror Death of Election Officials: What Are the Effects of Stress and Hypoxia?: A Literature Review Arif Rahman Nurdianto; Achmad Nurdin Himawan; Anis Dwi Anita Rini; Anita Devi; Hisnindarsyah Hisnindarsyah; Fery Setiawan; Rizal Fauzi Nurdianto
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 2 (2024): September 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i2.3853

Abstract

Background: This essay examines the most recent news, namely the passing of a voting committee member (PPS) in the general election (Pemilu), which included candidates for president, vice president, and legislature (Caleg). PPS saw 35 fatalities and 3.909 illnesses. Given that the counting and recapitulation process is still in progress, the likelihood of deaths and illnesses will only rise. Objective: The aim of this research is to find the relationship between hypoxia and stress in PPS officers who died due to physical exhaustion during election activities in Indonesia Methods: Articles containing information on hypoxia, comorbidity, stress, physical exhaustion, and its connection to death were included as inclusion criteria. There was a total of 25 papers that met the inclusion criteria after the literature analysis procedure was completed. Result: Along with the comorbid status, physical exhaustion, and stress play a significant part (comorbidities). This connection arises from the fact that physical exhaustion and stress induce hypoxia, which in turn affects immunity. The drop in blood oxygen levels, or hypoxia, disrupts and dysregulates the innate and adaptive immune systems. The chance of dying can rise when hypoxia and ongoing stress are present. Writing this paper proposes more investigation into the role that hypoxia and stress play as death risk factors. Conclusion: Hypoxia results from stress. what makes HIF the primary transcription factor active. When PPS officers activate their HIF in order to fulfill their mandate and fulfill their obligations under Law Number 7 of 2017 concerning General Elections, there is an elevated risk of death and morbidity.
Methicillin-Resistant Staphylococcus aureus Secondary Infection as a Comorbid in Crusted Scabies Patient Anggun Putri Yuniaswan; Arista Putri Rakhmana Sari
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 2 (2024): September 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i2.3630

Abstract

Introduction: Crusted scabies (CS) is characterized by uncontrolled proliferation of mites up to thousands. Complications include glomerulonephritis, rheumatic fever, and secondary infection which can cause bacteremia and sepsis. This case report describes a case of CS that was hospitalized with secondary complications of MRSA infection. Case Presentation: A 44-year-old woman complained of thick scales and itching all over her body for 6 months. Complaints begin with reddish bumps between the fingers, toes, body, genitals, and scalp, accompanied by itching, especially at night. The patient took self-purchased corticosteroids for this complaint for 6 months. Dermatology status all over the body showed erythematous papules plaques with greenish-yellow scales, blackish crusts, hyperkeratosis, and excoriation, also erythematous base erosions and blackish crusts in the right thoracic region. Ectoparasite scrapping examination showed large amounts of Sarcoptes scabiei, eggs, and scybala, so the patient was diagnosed with Crusted scabies. A wound culture and nasal swab showed MRSA. The patient died of septic shock on day 12 of treatment. Discussion: Crusted scabies is a highly contagious form of scabies, characterized by thickening of the skin layer and crusts. Long-term corticosteroid consumption in this case caused a compromised immune response so that the number of mites multiplied rapidly and increased the risk of MRSA infection. MRSA mortality rates range from 5-60%. Conclusion: Ignored cases of scabies can develop into crusted scabies which have a high risk of secondary infection, such as MRSA which can cause serious morbidity and even mortality.
Relationship between Lipid and Blood Glucose Levels with Stroke Risk in Dupak Surabaya Olivia Herliani; Chenny Andriani Wiyono; Noer Kumala Indahsari
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 2 (2024): September 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i2.3750

Abstract

Background: Stroke is a syndrome characterized by rapidly developing symptoms and/or clinical signs in the form of focal or global brain functional disorders lasting more than 24 hours which are not caused by causes other than vascular. Stroke is the number one cause of disability and the main cause of death in Indonesia (19.42% of total deaths). Dyslipidemia and diabetes mellitus are two-fold risk factors for stroke.This research is to determine the relationship between lipids and blood glucose and a high risk of stroke. Methods: This research uses descriptive analytical methods with a cross sectional approach. The population is residents in Dupak Surabaya. The sampling method is random sampling technique. The total research sample was 53 participants. The statistical test used is Chi Square. Result: Statistical results show that there is no relationship between high cholesterol levels and the risk of stroke and there is a relationship between high triglyceride and blood sugar levels and the risk of stroke.Conclusion:This research concluded that there was a significant relationship between high levels of triglycerides and blood glucose and the risk of stroke and there was no significant relationship between high cholesterol levels and the risk of stroke. This lack of significant association could be due to the heterogeneous population and the presence of previous anti-cholesterol medication.
Metagenomic Analysis of Intestinal Microbiota Derived from Stool Samples of Third-Trimester Pregnant Women Mudyawati Kamaruddin; Miftahul Khairiyah Zamzam; Rahadian Pratama; AbdurRahman Shakhr Nur; Cut Muthiadin; Christine Sembiring; Nurhidayat Triananinsi; Nurisyah Nurisyah; Ratnasari Dewi; Fatmawati Fatmawati; Erniawati Erniawati; Jusni Jusni; Basmiati Basmiati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4173

