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Disruption of Nutrient Transport, Especially Glucose, in Preeclampsia Triggers Stunted Fetal Growth Pribadi, Adhi
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.1095

Preeclampsia is a relatively common complication in obstetrics. The real problem currently faced is the adverse effects of preeclampsia on the mother and fetus, while the pathophysiology useful for prevention remains unclear. The clinical symptoms and complications that arise are highly variable and ultimately lead to multi-organ failure. This condition results in preeclampsia being one of the three causes of maternal death worldwide, including in Indonesia. The incidence of preeclampsia/eclampsia in various literature and studies ranges from 4to10% of pregnancies.

Correlation between Maternal Lactate Dehydrogenase Levels and APGAR Scores in Preeclampsia Patients at Margono Soekarjo Hospital from 2022–2024 Wicaksono, Bagas Satriyo; Aditiyono, Aditiyono; Susiarno, Hadi; Marlina, Dina; Grazielle, Grazielle
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.1036

Objective: This study aims to investigate the correlation between maternal lactate dehydrogenase (LDH) levels and neonatal APGAR scores in preeclamptic patients.Methods: This is an observational analytic study with a cross-sectional design conducted at Margono Soekarjo Hospital from January 2022 to May 2024, involving 78 women with preeclampsia who underwent cesarean delivery. Participants were categorized into early-onset (<34 weeks) and late-onset (≥34 weeks) preeclampsia groups. LDH levels and APGAR scores were analyzed using Spearman’s correlation and ROC analysis.Results: This study showed that elevated LDH levels were significantly associated with lower one-minute APGAR scores, showing moderate correlations in both groups, and were related to five-minute APGAR scores. The LDH cut-off points predicting poor one-minute APGAR outcomes were 284 IU/L (sensitivity 82.1%, specificity 66.7%) for early-onset and 491.5 IU/L (sensitivity 44.4%, specificity 96.2%) for late-onset preeclampsia.Conclusion: Elevated maternal LDH levels are associated with lower one-minute APGAR scores in preeclamptic patients, especially in early-onset cases, indicating they may serve as an early marker for fetal hypoxia and asphyxia risk. AbstrakTujuan: Penelitian ini bertujuan untuk meneliti hubungan antara kadar laktat dehidrogenase (LDH) maternal dan skor APGAR neonatus pada pasien preeklampsia.Metode: Penelitian ini merupakan studi analitik observasional dengan desain potong lintang yang dilakukan di RSUD Margono Soekarjo pada Januari 2022 hingga Mei 2024, melibatkan 78 wanita dengan preeklampsia yang menjalani persalinan melalui seksio sesarea. Peserta dibagi menjadi dua kelompok, yaitu preeklampsia onset dini (<34 minggu) dan onset lambat (≥34 minggu). Kadar LDH dan skor APGAR dianalisis menggunakan korelasi Spearman dan analisis ROC.Hasil: Hasil penelitian ini menunjukkan bahwa peningkatan kadar LDH berhubungan signifikan dengan skor APGAR satu menit yang lebih rendah, menunjukkan korelasi sedang pada kedua kelompok, serta menandai adanya kaitan dengan skor APGAR lima menit. Titik potong kadar LDH yang memprediksi hasil APGAR satu menit yang buruk adalah 284 IU/L (sensitivitas 82,1%, spesifisitas 66,7%) untuk preeklampsia onset dini dan 491,5 IU/L (sensitivitas 44,4%, spesifisitas 96,2%) untuk onset lambat.Kesimpulan: Kadar LDH maternal yang meningkat berhubungan dengan penurunan skor APGAR satu menit pada pasien preeklampsia, terutama pada kasus onset dini. Hal ini menunjukkan bahwa LDH dapat berfungsi sebagai penanda dini risiko hipoksia dan asfiksia janin.

