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JOPS (Journal Of Pharmacy and Science)
Published by Universitas Abdurrab
ISSN : 26229919     EISSN : 26151006     DOI : https://doi.org/10.36341/jops
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JOPS is Journal Of Pharmacy and Science with Scopes of Science : 1) Pharmacy 2) Food Chemistry 3) Biotechnology 4) Pharmacology 5) Microbiology 6) Food Analysis JOPS adalah Jurnal Farmasi dan Sains dengan Ruang Lingkup keilmuan : 1) Farmasi 2) Kimia makanan 3) Bioteknologi 4) Farmakologi 5) Mikrobiologi 6) Analisa Makanan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 130 Documents
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Hubungan Penggunaan Kombinasi Golongan Antidiabetes dan Antihipertensi Terhadap Kejadian Interaksi Obat Pada Pasien BPJS Rahmawaty, Annis; Agustina, Rika; Setyoningsih, Heni; Lina, Rifda Naufa
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4105

Abstract

Diabetes mellitus and hypertension are chronic diseases that require long-term therapy, patients will receive a combination of more than two types of drugs. Therapy with two or more types of drugs can cause drug interactions that have an impact on the patient's treatment. Chronic complications can affect body organs, including morbidity and mortality. The aim of this study was to determine the incidence of drug interactions when using a combination of antidiabetic and antihypertensive drug classes and to determine the relationship between the use of a combination of antidiabetic and antihypertensive drug classes on the incidence of drug interactions. This research was conducted prospectively on drug prescriptions for type 2 diabetes mellitus patients with hypertension in BPJS referral patients at Waras Purwodadi Pharmacy. A total of 51 samples were obtained. Data were analyzed descriptively to see the incidence of drug interactions using Stockley's Drug Interactions Eight Edition 2008, Drug Interaction Facts 2009, Medscape Drug Interaction Checker Application, and Drug Interaction Checker (Drugs.com). Data analysis was analyzed using SPSS using the Chi-Square test. There were drug interactions in 44 prescriptions (86.3%) and there were no drug interactions in 7 prescriptions (13.7%). The results of the Chi-Square test showed that there was a relationship between the use of combination of antidiabetic and antihypertensive drug of classes on the incidence of drug interactions in BPJS patients, with a value of P = 0.000 (P < 0.05). The conclusion is that there is a significant relationship Between The Use of Combination Antidiabetic and Antihipertensive drug of Classes On The Incidence Of Drug Interaction In BPJS Patients
Formulasi dan Uji Karakteristik Sediaan Gel Ekstrak Etanol Umbi Hati Tanah (Angiopteris evecta) handayani, Rezqi; Qamariah, Nurul
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4129

Abstract

Gel merupakan sediaan topikal semipadat yang memberikan sensasi dingin, mudah dibersihkan dan mudah tersebar serta penyerapannya yang baik pada kulit. Umbi Hati Tanah (Angiopteris evecta) mengandung senyawa flavonoid, tanin, dan saponin yang berperan sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol umbi Hati Tanah dapat diformulasikan menjadi sediaan gel antijerawat dan apakah sifat fisik sediaan gel tersebut memenuhi standar fisik. Metode yang digunakan dalam penelitian ini adalah eksperimental dengan membuat sediaan gel ekstrak etanol umbi Hati Tanah dengan variasi konsentrasi ekstrak 0%, 0,5%, 1% dan 5% serta dilakukan pengujian sifat fisik secara organoleptis, homogenitas, daya lekat, daya sebar, dan pH. Hasil penelitian diperoleh, formulasi sediaan gel yang ditambahkan ekstrak etanol umbi Hati Tanah memiliki bau dan warna yang khas dari ekstrak etanol umbi Hati Tanah. Sifat fisik sediaan gel ekstrak etanol umbi Hati Tanah yaitu F1, F2, dan F3 pada uji daya lekat memenuhi persyaratan, pada uji homogenitas hanya F2 yang memenuhi persyaratan. Sedangkan pada uji daya sebar hanya F1 yang memenuhi persyaratan, dan pada uji pH hanya F2 dan F3 yang memiliki nilai pH yang memenuhi persyaratan.
Validasi dan Penentuan Kadar Paracetamol dalam Jamu Pegal Linu yang Beredar di Pekanbaru Secara Spektrofotometri UV-Vis Serawaidi, Nadya Putri Auliya; Bali, Subardi; Aprilia, Suci
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4147