Abstract

Background: The human gut microbiota plays a unique role in metabolism, immunity, and nutrient absorption.  Various studies on the gut microbiota have identified a link between changes in bacterial abundance in the gut known as dysbiosis (imbalance) and the pathogenesis of certain disorders. It is known that an imbalance in the ratio of the phyla Firmicutes and Bacteroidetes has been associated with various chronic diseases, including inflammatory bowel disease and metabolic disorders. The Firmicutes/Bacteroidetes (F/B) ratio is a measure used to assess gut microbiota composition, which is believed to play a significant role in intestinal health and metabolism. Studies suggest that a higher F/B ratio is often associated with obesity and other metabolic conditions. Objective: This study aims to carry out metagenomic analysis of third-trimester pregnant women's faecal samples to predict degenerative diseases using third-generation whole genome sequencing, namely PromethION nanopore technology.  Method: Nanopore Technology: DNA sequencing of faecal samples from pregnant women in the third trimester was performed using the Oxford Nanopore Technology (ONT) device based on the Ligation Sequencing gDNA - Native Barcoding Kit 24 V14 and following its guidelines. Result: Based on the quality and quantity of total DNA reads from 20 stool samples from pregnant women, only 4 samples were continued for analysis (1A, 2A, 3A and 4A). The results of the abundance of intestinal microbiota based on the most abundant phylum are Proteobacteria, Bacteriodetes, and Firmicutes. Conclusion: Meanwhile, based on species abundance, it shows that Prevotella copri (phylum Bacteriodetes) is abundant in samples 2A, 3A and 4A, while in sample 1A the most abundant species is Succinivirio dextrinosolvens (phylum Proteobacteria). Bacteroidetes are a group of Gram-negative bacteria that are often found to increase in individuals with type 2 diabetes and obesity
Threshold Value of Blood Procalcitonin for the Diagnosis of Bacterial Meningitis in Children : A Systematic Review Fransiska Christela; Benedicta .; Christopher .
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.3957

Abstract

Introduction: Bacterial meningitis has a high mortality rate in children. Bacterial meningitis is diagnosed through medical history, physical and laboratory examinations, and mainly cerebrospinal fluid analysis through lumbar puncture (LP). The procedure on children might be challenging due to the multiple adverse effects; not all children comply with the procedure. There are studies with different blood biomarkers for the diagnosis because it is simple and less invasive in children. Objective: This review focused on the blood Procalcitonin (PCT) threshold value as a promising blood biomarker that might be useful for diagnosing bacterial meningitis in children. Methods: Literature search across 3 databases, Scopus, PubMed, and ScienceDirect, used PICO framework to structure the search, following the PRISMA standards. Of 759 articles, 11 articles met the criteria inclusion: children with meningitis under 18 years old, shows procalcitonin cut-off value and have lumbar puncture performed, sensitivity and specificity reported, in English. Exclusion criteria:  studies of systematic reviews, meta-analyses, and literature reviews, as well as the value of blood procalcitonin as part of a scoring system or machine learning model.Results: The analysis of 11 articles reveals a blood PCT cut-off value of 0.2 to 10 ng/ml, with sensitivity ranging from 24% to 100% and specificity ranging from 63% to 94%. Conclusions: Blood PCT helps diagnose bacterial meningitis, especially for children who are not eligible for LP procedures. The blood PCT levels between 0.2 and 5 ng/mL showed a sensitivity of over 85%. The cut-off value with 100% sensitivity was found to be 2 ng/mL. A cut-off value exceeding 5 ng/mL demonstrated a specificity of over 90%.
Correlation of Serum 25(OH) Vitamin D Levels With TNF-α and Caspase Levels in Sjögren’s Syndrome Patients Agus Joko Susanto; Agus Jati Sunggoro; Fatna Andika Wati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4136

Abstract

Background: Vitamin D deficiency is known to cause changes in disease pathogenesis in primary Sjögren's syndrome related to its immunological effects. Objective: This study aims to determine the correlation between serum 25(OH) vitamin D levels and TNF-α and caspase levels in Sjögren's syndrome patients. Methods: This study was a cross-sectional study involving 34 Sjögren's syndrome patients aged 18-59 years with vitamin D deficiency/insufficiency and measured levels of TNF-α and caspase. Result: The correlation between 25(OH) vitamin D levels and caspase levels obtained a value of r=-0.581, which means that there is a negative correlation in the moderate category (r=0.400-0.599) between 25(OH) vitamin D levels and caspase levels, and the p-value =<0.001 (p-value<0.05). The correlation between 25(OH) vitamin D levels and TNF-α levels obtained a value of r=-0.436, which means that there is a negative correlation in the moderate category (r=0.400-0.599) between 25(OH) vitamin D levels and a decrease in TNF-α, and p-value =<0.001 (p-value<0.05). Conclusion: There was a significant negative relationship between 25(OH) vitamin D levels and TNF-α and caspase levels.

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