Gene and Germline Editing in Maternal and Reproductive Health: A Narrative Review of Ethical Dilemmas and Scientific Advances Suhaimi, Donel; Andri, Sofyan; Hutapea, Anastasya; Arihta, Sandi
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.939

Introduction: In Utero Genetic Editing (IUGE) is an emerging technology intended to modify the fetal genome to prevent or treat genetic disorders before birth. While it presents significant medical potential, it raises complex ethical, legal, and regulatory challenges. Current interventions remain largely animal-based, with human applications at theoretical or preclinical stages.Methods: This review examines ethical guidelines, legal frameworks, and regulatory perspectives globally and in Indonesia. Sources included WHO, the Indonesian Obstetrics and Gynecology Association (POGI), Indonesian health laws, and journals such as the American Journal of Obstetrics and Gynecology (AJOG). Literature was drawn from PubMed, WHO databases, Indonesian archives, and AJOG publications (2015–2025).Results: WHO emphasized precaution and transparency, while POGI stressed maternal–fetal safety under strict oversight. Indonesia lacks specific regulation, requiring interventions to respect safety and human dignity. The United States and European Union maintain restrictive regulations, including embryo research bans.Conclusion: IUGE is promising for reproductive health but remains ethically and legally unresolved, requiring clearer frameworks before clinical translation. AbstrakPendahuluan: In Utero Genetic Editing (IUGE) merupakan teknologi baru untuk memodifikasi genom janin guna mencegah atau mengobati kelainan genetik sejak sebelum lahir. Teknologi ini menjanjikan manfaat medis, namun menimbulkan tantangan etik, hukum, dan regulasi. Hingga kini, sebagian besar intervensi masih berbasis penelitian hewan, sementara aplikasi pada manusia berada pada tahap teoritis atau pra-klinis.Metode: Kajian ini menelaah pedoman etik, kerangka hukum, dan regulasi dari perspektif global dan Indonesia. Sumber mencakup WHO, Perkumpulan Obstetri dan Ginekologi Indonesia (POGI), peraturan kesehatan nasional, serta jurnal internasional seperti American Journal of Obstetrics and Gynecology (AJOG). Literatur diperoleh dari PubMed, basis data WHO, arsip hukum Indonesia, dan publikasi AJOG (2015–2025).Hasil: WHO menekankan prinsip kehati-hatian dan transparansi, sementara POGI menegaskan keselamatan ibu–janin dengan pengawasan ketat. Indonesia belum memiliki regulasi khusus, tetapi mensyaratkan intervensi genetik menjaga keselamatan dan martabat manusia. Negara seperti Amerika Serikat dan Uni Eropa menetapkan aturan restriktif, termasuk larangan riset embrio.Kesimpulan: IUGE berpotensi meningkatkan kesehatan reproduksi, namun memerlukan regulasi yang lebih jelas sebelum penerapan klinis.Kata kunci: In Utero Genetic Editing, etika, regulasi, terapi janin, bioetika

A Descriptive Study of Fertility-Related Quality of Life in Women Receiving Infertility Treatment Afifah, Siti Jihan; Lubis, Hilma Putri; Siregar, Irma Sepala Sari; Sari, Mutiara Indah
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.1053

