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Radioterapi & Onkologi Indonesia

JORI
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Published by Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia

ISSN : 20869223 EISSN : - DOI : -

Core Subject : Health, Science, Education,

Education Health Professions Medicine & Pharmacology Physics Other

Majalah Radioterapi & Onkologi Radiasi Indonesia (Journal of the Indonesian Radiation Oncology Society) dengan ISSN 2086-9223, satu-satunya majalah dalam bidang Onkologi Radiasi di Indonesia, merupakan majalah di bawah penerbit Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI). Majalah ini rutin diterbitkan sejak tahun 2010 dengan frekuensi terbitan 2 kali dalam setahun.

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Articles 108 Documents

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Peran Substansi Kimia dalam Memodifikasi Respon Radiasi Adji Kusumadjati; H.M Djakaria
Radioterapi & Onkologi Indonesia Vol 6, No 1 (2015): Volume 6 No.1 Januari 2015
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Radioterapi merupakan modalitas klinis yang menggunakan radiasi sinar pengion untuk mengobati pasien dengan neoplasma ganas dalam rangka kontrol lokal dan meningkatkan kualitas hidup. Rasio terapeutik didefinisikan sebagai perbandingan antara tumor control probability (TCP) dan normal tissue control probability (NTCP) yang digambarkan dalam bentuk kurva sigmoid dosis-respons. Mencapai keseimbangan optimal antara TCP dan NTCP merupakan tujuan dari pengobatan. Peningkatan rasio terapeutik dalam rangka optimalisasi terapi dapat dilakukan dengan berbagai macam metode, salah satunya adalah dengan penggunaan substansi kimia yang dapat memodifikasi respons radiasi (chemical modifiers) dengan strategi antara lain: kombinasi radiasi dengan kemoterapi, penggunaan radiosensitiser dan radioprotektor, peningkatan oksigenasi serta penggunaan terapi target (targeted therapy).

Faktor Risiko Terjadinya Metastasis Jauh pada Pasien Kanker Payudara Juli Jamnasi; Soehartati Argadikoesoema Gondhowiardjo; Zubairi Djoerban; Nurjati C Siregar; Evert D.C Poetiray; Anna Puspita Tunggono
Radioterapi & Onkologi Indonesia Vol 7, No 2 (2016): Volume 7 No.2 Juli 2016
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Tujuan: Mengetahui faktor risiko yang berpengaruh dan lokasi tersering metastasis jauh pada pasien kanker payudara (KPD). Metodologi: Total 1.289 pasien kanker dari periode bulan Januari 2001 sampai Desember 2010 diteliti secara retrospektif. Dari 913 pasien yang memenuhi kriteria inklusi dikelompokan menjadi tiga kelompok. Faktor risiko dengan uji Chi-square pada kelompok dengan metastasis (Kelompok I+II) dibandingkan dengan kelompok bebas-metastasis (Kelompok III); dan uji Cox-regression untuk mengidentifikasi kesintasan bebas metastasis (DMFS) Hasil: Status T3-T4, pN positif dan subtipe triple-negative secara signifikan berhubungan dengan kejadian metastasis jauh di kelompok metastasis dibandingkan kelompok bebas-metastasis (p<0.05). Status pN positif (HR: 2,51; IK95%: 1,65–3,83) dan derajat histopatologis grade-3 (HR: 1,67; IK95%: 1,06–2,64) secara bermakna berhubungan dan dapat memprediksikan DMFS untuk 5 dan 10 tahun. Lokasi tersering metastasis pada Kelompok I adalah: tulang (n=73; 64,6%), paru (n=33; 29,2%), hati (n=24; 21,2%), otak (n=1; 0,8%) dan payudara kontralateral (n=5; 0,8%). Sedangkan lokasi metastasis pada Kelompok II adalah tulang (n=76; 62,3%), paru (n=34; 27,9%), payudara kontralateral (n=26; 21,3%), hati (n=22; 18%), dan otak (n=13; 10,7%). Kesimpulan: Status T3 – T4, status pN positif, dan subtipe triple-negative yang bermakna secara statistik pada metastasis jauh (p<0.05). Lokasi tersering metastasis adalah tulang.

