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INDONESIA
JURNAL KIMIA SAINS DAN APLIKASI
Published by Universitas Diponegoro
ISSN : 14108917     EISSN : 25979914     DOI : -
urnal Kimia Sains dan Aplikasi (p-ISSN: 1410-8917) and e-ISSN: 2597-9914) is published by Department of Chemistry, Diponegoro University. This journal is published four times per year and publishes research, review and short communication in field of Chemistry.
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Articles 804 Documents
Design and In-silico Study of ¹³¹Iodium Radiolabeled of Thiourea derivatives for Breast Cancer Treatment Miqdad Nurabdullah Al Anshari; Anindita Tri Kusuma Pratita; Ruswanto Ruswanto
Jurnal Kimia Sains dan Aplikasi Vol 27, No 9 (2024): Volume 27 Issue 9 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.9.426-435

Abstract

Breast cancer is a serious challenge in both developed and developing countries, with current therapies still limited and potentially producing adverse side effects. To optimize breast cancer drug development, this study adopted an in-silico design approach. The aim is to develop radiopharmaceutical drugs with minimal side effects. Methods involved molecular docking analysis, molecular dynamics, drug scan, and pharmacokinetic profile prediction of the original ligan as well as the radioligand. Results showed that the radioligand had better binding energy and inhibition constant than tamoxifen as a comparator drug which is -11.31 kcal/mol and 0.00511 µM. Molecular dynamics analysis revealed that the radioligand compound exhibits comparable RMSD, RMSF, and stability metrics to the native ligand at the GRPR receptor with average RMSD and RMSF of 5.263 Å and 2.285 Å, respectively. By considering the results of these various methods, the radioligand compound shows potential as an effective radiopharmaceutical drug in breast cancer therapy.
Chitosan-Based Coating Application to Enhance Antimicrobial and Water Vapor Barrier Properties of Industry-Manufactured Paper Akbarningrum Fatmawati; Natalia Suseno; Emma Savitri; Gloria Tifany Masui; Felia Azzahra Ivony
Jurnal Kimia Sains dan Aplikasi Vol 27, No 11 (2024): Volume 27 Issue 11 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.11.515-522

Abstract

Chitosan, a renowned natural polymer for its wide application, was exploited for industry paper coating solutions. This research aimed to investigate the antimicrobial and water vapor barrier of chitosan solution-coated industry-manufactured paper. The papers were obtained from a national company in Indonesia. The commercially available chitosan with three molecular weight levels (low, medium, and high) was solubilized in sodium acetate buffer and subsequently utilized as the coating solution. The other variable studied was the chitosan concentration in the coating solution, i.e., 1.0, 1.5, and 2.0% (w/w). The antimicrobial activity study was performed by testing against Gram-positive bacteria, represented by Staphylococcus aureus, and Gram-negative bacteria, represented by Escherichia coli. The low molecular weight chitosan showed the best antimicrobial activity and water vapor barrier performance. The 1 %w low molecular weight chitosan-coated paper had shown good antimicrobial activity, against both S. aureus and E. coli, with a growth reduction of > 95 %. The most effective antimicrobial activity against S. aureus was achieved by paper coated with a 1.5% solution of low molecular weight chitosan. For low molecular weight chitosan-coated paper the most effective water vapor barrier was exhibited at 1 %w chitosan concentration. Having shown the best water vapor barrier while maintaining good antimicrobial activity, the 1.0% solution of low molecular weight chitosan was appointed as the best coating solution in this research.
Enhanced Antibacterial Efficacy of Ag(I), Cu(II), and Zn(II) Modified Sodalite Zeolite Against Escherichia coli and Staphylococcus aureus Sriatun Sriatun; Khairini Pertiwi; Choiril Azmiyawati; Mukhammad Asy'ari; Damar Nurwahyu Bima; Nor Aida Zubir
Jurnal Kimia Sains dan Aplikasi Vol 27, No 10 (2024): Volume 27 Issue 10 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.10.477-484

