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Yan Hendrika
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JOPS (Journal Of Pharmacy and Science)
Published by Universitas Abdurrab
ISSN : 26229919     EISSN : 26151006     DOI : https://doi.org/10.36341/jops
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JOPS is Journal Of Pharmacy and Science with Scopes of Science : 1) Pharmacy 2) Food Chemistry 3) Biotechnology 4) Pharmacology 5) Microbiology 6) Food Analysis JOPS adalah Jurnal Farmasi dan Sains dengan Ruang Lingkup keilmuan : 1) Farmasi 2) Kimia makanan 3) Bioteknologi 4) Farmakologi 5) Mikrobiologi 6) Analisa Makanan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 220 Documents
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Hubungan Penggunaan Kombinasi Golongan Antidiabetes dan Antihipertensi Terhadap Kejadian Interaksi Obat Pada Pasien BPJS Annis Rahmawaty; Rika Agustina; Heni Setyoningsih; Rifda Naufa Lina
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4105

Abstract

Diabetes mellitus and hypertension are chronic diseases that require long-term therapy, patients will receive a combination of more than two types of drugs. Therapy with two or more types of drugs can cause drug interactions that have an impact on the patient's treatment. Chronic complications can affect body organs, including morbidity and mortality. The aim of this study was to determine the incidence of drug interactions when using a combination of antidiabetic and antihypertensive drug classes and to determine the relationship between the use of a combination of antidiabetic and antihypertensive drug classes on the incidence of drug interactions. This research was conducted prospectively on drug prescriptions for type 2 diabetes mellitus patients with hypertension in BPJS referral patients at Waras Purwodadi Pharmacy. A total of 51 samples were obtained. Data were analyzed descriptively to see the incidence of drug interactions using Stockley's Drug Interactions Eight Edition 2008, Drug Interaction Facts 2009, Medscape Drug Interaction Checker Application, and Drug Interaction Checker (Drugs.com). Data analysis was analyzed using SPSS using the Chi-Square test. There were drug interactions in 44 prescriptions (86.3%) and there were no drug interactions in 7 prescriptions (13.7%). The results of the Chi-Square test showed that there was a relationship between the use of combination of antidiabetic and antihypertensive drug of classes on the incidence of drug interactions in BPJS patients, with a value of P = 0.000 (P < 0.05). The conclusion is that there is a significant relationship Between The Use of Combination Antidiabetic and Antihipertensive drug of Classes On The Incidence Of Drug Interaction In BPJS Patients
Formulasi dan Uji Karakteristik Sediaan Gel Ekstrak Etanol Umbi Hati Tanah (Angiopteris evecta) Rezqi handayani; Nurul Qamariah
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4129

Abstract

Gel is a semisolid topical preparation that provides a cool sensation, easy to clean easy to spread, and has good absorption on the skin. Hati Tanah tuber (Angiopteris evecta) contain Flavonoids, Tannins, and Saponins compounds that act as antibacterials. This study aims to determine whether the ethanol extract of Hati Tanah tuber can be formulated into an anti-acne gel preparation and whether the physical properties of the gel preparation meet the physical standards. The method used in this study was experiment by making gel preparations of ethanol extract of Hati Tanah tuber with variations in extract concentrations of 0%, 0,5%, 1%, and 5% and testing the physical properties of organoleptic, homogeneity, adhesion, dispersion, and pH. The results obtained showed that the gel preparation formulation add with ethanol extract of Hati Tanah tuber had a distinctive smell and color from ethanol extract of Hati Tanah tuber. The physical properties of gel preparations of ethanol extracts of Hati Tanah tuber, namely F1, F2, and F3 in the adhesion test meet the requirements, in the homogeneity test only F2 meets the requirements. While in the dispersion test, only F1 meets the requirements, and in the pH test only F2 and F3 have pH values that meet the requirements.
Validasi dan Penentuan Kadar Paracetamol dalam Jamu Pegal Linu yang Beredar di Pekanbaru Secara Spektrofotometri UV-Vis Nadya Putri Auliya Serawaidi; Subardi Bali; Suci Aprilia
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4147