Angiofibroma Nasofaring Juvenil Hezron K Ginting; Nana Supriana
Radioterapi & Onkologi Indonesia Vol 9, No 1 (2018): Volume 9 No.1 Januari 2018
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Juvenile Nasopharyngeal Angiofibroma merupakan tumor jinak kepala leher langka pada remaja laki-laki namun mempunyai risiko invasi yang tinggi karena sifatnya yang agresif dan merusak tulang - tulang tengkorak. Pembedahan masih merupakan terapi utama untuk kasus ini. Terapi lain yang dapat diberikan meliputi tatalaksana hormonal, embolisasi dan radiasi. Radiasi memiliki peran pada kasus Juvenile Nasopharyngeal Angiofibroma lanjut di mana tidak dapat dilakukan operasi atau operasi yang dilakukan tidak dapat mengangkat tumor secara keseluruhan.

Teknik Radiosurgery Henry Kodrat; Rima Novirianthy
Radioterapi & Onkologi Indonesia Vol 7, No 2 (2016): Volume 7 No.2 Juli 2016
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Stereotactic radiosurgery (SRS) merupakan teknik radioterapi lanjutan yang menggunakan prinsip navigasi stereotaktik untuk penentuan target radiasi, pencitraan 3 dimensi untuk pendefinisian target dan pemberian radiasi dosis tinggi dalam fraksi tunggal yang bersifat ablatif. Modalitas terapi ini banyak digunakan untuk tatalaksana berbagai kelainan Intrakranial karena bersifat non-invasif. SRS dapat diberikan dengan berbagai alat dan teknik. Tujuan artikel ini untuk memberikan gambaran umum berbagai teknik SRS disertai keuntungan dan kerugian dari masing-masing teknik.

Cancer Profile in South Jakarta : A 5-year descriptive study Gondhowiardjo, Soehartati Argadikoesoema; Raharjo, Febryono Basuki; Hudiya, Elian; Priharto, R Koesmedi; Yekti, Widyastuti Endro
Radioterapi & Onkologi Indonesia Vol 9, No 2 (2018): Volume 9 No.2 Juli 2018
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

There has been an effort of cancer registry in Cancer Control Program, especially Hospital-based, but it would not be useful if the data and procedure was not standardized. This study was a cross-sectional study with cancer data collected from every health facility in South Jakarta from 2017, April to May. Inclusion criteria was every patient that resided in South Jakarta from 2008, January 1st to 2012, December 31st with no exclusion criteria. Five most common cancers for male are hematopoietic and reticuloendothelial systems, nasopharynx, lung, lymph nodes, and liver cancer, respectively. Five most common cancers in female are breast, cervix uteri, ovarium, hematopoietic and reticuloendothelial systems, thyroid gland cancer, respectively. Cancer patients were comprised by female a lot more than male with 1.86:1 frequency comparison. Compared to data from Malaysia and Singapore in the same period of time, there were some differences in cancer profile between the countries. Based on the data reviewed, the quality was not perfect, one of the examples is shortcoming of SriKandi form which was used to input the data, especially occupation data. This can be a refinement point for future research and registry of cancer in Indonesia

