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Rachmat Kosman
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Fakultas Farmasi UMI, Kampus II, Universitas Muslim Indonesia, Jl. Urip Sumohardjo Km.5, Makassar
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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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STUDI IN SILICO SENYAWA AKTIF DARI JAHE (Zingiber officinale) DAN KERSEN (Muntingia calabura L.) SEBAGAI INHIBITOR MAIN PROTEASE (Mpro) DARI SARS-CoV-2 Tahir, Masdiana; Maryam, St.
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1070

Abstract

Coronavirus disease is an infectious disease caused by the SARS-CoV-2 coronavirus, which is an RNA virus consisting of four structural proteins and sixteen non-structural proteins responsible for viral multiplication. One of the proteins is the main protease (Mpro). Inhibition of Mpro is potentially effective as a COVID-19 drug because it will cause the loss of the virus's replication and transcription abilities, so that the virus is unable to survive. The purpose of this study is to determine what chemical compounds in ginger (Zingiber officinale) and kersen (Muntigia calabura) plants have the potential as COVID-19 drugs with the Mpro inhibition mechanism. This research method is in silico using molecular docking method with PyRX software. The results showed that of the 70 chemical compounds from ginger (Zingiber officinale), there are 3 compounds that have potential because they have better activity than the N3 inhibitor comparison ΔG -8.0 kcal/mol, namely Zingiberoside B (-8.6 kcal/mol), Zingiberoside C (-8.5 kcal/mol) and Shogasulfonic acid D (-8.2 kcal/mol). Meanwhile, of the 10 chemical compounds from Jamaica cherry (Muntigia calabura), there are 4 chemical compounds that have potential as Mpro SARS-CoV-2 inhibitors, namely Kempferol 7-(6''-p-coumarylglucoside) or Biondnoid A (-9. 1 kcal/mol), Hiravanone (-8.4 kcal/mol), 5,7,3',4' - Tetrahydroxy - 6, 8 - di - C -prenylflavanone (-8.4 kcal/mol), and Myrtillin (-8.3 kcal/mol).
DAFTAR ISI AS-SYIFAA JURNAL FARMASI 15.2 (2023) ISI, DAFTAR
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1078

Abstract

DAFTAR ISI AS-SYIFAA JURNAL FARMASI 16.1 (2024) ISI, DAFTAR
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1198

Abstract

POTENSI EKSTRAK ETANOL BATANG WOLE WOE ASAL KABUPATEN HALMAHERA TENGAH SEBAGAI ANTIBAKTERI MENGGUNAKAN METODE KLT-BIOAUTOGRAFI Fitriana, Fitriana; Amirah, Sitti; Rahman, Safriani; Rusli, Rusli; Nurung, Ayyub Harly
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1066

Abstract

The development of natural materials both from plants and from other materials as traditional medicines can be done by taking habits from the community in utilizing natural materials empirically. The wole woe plant is one of the plants that comes from the forest and grows wildly and is empirically used as a traditional medicine by the Weda community in Central Halmahera Regency. This study aims to see the chromatogram of wole woe stem extract and the group of chemical components that have potential as antibacterial using KLT-Bioautography method. The results of the chromatogram of the ethanol extract of wole woe stem, obtained 6 spots and there are 2 spots with rf values of 0.65 and 0.09 which have activity against bacteria Staphylococcus aureus, Streptococcus mutans, Bacillus subtilis and Pseudomonas aeruginosa. The results of the identification of chemical components using specific reagents, obtained chemical groups of anthraquinones, flavonoids, phenolics and alkaloids have potential as antibacterial, so that the ethanol extract of wole woe stem has potential as antibacterial.
UJI TOKSISITAS SUBKRONIS EKSTRAK ETANOL DAUN MENGKUDU (Morinda citrifolia L.) DENGAN PENETAPAN KADAR KREATININ DAN BUN TIKUS PUTIH Rahmatudina, Farikha; Harjanti, Reslely; Widyasti, Jena Hayu
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1054

Abstract

The subchronic toxicity test of Noni (Morinda citrifolia L.) ethanol leaf extract have been studied. The purpose of this study was to determine the effect of subchronic toxicity of noni ethanol leaf extract (Morinda citrifolia L.) on increased levels of creatinine and BUN (Blood Urea Nitrogen) of white rats. Noni leaves were extracted by using the maceration method with 96% ethanol dissolution for 3 times 24 hours while occasionally stirring until a thick extract was obtained. Then the blood creatinine and BUN levels were determined before administering the test preparation and on day 28. The research was carried out for 28 days then continued for 14 days for the satellite group. The results of the subchronic toxicity testing that was carried out showed a double increase in creatinine and BUN levels compared to normal values. Noni leaf extract treatment caused an increase in creatinine and BUN levels in the subchronic toxicity test at doses of 250, 500 and 1000 mg/kg BW, and the highest increase in levels occurred in the 1000 mg/kg BW group
ANALISIS NILAI SUN PROTECTION FACTOR EKSTRAK ETANOL DAUN KOPASANDA (Chromolaena odorata L.) MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Rahmawati, Rahmawati; Muflihunna, A.; Ramadani, Aulia
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1096

