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Yan Hendrika
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JOPS (Journal Of Pharmacy and Science)
Published by Universitas Abdurrab
ISSN : 26229919     EISSN : 26151006     DOI : https://doi.org/10.36341/jops
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JOPS is Journal Of Pharmacy and Science with Scopes of Science : 1) Pharmacy 2) Food Chemistry 3) Biotechnology 4) Pharmacology 5) Microbiology 6) Food Analysis JOPS adalah Jurnal Farmasi dan Sains dengan Ruang Lingkup keilmuan : 1) Farmasi 2) Kimia makanan 3) Bioteknologi 4) Farmakologi 5) Mikrobiologi 6) Analisa Makanan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 130 Documents
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Analysis of Oral Albumin Use and Factors Affecting the Success of its Therapy Wati, Umi Fatma
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4682

Abstract

Hypoalbuminemia is a risk factor for medical treatment. Albumin has been shown to be a predictor in a number of studies in various settings. Several studies examined albumin as a marker of nutritional status and its association with outcomes (eg, mortality and length of hospital stay). In critical illness, the Acute Physiology and Chronic Health Evaluation (APACHE III) risk score includes serum albumin levels and shows a strong inverse correlation between serum albumin and mortality in critically ill patients. This research was conducted observationally to analyze the use of oral albumin and the factors that influence the success of therapy in the Lung Inpatient Room at Dr Soetomo Regional Hospital for the period 1 January – 31 October 2022. Patients diagnosed with Community Pneumonia, Lung Cancer and Lung Tuberculosis. This research was carried out by collecting secondary data via e-medical records. Data taken were patient demographic data (name, gender, weight, age, length of stay) and albumin data before and after receiving oral albumin. From the research results, the number of samples was 87. The number of samples was 87 patients. Of the 87 patients, 66 male patients (75.86%) were 21 female patients (24.14%), the largest age range was 51 - 60 years, 21 patients (24.14%). The highest body weight ranged from 61-70 kg for 50 patients (57.47%), the longest length of stay ( Length of Stay ) was 10-20 days for 45 patients (51.72%). The most common primary diagnosis was new tuberculosis in 42 patients (48.28%). The highest use of oral albumin was more than 100 capsules, as many as 20 patients (22.99%) with the highest duration of use being 10-19 days, namely 38 patients (43.68%). The statistical results show that there is no significant difference between before receiving oral albumin and after receiving oral albumin with a value of P = 0.541. Factors that influence the success of oral albumin therapy are length of stay with a value of P = 0.001 * Keywords: Oral albumin, pulmonary tuberculosis, lung cancer, pneumonia, length of stay
Pengaruh Variasi Setil Alkohol dan Cera Alba terhadap Sifat Fisik Lotion Virgin Coconut Oil Wahyuni, Fitri; Ningsih, Wida; Rasyadi, Yahdian
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4685

Abstract

One of the cosmetics that is widely used topically is lotion, which consists of two phases that do not mix, and can be stabilized using an emulsifying agent. Cetyl alcohol and cera alba have properties as softeners, emulsifiers and absorb water which were chosen as emulsifying agents because they can improve the texture of the preparation. The aim of this research was to see the effect of varying concentrations of cetyl alcohol and cera alba as emulsifying agents in VCO lotion preparations. The research design in this study was pre-experimental with the lotion formula divided into 4 sample groups with different concentrations of cetyl alcohol and cera alba. Physical property tests carried out include organoleptic tests, pH tests, homogeneity tests, spreadability tests and lotion type. The results showed that variations in the concentration of cetyl alcohol and cera alba did not show differences in organoleptic, homogeneity, pH, spreadability and type of lotion for all formulas. It can be concluded that in making VCO lotion with varying concentrations of cetyl alcohol and cera alba it does not affect the physical properties of the lotion
Evaluasi Penggunaan Antibiotik pada Pasien Rawat Jalan di Puskesmas Pekan Heran dengan Metode Anatomical Theraupetic Chemical/ Defined Daily Dose and Drug Utilization Drug Utami, Ayu Dwi; Wahyuni, Lila; Handayani, Futri; Sumitra, Jhoti; Sukria, Sri; Marnovy, Nova
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4694