Abstract

Pengobatan herbal, salah satu cara pencegahan dan pengobatan yang berbahan dasar alam, telah dilakukan secara turun-temurun. Bahan Kimia Obat (BKO) ditambahkan pada sediaan obat konvensional untuk mempercepat efek terapeutik, karena produk ini banyak diminati konsumen. Peredaran obat herbal mengandung BKO yang berbahaya bagi masyarakat dilarang berdasarkan Peraturan Menteri Kesehatan No. 007 Tahun 2012. Obat herbal nyeri reumatik dan kekakuan yang dijual di Kota Pekanbaru akan dianalisis kandungan paracetamol BKO pada penelitian ini. Sampel b ditemukan tidak mengandung parasetamol, sebagaimana ditentukan melalui analisis kualitatif menggunakan kromatografi lapis tipis. Untuk analisis kuantitatif dengan Spektrofotometri UV-Vis dan metode ini divalidasi. Persamaan garis regresi linier yang diperoleh untuk parasetamol pada rentang konsentrasi 2-10 ppm adalah y = 0,0745x + 0,0422 yang memenuhi kriteria SNI, AOAC, dan Eurachem. Nilai r sebesar 0,9993. Kisaran persentase pemulihan yang dihasilkan adalah 96,375 hingga 96,822, yang memenuhi spesifikasi AOAC. RSD yang diperoleh sebesar 0,28% memenuhi kriteria yang ditentukan. Hasil perhitungan LOD yang diperoleh sebesar 0,6523 bagian per juta (ppm), sedangkan LOQ sebesar 2,174 ppm. Hasil analisis spektrofotometri UV-Vis menunjukkan sampel a, c, d, e, dan f mengandung parasetamol dengan konsentrasi masing-masing 3,54%, 6,65%, 7,71%, 6,00%, dan 5,84%.
Pengaruh Jenis Minyak Terhadap Karakterisasi Sifat Fisik dan Disolusi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Asam Fenofibrat Suhery, Wira Noviana; Djohari, Meiriza; Nur, Novia Risky
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4161

Abstract

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh komponen minyak pada sistem penghantaran obat self nanoemulsifying asam fenofibrat. Minyak yang diteliti adalah trigliserida rantai panjang (LCT) dan trigliserida rantai menengah (MCT). Minyak yang digunakan adalah minyak kacang tanah (F1), minyak jarak (F2), minyak kelapa murni (F3), dan minyak sawit (F4). Hasil penelitian menunjukkan bahwa kelarutan asam fenofibrat pada masing-masing minyak F1 (0,57 ± 0,009 mg/ml), F2 (5,45 ± 0,17 mg/ml), F3 (0,85±0,007 mg/ml), F4 (1,04±0,03 mg/ml) Kelarutan asam fenofibrat dalam SNEDDS; F1 (27,72±0,54 mg/ml), F2 (35,50±0,96mg/ml), F3 (29,58±0,47 mg/ml), dan F4 (32,14±0,44 mg/ml). Waktu emulsifikasi spontan yang berbeda yaitu F1 (146,51 ± 2,85 detik), F2 (37,11 ± 1,83 detik), F3 (99,98 ± 0,63 detik), dan F4 (56,40 ± 1,71 detik), dan hasil disolusi pada waktu 60 menit adalah F1 ( 73,66 ± 0,56%), F2 (96,52 ± 0,34%), F3 (77,87±0,81%), F4 (85,23 ± 0,98%). Jenis minyak dapat mempengaruhi karakterisasi sifat fisik dan disolusi asam fenofibrat SNEDDS. Formula terbaik adalah F2 yang mengandung minyak jarak sebagai komponen minyak.
Formulasi dan Uji Efektivitas Sediaan Lip cream dari Ekstrak Etanol Biji Buah Merah (Pandanus conoideus L) sebagai Pewarna Alami dengan Menggunakan Metode DPPH (1,1-Difenil-2-Pikrihidrazil) Primadani, Nur Baetty; Alyidrus, Rugayyah; Farid, Nurfiddin; Auliah, Nielma
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4173