Abstract

Sodalite zeolite modified with metal ions Ag+, Cu2+, Cu2+, and Zn2+ was successfully synthesized and evaluated for antibacterial activity. The research aims to obtain silver, copper, and zinc metal-modified sodalite separately and determine their antibacterial activity on Escherichia coli and Staphylococcus aureus bacteria. Sodalite zeolite was synthesized using ludox and sodium aluminate through hydrothermal methods, ensuring uniform crystal growth and optimal crystallinity, as confirmed by X-ray diffraction (XRD) analysis. The average particle sizes of the modified zeolites were determined to be 54.9 nm for Ag-Zeolite, 37.2 nm for Cu-Zeolite, and 28.56 nm for Zn-Zeolite, with structural changes observed through alterations in peak intensity. Scanning Electron Microscopy - Energy Dispersive X-ray (SEM-EDX) analysis showed no significant change in the zeolite’s morphology. In addition, the EDX results showed the presence of Ag (3.15%), Cu (3%), and Zn (2.41%) metals indicating successful ion exchange. Antibacterial assays revealed that Cu-Zeolite demonstrated superior efficacy inhibition zones against Escherichia coli (14.04±1.26) and Staphylococcus aureus (20.74±0.48), highlighting its potential as an antimicrobial agent. The mechanism of action involved the controlled release of metal ions, disrupting bacterial cell membranes and metabolic processes. Notably, Cu2+ ions exhibited the strongest antibacterial properties due to their smaller ionic radius and higher electronegativity than Ag+ and Zn2+. This research underscores the promising applications of metal-ion-modified sodalite zeolite in medical and environmental contexts.
Crystallization of [Zn(Pyrazinamide)₂(Cl)₂] Complex and In Vitro Antibacterial Activity of the Complex Against E. coli and S. aureus Naila Azmi Adiba; Danar Purwonugroho; Arie Srihardyastutie; Yuniar Ponco Prananto
Jurnal Kimia Sains dan Aplikasi Vol 27, No 9 (2024): Volume 27 Issue 9 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.9.436-443

Abstract

A complex of [Zn(pza)2(Cl)2], pza = pyrazinamide, was successfully crystallized from methanol or ethanol solvents with different morphology. The complex was synthesized using the solution method in ZnCl2: pza mol ratios of 1:2 and 1:4 in both ethanol and methanol solvents. FTIR and single crystal XRD analyses were done to confirm the complex. The complex was then used for in vitro antibacterial test against E. coli and S. aureus. Experimental data shows that the type of solvent and metal-to-ligand mol ratio yields the same compound, resulting in colorless crystals that melt at 234-236°C. Large block crystals were obtained from the methanolic solution, while a higher yield was obtained from the use of a higher mol ratio of 1:4. Infrared spectra analysis confirms the presence of characteristic carbonyl and amide groups of the pza ligand. Meanwhile, single crystal XRD screening indicates that unit cell parameters of the crystals from both solvents are identical to a known zinc(II)-pza complex. In vitro antibacterial tests against E. coli and S. aureus show that the complex had much better activity than the ZnCl2 and the free pza. In addition, the complex performs better antibacterial activity toward gram-positive S. aureus than the gram-negative E. coli.
Sulfonation of Eugenol-Diallyl Phthalate Copolymer as Base Material of Supercapacitor Electrode Material Ngadiwiyana Ngadiwiyana; Cinta Nur Nabila; Ismiyarto Ismiyarto; Marcelinus Christwardana
Jurnal Kimia Sains dan Aplikasi Vol 27, No 11 (2024): Volume 27 Issue 11 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.11.523-530

Abstract

Polyeugenol is a polymer synthesized from renewable natural resources and has potential as a supercapacitor electrode material. Polyeugenol was modified by the addition of diallyl phthalate to increase structural density and thermal stability and the addition of sulfonate groups to increase ion exchange capacity and electrical conductivity. This research begins with the synthesis of eugenol-diallyl phthalate copolymer (PEGDAF) carried out by cationic polymerization using BF3O(C2H5)2 catalyst and sulfonation of eugenol-diallyl phthalate copolymer (SPEGDAF) using sulfuric acid. The synthesis of PEGDAF in the form of pink solids with a yield of 68.44%, a molecular weight of 6739.99 Daltons, and a melting point of 85°C, FTIR analysis showed that the formation of PEGDAF was characterized by the loss of vinyl groups with the absence of C=C alkene wavenumber absorption which is the wavenumber absorption of eugenol and diallyl phthalate, respectively 1640 cm-1 and 1647 cm-1 and TGA with a mass loss of 5% and 10% at 176°C and 219°C. SPEGDAF results in dark purple solids with a sulfonation degree of 17.18% and a cation exchange capacity of 0.4186 meq/g, molecular weight 8342.25 Daltons, melting point 114°C. Analysis using FTIR showed the presence of sulfonate groups with the resulting absorption peaks of 1218 cm-1 (S=O), 1065 cm-1 (S-O), and 578 cm-1 (C-S) and TGA with a mass decrease of 5% and 10% at temperatures of 169°C and 215°C. Potential test of supercapacitor electrode material with Cyclic Voltammetry and Electrochemical Impedance Spectroscopy obtained a specific capacitance value of 3.23 × 10-3 F/g and ion conductivity of 7.58 × 10-6 S/cm.
Synthesis of Styrofoam Waste-Derived Activated Carbon as an Electron Extractor for Modifying Cu/P-CuSCN/N-Cu₂O/ITO Photovoltaic Cells Dheani Laily; Aisyah Wahyu Fitriani; Endar Aldi Hanantya; Rahmad Nuryanto
Jurnal Kimia Sains dan Aplikasi Vol 27, No 10 (2024): Volume 27 Issue 10 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.10.485-490