Abstract

Herbal medicine, a method of prevention and treatment based on nature, has been used for generations. Medicinal Chemicals (BKO) are added to conventional medicinal preparations to accelerate the therapeutic effect, because these products are in great demand by consumers. The distribution of herbal medicines containing BKO which is dangerous to the public is prohibited based on Minister of Health Regulation No. 007 of 2012. Herbal medicines for rheumatic pain and stiffness sold in Pekanbaru City will be analyzed for the BKO paracetamol content in this study. Sample b was found not to contain paracetamol, as determined through qualitative analysis using thin layer chromatography. For quantitative analysis using UV-Vis Spectrophotometry and this method was validated. The linear regression line equation obtained for paracetamol in the concentration range of 2-10 ppm is y = 0.0745x + 0.0422 which meets the SNI, AOAC and Eurachem criteria. The r value is 0.9993. The resulting recovery percentage range was 96.375 to 96.822, which meets AOAC specifications. The obtained RSD of 0.28% meets the specified criteria. The LOD calculation results obtained were 0.6523 parts per million (ppm), while the LOQ was 2.174 ppm. The results of UV-Vis spectrophotometric analysis show that samples a, c, d, e, and f contain paracetamol with concentrations of 3.54%, 6.65%, 7.71%, 6.00%, and 5.84% respectively.
Pengaruh Jenis Minyak Terhadap Karakterisasi Sifat Fisik dan Disolusi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Asam Fenofibrat Wira Noviana Suhery; Meiriza Djohari; Novia Risky Nur
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4161

Abstract

The purpose of this study was to determine the effect of oil components of fenofibric acid self nanoemulsifying drug delivery systems. The investigated oils are long chain triglycerides (LCT) and medium chain triglycerides (MCT). The oils used are peanut oil (F1), castor oil (F2), virgin coconut oil (F3), and palm oil (F4). The study showed that the solubility of fenofibric acid in each oil F1 (0.57 ± 0.009 mg/ml), F2 (5.45 ± 0.17 mg/ml), F3 (0.85±0.007 mg/ml), F4 (1.04±0.03 mg/ml. The solubility of fenofibric acid in SNEDDS; F1 (27.72±0.54 mg/ml), F2 (35.50±0.96mg/ml), F3 (29.58±0.47 mg/ml), and F4 (32.14±0.44 mg/ml). The different spontaneous emulsification times were F1 (146.51 ± 2.85 seconds), F2 (37.11 ± 1.83 seconds), F3 (99.98 ± 0.63 seconds), and F4 (56.40 ± 1.71 seconds), and the results of dissolution at 60 minutes are F1 (73.66 ± 0.56%), F2 (96.52 ± 0.34%), F3 (77.87±0.81%), F4 (85.23 ± 0.98%). The type of oil can affect the characterization physical properties and dissolution of fenofibric acid SNEDDS. The best formula was shown by F2, which was a formula containing castor oil as an oil component.
Formulasi dan Uji Efektivitas Sediaan Lip cream dari Ekstrak Etanol Biji Buah Merah (Pandanus conoideus L) sebagai Pewarna Alami dengan Menggunakan Metode DPPH (1,1-Difenil-2-Pikrihidrazil) Nur Baetty Primadani; Rugayyah Alyidrus; Nurfiddin Farid; Nielma Auliah
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4173

Abstract

Formulation and Effectiveness Test of Lip Cream Preparations from Ethanol Extract of Red Fruit Seeds (Pandanus conoideus L) as A Natural Dye Using The DPPH (1,1-Diphenyl-2-Pikrihidrazil) Method. Red fruit seeds are botanical specimens that possess keratenoid chemicals, specifically b-carotene and a-carotene, which exhibit antioxidant properties. The objective of this study is to develop a stable Lipcream formulation and measure the IC50 value of the lipcream prepared from the ethanol extract of red fruit seeds (Pandanus conoideus L), which has antioxidant properties. An experimental research approach utilizing a solvent maceration technique with a solvent concentration of 96%. The obtained concentrated extract was subjected to rotation, followed by the fabrication of solutions with concentrations of 2%, 4%, and 6%, utilizing beeswax as a thickening agent. Kaolin is used as a texturizer. The emollients used are castor oil, cetyl alcohol, and dimethicon. Methyl paraben and propyl paraben are utilized as preservatives. Titanium dioxide serves as a pigment. The scent of vanilla. The preparation was evaluated by a cycling test consisting of 6 cycles over a period of 12 days. Organoleptic observations revealed a semi-solid texture, cream-like form, and a vanilla scent. The homogeneity test yielded consistent results, with pH measurements exceeding 0.05p, spreadability test results surpassing 0.05p, and adhesiveness test results meeting the specified standards. In addition to doing antioxidant testing, the DPPH method is employed using a UV-Vis spectrophotometer. The research findings indicate that the ethanol extract derived from red fruit seeds (Pandanus conoideus L) can be effectively made into a stable lip cream formulation, both in terms of its physical and chemical properties. The IC50 values obtained from the lip cream formulation including the ethanol extract of red fruit seeds (Pandanus conoideus L) were 59,496 ppm, 52,817 ppm, and 5,581 ppm, respectively. Formula 3 contains the most potent antioxidant value among all lip cream preparations.
Perbandingan Aktivitas Antijamur Ekstrak dan Fraksi Daun Gelinggang (Cassia alata L.) Terhadap Malassezia globosa dan Microsporum canis Wahyu Margi Sidoretno
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4181