Cancer profile in Central Jakarta: A 5-year descriptive study Gondhowiardjo, Soehartati Argadikoesoema; Silalahi, Montesqieu; Manuain, Donald Arinanda; Priharto, R Koesmedi; Yekti, Widyastuti Endro
Radioterapi & Onkologi Indonesia Vol 9, No 2 (2018): Volume 9 No.2 Juli 2018
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Introduction: Global Burden of Cancer 2012 (GLOBOCAN 2012) estimated 14.1 million new cases of cancer worldwide in 2012. This data was obtained from countries that have a population-based cancer registry. Cancer registration is useful in classifying information from all cancer cases to generate statistics of cancer incidence in a particular population as well as providing a framework for interpreting and controlling the impact of cancer in the community. Indonesia has not had a population-based cancer registry currently. The Minister of Health of Indonesia has designated Dr. Cipto Mangunkusumo Hospital as a control center for cancer registration to establish a population-based cancer registry in Jakarta province.Methods: This cross-sectional descriptive study aimed to describe the cancer profile in Central Jakarta 2008-2012 based on data of RSCM as cancer registry control center in Jakarta province. The data were collected using Srikandi form, a form for cancer registry in Dr. Cipto Mangunkusumo Hospital.Result: The results obtained 1,797 cases of cancer in Central Jakarta from 2008- 2012 with male and female ratio of 1:1.9. The majority of patients came to health providers with advanced stage. The most common cancers were breast cancer, uterine cervical cancer, hematopoietic and reticuloendothelial system cancer, nasopharyngeal cancer, lung and bronchial cancer and lymph node cancer.Conclusions: This research has some similarities with data from GLOBOCAN 2012. However, it is to be noted that data showed that many patients come in an advanced stage of cancer. Moreover, some part of the research data is incomplete due to inadequacy in the filling process of Srikandi form.

Cancer Profile in West Jakarta : A 5-year descriptive study Gondhowiardjo, Soehartati Argadikoesoema; Handoyo, Denny; Auzan, Mahesa; Priharto, R Koesmedi; Yekti, Widyastuti Endro
Radioterapi & Onkologi Indonesia Vol 9, No 2 (2018): Volume 9 No.2 Juli 2018
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Background. Cancer burdens the government in terms of health care funding. Unlike Indonesia, cancer information and data in other several countries are handled by a program called The National Program of Cancer Registries (NPCR), managed by Centers for Disease Control and Prevention (CDC). This study was aimed to describe cancer profile in West Jakarta Region from 2008 to 2012 due to insufficient data provided by the government.Methods. This was a cross-sectional, descriptive study involving all cancer patients residing in West Jakarta based on the medical record of Cipto Mangunkusumo Hospital, acting as DKI Jakarta Cancer Registry Control Center.Results This study found 4,057 cancer cases in the area. Five most commonly diagnosed cancer cases based on the sites of disease are breast cancer (22,5%), cervical cancer (10,3%), lung and bronchus cancer (7,5%), nasopharyngeal cancer (5,3%), and hemopoietic and reticuloendothelial malignancies (5,3%). Most cases were diagnosed in advance stage (III and IV) and predominantly in women aged 45 ? 54 years old. Intraductal carcinoma was the most common morphology type for breast cancer cases.

Cancer Profile in North Jakarta and Kepulauan Seribu : A 5-year descriptive study Gondhowiardjo, Soehartati Argadikoesoema; Bramantyo, Dion Firli; Octavianus, Steven; Priharto, R Koesmedi; Yekti, Widyastuti Endro
Radioterapi & Onkologi Indonesia Vol 9, No 2 (2018): Volume 9 No.2 Juli 2018
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Background: Cancer is the leading causes of death with a comparable number of mortality rate to coronary heart disease and stroke. The burden of cancer will continue to increase, especially in developing countries including Indonesia. This study reports the profile of cancer patients domiciled in the administrative area of North Jakarta and Kepulauan Seribu in 2008 ? 2012.Materials and Methods: This was a descriptive study. Patients data were collected from cancer registries all hospitals located in administrative area of North Jakarta and Kepulauan Seribu. This data was pooled and extracted from DKI Jakarta Cancer Registry Control Center at RSCM. The primary site and histology of malignancies were verified and coded based on the International Classification of Diseases for Oncology (ICD-O). Data were analyzed using descriptive statistics in SPSS 20.0Results: There are 2185 cases or around 14.8% of all cases of cancer patients verified in the database. Of those, 740 were male and 1445 female. The most prevalent age group was 45 - 54 years old, which was 29%. The highest distribution of cancer stage was in stage 3, which is 21.1%. The most common cancer in all sex groups were breast cancer, cervical cancer, nasopharyngeal cancer, hematopoietic system malignancy, and ovarian cancer. In men, the top five most cancers were nasopharyngeal cancer, lung cancer, hematopoietic system, lymphoma, and liver cancer. Whereas in women, most cancer sequences were breast cancer, cervical cancer, ovarian cancer, thyroid cancer, and hematopoietic system.

