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Yan Hendrika
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JOPS (Journal Of Pharmacy and Science)
Published by Universitas Abdurrab
ISSN : 26229919     EISSN : 26151006     DOI : https://doi.org/10.36341/jops
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JOPS is Journal Of Pharmacy and Science with Scopes of Science : 1) Pharmacy 2) Food Chemistry 3) Biotechnology 4) Pharmacology 5) Microbiology 6) Food Analysis JOPS adalah Jurnal Farmasi dan Sains dengan Ruang Lingkup keilmuan : 1) Farmasi 2) Kimia makanan 3) Bioteknologi 4) Farmakologi 5) Mikrobiologi 6) Analisa Makanan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 220 Documents
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Potensi Antimikroba Fraksi Etil Asetat Daun Mangkokan (Nothopanax scutellarius (Brum.f.) Fosberg) Terhadap Berbagai Mikroba Patogen Goldha Faroliu; Annisa Fitri Angraini; Atyka Putri Wisni
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4227

Abstract

Mangkokan leaves (Nothopanax scutellarius (Brum.f.) Fosberg) is an ornamental plant that usually grows in home gardens, relatively popular and is used as an alternative medicine such as improving the digestive system, preventing hair loss, treating wounds, anti-inflammation, improving blood flow, preventing the appearance of symptoms of anemia and antioxidants. This study aims to determine the inhibitory power of extracts and ethyl acetate fractions towards Salmonella gastroenterites, Lactobacillus rhamnosus, Eschericia coli, Bacillus subtilis, and Candida albicans. The ethanol extract of mangkokan leaves contains alkaloids, saponins, phenolics, steroids and terpenoids, and the ethyl acetate fraction of mangkokan leaves shows that it contains phenolic, steroids and terpenoids. The ethanol extract and ethyl acetate fraction of mangkokan leaves has the ability to inhibit the growth of Salmonella gastroenterite, Lactobacillus rhamnosus, E.coli, B.subtilis, and C.albicans, with moderate categories of antibacterial activity and weak category for antifungal activity. It can be concluded that mangkokan leaf extracts and fractions have the potential to be antimicrobial.
Bahasa Inggris Urmatul Waznah; Khusna Santika Rahmasari; Wulan Agustin Ningrum; Hilda Fitria Wulandari
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4258

Abstract

Diabetes mellitus is a disease characterized by increased blood sugar levels (hyperglycemia). One of the enzymes that plays an important role in breaking down oligosaccharides and disaccharides into monosaccharides so that they are ready for absorption is the α-amylase enzyme which can delay and lengthen the digestion time of carbohydrates. Moringa (Moringa oleifera L) is a plant that originates from India and has now spread widely to tropical and subtropical areas throughout the world. Moringa leaves are known to contain the flavonoid, β-sitosterol, which can reduce sugar levels. The aim of this research was to examine inhibitory activity of α-amylase on methanol, n-hexane fraction and ethanol extract of Moringa leaves. The method for data analysis was carried out by obtaining antidiabetic test data, namely the % inhibition value of the α-amylase enzyme activity. From the results of the research that has been carried out, it can be concluded that there is α-Amylase enzyme inhibitory activity with moderate strength in samples of methanol partition and n-hexane partition of Moringa leaves carried out in vitro, with IC50 values of 105.302µg/ ml and 158.29µg/ml. Meanwhile, theMoringa leaves ethanol extract sample was carried out in vitro, with an IC50 value of 81,74 µg/ml.
Hubungan Penggunaan Antidiabetes Oral terhadap Nilai Klirens Kreatinin pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Umum di Jakarta Dini Permata Sari; Hanan Al Jabri
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4442

Abstract

Diabetes mellitus can cause various complications such as stroke, coronary heart disease, peripheral artery disease, retinopathy, neuropathy and nephropathy. Choosing the right drug in diabetes mellitus patients is very important because most antidiabetic drugs are excreted through the kidneys, so it is necessary to monitor creatinine clearance values as an indicator of impaired kidney function. The aim of this research is to find out the relationship between the use of oral antidiabetics and creatinine clearance values ​​in type 2 diabetes mellitus. This research is an observational analytical study with a cross-sectional data collection method on patients type 2 diabetes mellitusbetween January 2023 - December 2023 at a public hospital in Jakarta. This study obtained 39 patients, including the majority of patients who used oral anti-diabetics were women, 56.4%.The largest age was in the range 46 – 55 years at 38.5%. The most common type of drug is a combination of two drugs glimepirid + metformin as much as 35.9% and the creatinine clearance value in type 2 diabetes mellitus patients is a klirens kreatinin value < 90 mL/min/1.73m2 of 66.7%. The results of the chi-square test obtainedp=0.093. Based on the values obtained, there was no significant relationship between the use of oral antidiabetics and creatinine clearance values.
Faktor-Faktor yang Berhubungan dengan Pengendalian Tekanan Darah Pasien Hipertensi Pengguna Kaptopril dan Amlodipin Yopi Rikmasari; Noprizon Noprizon; Yunita Listiani Imanda
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4475