Abstract

Formulation and Effectiveness Test of Lip Cream Preparations from Ethanol Extract of Red Fruit Seeds (Pandanus conoideus L) as A Natural Dye Using The DPPH (1,1-Diphenyl-2-Pikrihidrazil) Method. Red fruit seeds are botanical specimens that possess keratenoid chemicals, specifically b-carotene and a-carotene, which exhibit antioxidant properties. The objective of this study is to develop a stable Lipcream formulation and measure the IC50 value of the lipcream prepared from the ethanol extract of red fruit seeds (Pandanus conoideus L), which has antioxidant properties. An experimental research approach utilizing a solvent maceration technique with a solvent concentration of 96%. The obtained concentrated extract was subjected to rotation, followed by the fabrication of solutions with concentrations of 2%, 4%, and 6%, utilizing beeswax as a thickening agent. Kaolin is used as a texturizer. The emollients used are castor oil, cetyl alcohol, and dimethicon. Methyl paraben and propyl paraben are utilized as preservatives. Titanium dioxide serves as a pigment. The scent of vanilla. The preparation was evaluated by a cycling test consisting of 6 cycles over a period of 12 days. Organoleptic observations revealed a semi-solid texture, cream-like form, and a vanilla scent. The homogeneity test yielded consistent results, with pH measurements exceeding 0.05p, spreadability test results surpassing 0.05p, and adhesiveness test results meeting the specified standards. In addition to doing antioxidant testing, the DPPH method is employed using a UV-Vis spectrophotometer. The research findings indicate that the ethanol extract derived from red fruit seeds (Pandanus conoideus L) can be effectively made into a stable lip cream formulation, both in terms of its physical and chemical properties. The IC50 values obtained from the lip cream formulation including the ethanol extract of red fruit seeds (Pandanus conoideus L) were 59,496 ppm, 52,817 ppm, and 5,581 ppm, respectively. Formula 3 contains the most potent antioxidant value among all lip cream preparations.
Perbandingan Aktivitas Antijamur Ekstrak dan Fraksi Daun Gelinggang (Cassia alata L.) Terhadap Malassezia globosa dan Microsporum canis Sidoretno, Wahyu Margi
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4181

Abstract

Gelinggang (Cassia alata L.) leaves are traditionally used by Indonesian people to treat skin diseases such as ringworm, tinea versicolor and scabies. This study aims to determine the comparison of extract and fraction of gelinggang leaves against Malassezia globosa and Microsporum canis. The samples used were ethanol extract, n-hexane fraction, ethyl acetate fraction, ethanol fraction from gelinggang leaf. Based on phytochemical screening tests, flavonoids and alkaloids contained in gelinggang leaf ethyl acetate fraction and ethanol fraction. Terpenoids contained in the leaves gelinggang n-hexane fraction and ethyl acetate fraction. Saponins contained in the leaves gelinggang ethanol fraction. Phenolic contained in gelinggang leaf n-hexane fraction, ethyl acetate fraction and ethanol fraction. Antifungal activity testing using Kirby-Bauer method on Malassezia globosa obtained MIC with ethanol extract gelinggang leaf sample (1%) 10.4 mm; n-hexane fraction (1%) 7.8 mm; ethyl acetate fraction (1%) 16.3 mm; ethanol fraction (5%) 8,8 mm. Against Microsporum canis with gelinggang leaf sample ethanol extract (1%) obtained inhibition zone 15.5 mm; n-hexane fraction (1%) 9.9 mm; ethyl acetate fraction (1%) 18.2 mm; ethanol fraction (1%) 8.3 mm. It can be concluded that the extract and fraction gelinggang leaf able to inhibit are growth Malassezia globosa and Microsporum canis.
Uji Aktivitas Antidiabetes Ekstrak Etanol Daun Babandotan (Ageratum conyzoides L.) pada Mencit Putih (Mus musculus L.) Jantan yang Diinduksi Aloksan Febrina, Mira; Hasti, Syilfia; Nurisma, Arnel; Nanang, Nanang
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4192

