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As-syifaa Jurnal Farmasi
Published by Universitas Muslim Indonesia
ISSN : 20854714     EISSN : 25029444     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 397 Documents
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PROFIL PENGKAJIAN RESEP RACIKAN PEDIATRI PASIEN RAWAT JALAN DI RUMAH SAKIT MUJAISYAH KOTA PALOPO Syamsuddin, Puja; Nurlina, Nurlina; Purnamasari M., Vina
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1142

Abstract

Prescription review is an activity in pharmaceutical services that is used to minimize errors in drug prescribing. This study aims to assess the prescription of pediatric concoctions at Mujaisyah Hospital, Palopo City. This research method is descriptive non-experimental with retrospective data collection. The population in this study were all incoming prescriptions in the pharmaceutical installation of Mujaisyah Hospital, Palopo City for the period January - June 2023 which met the inclusion criteria, namely 115 prescription sheets. The results showed the percentage of completeness of administrative aspects, namely the patient's name and age 100%, gender 0%, weight 73.04%, height 0%, name, address, initials, and doctor's license number 98.26%, prescription date 99.13%, prescription origin unit 98.26%. The suitability of pharmaceutical aspects, namely drug name, dosage form, drug dose, drug amount, rules and method of use 100%, dosage strength 10.43%, incompatibility 29.56%, hygroscopic stable drugs 52.79% and photolysis 47.21%. The suitability of clinical aspects, namely the accuracy of indications and the accuracy of time of use 100%, the accuracy of dosage 86.48%, and drug interactions 50.44%. From the results of this study, it can be concluded that the prescription at Mujaisyah Hospital, Palopo City has not fully complied with Permenkes RI No. 72 of 2016 concerning Pharmaceutical Service Standards in Hospitals
UJI AKTIVITAS ANTIBAKTERI EKSTRAK AIR DAN ETANOL UMBI BAWANG DAYAK (Eleutherine palmifolia (L.) Merr) TERHADAP BAKTERI PENYEBAB INFEKSI SALURAN PENCERNAAN Rusli, Rusli; Nurung, Ayyub Harly; Erwing, Erwing; Massaressung, Andi
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1085

Abstract

Umbi bawang dayak (Eleutherine palmifolia (L.) Merr) is a traditional medicinal plant that has been used empirically to treat dysentery, stomach pain, and cancer. This plant has antimicrobial properties and contains naphthoquinone, alkaloids, flavonoids, saponins, tannins, and steroids. This study aims to assess the antibacterial effectiveness of water and ethanol extracts of umbi bawang dayak against E. coli, S. thypi, V. cholerae, and S. dysentriae. Minimum Inhibitory Concentration and Minimum Bactericidal Concentration values using the agar diffusion method with concentrations ranging from 25.6%, to 0.025% and its bioautgram profile, indicated notable antibacterial activity from both extracts. The MIC and MBC values for the aqueous extract against E. coli, S. thypi, and V. cholerae were at 1.6% concentration, while for S. dysentriae, at 0.8% concentration. The ethanol extract showed MIC values of 1.6% for E. coli, S. thypi, and V. cholerae, with 0.8% for S. dysentriae while MBC was 1.6% against all test bacteria. KLT-Bioautography analysis using n-hexane 4:1 ethyl acetate eluent revealed distinct compound profiles in both extracts, confirming efficient inhibition against the evaluated bacteria. Furthermore, while E. coli, S. thypi, and V. cholerae evidenced consistent MIC values in both extracts, S. dysentriae showcased ethanol extract superior MBC efficacy at 0.8% versus the water extract at 1.6%. Moreover, the ethanol extract demonstrated a richer compound composition with six active spots compared to the three spots apparent in the aqueous extract of umbi bawang dayak (Eleutherine palmifolia (L.) Merr).
UJI EFEK ANTIDIARE EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R Forst & G. Forst) PADA TIKUS PUTIH JANTAN (Rattus novergicus) Santi, Irma; Putra, Bayu; Kosman, Rachmat; Ramadhani, Fitrah Anggun; Hativa, Hativa
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.991

Abstract

Diarrhea is a condition where defecation with a frequency of more than 3 times a day and the consistency of liquid or semi-liquid feces with water content that exceeds normal limits. One plant that is thought to have antidiarrheal effects with tannin content in it is matoa leaves (Pometia pinnata J.R Forst &; G. Forst). This study was conducted experimentally using 25 male white rats induced castor oil (Oleum ricini) as a laxative. After being induced, experimental animals were divided into 5 groups, namely the negative control group (NaCMC), the positive control group (Loperamid), the the ethanol extract of matoa leaves group with doses of 200 mg/KgBB, 400 mg/KgBB, 800 mg/KgBB. All treatments were carried out orally. Then observed the frequency of diarrhea and the consistency of feces every 30 minutes for 5 hours. Furthermore, the results of the study were analyzed statistically using the Kruskal Wallis test then continued with the Post Hoc LSD test. From the results of the study it can be concluded that the ethanol extract of matoa leaves has an antidiarrheal effect on male white rats induced castor oil with an effective dose of 800 mg/KgBB
UJI EFEK KOMBINASI EKSTRAK DAUN ALPUKAT (Persea americana Mill.) DAN DAUN SRIKAYA (Annona squamosa L.) SEBAGAI ANTIOBESITAS PADA TIKUS JANTAN Wati, Aulia; Asmaliani, Ira; Herman, Hendra; Fira, Alfiah
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.975