Abstract

Sunlight contains UV rays which have a negative impact on the skin. These bad impacts can be minimized by using UV protective materials, both natural and synthetic. Kopasanda leaves (Chromolaena odorata L) contain high levels of phenolic compounds, flavonoids and tannins. This research aims to determine the UV protection activity of kopasanda leaves (Chromolaena odorata L) using Sun Protection Factor (SPF) calculations. The SPF value was measured using the UV-VIS spectrophotometry method in the wavelength range 290-320 nm. The results of the research showed that kopasanda leaves (Chromolaena odorata L) had protective activity against UV rays at a 1, 3 and 5% re respectively of 31,794, 32,902 and 33,737 (the SPF value categories are ultra).
AKTIVITAS ANTIBAKTERI FORMULASI KRIM EKSTRAK DAUN JAMBU AIR (Syzygium aqueum) TERHADAP BAKTERI Propionibacterium acnes Suci, Panji Ratih; Hamidah S, Cikra Ikhda Nur; Legowo, Deni Budi; Pangestutik, Zuanta
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1036

Abstract

The skin is the outermost layer or tissue that covers the entire body and protects the body from external threats, especially bacteria that cause acne which is a skin problem because it is caused by gram-positive bacteria, namely Propionibacterium acnes. Guava leaves (Syzygium aqueum) are known to contain flavonoids, tannins, alkaloids, and saponins which have antibacterial effects. This study aims to determine the water guava leaf extract cream and its antibacterial activity against Propionibacterium acnes. This research method is laboratory experimental. Testing the quality of the formulation was carried out by testing the organoletic, spreadability, homogeneity test and PH test. Testing the antibacterial activity using diffusion by measuring the value of the diameter of the zone of inhibition. The results showed that the ethanol extract cream complied with the organoleptic, potency, dispersion, homogeneity and pH tests, and had antibacterial activity with a concentration of 30% with an inhibition zone of 32.2 ± 0.31
SAMPUL AS-SYIFAA JURNAL FARMASI 16.1 (2024) 16.1 (2024), SAMPUL
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1197

Abstract

FORMULASI DAN EVALUASI SIFAT FISIK DARI SEDIAAN FACE WASH YANG MENGANDUNG EKSTRAK AIR BUNGA KESUMBA TURATE (Carthamus tinctorius L). Hamka, Nurhafizah; Hasrawati, Andi; Zulkarnain, Iskandar; Mirawati, Mirawati
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1041

Abstract

Carthamus tinctorius L. has antioxidant activity and contains polyphenols and flavonoids so it can be used for skin care such as face wash. The aim of this research is to formulate and evaluate a face wash preparation from water extract of Carthamus tinctorius L flowers that is physically stable. Carthamus tinctorius L water extract face wash preparations have been made in 4 formulas with different gelling agent variations, namely Carbopol and HPMC with concentrations of 1% and 1.5%. Preparation tests that have been carried out include organoleptic tests, homogeneity tests, pH tests, syneresis tests, viscosity tests, flow properties and stability tests. Research results have shown that Carthamus tinctorius L water extract can be made into a face wash preparation with a thick consistency, odorless and brown in color. The preparation that has been made is homogeneous and has a pH between 3-6. The viscosity ranges from 30.4 – 159.8 P with a plastic flow type with a yield value between 13.5 – 32.9 dyne/cm2. Syneresis tests have shown water loss between 7.13 – 19.7%. The results of the stability test have shown that the formula with gelling agent HPMC at a concentration of 1.5% has pharmaceutical properties that do not change after stress conditions.
ANALISIS BAHAN KIMIA OBAT NATRIUM DIKLOFENAK DALAM SEDIAAN JAMU ASAM URAT YANG BEREDAR DI KOTA TIMIKA Maryam, St.; Suhaenah, Asriani; Rusniyanti, Rusniyanti
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1031

Abstract

Uric acid herbs are an alternative that is still widely used by the community as an anti-inflammatory and pain reliever. The increasing public interest in returning to traditional medicine has prompted several manufacturers to add medicinal chemicals to their preparations to produce a faster and maximum therapeutic effect, one of which is diclofenac sodium. The study aimed to analyze the chemical ingredients of the uric acid herbs circulating in Timika City and to find out the level of diclofenac sodium contained therein. The method used is High Performance Liquid Chromatography (HPLC) with reverse phase, where the mobile phase is methanol: aquabidestilata (80:20) and the stationary phase is column C-18. Based on the test results, nine uric acid herbs showed positive results with retention times at the same value as diclofenac sodium. The content of diclofenac sodium obtained were code A herb of 4.135 mg/L, B herb : 36.300 mg/L, C herb : 18.530 mg/L, herb D : 473.219 mg/L, herb E : 40.991 mg/L, herb F : 77.165 mg/L L, herb G : 93.109 mg/L, herb H : 52.700 mg/L, and herb I : 297.123 mg/L. All herb samples tested were unfit for public use because they contained the chemical drug sodium diclofenac

Page 36 of 40 | Total Record : 397

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