Abstract

Gelinggang (Cassia alata L.) leaves are traditionally used by Indonesian people to treat skin diseases such as ringworm, tinea versicolor and scabies. This study aims to determine the comparison of extract and fraction of gelinggang leaves against Malassezia globosa and Microsporum canis. The samples used were ethanol extract, n-hexane fraction, ethyl acetate fraction, ethanol fraction from gelinggang leaf. Based on phytochemical screening tests, flavonoids and alkaloids contained in gelinggang leaf ethyl acetate fraction and ethanol fraction. Terpenoids contained in the leaves gelinggang n-hexane fraction and ethyl acetate fraction. Saponins contained in the leaves gelinggang ethanol fraction. Phenolic contained in gelinggang leaf n-hexane fraction, ethyl acetate fraction and ethanol fraction. Antifungal activity testing using Kirby-Bauer method on Malassezia globosa obtained MIC with ethanol extract gelinggang leaf sample (1%) 10.4 mm; n-hexane fraction (1%) 7.8 mm; ethyl acetate fraction (1%) 16.3 mm; ethanol fraction (5%) 8,8 mm. Against Microsporum canis with gelinggang leaf sample ethanol extract (1%) obtained inhibition zone 15.5 mm; n-hexane fraction (1%) 9.9 mm; ethyl acetate fraction (1%) 18.2 mm; ethanol fraction (1%) 8.3 mm. It can be concluded that the extract and fraction gelinggang leaf able to inhibit are growth Malassezia globosa and Microsporum canis.
Uji Aktivitas Antidiabetes Ekstrak Etanol Daun Babandotan (Ageratum conyzoides L.) pada Mencit Putih (Mus musculus L.) Jantan yang Diinduksi Aloksan Mira Febrina; Syilfia Hasti; Arnel Nurisma; Nanang Nanang
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4192

Abstract

Diabetes mellitus is a disease caused by an increased blood glucose level due to insulin deficiency, either absolute or relative. This study aims to determine the antidiabetic activity of the babandotan (Ageratum conyzoides L.) leaves ethanol extract against alloxan-induced male white mice (Mus musculus L.). The inducer used was 175 mg/kgBW of alloxan monohydrate intraperitoneally. The parameters observed were blood glucose level, body weight, 24-hour drinking water volume, and 24-hour urine volume. A total of 30 mice were divided randomly into 6 treatment groups, group 1 served as the normal group, namely mice with blood glucose levels < 200 mg/dL and were only given food or drink, group 2 served as the negative control, that is diabetic mice were given Na CMC 1 %, group 3 served as the positive control, namely diabetic mice that were given 0.65 mg/kgBW of glibenclamide and group 4, 5 and 6 were groups of diabetic mice that were given babandotan leaves ethanol extract doses of 200, 400, and 600 mg/kgBW. The ethanol extract of babandotan leaves was administered once a day for 15 consecutive days. The results showed that the administration of babandotan leaves ethanol extract significantly reduced blood glucose levels (p < 0.05) in diabetic mice, a significant difference in body weight observations (p < 0.05) compared to the negative control, a decreased of 24-hour drinking water volume (p < 0.05) and also a decreased of 24-hour urine volume (p < 0.05).
Pengembangan Dan Validasi Kueisoner Untuk Mengukur Kepuasan Pasien Terhadap Penerapan Telefarmasi Di Apotek Martania Pratiwi; Umatul Khoiriyah; Suci Hanifah
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4194