Abstract

Obesity is a condition where there is a buildup of excess body fat so that a person's weight is far above normal.  This study aims to determine the effectiveness  of the combination of avocado leaf extract (Persea americana Mill. ) and srikaya leaves (Annona squamosa L.) as antiobesity in male rats. This study used 18 mice. Rats were given high-fat carbohydrate feed as much as 25 grams a day for 28 days to get obese conditions, followed by oral trial preparation therapy for 14 days with dose variations, namely group I (negative control), group II (positive control), group III avocado leaf extract 60 mg / kg BB, group IV srikaya leaf extract 125 mg / kg BB,  group V extract combination small dose avocado leaf extract 60 mg/kgBB and srikaya leaf 125 mg/kgBB, and group VI extract combination large dose avocado leaf extract 120 mg/kgBB and srikaya leaf extract 250 mg/kgBB. Measurement  of the  Lee index of  test animals was carried out before induction, after induction and after therapy then continued with surgery to determine the weight of perianal, perirenal, and peritonial fat. The results showed that a combination extract of small doses of avocado leaves 60 mg/kgBB and srikaya leaves 125 mg/kgBB had the most effective effect compared to other treatment groups
EVALUASI WAKTU KONTAK ADSORPSI TIMBAL (Pb) OLEH ADSORBEN DAUN NANAS (Ananas comosus) PADA OLI YANG DIGUNAKAN LANGSUNG Octavia, Rizka; Ramli, Irawati; Kamri, Andi Maulana
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1124

Abstract

Motor vehicle users in Indonesia are among the highest in Southeast Asia. The increase in the population of motor vehicles can lead to increased use of vehicle lubricants. However, it also threatens the environment by leaving lead (Pb) waste on the oil that has been used, which, if not properly managed, can harm the environment. Because used oil contains some heavy metals, one of them is Pb metal, or lead. It's one of the B3 wastes, which is a dangerous and toxic material that will cause pollution in the environment. Using pineapple leaves is one way to handle waste with natural ingredients. The aim of this study was to find out whether the pineapple leaf can adsorb lead metal (Pb) from waste oil and how the contact time of the adsorptive leaf best affects the amount of Pb ions adsorbed into waste oil. The study was conducted using experimental in vitro techniques. The first process in this study was to activate the pineapple leaf with 2% NaOH. Then, the adsorbent from the activated pineapan leaf was linked to the used oil at different times (10, 20, 30, and 40 minutes) to cause the Pb metal adsorption. (timbal). With the cellulose contained in pineapple leaves, heavy metals can be reduced in waste oils through adsorption or absorption processes. Contact time is the component that affects the adsorption process
FORMULASI DAN EVALUASI PASTA GIGI YANG MENGANDUNG EKSTRAK DAUN TEH HIJAU (Camellia sinensis L.) DAN KULIT JERUK KEPROK (Citrus reticulata Blanco.) Hasrawati, A.; Julyani, Sri; Aztriana, Aztriana
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1065

Abstract

Dental caries is one disease that occurs both in children and adults. One of the dental caries pathogenic microbial found in cariogenic biofilm or plaques is Streptococcus mutans. Natural material is one of the alternatives which can be used to treat the disease, some of them are green tea and tangerine peel. Both contain antibacterial active components against the Streptococcus mutans. This research used the ethanol extract of green tea and tangerine peel. Activity test of both extracts showed inhibition on Streptococcus mutans and Porphyromonas gingivalis 1.6%; 3.25% and 6.4% by green extract and 20%, 25% and 30% by tangerine peel. The goal of the research was to formulate the extract ethanol of green tea and tangerine peel into pharmaceutically stable toothpaste. Toothpaste is a semisolid disperse system preparations that contain amounts of insoluble solid. One of the functions of toothpaste is to clean the teeth. Physical stability test has been done to obtain the most optimum preparations. Formulation and evaluation of physical properties including organoleptic, homogeneity, pH measurement, viscosity, foam height and spreadability. Optimation base result showed that 1% Na CMC is the most stable in consistency. The formulation then continued with formulation into preparations and carried out the stability test and physical evaluations. Based on storage condition and physical test results showed that the preparations were stable pharmaceutically.
AKTIVITAS ANTIBAKTERI ISOLAT FUNGI ENDOFIT BIJI LABU KUNING (Cucurbita moschata ex. Poir) Nuryanti, Siska; Fitriana, Fitriana; Ohorella, Fitriah Anggraini
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1069