Abstract

Antibiotics are one of the highest used drugs in the world. Relatively high use of antibiotics can increase the risk of antibiotic resistance. Based on several studies in Indonesia, the use of antibiotics in several Public health center shows the high use of antibiotics. This study aims to find out how antibiotics are used at the Pekan Heran health center in 2019-2022 using the ATC/DDD method and to see changes in the profile of antibiotic use based on the 90% DU profile which is calculated in units of DDD/1000 KPRJ. In this study, there were 8 drugs used at Pekan Heran Public Health Center, namelyamoxicillin, clindamyycin, erythromycin, cefixime, contrimoxazol, metronidazole, chloramphanicol and cefadroxil. Data collection was obtained from the Pekan Heran Public health center. The data processing uses the ATC / DDD method which is processed using Microsoft Excel. The results show that the quantity of antibiotic use has always fluctuating during the 2019-2022 period. The highest use of antibiotic drugs was in 2019 amounting to 708,233 DDD / 1000 KPRJ, and the smallest use was in 2021 amounting to 1,157 DDD / 1000 KPRJ. The profile of the use of antibiotic drugs at the Pekan Heran Public health centerfor the period 2019-2022 was based on DU90%, namely amoxicillin, erythromycin and metronidazole. Amoxicillin is the highest drug used with a percentage in 2019, namely 48,006%, in 2020 amounting to 58,054%, in 2021 it was 27,072%, in 2022 it was equal to 28,437%
Uji Aktivitas Penghambatan Tirosinase dan Antioksidan Ekstrak Akar Murbei (Morus alba) dengan Metode Ekstraksi Hijau NADES Sebagai Agen Pencerah Kulit Alishlah, Tanfidz; Mun’im, Abdul; Jufri, Mahdi
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4699

Abstract

Morus alba (mulberry) root contains a secondary metabolite of oxyresveratrol with its potential skin-brightening activity. The application of the green extraction method using Ultrasonic-Assisted Extraction with Natural Deep Eutectic Solution (NADES-UAE) was developed because of its advantages, namely it can increase extract yields, low toxicity profile, reduce extraction time, shorter extraction stages without evaporation, and can be applied directly in topical preparations for cosmetic products. To ensure the potential for skin-brightening activity, some activity tests on mulberry root extract are needed. The purpose of this study was to determine the in vitro skin-brightening activity of mulberry root extract using NADES-UAE method. The method used was an in vitro tyrosinase enzyme inhibition test using a microplate reader and an antioxidant activity test using the DPPH method. The IC50 value of the best mulberry root extract (glycerin: urea 1:3 for 15 minutes) showed tyrosinase inhibition activity was 178.43 μg/mL. While the IC50 value in the best antioxidant activity test was 1392.14 μg/mL. Tyrosinase inhibitory and antioxidant activities in three samples showed the best results having the highest oxyresveratrol content. NADES-UAE mulberry root extract has the potential as a cosmetic preparation for skin lightening and has antioxidant effects for skin health.
Utilization of Methanol Extract Sea Pandan Fruit (Pandanus tectorius) in Hand and Body Cream as an Antioxidants Retno Sari, Dwi; Wutsqa, Yusfia Urwatul; Hikmah, Siti Nur
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4706

Abstract

Sea pandanus is a coastal plant with great potential in the cosmetic industry due to its rich contains phenolic and flavonoid compounds that are abundant in the fruits. The purpose of this research is determine the antioxidant activity of sea pandanus fruit and to evaluate the result of hand and body cream formulation. Pandanus was chosen because it is not widely explored.The result of study showed that the methanol extract of sea pandanus contains phenolic, flavonoid, saponin, and steroid compounds. The antioxidant activity in the hand and body cream formulation was 33,183 µg/mL, indicating strong antioxidant activity below the IC50. The high level antioxidant activity from the methanol extract of sea pandanus can be used in the formulation of hand and body cream. Characteristics in the quality assessment of all the hand and body cream did not meet the requirements.
Uji Efektivitas Fraksi Etil Asetat Eleutherine Bulbosa Terhadap Penurunan Kadar Kolesterol Total, Tekanan Darah Sistolik-Diastolik Pada Tikus Putih Jantan Fauzia, Haliza Diny; Andika, Miming; Sari, Putri Nilam; Hasanah, Rizqa; Putra, Fajrian Aulia; Fitriani, Oryza Sativa; Rahmadasmi, Nola
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4707

Abstract

Eleutherine Bulbosa is one of the plants cultivated by the community for traditional medicine. It's like lowering hypercholesterolemia. Hypercholesterolemia is a condition characterized by high levels of cholesterol in the blood. Besides, it can also lower hypertension. Hypertension is a condition in which blood pressure exceeds the normal limit, with systolic pressure above 140 mmHg and diastolic blood pressure above 90 mmHg. The study aims to look at the effectiveness of the Eleutherine Bulbosa ethyl acetate fraction against the reduction in total cholesterol levels, systolic blood pressure, and diastolic blood pressure in male white rats. Animal cholesterol levels were raised using MLT for 22 days. Cholesterol parameters were tested using a Dumolab DC20 photometer. The inducer used to raise blood pressure is 8% NaCl for 14 days. Blood pressure is measured using non-invasive blood pressure. (NIBP). The results of the research showed that the flavonoid groups that play a role in lowering high cholesterol levels are the anthocyanins and quercetin, while the alkaloid compounds play a part in lowering high blood pressure. Data analysis showed significant results (p<0.05). It can be concluded that the administration of the ethyl acetate fraction Eleutherine Bulbosa is capable of lowering high cholesterol levels and high systolic-diastolic blood pressure.
MSC Secretome's Antibacterial Activity on P. aeruginosa Isolated from Diabetic Ulcer Patient Assyfa, Dini; Marlina, Marlina; Djamaan, Akmal
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4717