Abstract

Diabetes mellitus adalah suatu penyakit yang disebabkan oleh adanya peningkatan kadar glukosa darah akibat kekurangan insulin baik absolut maupun relatif. Penelitian ini bertujuan untuk mengetahui aktivitas antidiabetes ekstrak etanol daun babandotan (Ageratum conyzoides L.) terhadap mencit putih (Mus musculus L.) jantan yang diinduksi aloksan. Penginduksi yang digunakan adalah aloksan monohidrat 175 mg/kgBB secara intraperitonial. Parameter yang diamati pada penelitian ini adalah kadar glukosa darah, berat badan, volume air minum 24 jam dan volume urin 24 jam. Sebanyak 30 ekor mencit dibagi secara acak ke dalam 6 kelompok perlakuan yaitu kelompok 1 merupakan kelompok normal yaitu mencit dengan kadar glukosa darah < 200 mg/dL dan hanya diberikan makan atau minum saja, kelompok 2 merupakan kontrol negatif yaitu mencit diabetes yang diberikan Na CMC 1%, kelompok 3 merupakan kontrol positif yaitu mencit diabetes yang diberikan glibenklamid 0,65 mg/kgBB dan kelompok 4, 5, 6 merupakan kelompok mencit diabetes yang diberikan ekstrak etanol daun babandotan dosis 200, 400 dan 600 mg/kgBB. Ekstrak etanol daun babandotan diberikan satu kali sehari selama 15 hari. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol daun babandotan dapat menurunkan kadar glukosa darah secara signifikan (p < 0,05) pada mencit diabetes, pada pengamatan berat badan terdapat perbedaan yang signifikan (p < 0,05) apabila dibandingkan dengan kontrol negatif dan terjadi penurunan volume air minum 24 jam (p < 0,05) serta penurunan volume urin 24 jam (p < 0,05).
Pengembangan Dan Validasi Kueisoner Untuk Mengukur Kepuasan Pasien Terhadap Penerapan Telefarmasi Di Apotek Pratiwi, Martania; Khoiriyah, Umatul; Hanifah, Suci
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4194

Abstract

Customer satisfaction surveys measure how satisfied consumers are with relevant product or service attributes and the importance of those attributes. In general, surveys use a five-point scale (Schiffman et al., 2010). Patient satisfaction can be revealed through several measuring tools. Questionnaires or assessment instruments are tools used to apply all content validity methods. The final result of content validity is an assessment of the appropriateness of the test content. Lawshe proposed a method called the content validity ratio as a result of measuring expert assessments of their agreement on content validity using statistical techniques of agreement between raters. The process of reviewing items by a panel of experts by providing input from validators is used as a reference to compose sentences that are more appropriate to the aspects and easy to understand. So to get a patient satisfaction questionnaire regarding the implementation of telepharmacy in pharmacies, some validation evidence is needed which can then produce a proper, valid questionnaire. and reliable for use in analysis of pharmacy telepharmacy patient satisfaction. To collect evidence of the validity of knowing and obtaining an instrument (questionnaire) that can be used to measure patient satisfaction with the implementation of telepharmacy services in pharmacies. Expert review (dianalisis CVI), Proses respon, Evaluasi struktur : internal struktur dengan EFA (eksplratory factor analysis) dan reliabilitas. From the SPSS results, analysis of factor loading values ​​with Cronbach's alpha shows that the total reliability score for the expected attribute is 0.977 for factor 1, expected 0.973 and 0.926 for factor 2, expected 0.926. Meanwhile, the results of the reality reliability test, the total Cronbach's alpha score, was 0.979, with the Cronbach's alpha value for factor 1 being 0.976 and factor 2 being 0.931. From the reliability data used for each subscale it is above 0.9 so that the question statement items with Cronbach's alpha values ​​are below 0.9 will experience elimination. A total of 10 questions were eliminated because the reliability value was below 0.9. The higher the Cronbach' alpha value, the more valid, good and reliable an item is said to be. The patient satisfaction questionnaire has sufficient evidence of validity including evidence of content validity, response process and internal structure.
Formulation and Evaluation of Ointment Preparations with Nutgrass Extract (Cyperus rotundus L.) Using Different Ointment Bases Wutsqa, Yusfia Urwatul; Munif, Abdul; Sari, Dwi Retno
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4199