Abstract

Activated carbon synthesized from styrofoam waste was applied as an electron extractor to enhance the performance of Cu/p-CuSCN/n-Cu2O/ITO-based photovoltaic cells. The widespread use of plastic products, particularly styrofoam, has led to severe environmental pollution due to its long decomposition time. Styrofoam waste-derived activated carbon utilizes polystyrene, which is rich in carbon, to produce high-surface-area materials. In this study, the activated carbon enhances the efficiency of photogenerated electron separation and extraction in photovoltaic cells. Characterization results indicate that the activated carbon has a surface area of 1,865.04 m2/g, a pore volume of 1.25 cm3/g, and a pore diameter of 2.53–2.68 nm, with a direct band gap energy of 4.33 eV. Voltage testing on the photovoltaic cells demonstrated a significant increase, with the highest voltage reaching 209.67 mV in the 5 mg activated carbon variation, representing a 34.84% improvement. The application of activated carbon in Cu/p-CuSCN/n-Cu2O/ITO-based photovoltaic cells provided a notable voltage increase, confirming its effectiveness as an electron extractor.
Development of the Diffusive Gradient in Thin Film (DGT) Method with CaO/Biochar Binding Agent from Eggshells and Rice Straw Waste for Determining the Concentration of Phosphate Asep Saefumillah; Siti Zahara
Jurnal Kimia Sains dan Aplikasi Vol 27, No 9 (2024): Volume 27 Issue 9 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.9.444-455

Abstract

Phosphorus, often found in the form of phosphate in the environment, especially aquatic environments, has been identified as the primary contaminant that causes algae blooms and eutrophication. Phosphate adsorption in the aquatic environment was carried out by comparing the adsorption capabilities of eggshell (CaO), rice straw (BC) and CaO/biochar materials at mass variations of 1:1, 1:2 and 2:1 from the use of eggshell and rice straw waste. Each material was synthesized using ball milling and pyrolysis methods. The adsorption isotherm and kinetics of the material are by the Langmuir adsorption isotherm and are pseudo-second-order (PSO) adsorption kinetics. The CaO/biochar 1:2 material shows the highest phosphate adsorption capacity at pH 12 with a contact time of 24 hours. CaO/biochar 1:2 was applied in the phosphate adsorption process using the Diffusive Gradient in Thin Film method as a binding agent, which acts as an adsorbent. The DGT technique is an in situ sample preparation technique for identifying the presence of phosphate, a labile species. The binding agent material was characterized using FTIR, XRD, and BJH-BET instruments. The success of synthesizing CaO/biochar 1:2 binding gel and ferrihydrite was demonstrated by the appearance of the same adsorption as the diffusive gel using FTIR. The CaO/biochar binding gel demonstrated that it is a better material compared to the ferrihydrite binding gel for phosphate adsorption, achieving CDGT values of 10.1727 mg/L and 2.5959 mg/L at pH 5 and 3, respectively, with a phosphate concentration of 10 mg/L. These findings underscore the potential of CaO/biochar as a more effective material for phosphate removal applications.
Antibacterial Activity of Endophytic Bacterial Isolates from Kaempferia galanga Leaves Rafifa Ridha; Dira Hefni; Zetryana Puteri Tachrim; Gian Primahana; Jepri Agung Priyanto; Linosefa Linosefa; Adrial Adrial; Endrinaldi Endrinaldi; Muhammad Eka Prastya
Jurnal Kimia Sains dan Aplikasi Vol 27, No 11 (2024): Volume 27 Issue 11 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.11.538-548

