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Irma Antasionasti
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PS. Farmasi FMIPA Universitas Sam Ratulangi
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Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ
Published by Universitas Sam Ratulangi
ISSN : 26229463     EISSN : 2654640X     DOI : https://doi.org/10.35799/pmj.v4i1
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Medika merupakan jurnal yang diterbitkan oleh PS. Farmasi FMIPA Universitas Sam Ratulangi dengan frekuensi terbit 2 kali dalam setahun di bulan Juni dan Desember. Tujuan pernebitan jurnal ini adalah untuk memberikan sarana bagi para akademisi, peneliti maupun praktisi untuk mempublikasikan artikel penelitian atau telaah artikel. Jurnal ini menyediakan isi yang dapat diakses secara bebas dan terbuka untuk umum sehingga dapat mendukung pertukaran pengetahuan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 98 Documents
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Pengaruh Metode Ekstraksi (Maserasi dan Infusa) terhadap Potensi Antibakteri Ekstrak Daun Nasi (Phrynium pubinerve Blume) dalam Menghambat Pertumbuhan Propionibacterium acnes Sambou, Christel Nataniel; Yudistira, Adithya; Rumondor, Erladys Melindah; Lontaan, Gloria J.; Lumbu, Alisa W. R.; Rolos, Tesalonika N.; Kanter, Yabes
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64402

Abstract

Pencarian alternatif antibakteri berbasis tanaman menjadi krusial seiring dengan meningkatnya resistensi bakteri terhadap antibiotik konvensional, di mana metode ekstraksi merupakan faktor penentu potensi. Penelitian ini bertujuan mengevaluasi dan membandingkan efektivitas metode maserasi dan infusa dalam memperoleh ekstrak Phrynium pubinerve Blume yang aktif melawan Propionibacterium acnes, serta mengidentifikasi metode mana yang paling efektif. Dengan menggunakan metode difusi agar (kertas cakram), diameter zona hambat kedua jenis ekstrak diukur dan diuji secara statistik dengan Uji-t Welch. Hasil Uji-t menunjukkan adanya perbedaan signifikan pada rata-rata zona hambat kedua kelompok. Kesimpulannya, ekstrak Phrynium pubinerve Blume yang dihasilkan dari metode ekstraksi dengan rata-rata zona hambat terbesar yaitu maserasi menjadi metode yang paling efektif dalam aktivitas antibakteri.
Formulasi dan Evaluasi Foot Crack Cream Kombinasi Hyaluronic Acid dan Ekstrak Kunyit (Curcuma longa): Pendekatan Peningkatan Kelembaban Siampa, Jainer Pasca; Datu, Olvie Syenni; Lebang, Julianri Sari
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64663

Abstract

Daily routine activities exposed to sunlight, air pollution, changes in air humidity and ambient temperature, the use of cleansing soap, and even activities using air conditioning can cause a decrease in skin moisture. This study aimed to formulate a foot crack cream preparation using a combination of hyaluronic acid and turmeric extract that met the requirements for physical characterization of the preparation. The formulas to be made were 3 formulas with varying concentrations of turmeric extract combined with hyaluronic acid at a constant concentration. The obtained formulas were then evaluated physically including organoleptic observations, pH measurements, spreadability testing, adhesion testing and emulsion type testing. The results obtained a semi-solid foot crack cream formula, light canary to mustard in color; pH 6; spreadability value of 6.1 cm- 6.5 cm; adhesion of more than 1 second and had an oil-in-water emulsion type. From the results of this study, could be concluded that the obtained foot crack cream preparation formula using a combination of hyaluronic acid and turmeric extract met the requirements for physical characterization of the preparation.
ANALISIS KUALITATIF SENYAWA KATEKIN PADA EKSTRAK KULIT KACANG TANAH KAWANGKOAN YANG BERPOTENSI SEBAGAI ANTIOKSIDAN Antasionasti, Irma; Abdullah, Surya Sumantri; Lestari, Utami Sasmita
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64699