Objective: This study aimed to describe fertility-related quality of life among women with infertility who are undergoing fertility treatment at a single tertiary fertility center, based on sociodemographic, clinical, and treatment characteristics.Methods: The study design was descriptive with a cross-sectional approach, using a consecutive sampling technique. The study sample consisted of infertile women undergoing pregnancy programs at Halim Fertility Center (HFC) RSIA Stella Maris Medan and met the inclusion and exclusion criteria. Data were collected using the FertiQoL (Fertility Quality of Life Tool) questionnaire and were presented as a frequency distribution. Results: Of the 60 respondents, most were in the 31–35 age group (38.3%) and were overweight (55%), followed by normal weight (41.7%). Most of them experienced primary infertility (83.3%), with infertility lasting 2–5 years (41.7%), and the most common cause was ovulation disorders (31.7%). Based on the type of pregnancy program, In Vitro Fertilization (76.7%) was the most common procedure. FertiQoL assessment revealed a wide range of fertility-related quality-of-life scores across treatment options.Conclusion: Most women undergoing infertility treatment reported a high fertility-related quality of life (60%), with higher average scores seen in those undergoing in vitro fertilization (58.7%). AbstrakTujuan: Penelitian ini bertujuan untuk menggambarkan tingkat kualitas hidup terkait fertilitas pada wanita infertil yang menjalani program kehamilan berdasarkan karakteristik sosiodemografi, klinis, dan jenis terapi. Metode: Desain penelitian adalah deskriptif dengan pendekatan cross-sectional menggunakan teknik consecutive sampling. Sampel penelitian adalah wanita infertil yang menjalani program kehamilan di Halim Fertility Center (HFC) RSIA Stella Maris Medan serta memenuhi kriteria inklusi dan eksklusi. Data dikumpulkan menggunakan kuesioner FertiQoL (Fertility Quality of Life Tool) dan disajikan dalam bentuk distribusi frekuensi.Hasil: Dari 60 responden, mayoritas berada pada kelompok usia 31 – 35 tahun (38,3%) dan memiliki status berat badan berlebih (55%) dan diikuti normoweight (41,7%). Sebagian besar responden mengalami infertilitas primer (83,3%) dengan durasi infertilitas 2 – 5 tahun (41,7%), dan penyebab tersering adalah gangguan ovulasi (31,7%). Berdasarkan jenis program kehamilan, Fertilisasi In Vitro (76,7%) merupakan prosedur yang paling banyak dilakukan. Pengukuran menggunakan FertiQoL menunjukkan bahwa responden memiliki kualitas hidup yang bervariasi. Kesimpulan: Hasil penelitian menunjukkan bahwa sebagian besar wanita infertil yang sedang menjalani program kehamilan memiliki kualitas hidup tinggi (60%), dengan proporsi tertinggi pada kelompok Fertilisasi In Vitro (58,7%).

Management of Incompletely Staged Endometrial Carcinoma: A Case-Based Review Fakhmi, Muhammad; Kurniadi, Andi
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.959

Introduction: Endometrial carcinoma is the most common gynecologic malignancy in developed countries, driven by risk factors such as obesity and unopposed estrogen exposure. Early-stage detection is common due to early symptom onset. Surgical management remains the cornerstone of therapy and serves a dual role in staging the disease. This report presents the initial management of atypical endometrial hyperplasia, evaluation strategies, and treatment planning in a case of advanced-stage endometrial carcinoma with incomplete surgical staging.Case Illustration: A 50-year-old woman presented with persistent vaginal discharge one week following a supracervical hysterectomy and bilateral salpingo-oophorectomy was referred to Hasan Sadikin Hospital Bandung performed for presumed benign disease. Histopathological and immunohistochemical evaluations confirmed the diagnosis of endometrioid adenocarcinoma of endometrial origin. Although chest imaging was negative for distant metastases, further evaluation suggested local extension consistent with FIGO Stage IIIB. Given the incomplete surgical staging and advanced local disease, the patient was referred for multimodal adjuvant therapy consisting of External Beam Radiotherapy (EBRT) and vaginal brachytherapy.Conclusion: Total hysterectomy with bilateral salpingo-oophorectomy and appropriate surgical staging per FIGO guidelines represents the standard treatment for endometrial carcinoma. This case highlights that tailored adjuvant radiotherapy (EBRT and brachytherapy) is critical for effective disease management in incompletely staged high-grade or advanced-stage patients. AbstrakPendahuluan: Karsinoma endometrium merupakan kanker ginekologi yang paling sering terjadi di negara-negara maju, dengan angka kejadian yang terus meningkat secara global. Faktor risiko utama meliputi obesitas, gangguan metabolik, serta paparan estrogen tanpa antagonis progesteron. Deteksi dini sering terjadi karena gejala muncul pada tahap awal penyakit. Penanganan bedah tetap menjadi pilar utama terapi dan sekaligus berperan dalam penentuan stadium penyakit. Laporan ini memaparkan tata laksana awal hiperplasia endometrium atipikal, strategi evaluasi, serta perencanaan terapi pada kasus karsinoma endometrium stadium lanjut dengan staging bedah yang tidak lengkap.Ilustrasi Kasus: Seorang wanita berusia 50 tahun dengan diagnosis karsinoma endometrium dan riwayat histerektomi supraservikal serta salpingoovarektomi bilateral dirujuk ke Rumah Sakit Hasan Sadikin Bandung dengan keluhan keluarnya lendir berwarna kecokelatan dari vagina yang menetap satu minggu pascaoperasi. Pemeriksaan histopatologi dan imunohistokimia mengonfirmasi diagnosis adenokarsinoma endometrioid yang berasal dari endometrium. Tidak ditemukan metastasis pulmonal pada pemeriksaan radiologi. Pemeriksaan laboratorium menunjukkan anemia ringan, leukositosis, dan trombositosis. Diagnosis akhir yang ditegakkan adalah karsinoma endometrium suspek stadium IIIB menurut FIGO. Pasien kemudian dirujuk untuk menjalani radioterapi eksternal (EBRT) dan brakiterapi vagina sebagai terapi adjuvan.Kesimpulan: Histerektomi total disertai salpingoovarektomi bilateral dan staging bedah yang sesuai dengan pedoman FIGO merupakan standar penatalaksanaan karsinoma endometrium. Terapi adjuvan seperti brakiterapi vagina dan EBRT berperan penting dalam penanganan kasus dengan staging yang tidak lengkap, seperti yang dijumpai pada pasien ini.