Abstract

The study aims to determine the antibacterial activity of adipose tissue-derived Mesenchymal Stem Cell (MSC) secretome against P. aeruginosa bacteria isolated from diabetic ulcer patients. Bacteria were isolated from specimens obtained from diabetic ulcer patient and identified using MacConkey and Blood Agar media followed by Polymerase Chain Reaction (PCR) molecular identification. Confirmed P. aeruginosa bacteria were used to evaluate the MSC secretome's antibacterial activity via the Kirby-Bauer method. Isolated bacteria grew on MacConkey media as gram-negative, non-lactose-fermenting bacteria, showing hemolytic capabilities on Blood Agar media. PCR identification yielded positive results for P. aeruginosa. In antibacterial activity testing against isolated bacteria, MSC secretome at concentrations of 1.25%, 2.5%, 5%, and 10% exhibited efficacy with average inhibitory zones measuring 8.17 mm, 8.23 mm, 8.52 mm, and 9.30 mm, respectively. The MSC secretome demonstrates antibacterial activity against P. aeruginosa bacteria isolated from diabetic ulcer patients.
DAMPAK PENGGUNAAN OBAT BERPOTENSI HEPATOTOKSIK TERHADAP LUARAN KLINIS PADA PASIEN SIROSIS HATI Efmisa, Ariesta Kirana; Rosi, Devahimer Harsep; Farnandi, Rido; Rahmi, Azimatur; Deswati, Deswati; Armal, Khairil
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4719

Abstract

Liver cirrhosis is a pathological liver disease characterized by the formation of fibrous tissue and regenerative nodules in liver cells. The potential for hepatotoxicity due to the use of hepatotoxic drugs leads to worsening of the liver disease suffered by these patients. This study aims to assess the impact of using potentially hepatotoxic drugs on patients' clinical outcomes. This study was an observational study with a cross-sectional design. Data were collected retrospectively through the medical records of patients with liver cirrhosis hospitalized in 2021. The clinical outcomes studied were SGOT, SGPT, albumin, total bilirubin and length of hospitalization. The results obtained were tested using the Kruskal-Wallis statistical test. A total of 62 patients with liver cirrhosis met the inclusion criteria as the study sample. The number of potentially hepatotoxic drug prescriptions received by patients based on Likelihood scores with categories A, B, C, D and E was 368 drugs out of 776 total drug prescriptions (47.4%). The most commonly prescribed potentially hepatotoxic drugs were paracetamol, ceftriaxon, and levofloxacin. It can be concluded that potentially hepatotoxic drugs are still prescribed to patients with liver cirrhosis. Age, gender, child pugh-score, number of drugs, and number of potentially hepatotoxic drugs had no significant effect (p>0.1) on SGOT, SGPT, albumin and total bilirubin. However, patients who received more drugs would have a higher.
Phytochemical Screening and Antioxidant Activity Evaluasi of Ethanol Extract of curcuma caesia Roxb by DPPH Method Kartini, Sri; Yusnita, Fitri; Serawaldi, Nadya Putri Auliya
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4739

Abstract

Black turmeric (Curcuma caesia Roxb) comes from the Zingberaceae family and is one of the natural antioxidant plants capable of combating free radicals. This study aims to determine the secondary metabolite compounds and antioxidant activity test of black turmeric ethanol extract. Extraction was carried out using 96% ethanol solvent by maceration method, secondary metabolite analysis by phytochemical screening method, and antioxidant activity test using DPPH (1,1 diphenyl-2-picrylhydrazyl) method with ascorbic acid as a comparator. The instrument used was a microplate reader with a maximum measurement wavelength of 520 nm. The parameter used to determine antioxidant activity is IC50 (Inhibition concentration). In this study, the results of phytochemical screening test on black turmeric positively contained alkaloids, flavonoids, tannins, saponins, steroids, and triterpenoids. The antioxidant activity test results of black turmeric ethanol extract (Curcuma caesia Roxb) as a sample obtained an IC50 value of 124.33 ppm, while ascorbic acid as a comparator had an IC50 value of 2.49 ppm. Based on these IC50 values, black turmeric ethanol extract has moderate antioxidant activity and ascorbic acid has very strong activity.
Analisis Kadar Kalsium Dari Maman Dan Fermentasi Maman (Cleome gynandra L) Jannah, Fathul; Agritubella, Syafrisar Meri; RZ, Ira Oktaviani; Uthia, Rahimatul
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Calcium is an important micronutrient that helps prevent stunting. It plays a crucial role in bone growth. Maman (Cleome gynandra L.) is a local plant that grows in the Riau province and is used by local people as a fermented food. To utilize this local plant, it is necessary to analyze its nutrients, including calcium levels. Calcium analysis was carried out using a quantitative descriptive method with an atomic absorption spectrophotometer. Validation of the atomic absorption spectrophotometry method yielded a correlation coefficient (r) of 0.9997, with calcium levels in maman leaves and fermented maman being 3132.33 mg/g and 1976.31 mg/g, respectively.

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