Cancer Profile in East Jakarta: A 5-year descriptive study Gondhowiardjo, Soehartati Argadikoesoema; Hanum, Fathiya Juwita; Hanifah, Rizka; Priharto, R Koesmedi; Yekti, Widyastuti Endro
Radioterapi & Onkologi Indonesia Vol 9, No 2 (2018): Volume 9 No.2 Juli 2018
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Background: Global Burden of Cancer (GLOBOCAN) 2012 estimated there were 8.2 million cancer deaths worldwide, 65% of them were in developing countries. In Indonesia, the cancer incidence is 134 per 100,000 population. The magnitude of the burden caused by cancer requires a valid data collection in each country in an effort to plan and evaluate cancer prevention programs in the future. Based on Indonesian Minister of health decree, Dr. Cipto Mangunkusumo Hospital (RSCM) was determined as Cancer Registry Control Center in DKI Jakarta Province. This study aims to report Cancer Profile in East Jakarta 2008-2012 based on RSCM Data.Methods: This research was a cross-sectional descriptive study. Patient data were extracted from DKI Jakarta Cancer Registry Control Center Located at RSCM. The primary site and histology of malignancies were identified and coded based on the International Classification of Diseases for Oncology.Results: There were 3748 cancer patients who live in East Jakarta, with male and female ratio of 1:1.9. Most of them were between 45-54 years old. The majority of patients came to health providers with advanced stage (stage 3 and 4). At both sexes the most frequent cancer were breast cancer, followed by cervical cancer, hematopoietic and reticuloendothelial system malignancy, nasopharyngeal cancer, and lung and bronchial cancer. The five most common cancers in men were nasopharyngeal cancer, hematopoietic and reticuloendothelial system malignancy, lung and bronchial cancer, liver and intrahepatic bile duct cancer, and lymph node cancer, respectively. While in women, the five most common cancers were breast cancer, cervical cancer, ovarian cancer, hematopoietic and reticuloendothelial system malignancy and thyroid gland cancer, respectively.Conclusion: Most of cancer patients are in productive age and the majority of them came at advanced stage. Furthermore, three of five most common cancer charge both genders (hematopoietic and reticuloendothelial system malignancy, nasopharyngeal cancer, and lung and bronchial cancer).

Cancer Profile in North Jakarta and Kepulauan Seribu : A 5-year descriptive study Soehartati Argadikoesoema Gondhowiardjo; Dion Firli Bramantyo; Steven Octavianus; Sri Mutya Sekarutami; Nadia Christina; R. Koesmedi Priharto; - Widyastuti
Radioterapi & Onkologi Indonesia Vol 9, No 2 (2018): VOLUME 9 NO. 2 JULI 2018
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Background: Cancer is the leading causes of death with a comparable number of mortality rate to coronary heart disease and stroke. The burden of cancer will continue to increase, especially in developing countries including Indonesia. This study reports the profile of cancer patients domiciled in the administrative area of North Jakarta and Kepulauan Seribu in 2008 – 2012.Materials and Methods: This was a descriptive study. Patients data were collected from cancer registries all hospitals located in administrative area of North Jakarta and Kepulauan Seribu. This data was pooled and extracted from DKI Jakarta Cancer Registry Control Center at RSCM. The primary site and histology of malignancies were verified and coded based on the International Classification of Diseases for Oncology (ICD-O). Data were analyzed using descriptive statistics in SPSS 20.0Results: There are 2185 cases or around 14.8% of all cases of cancer patients verified in the database. Of those, 740 were male and 1445 female. The most prevalent age group was 45 - 54 years old, which was 29%. The highest distribution of cancer stage was in stage 3, which is 21.1%. The most common cancer in all sex groups were breast cancer, cervical cancer, nasopharyngeal cancer, hematopoietic system malignancy, and ovarian cancer. In men, the top five most cancers were nasopharyngeal cancer, lung cancer, hematopoietic system, lymphoma, and liver cancer. Whereas in women, most cancer sequences were breast cancer, cervical cancer, ovarian cancer, thyroid cancer, and hematopoietic system.

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