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Florentinus Dika Octa Riswanto
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Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 13 Documents
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Search results for , issue "Vol 21, No 2 (2024)" : 13 Documents clear
A Network Pharmacology Analysis of Secondary Metabolites of Noni (Morinda citrifolia) as Immunomodulators Helmi, M.; Jamil, Ahmad Shobrun; Muchlisin, M. Artabah; Almuhtarihan, Irsan Fahmi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006183

Abstract

Immunomodulators are substances or compounds that can modulate or help increase the activity and function of the immune system. The medicinal use of herbal plants is now increasing again among Indonesian people. Noni (Morinda citrifolia) is a plant commonly found in Indonesia that has long been known to have many benefits for treating and preventing various diseases and the secondary metabolites have potential as immunomodulators. This study aimed to determine the protein network associated with the body's immune system, which was activated by the administration of noni. The explorative descriptive research was conducted with in silico analysis using a computational model with software, including KNApSAck, Dr. Duke, Pubchem, Swiss ADME, Swiss Target Prediction, Gene Cards, Venny, STRING, and KEGG. Based on the results of pharmacological network analysis, noni contains 128 secondary metabolites, and 83 of them have high bioavailability. Based on pharmacological network analysis, (z,z,z)-8,11,14-eicosatrienoic-acid and 1-5-6-trihydroxy-anthraquinone are important compounds that play a role in the immune system because they are expected to interact with five crucial pathways related to immunomodulators.
Antioxidant and Antiaging Activity of Ethanolic Extract of Red Beetroot (Beta vulgaris L.): An In Vitro Study Winanta, Aji; Saffriza, Maitsa Via
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004722

Abstract

Aging is a process of gradual changes in the skin caused by intrinsic and extrinsic factors. Intrinsic and extrinsic aging is the effect of increasing the reactive oxygen species (ROS) produced by cells resulting in cell damage. The use of natural materials has expanded for skin damage therapy, one of which is the utilization of red beetroot (Beta vulgaris L.). This study aims to discover the antioxidant and antiaging activity of Beta vulgaris L. in vitro. The process begins with the extraction of the maceration method using 70% ethanol as a solvent followed by identification of secondary metabolite compounds by phytochemical screening. Antioxidant activity test used the DPPH method with quercetin as a comparison. Antiaging activity testing was conducted in vitro with cell viability test using Human Dermal Fibroblast adult (HDF-a) by MTT Assay and the inhibitory effect of skin degradation enzymes (antiaging) was carried out with elastase using Human Neutrophil Elastase (HNE). The result of phytochemical screening tests showed Beta vulgaris L. contains alkaloids, saponins, and triterpenoid compounds. Red beetroot extract has weak antioxidant activity with IC50 of 3284.42 μg/mL. Antiaging activity testing showed that the extract can maintain cell viability and has the inhibitory activity of the enzyme elastase. This study concludes that red beetroot extract (Beta vulgaris L.) has potential as a cosmetic active ingredient for antiaging.
Stability Model Prediction Using the Response Surface Approach to Assess the Outcomes of Vitamin B12 Injection Post-Market Sampling Yulia, Yulia; Yuliani, Sri Hartati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007779

Abstract

B12 injections are one of the most widely used vitamins in Indonesia. The nature of vitamin B12, which is easily degraded by environmental factors, has been widely reported. This research aimed to determine the effect of stability optimization model predictions with post-market sampling of vitamin B12 injection preparations by considering the variables of temperature, humidity, and distribution time. Factorial design was used to determine the stability optimization model. Validation of the analysis method using ultraviolet (UV) spectrophotometry showed valid results for testing. Stable product outcomes were seen during the research period based on the results of post-market sampling, optimization of stability conditions by evaluating pH parameters, and content determination. Post-market sampling data showed a pH decrease of 3.46% in the Palembang distribution area and an increase in pH of 4.54% and 5.33% in the Cirebon and Denpasar distribution areas. In the Palembang distribution area, the content of cyanocobalamin decreased by 0.90%, while in the Cirebon distribution area, it decreased by 0.94%. A paired t test for statistical analysis was used to determine the significance of the model. The results obtained show that there was no significant difference between the prediction model and the results of post-market sampling (p-values of 0.065 and 0.491) or H0 received
Gastroprotective Potential of Hantap Leaves (Sterculia coccinea Jack) Extract in Stress-Induced Gastric Ulcers of Male White Rats Yuliet, Yuliet -; Khaerati, Khildah; Lokong, Gladies Melinda
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006398