Abstract

Customer satisfaction surveys measure how satisfied consumers are with relevant product or service attributes and the importance of those attributes. In general, surveys use a five-point scale (Schiffman et al., 2010). Patient satisfaction can be revealed through several measuring tools. Questionnaires or assessment instruments are tools used to apply all content validity methods. The final result of content validity is an assessment of the appropriateness of the test content. Lawshe proposed a method called the content validity ratio as a result of measuring expert assessments of their agreement on content validity using statistical techniques of agreement between raters. The process of reviewing items by a panel of experts by providing input from validators is used as a reference to compose sentences that are more appropriate to the aspects and easy to understand. So to get a patient satisfaction questionnaire regarding the implementation of telepharmacy in pharmacies, some validation evidence is needed which can then produce a proper, valid questionnaire. and reliable for use in analysis of pharmacy telepharmacy patient satisfaction. To collect evidence of the validity of knowing and obtaining an instrument (questionnaire) that can be used to measure patient satisfaction with the implementation of telepharmacy services in pharmacies. Expert review (dianalisis CVI), Proses respon, Evaluasi struktur : internal struktur dengan EFA (eksplratory factor analysis) dan reliabilitas. From the SPSS results, analysis of factor loading values ​​with Cronbach's alpha shows that the total reliability score for the expected attribute is 0.977 for factor 1, expected 0.973 and 0.926 for factor 2, expected 0.926. Meanwhile, the results of the reality reliability test, the total Cronbach's alpha score, was 0.979, with the Cronbach's alpha value for factor 1 being 0.976 and factor 2 being 0.931. From the reliability data used for each subscale it is above 0.9 so that the question statement items with Cronbach's alpha values ​​are below 0.9 will experience elimination. A total of 10 questions were eliminated because the reliability value was below 0.9. The higher the Cronbach' alpha value, the more valid, good and reliable an item is said to be. The patient satisfaction questionnaire has sufficient evidence of validity including evidence of content validity, response process and internal structure.
Formulation and Evaluation of Ointment Preparations with Nutgrass Extract (Cyperus rotundus L.) Using Different Ointment Bases Yusfia Urwatul Wutsqa; Abdul Munif; Dwi Retno Sari
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4199

Abstract

Nutgrass (Cyperus rotundus L.) is a medicinal plant that belongs to the Cyperaceae family. Nutgrass (Cyperus rotundus L.) is often used as a remedy to treat diseases caused by bacterial activity such as skin itching, boils, and vaginal discharge. The aim of this research is to determine the physical properties of the ointment containing nutgrass extract (Cyperus rotundus L.). Nutgrass (Cyperus rotundus L.) is extracted using 70% ethanol solvent and then formulated into ointments with different concentrations of hydrocarbon and absorbent bases. The ointment preparations made consist of three formulations with extract concentrations of 20%, 30%, and 40% to allow for comparison. The evaluation tests for the ointment preparations containing nutgrass extract (Cyperus rotundus L.) include organoleptic tests, homogeneity tests, pH tests, spreadability tests, adhesion tests, and stability tests. The analysis method used in this research is descriptive, which involves describing the results of the formulations of ointment preparations with nutgrass extract (Cyperus rotundus L.). The research results indicate that ethanol extract can be formulated into ointment preparations, and there are several tests that meet the evaluation criteria, namely organoleptic tests, adhesion tests, and homogeneity tests.
Activity Antibacterial Assay of Coffee Mistletoe Leaves (Loranthus Ferrugineus Roxb) Ethanol Extract is Against Bacteria Staphylococcus aureus and Escherichia coli: UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN BENALU KOPI (Loranthus ferrugineus Roxb) TERHADAP BAKTERI Staphylococus aureus dan Escherichia coli Siti Rahmi Ningrum; Kanne Dachi; Muharni Saputri
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coffee mistletoe (Loranthus ferrugineus Roxb) is a plant that has been researched globally and contains metabolite compounds such as flavonoids, tannins, saponins, and alkaloids, which have been extensively researched to have natural antimicrobial and antioxidant effects. For centuries, mistletoe has been widely used in traditional medicine as an anti-cancer agent for diarrhea and other infectious diseases. The study's goals are to find out what kind of metabolite compounds are in the ethanol extract of mistletoe coffee leaves and how well that extract kills Staphylococcus aureus and Escherichia coli bacteria. This research method is experimental, which includes collecting plant material, identifying plants, processing samples of coffee mistletoe into an ethanol extract of coffee mistletoe with a 96% ethanol solvent, and then testing phytochemical screening against coffee mistletoe simplisa. Antibacterial activity of an ethanol extract of coffee mistletoe against Staphylococcus aureus and Escherichia coli bacteria using the well diffusion test method. The ethanol extract of coffee mistletoe provides phytochemical screening results, including phenyl, terpenoids, and alkaloids. From the test results, it can be seen that the ethanol extract of coffee mistletoe can kill bacteria with the inhibitory power value of the extract on Staphylococcus aureus and Escherichia coli bacteria, with a minimum inhibitory power of 7.5 mm at a concentration of 3.125 mg/ml against Staphylococcus aureus and 8.9 mm at a concentration of 3.125 mg/ml against Escherichia coli bacteria. Judging from the inhibitory zone value, it is in the weak category for the lowest concentration in inhibiting the growth of Staphylococcus aureus and Escherichia coli bacteria.

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