Abstract

Cucurbita moschata ex. Poir are one of the medicinal plants that have many benefits, including antidiabetic, antifungal, antibacterial, anti-inflammatory, and antioxidant effects. The content of compounds in yellow pumpkin seeds, such as phenols, alkaloids, and triterpenoids, This study aims to isolate endophytic fungi from yellow pumpkin seeds and test the antibacterial activity of isolates of yellow pumpkin bii endophytic fungi using the Agar diffusion method. The results of the isolation of yellow pumpkin seed endophytic fungi obtained 3 isolates, followed by macroscopic examination and fermentation of the 3 isolates with Maltose Yeast Broth (MYB) media and testing antibacterial activity by Agar diffusion method. Based on the results of the study, 3 isolates with the codes IJBL1, IJBL2, and IJBL3 were obtained that have antibacterial potential. The highest inhibitory zone was produced by IJBL3 endophytic fungi isolate with an inhibitory zone diameter of 12.39 mm against Staphylococcus aureus bacteria
EFEK ANALGETIK EKSTRAK AKUADES DAUN MELINJO (Gnetum gnemon L.) PADA MENCIT PUTIH (Mus musculus L.) JANTAN DENGAN METODE INDUKSI ASAM ASETAT 1% Dewi, Evelyne Citra; Sodik, Anwar; Khuluq, Husnul; Intiyani, Rafila
As-Syifaa Jurnal Farmasi Vol 15, No 2 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i2.1055

Abstract

Pain is an unpleasant sensory and emotional feeling, associated with tissue damage. Melinjo leaves (Gnetum gnemon L.) are a plant that is useful as a traditional medicine for reducing and treating diseases, one of which is pain. The use of traditional medicine has fewer side effects than chemical medicine. This study aims to determine the analgesic activity and best dose of melinjo leaf distilled water extract in male white mice induced by 1% acetic acid. This research is experimental research. The subjects of this research were 25 male white mice. Mice were divided into 5 treatment groups with each group consisting of 5 mice. The treatment groups consisted of negative control CMC-Na 1%, positive control, melinjo leaf aqueous extract group at doses of 50, 100, and 150 mg/kgBW. The pain inducer was given 1% acetic acid. Observations were made by observing the movements of mice to calculate the % of analgesic protection. The data that has been obtained is then tested using One Way Anova and Post Hoc LSD or Games-Howell statistical tests. The results obtained by melinjo leaf aqueous extract at a dose of 150 mg/kgBW had the best analgesic effect because it had the largest % protection, namely 66.89%, and provided a significant effect (p<0.05) in mice induced by 1% acetic acid. Melinjo leaf aqueous extract at a dose of 150 mg/kgBW had the best analgesic effect on male white mice which was declared significant (p<0.05) and the mean difference value was greater.
PENGARUH PEMBERIAN EKSTRAK DAUN BIDARA (Zizipus mauritiana Lam.) TERHADAP FUNGSI HATI TIKUS DENGAN PARAMETER SGPT Amirah, Sitti; Rahman, Safriani; Fitriana, Fitriana; Wati, Aulia; Putra, Bayu; Rakhmat, Syahgita; Mustakim, Putri Dwiyanti Adha; Resvani, Syahyu; Hasbullah, Nurhijjah; Arini, Arini
As-Syifaa Jurnal Farmasi Vol 16, No 1 (2024): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v16i1.1127

Abstract

Repeated administration of traditional medicines can be potentially poisonous and damage vital organs such as the heart, lungs, liver and kidneys. Tests of safety need to be carried out. Bidara leaves are used traditionally used as antimicrobial, analgesic, antipyretic, anti-inflammatory, anti-diabetic. This study aims to determine safety of ethanol extract of bidara leaves on liver function. This research used wistar rats as test animals which were divided into 4 groups. Test animals were given ethanol extract of bidara leaves at a dose of 50 mg/kgBW, 500 mg/kgBW and 2000 mg/kgBW given orally for 14 days. SGPT rate checks are carried out before and after administering the extract. The results showed that giving ethanol extract of bidara leaves for 14 days did not have a significant effect on rat SGPT levels (p<0.05).
KANDUNGAN SENYAWA KIMIA DAN AKTIVITAS FARMAKOLOGI TANAMAN MATOA (Pometia Pinnata J.R. Forster & J.G. Forster) Rahmawati, Rahmawati; Tahir, Masdiana; Amir, A. Hesti Wulandasari
As-Syifaa Jurnal Farmasi Vol 13, No 2 (2021): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v13i2.778

Abstract

Island lychee (Pometia pinnata J.R.Forster & J.G.Forster) is a plant species from the Sapidaecae family used as a medical plant that plays a role in healing or improving health condition of the community. This research aimed to determine the content of chemicah compound and pharmacologycal activity of several types of island lychee extract. The review on the study of the chemical content and pharmacologycal activity of island lychee was conducted by searching the literature related to chemical and pharmacologyal review accessed on several journal provide sites (google scholar). Then it was proceeded with screening on these journal to obtain sources that fall with in the inclution criteria. Island lychee has many properties that have been scientifically proven. Several types of the extract are reported to have pharmacologycal activity that can be develop as antioxidans, antibacterials, antimicrobials, antiperusemia, antihyperglycemic/antidiabetic, anticancer and diuretic. The pharmacologycal activity is due to the compound group of alkaloids, flavonoids, phenols, coumarin, polyphenol, saponin, steroids, tannins and terpenoids

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