Abstract

Stomach ulcer is a prevalent digestive problem that can lead to serious complications such as bleeding in the digestive tract, perforation, recurrence, cancer, and even death. One of its potential remedies lies in the antioxidant compounds contained in hantap leaves. Accordingly, this study aimed to investigate the anti-gastric ulcer effects of hantap leaf extract in white male rats induced by water immersion and cold-resistant stress methods. Hantap leaf extract (EEDH) was obtained by maceration using 96% ethanol, resulting in a yield of 7.8%. The results of gastric macroscopic observations based on percentage of ulcer inhibition showed that EEDH doses of 50, 100, and 200 mg/kg BW did not have a significant difference (p0.05) with ranitidine, exhibiting the same gastroprotective effects. An increase in the dose does not lead to a corresponding rise in the gastroprotective effect. Therefore, 50 mg/kg BW of EEDH was considered to be the optimum dose.
Antihyperlipidemic Effectivity of Sweet Orange Peel Extract (Citrus sinensis) on Triglyceride Levels in Male Mice (Mus musculus) Induced by High Cholesterol Lumbantoruan, Ellya Catharine Romanna Aprilya; Zakiah, Mistika; Fahrurroji, Andhi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005944

Abstract

Hyperlipidemia is a significant risk factor for atherosclerosis in arteries and cardiovascular disease, especially coronary heart disease (CHD), the leading cause of global mortality. Treatment of hyperlipidemia can be done through chemical treatment. However, statins have potentially dangerous side effects such as myopathy and rhabdomyolysis, so a therapeutic solution with minimal toxicity is needed. One of the potential treatments is Citrus sinensis orange peel, which contains antihyperlipidemic bioactive compounds, namely hesperidin, and naringenin. The aim of this research is to determine the effectivity of sweet orange peel extract (Citrus sinensis) on high cholesterol-induced male mice (Mus musculus) triglyceride levels. Citrus sinensis orange peel was extracted by maceration method using 50% ethanol as solvent. Lipid profile measurements were performed three times using the GPO-PAP method. The concentration of orange peel extract in the treatment group (P1, P2, P3) was 10%, 5%, and 1%. The positive control received 40 mg atorvastatin treatment, the negative control received 1% CMC Na, and the control received abnormal treatment. Antihyperlipidemic therapy with Citrus sinensis sweet orange peel extract has a strong relationship/influence on triglyceride levels in mice. Sweet orange peel extract (Citrus sinensis) has antihyperlipidemic effectiveness in reducing blood triglyceride levels in mice (Mus musculus) induced by high cholesterol. The effective dose is 1% dose.
Exposure of Histone Deacetylase-2 Inhibitor Curcumin and Its Analogues in Self-Nano Emulsifying Drug Delivery System Change Memory and Cognitive Function, Anxiety, and Social Interaction Behavior in Mouse Yuniarti, Nunung; Wulandari, Febri; Azizah, Ulfah Laily; Anas, Yance; Murwanti, Retno
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009660

Abstract

Class 1 and 2 histone deacetylase inhibitors (HDACI) have been reported as novel therapeutic approaches to treat neurodegenerative disorders, depression, anxiety, and cognitive deficits. HDACI ameliorated deficits in cognition and stress-related behaviors in a wide range of neurologic and psychiatric disorders. Preclinically, behavioral bioassay can be used to predict the influence of new compounds for treatment of these illnesses. Curcumin and its new analogues PGV-0 and PGV-1 have been reported to inhibit HDAC2. However, reports regarding the effect of curcumin and its analogues on memory and cognitive function, anxiety, and social interaction behavior are as yet to be examined. Mice were divided into control and treated groups. Brain disorder was induced by oral administration of 10% ethanol in sodium-CMC for 7 days. Curcumin, PGV-0, PGV-1, and sodium butyrate (as positive control) were then given orally once a day for 21 days. The behavior tests of social interaction, open field, radial 8-arm-maze, and passive avoidance were performed on day 29. To increase dissolution and bioavailability of the compounds, they were formulated in a self-nano emulsifying drug delivery system (SNEDDS). Brains were isolated and analyzed using PCR to investigate the expression of genes related to neurobehavioral disorders hdac2, trkB, and bdnf. In different doses, curcumin, PGV-0, and PGV-1 increased social interaction capability, declined anxiety level, and improved long-term memory and cognitive function. The mechanism proposed is: HDACI curcumin and its analogues (PGV-0 and PGV-1) that keep the histone protein in acetylation state increase bdnf expression. The increased trkB expression is increasing the activation of the bdnf gene because trkB is the primary receptor of bdnf that supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses. Thus, those mechanisms could improve long-term memory and cognitive function, increase social interaction, and reduce anxiety in ethanol-induced mice with brain disorders.
Nanostructured Lipid Carrier (NLC) as a Topical Drug Delivery System : A Review Latifah, Luluk; Hendradi, Esti; Isadiartuti, Dewi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006789