Abstract

Katekin adalah senyawa flavonoid yang memiliki aktivitas antioksidan, antiinflamasi, antikanker, antimikroba, dan antidiabetes. Senyawa ini dapat ditemukan pada kulit kacang tanah. Oleh karena itu, perlu dilakukan uji aktivitas antioksidan dan analisis secara kualitatif senyawa katekin kulit kacang tanah Kawangkoan. Proses ekstraksi menggunakan empat pelarut yaitu etanol, methanol, aseton dan aquades dengan metode maserasi. Pengujian aktivitas antioksidan dilakukan berdasarkan metode 2,2-difenil-1-pikrihidrazil (DPPH) dan Asam 2,2-Azinobis (3-etilbenzatiazolin)-6-sulfonat (ABTS). Analisis kualitatif senyawa katekin dilakukan berdasarkan panjang gelombang maksimum (λmax) pada spektrofotometri UV-Vis menggunakan metode spiking. Berdasarkan hasil penelitian diperoleh rendemen ekstrak aquadest, methanol, etanol, dan aseton secara berturut-turut sebesar 5,75%, 10,56%, 3,46%, dan 3,74%. Aktivitas antioksidan terbesar diberikan oleh ekstrak aseton dengan IC50 sebesar 52,832 ± 2,143 µg/mL untuk uji DPPH dan 22,078 ± 5,690 µg/mL untuk uji ABTS. Hal ini berbanding lurus dengan keberadaan senyawa katekin yang hanya terdapat pada ekstrak aseton yang ditandai dengan 1 puncak pada panjang gelombang maksimum 535 nm. Hal ini menunjukkan bahwa ekstrak aseton kulit kacang tanah kawangkoan memiliki aktivitas antioksidan sangat kuat yang dipengaruhi oleh senyawa katekin.
Physicochemical Profile of Red Ginger (Zingiber officinale) SNEDDS as Potential Antidiabetic Sumantri Abdullah, Surya; Sudewi, Sri; Antasionasti, Irma; Rezky Putri Indarwati Abdullah
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64731

Abstract

This study developed a Self-Nanoemulsifying Drug Delivery System (SNEDDS) of red ginger (Zingiber officinale var. rubrum) to enhance its stability and bioavailability. 8 formulations (F1–F8) were tested with varying Tween 80 : PEG 400 ratios (Smix 4.5 mL). Formula F7 (2.8 : 1.8 mL) produced a water-clear emulsion with pH 5.20 ± 0.02 and excellent stability for 28 days. PSA results showed droplet size 20.33 ± 0.57 nm, PDI 0.430 ± 0.053, and zeta potential −19.58 ± 1.50 mV. These findings indicated that F7 is the optimum, physicochemically stable SNEDDS formulation, potentially improving solubility and oral bioavailability of red ginger’s active compounds as a phytopharmaceutical antidiabetic candidate Keywords: red ginger, SNEDDS, nanoemulsion, physicochemical stability
Studi In Silico Jatropon, Jatropolon A, Jatropolon B, dan Turunan Sebagai Anti Kanker Terhadap Reseptor Bcl-2 Syaifullah, Ramanda R; Sholeh, Muhammad; Azizah, Wafiq; Kasman, Nur F; Nursamsiar; Paluseri, Andi; Lukman
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64761

Abstract

Jatrophone and its congeners jatropholone A and B, have shown potent cytotoxicity by triggering apoptosis through Bcl-2–regulated mechanisms. We evaluated jatrophone, jatropholones A and B and twenty-two related derivatives as Bcl-2–targeting anticancer leads using in silico approaches. Molecular properties and preliminary affinity estimates were obtained with ChemOffice; molecular docking to the Bcl-2 binding site was performed with AutoDock Tools. ADME predictions used PreADMET and toxicity risk assessment applied Toxtree with the Benigni/Bossa rule-base. Twelve compounds violated Lipinski’s rule of five, while thirteen displayed identical amino-acid contacts at the receptor, suggesting a conserved binding mode. Predicted plasma protein binding was high for most derivatives except compounds 20 and 22. Six derivatives were flagged as potentially genotoxic; none were predicted mutagenic. Docking ranked jatropholone A as the top candidate (binding energy −8.67 kcal/mol). These results prioritize jatropholone A for experimental validation as a promising Bcl-2–targeting anticancer agent.
ANALISIS KESESUAIAN BIAYA RIIL DENGAN TARIF INA-CBG’s PASIEN HIPERTENSI RAWAT INAP DI RSUD MITRA SEHAT : Indonesia Tatilu, Joice Ester; Ruindungan, Putrinesia Kinanti; Manawan, Fridly
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64316