Abstract

Nutgrass (Cyperus rotundus L.) is a medicinal plant that belongs to the Cyperaceae family. Nutgrass (Cyperus rotundus L.) is often used as a remedy to treat diseases caused by bacterial activity such as skin itching, boils, and vaginal discharge. The aim of this research is to determine the physical properties of the ointment containing nutgrass extract (Cyperus rotundus L.). Nutgrass (Cyperus rotundus L.) is extracted using 70% ethanol solvent and then formulated into ointments with different concentrations of hydrocarbon and absorbent bases. The ointment preparations made consist of three formulations with extract concentrations of 20%, 30%, and 40% to allow for comparison. The evaluation tests for the ointment preparations containing nutgrass extract (Cyperus rotundus L.) include organoleptic tests, homogeneity tests, pH tests, spreadability tests, adhesion tests, and stability tests. The analysis method used in this research is descriptive, which involves describing the results of the formulations of ointment preparations with nutgrass extract (Cyperus rotundus L.). The research results indicate that ethanol extract can be formulated into ointment preparations, and there are several tests that meet the evaluation criteria, namely organoleptic tests, adhesion tests, and homogeneity tests.
Activity Antibacterial Assay of Coffee Mistletoe Leaves (Loranthus Ferrugineus Roxb) Ethanol Extract is Against Bacteria Staphylococcus aureus and Escherichia coli Ningrum, Siti Rahmi; Dachi, Kanne; Saputri, Muharni
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coffee mistletoe (Loranthus ferrugineus Roxb) is a plant that has been researched globally and contains metabolite compounds such as flavonoids, tannins, saponins, and alkaloids, which have been extensively researched to have natural antimicrobial and antioxidant effects. For centuries, mistletoe has been widely used in traditional medicine as an anti-cancer agent for diarrhea and other infectious diseases. The study's goals are to find out what kind of metabolite compounds are in the ethanol extract of mistletoe coffee leaves and how well that extract kills Staphylococcus aureus and Escherichia coli bacteria. This research method is experimental, which includes collecting plant material, identifying plants, processing samples of coffee mistletoe into an ethanol extract of coffee mistletoe with a 96% ethanol solvent, and then testing phytochemical screening against coffee mistletoe simplisa. Antibacterial activity of an ethanol extract of coffee mistletoe against Staphylococcus aureus and Escherichia coli bacteria using the well diffusion test method. The ethanol extract of coffee mistletoe provides phytochemical screening results, including phenyl, terpenoids, and alkaloids. From the test results, it can be seen that the ethanol extract of coffee mistletoe can kill bacteria with the inhibitory power value of the extract on Staphylococcus aureus and Escherichia coli bacteria, with a minimum inhibitory power of 7.5 mm at a concentration of 3.125 mg/ml against Staphylococcus aureus and 8.9 mm at a concentration of 3.125 mg/ml against Escherichia coli bacteria. Judging from the inhibitory zone value, it is in the weak category for the lowest concentration in inhibiting the growth of Staphylococcus aureus and Escherichia coli bacteria.

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