Unopposed Estrogen and Endometrial Carcinogenesis: Current Concepts Salima, Siti
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.1105

Endometrial carcinoma represents the sixth most frequently diagnosed malignancy affecting the female genital tract globally.1 In 2020, approximately 417,000 new cases were identified worldwide, accompanied by an estimated 97,000 related deaths.2 Across Europe, the burden of disease remains substantial, with projections indicating 124,874 newly diagnosed cases and 30,272 deaths in 2022.3-5 The incidence of endometrial cancer continues to increase, largely driven by demographic aging and the rising prevalence of obesity. Over a woman’s lifetime, the risk of developing endometrial cancer is estimated at around 3%, with a median age at diagnosis of 61 years.6 Notably, the global incidence has risen by approximately 132% during the past three decades, underscoring the expanding impact of key risk factors, particularly obesity and population aging.

Uncommon Metastatic Spread of Endometrial Carcinoma to the Posterior Thoracic Wall and Genital Tract in a Young Adult: A Case Report Mawardinata, Phindo; Suardi, Dodi; Harsono, Ali Budi; Homenta, Christian; Sinaga, Ferry Iskandar Kharisma; Susilo, Sulaeman Andrianto; Hernowo, Bethy S.; Harahap, Reza Rinaldy; Lubis, Munawar Adhar
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.984

Introduction: Endometrial carcinoma is a common gynecologic malignancy that predominantly affects postmenopausal women. Approximately 15% of cases occur in premenopausal patients, and more than 1% are diagnosed in women younger than 40 years. Distant metastases are uncommon and typically involve lymph nodes, lungs, or liver, whereas cutaneous and genital metastases are exceptionally rare. The micropapillary growth pattern, initially described in breast carcinoma, has also been identified in various organs and is associated with aggressive biological behavior, including frequent lymphovascular invasion and widespread dissemination. Case Report: A case of a 24-year-old woman with a prior history of micropapillary carcinoma excised from the posterior thoracic wall is reported. The patient presented with palpable vulvar and cervical masses. Pelvic MRI and PET-CT revealed stage IV C endometrial carcinoma with extensive dissemination involving the cervix, vulva, vagina, peritoneum, thoracic wall, and pleural cavity. Histopathological and immunohistochemical analyses confirmed endometrioid carcinoma with micropapillary features. Conclusion: This study demonstrates that the rare presentation of micropapillary endometrial carcinoma in a young patient highlights the importance of comprehensive diagnostic evaluation when unusual metastatic sites are encountered, to guide treatment and multidisciplinary management. Abstrak Pendahuluan: Karsinoma endometrium merupakan keganasan ginekologi yang umum dan terutama mengenai wanita pascamenopause. Sekitar 15% kasus terjadi pada pasien pramenopause dan lebih dari 1% pada wanita berusia di bawah 40 tahun. Metastasis jauh jarang terjadi dan biasanya melibatkan kelenjar getah bening, paru, atau hati, sedangkan metastasis ke kulit dan traktus genital sangat jarang dilaporkan. Pola pertumbuhan mikropapiler, yang awalnya dideskripsikan pada karsinoma payudara, juga ditemukan pada berbagai organ dan dikaitkan dengan perilaku biologis agresif, termasuk invasi limfovaskular dan penyebaran luas. Laporan Kasus: Dilaporkan kasus wanita berusia 24 tahun dengan riwayat karsinoma mikropapiler yang sebelumnya dieksisi dari dinding toraks posterior, datang dengan massa vulva dan serviks yang teraba. MRI pelvis dan PET-CT menunjukkan karsinoma endometrium stadium IV C dengan penyebaran luas ke serviks, vulva, vagina, peritoneum, dinding toraks, dan rongga pleura. Pemeriksaan histopatologi dan imunohistokimia menegakkan diagnosis karsinoma endometrioid dengan gambaran mikropapiler.Kesimpulan: Penelitian ini menunjukkan bahwa presentasi langka karsinoma endometrium dengan pola mikropapiler pada pasien usia muda menekankan pentingnya evaluasi diagnostik komprehensif pada lokasi metastasis tidak lazim untuk menentukan terapi dan tata laksana multidisiplin.