Abstract

Despite the government's intensified efforts to implement budget efficiency, Indonesia still faces challenges with the deficit in social security spending for healthcare management. Hypertension is one of the cardiovascular diseases that can lead to complications such as kidney failure, stroke, and coronary heart disease, which can create a domino effect, further inflating the treatment costs for patients. This study aims to determine the magnitude of the difference between actual costs and the INA-CBG’s tariff for inpatient hypertension patients at RSUD MITRA Sehat. This study is an analytical observational study using a cross-sectional approach with purposive sampling. Data on inpatient hypertension patients were obtained retrospectively from the medical records and BPJS claims department of RSUD MITRA Sehat. A total of 42 patients met the inclusion and exclusion criteria and became the study sample. There was a difference of Rp 1,925,000 between the actual costs and the INA-CBG tariff.
ANALISIS KUALITAS PELAYANAN SWAMEDIKASI DI APOTEK WILAYAH KOTA MANADO MENGGUNAKAN PENDEKATAN MYSTERY CUSTOMER Lolo, Widya Astuty; Wiyono, Weny Indayany; Mpila, Deby Afriani; Manawan, Fridly; Tatuh, Heru Andika
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.64900

Abstract

Self-medication is an effort by the community to maintain their own health, which can have both positive and negative effects. This study aims to analyse the quality of self-medication services in Manado City using a mystery customer approach. The study was conducted in 96 pharmacies from March to June 2025 using a cross-sectional design. The subjects of this study consisted of pharmacists, pharmacy vocational workers and pharmacy staff. Based on the results of the study, the highest percentages in the demographic data included pharmacy ownership 73.96% (individual), pharmacy location 30,21% (South Manado), time of visit 60,42% (afternoon or evening), disease cases 16,67% (fever), and service providers 46,88% (pharmacy vocational workers). The highest percentages in patient examination and drug information were for whom the drug was intended (57,29%), rational drug use (68,75%), and instructions for use (59,38%). The lowest percentage related to the information provided was on specific medical conditions, one of which was pregnancy (0%). It can be concluded that the quality of self-medication services at pharmacies in the Manado City area varies, mainly depending on the service provider. Keywords: Self-medication, Mystery customer, Patient assessment, Drug selection, Drug information
Uji Fitokimia Dan Aktivitas Antibakteri Ekstrak Dan Fraksi Daun Suji (Dracaena angustifolia Roxb.) Pada Bakteri Staphylococcus aureus ATCC 25923 suyono saputri, alip desi
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 2 (2025): Jurnal Farmasi Medica
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i2.65891

Abstract

Staphylococcus aureus is the bacteria that causes the most cases of infection in the world. Most infectious disease therapy in Indonesia uses antibiotics. Incorrect use of antibiotics can increase resistance. One of the plants that has the potential as an alternative treatment for infections is suji leaves. The purpose of this study was to determine the potential of suji leaf extract and fraction on antibacterial activity in Staphylococcus aureus ATCC 25923 bacteria. Samples were extracted using the maceration method with 70% ethanol solvent and then fractionated using n-hexane, ethyl acetate, and water solvents. Phytochemical tests were carried out to determine alkaloids, flavonoids, tannins, saponins, polyphenols, triterpenoids and steroids. Antibacterial activity tests of suji leaf extracts and fractions were carried out using the well method at concentrations of 5%, 10%, and 15% respectively with a negative control of 70% ethanol and a positive control of ciprofloxacin. Suji leaf extracts and fractions contain alkaloids, flavonoids, tannins, saponins, steroids, and polyphenols. The extract, n-hexane fraction, and ethyl acetate fraction of suji leaves have antibacterial activity against Staphylococcus aureus ATCC 25923 bacteria. The inhibitory activity against Staphylococcus aureus ATCC 25923 bacteria was greatest in the ethyl acetate fraction at a concentration of 15% with an average inhibition zone of 19.6 mm but was not equivalent to the inhibition of the positive control ciprofloxacin

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