Abstract

Nanostructured Lipid Carrier (NLC) appears as the next generation of lipid nanoparticles which overcomes the weaknesses of Solid Lipid Nanoparticles (SLN). NLC is a delivery system that offers several advantages, such as significantly improved entrapment efficiency, reduced drug expulsion during long-term storage, and increased contact between the drug and the stratum corneum, thereby enhancing drug penetration. The methods used to manufacture NLC have high energy-required such as high-pressure homogenization and high shear homogenization, low energy-required such as microemulsification and phase inversion, and very low or no energy-required such as solvent evaporation and solvent injection. The basic components of an NLC are solid lipids, liquid lipids, and surfactants or mixtures of surfactants. This narrative review refers to several previously published databases on the types, preparation methods, and physical properties of NLC. This review focuses on descriptions related to the NLC as a topical drug delivery system.
The Immunomodulator Effects of Biosynthetic Nanosilver Based on Immunoglobulin G Level of Mice Induced by Measles Vaccine Compared with Immunostimulant Agent Ermawati, Dian Eka; Nuraini, Putri Indah; Anjani, Niki Putri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005834

Abstract

Inulin is a carbohydrate class contained in gembili tuber (Dioscorea esculenta (Lour.) Burkill) as a source of prebiotics to maintain immunity. Inulin can be used as a nanosilver bioreductor and increase the solubility of gembili's inulin. This study aims to determine the effectiveness of gembili's inulin nanosilver as an immunomodulator based on IgG levels of vaccine-induced Mice. Nanosilver at doses of 2 mg/KgBW, 4 mg/KgBW, 8 mg/KgBW, and 12 mg/KgBW was compared with synthetic immunostimulants to observe the type of immunomodulatory activity. This research was conducted in several stages, including the biosynthesis process, characterization, determination of nanosilver dose, animal conditioning, animal treatments, taking blood from retro-orbital sinuses, and ELISA reader. Blood serum obtained from the animals was analyzed for IgG levels using Mice IgG ELISA Kit and Spectrophotometer UV-VIS. The pH variation test was also conducted in this study which aims to determine the stability of the nanosilver solution at pH 8, 10, and 12. The results of the ELISA reader showed that the dose of 4 mg/KgBW. had the highest Optical Density value compared to other doses. Then, the comparison with synthetic immunostimulants produces p values of 0.13 0.05, which is not significantly different. Nanosilver inulin at 4 mg/KgBW. is the chosen dose as an immunomodulator with immunostimulant activity. The stability results showed that increasing pH changes do not affect the pH change of gembili's inulin nanosilver solution. It is because nanosilver's pH control and adjustment are still in the alkaline range.
The Effect of Adherence to Antihypertensive Therapy and Cardiovascular Risk Among Hypertensive Patients in Purworejo Regency Arwinda, Prili; Virginia, Dita Maria; Hendra, Phebe
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007334

Abstract

Uncontrolled hypertension will increase mortality and morbidity rates. The adherence is an important factor in controlling blood pressure. Uncontrolled blood pressure will affect cardiovascular risk. Therefore, hypertensive patients must comply with taking medication to control blood pressure and cardiovascular risk. This study was an analytical observational study with a cross-sectional design. A total of 85 respondents who met the inclusion criteria were measured for adherence using the MPR (Medication Possession Ratio) method and the MARS-5 (Medication Adherence Report Scale-5) questionnaire.  A patient who had blood pressure 140/90 mmHg was categorized as controlled hypertension. The cardiovascular risk was measured using the ACC/AHA criteria method. Data were analyzed using chi-square tests and odds ratio (OR) with 95% confidence interval (CI) and p0.05 considered significant. This study showed that there was a significant association between adherence to antihypertensive therapy to controlled blood pressure, either according to MPR (OR=18.262; 95%CI=5.259-63.412; p=0.000) and MARS-5 (OR=31.607; 95%CI=8.170-122.277; p=0.000). A significant association was found between antihypertensive adherence and cardiovascular risk, either according to MPR (OR=3.733; 95%CI=1.269-10.983; p=0.020) and MARS-5 (OR=9.000; 95%CI=2.702-29.983; p=0.000). Therefore, this study concludes a significant relationship between antihypertensive adherence to controlled blood pressure and cardiovascular risk in Purworejo Regency.
Cost-Effectiveness of Antithrombotic Agents for STEMI Zulpadly, M Fiqri; Thobari, Jarir At; Dinarti, Lucia Kris
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006073

Abstract

In Indonesia, the prevalence of Acute Coronary Syndrome (ACS) continues to rise annually and remains high. Aspirin and adenosine diphosphate receptor inhibitors are recommended as part of the dual antiplatelet therapy that is recommended by the standard guidelines for managing ACS. Ticagrelor, a new treatment option for ACS, has been made available during the current period of Indonesia's National Health Insurance. Ticagrelor is more effective, but it costs more. Objective: In patients with ST-Elevation Myocardial Infarction (STEMI), the goal of this study was to compare how much ticagrelor and clopidogrel cost when compared to one another with relative ratio (RR) analysis and 95% confidence interval (CI) with p

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