The Surgical Approach for Adenomyosis in Nulligravid Women: A Case Report Diputri, Marlina Jaya; Triastuti, Prastika Candra; Priyanto, Edy
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.913

Introduction: Adenomyosis is a benign uterine condition characterized by endometrial tissue invasion into the myometrium. This often leading to chronic pelvic pain, dysmenorrhea, and infertility. A meta-analysis in 2025 reported prevalence ranging from 5.9% to 46.0%, with a mean of 20.7%. The Osada triple-flap technique was developed to remove adenomyotic tissue while preserving uterine function, serving as an alternative to total hysterectomy. However, intraoperative findings may require surgical adjustment.Case Report: A 32-year-old woman presented with severe abnormal uterine bleeding. Married for 11 years without children, she had a history of recurrent bleeding, multiple hospitalizations, blood transfusions, and myomectomy. Ultrasound showed an enlarged, globular, and heterogenous uterus with asymmetrical thickening. An exploratory laparotomy was performed with the intention of using the Osada technique, but, due to deep cul-de-sac adhesions and suspected malignancy, the surgery proceeded to total abdominal hysterectomy.Conclusions: Adenomyosis significantlyaffects fertility and uterus-preserving techniques like the Osada method may benefit selected patients. However, in cases with extensive adhesions, distorted anatomy, or suspected malignancy, hysterectomy remains the safest and most definitive treatment. AbstrakPendahuluan: Adenomiosis adalah kelainan jinak pada uterus akibat invasi endometrium ke miometrium. Kondisi ini sering menimbulkan nyeri panggul, dismenore, dan infertilitas. Meta-analisis tahun 2025 melaporkan bahwa prevalensi 5,9% hingga 46,0% (rata-rata 20,7%). Teknik Osada triple-flap dikembangkan untuk mengangkat jaringan adenomyosis sambil mempertahankan fungsi uterus, sebagai alternatif histerektomi total. Namun, temuan intra-operatif dapat mengubah rencana tindakan. Laporan Kasus: Perempuan 32 tahun datang dengan perdarahan uterus abnormal berat. Menikah 11 tahun tanpa anak, riwayat perdarahan berulang, beberapa kali rawat inap, transfusi darah, dan miomektomi. Ultrasonografi menunjukkan uterus membesar dan heterogen. Laparatomi eksplorasi direncanakan dengan teknik Osada (triple-flap), namun karena adanya adhesi dalam dan kecurigaan keganasan, dilakukan histerektomi total. Kesimpulan: Adenomiosis dapat mengganggu kesuburan. Metode preservasi uterus seperti metode Osada bermanfaat pada kasus terpilih, tetapi histerektomi total tetap menjadi pilihan paling aman dan efektif pada kasus kompleks dengan adhesi dan kecurigaan keganasan.