Abstract

Indonesia has a high biodiversity, which can be relied upon as a potential source of medicinal materials. One of the medicinal plants in Indonesia is Kaempferia galanga, which demonstrates various pharmacological properties, including antibacterial, anti-inflammatory, antioxidant, anticancer, and antiangiogenic effects. However, directly extracting active compounds from plants requires a considerable amount of biomass. To address this challenge, utilizing endophytic bacteria associated with these plants presents a promising alternative. Consequently, the antibacterial activity of endophytic bacterial isolates from K. galanga leaves needs to be investigated. This study is an experimental laboratory investigation conducted in vitro. Two isolates demonstrated antibacterial activity: isolate code DR4 inhibited the growth of Escherichia coli (3 ± 0.5 mm), while isolate DR10 inhibited the growth of four bacteria: Bacillus subtilis (5 ± 0 mm), Staphylococcus aureus (1.5 ± 0.5 mm), Escherichia coli (1 ± 0 mm), and Pseudomonas aeruginosa (1 ± 0 mm). Disc diffusion tests using ethyl acetate extracts of isolate DR10 showed the highest antibacterial activity at a concentration of 10,000 ppm. The Minimum Inhibitory Concentration (MIC) was determined to be 156.2 ppm against B. subtilis, while the Minimum Bactericidal Concentration (MBC) was >625 ppm. Molecular identification showed that isolate DR 10 had 100% similarity to Bacillus sp. TS8. The active compound suspected to have antibacterial properties is pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, with the highest abundance.
Evaluation of Sealing Strength in Multilayer LLDPE Packaging for Impact-Resistant Rice Pouches Bayu Krisnamurti; Henny Irawati; Mas Ayu Elita Hafizah; Azwar Manaf
Jurnal Kimia Sains dan Aplikasi Vol 27, No 10 (2024): Volume 27 Issue 10 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.10.491-498

Abstract

In this study, we evaluate the mechanical integrity, thermal stability, and impact resilience of three different laminated polymer materials—PA/LLDPE, MDO-PE/LLDPE, and BOPE/LLDPE—to assess their suitability for rice packaging applications. Our experiments include tests to determine the temperature at which sealing begins, evaluations of thermal durability, assessments of seal integrity, and impact resistance tests. PA/LLDPE exhibited excellent sealing ability, displaying the highest seal strength of 6,411 gr/15 mm at 150°C, and maintained structural integrity up to 200°C, making it particularly suitable for high-temperature applications. MDO-PE/LLDPE also performed well, especially at lower temperatures, with a seal strength of 5,327 gr/15 mm at 130°C. The addition of a plastomer significantly improved its low-temperature effectiveness. Conversely, BOPE/LLDPE reached its peak seal strength at 3,825 gr/15 mm at 140°C but showed lower stability at higher temperatures. During drop tests, PA/LLDPE and MDO-PE/LLDPE demonstrated good impact resistance, absorbing up to 245.250 Joules, while BOPE/LLDPE absorbed only up to 196.240 Joules, indicating its limited ability to withstand impact. These results suggest that PA/LLDPE and MDO-PE/LLDPE are more effective in preventing environmental ingress, even under stress at temperatures up to 200°C. This research underscores the critical role of polymer composition and structure in enhancing the mechanical performance and durability of packaging materials. The practical applications of these findings are substantial, offering packaging developers insights into selecting appropriate materials that meet industry standards for safety and environmental responsibility, particularly in the food sector. These insights could lead to the development of more sustainable, high-performance packaging solutions, aligning with global trends toward sustainability and safety in food packaging.
Fabrication of Coconut Shell-Derived Graphitic Activated Carbon for Carbon-based Electrode Materials Irma Fifa Yanti; Pratama Jujur Wibawa; Aris Mukimin
Jurnal Kimia Sains dan Aplikasi Vol 27, No 9 (2024): Volume 27 Issue 9 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.9.456-463

Abstract

This study aims to convert low-value plantation biomass waste into high-value materials. The process involves transforming coconut shell charcoal (CSC) into activated carbon and subsequently producing coconut shell graphitic-like activated carbon (CSGAC). Using a thermal graphitization method with a FeCl3 catalyst at 900°C for 1 hour in a nitrogen atmosphere, graphite microstructures (CSGAC) were formed on the coconut shell activated carbon (CSAC) framework. XRD, FTIR, SEM, and BET analyses confirmed the successful formation of CSGAC. The electrical conductivity of CSGAC, measured at 148 µS, highlights its potential as a cost-effective, renewable, and environmentally friendly raw material for carbon-based electrodes.

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