Pelvic Floor Ultrasound for the Evaluation of Urethral Mobility in Women with Stress Urinary Incontinence: A Literature Review Utari, Sania; Fakhrizal, Edy
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.1006

Introduction: Stress urinary incontinence (SUI) is the most common urinary incontinence in women, mainly associated with urethral hypermobility and reduced intrinsic sphincter function. Transperineal pelvic floor ultrasound (PFU) is a minimally invasive, low-cost imaging method that quantifies urethral mobility through bladder neck descent (BND), urethral rotation angle (URA), and retrovesical angle (RVA).Objectives: To summarize available evidence on PFU diagnostic performance and its potential clinical role in identifying urethral hypermobility in women with SUI.Methods: This literature review focuses on transperineal PFU as a noninvasive approach to assess urethral hypermobility, primarily using BND, URA, and RVA measurements.Results: Multiple studies report PFU provides reproducible measurements with acceptable sensitivity and specificity for diagnosing SUI. Although cutoff values for URA and RVA vary depending on study quality and methodology, these parameters consistently serve as key indicators of urethral hypermobility. Compared with standard invasive techniques, PFU improves patient comfort, offers real-time dynamic visualization, and allows greater clinical flexibility.Conclusion: PFU is a promising adjunct for diagnosing passive urethral hypermobility and may reduce reliance on invasive tests while maintaining accuracy. Larger studies are needed to standardize protocols and validate cutoff values across diverse populations. AbstrakPendahuluan: Stress urinary incontinence (SUI) merupakan jenis inkontinensia urin yang paling sering pada perempuan, terutama berkaitan dengan hipermobilitas uretra dan penurunan fungsi sfingter intrinsik. Ultrasonografi dasar panggul (PFU) transperineal adalah metode pencitraan yang minim invasif dan berbiaya rendah untuk menilai mobilitas uretra secara kuantitatif melalui penurunan leher kandung kemih (BND), sudut rotasi uretra (URA), dan sudut retrovesikal (RVA).Tujuan: Merangkum bukti yang tersedia mengenai kinerja diagnostik PFU serta potensi perannya dalam praktik klinis untuk mengidentifikasi hipermobilitas uretra pada perempuan dengan SUI.Metode: Tinjauan pustaka ini berfokus pada PFU transperineal sebagai metode noninvasif untuk menilai hipermobilitas uretra, dengan parameter utama berupa BND, URA, dan RVA.Hasil: Berbagai studi melaporkan bahwa PFU menghasilkan pengukuran yang reprodusibel dengan sensitivitas dan spesifisitas yang dapat diterima untuk diagnosis SUI. Meskipun nilai ambang URA dan RVA bervariasi bergantung pada kualitas dan metodologi studi, kedua parameter tersebut secara konsisten menjadi indikator penting hipermobilitas uretra. Dibandingkan teknik invasif standar, PFU meningkatkan kenyamanan pasien, menyediakan visualisasi dinamis secara real-time, dan menawarkan fleksibilitas klinis yang lebih tinggi.Kesimpulan: PFU merupakan pemeriksaan tambahan yang menjanjikan untuk mendiagnosis hipermobilitas uretra pasif dan berpotensi mengurangi ketergantungan pada tes invasif tanpa menurunkan akurasi. Namun, diperlukan studi berskala lebih besar untuk menstandardisasi protokol dan memvalidasi nilai ambang pada berbagai populasi.

Comparison of Quality of Life and Sexual Function between Pelvic Organ Prolapse Patients Using Pessary and Surgical Intervention Nurtanio, Setyawan; Sasotya, RM Sonny; Sukarsa, M. Rizkar Aref; Achmad, Eppy Darmadi; Rinaldi, Andi; Ma'soem, Aria Prasetya; Praharsini, Kania
Indonesian Journal of Obstetrics & Gynecology Science Volume 9 Number 1 March 2026
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v9i1.1035

Objective: This study aims to compare the improvement in QoL (measured by PFDI-20) and sexual function (measured by FSFI) in POP patients (stage II-IV) treated with either surgical intervention or pessary insertion.Methods: The study employed a quasi-experimental pre–posttest design involving 60 patients with stage II–IV pelvic organ prolapse (POP), consisting of 30 patients in the surgical group and 30 patients in the pessary group, conducted at two tertiary referral hospitals in Bandung. Quality of life and sexual function were assessed using the Pelvic Floor Distress Inventory-20 (PFDI-20) and the Female Sexual Function Index (FSFI) before and three months after the intervention. Statistical analyses included paired t-tests to evaluate within-group changes before and after the intervention and independent t-tests to compare post-intervention outcomes between the two groups.Results: The results demonstrated that both the surgical group and the pessary group showed significant improvements in quality of life and sexual function (p<0.001). In the surgical group, the FSFI score increased from 16.46 ± 6.88 to 27.68 ± 3.17, surpassing the threshold for normal sexual function, while the PFDI-20 score decreased from 114.34 ± 57.44 to 14.93 ± 7.37. The pessary group also showed significant improvement, with the FSFI score increasing from 18.69 ± 4.76 to 24.80 ± 3.83 and the PFDI-20 score decreasing from 130.24 ± 48.80 to 36.98 ± 21.37. Post-intervention comparative analysis showed statistically better outcomes in the surgical group for both the FSFI score (p=0.002) and the PFDI-20 score (p<0.001).Conclusion: Both surgical and pessary interventions are effective in improving the quality of life and sexual function in women with pelvic organ prolapse. Surgical intervention, however, offers superior and lasting outcomes. Pessary usage remains an important non-surgical option for patients seeking conservative management. AbstrakTujuan: Penelitian ini bertujuan membandingkan perubahan kualitas hidup dan fungsi seksual pada pasien POP stadium II–IV yang menjalani terapi bedah dan penggunaan pessarium.Metode: Metode penelitian yang digunakan yaitu kuasi-eksperimental dengan desain pre–posttest yang dilakukan pada 60 pasien POP stadium II–IV, terdiri atas 30 pasien kelompok bedah dan 30 pasien kelompok pessarium, di dua rumah sakit rujukan tersier di Bandung. Penilaian kualitas hidup dan fungsi seksual dilakukan menggunakan kuesioner Pelvic Floor Distress Inventory-20 (PFDI-20) dan Female Sexual Function Index (FSFI) sebelum dan tiga bulan setelah intervensi. Analisis statistik menggunakan uji t berpasangan untuk menilai perubahan sebelum dan sesudah intervensi pada tiap-tiap kelompok serta uji t tidak berpasangan untuk membandingkan luaran pascaintervensi antar kelompok.Hasil: Hasil penelitian menunjukkan bahwa kelompok dengan terapi bedah dan kelompok dengan pessarium menunjukkan peningkatan bermakna pada kualitas hidup dan fungsi seksual (p<0,001). Pada kelompok bedah, skor FSFI meningkat dari 16,46 ± 6,88 menjadi 27,68 ± 3,17, melewati ambang fungsi seksual normal, sedangkan skor PFDI-20 menurun dari 114,34 ± 57,44 menjadi 14,93 ± 7,37. Kelompok pessarium juga menunjukkan perbaikan yang bermakna, dengan peningkatan skor FSFI dari 18,69 ± 4,76 menjadi 24,80 ± 3,83 dan penurunan skor PFDI-20 dari 130,24 ± 48,80 menjadi 36,98 ± 21,37. Analisis perbandingan pascaintervensi menunjukkan hasil yang secara statistik lebih baik pada kelompok bedah baik untuk skor FSFI (p=0,002) maupun PFDI-20 (p<0,001).Kesimpulan:Terapi bedah dan penggunaan pessarium secara bermakna meningkatkan kualitas hidup dan fungsi seksual pada pasien prolaps organ panggul. Terapi bedah memberikan perbaikan yang lebih besar dan lebih menyeluruh, sedangkan penggunaan pessarium tetap merupakan pilihan nonbedah yang efektif dan aman pada pasien terpilih.

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Wiryawan Permadi

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Wiryawan Permadi

Contact Email obgyniajurnal@gmail.com

Phone -

Journal Mail Official obgyniajurnal@gmail.com

Editorial Address -

Location Kota bandung, Jawa barat INDONESIA

Abstract

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Abstract

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Abstract

Contact Name
Wiryawan Permadi

Contact Email
obgyniajurnal@gmail.com

Phone
-

Journal Mail Official
obgyniajurnal@gmail.com

Editorial Address
-

Location
Kota bandung,

Jawa barat

INDONESIA