Abstract

Objective: Captopril and amlodipine are the antihypertensive drugs most widely used in primary health care facilities to control blood pressure in hypertensive patients, however, blood pressure control is influenced by many factors other than drug use. This study aims to analyze the differences in the effectiveness of captopril and amlodipine as well as factors related to controlling blood pressure in hypertensive patients Methods: The research design used cross-sectional correlational analysis using accidental sampling at two community health centers in the city of Palembang. Data sources are secondary data (medical records) and primary data (MMAS-8 questionnaire). Effectiveness is assessed by reducing systolic and diastolic blood pressure. Data were analyzed using descriptive statistics, Mann-Whitney and chi-square tests. Results: The research subjects were 94 people. The difference in the effectiveness of captopril and amlodipine using the Mann-Whitney test showed p=0.625 for systolic blood pressure and p=0.916 for diastolic blood pressure. The results of the chi-square test showed that the factors age (p=0.035), presence of comorbidities (p=0.015), accuracy of drug selection (p=0.009), medication compliance (p=0.011) were related to blood pressure control, while the gender factor (p=0.418 ), degree of hypertension (p=0.095), duration of therapy (p=0.074) and type of medication (p=0.216) were not related to blood pressure control. Conclusion: There was no difference in the effectiveness of captopril and amlodipine in this study. Factors related to blood pressure control are age, presence of comorbidities, choice of medication and adherence to medication
Evaluasi Kesesuaian Penggunaan Obat Antituberkulosis Pada Pasien Tuberkulosis Paru Lili Musnelina; Elvina Triana Putri; Jenny Pontoan; Syifa Nadila Putri
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4492

Abstract

Tuberculosis, caused by the bacterium Mycobacterium tuberculosis, primarily affects the lungs. This study aims to evaluate the precise use of antituberculosis drugs, focusing on factors such as patient suitability, correct indication, drug selection, dosage, administration method, and treatment duration. Sampling involved Purposive Sampling of pulmonary tuberculosis outpatients Dr. RSUD. H. Abdul Moeloek Bandar Lampung from January to December 2021, resulting in 89 patients. The data showed a majority of male patients, with 52 (58.4%) aged between 36 and 45 years, and 24 (26.9%) weighing between 46 kg and 55 kg. Additionally, 50 patients (56%) tested positive for sputum BTA and had undergone category I treatment previously. Evaluation of antituberculosis drug usage in these outpatients revealed 100% accuracy in patient suitability, indication, drug selection, dosage, and administration method, with a treatment duration of 15 days. Hence, it can be inferred that the utilization of antituberculosis drugs is appropriate.
Pengaruh Video Edukasi Penggunaan Suplemen Kesehatan saat Pandemi Covid-19 terhadap Tingkat Pengetahuan Masyarakat di Kecamatan Binawidya Pekanbaru Husnawati - Husnawati; R. Pebliana Syahara; Seftika Sari; Putri Lestari
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4513

Abstract

The significant increase in confirmed cases of COVID-19 necessitates the implementation of preventive measures by the general public to mitigate the risk of contracting the disease. One strategy that can be employed involves the consumption of health supplements. Among the most prevalent health supplements consumed by the public during the COVID-19 pandemic is vitamin C, which is taken to enhance immunity as part of the preventive measures against COVID-19. This research aims to see the effect of providing educational videos on the use of health supplements during the COVID-19 pandemic on the level of community knowledge in the Binawidya sub-district of Pekanbaru. This research is a quasi-experimental research with a non-randomized control group pretest-posttest design with data collection techniques, namely purposive sampling using a Google form questionnaire. In this research, the sample consisted of individuals from the Binawidya sub-district who met the inclusion criteria, totaling 100 respondents. The analysis of the knowledge data revealed a significant impact of educational videos on the utilization of health supplements amidst the COVID-19 pandemic, as evidenced by an obtained P value of 0.000, which is less than the predetermined significance level of 0.05.
Temuan Baru Ekstrak Kulit Nanas Sebagai Potensi Antidiabetes pada Tikus Putih (Rattus Norvegicus) Diinduksi Streptozotocin Eva Oktariani; Santi Widiasari; Faisal Faisal; Mega Rahayu Putri; Nurfadhilatusholiha Nurfadhilatusholiha
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4613

Abstract

Diabetes mellitus is chronic and metabolic disease which occurs because of the increase of blood glucose level or hyperglycemia caused the body which cannot produce or use insulin effectively. Hyperglycemia has a glucotoxic effect resulting in an increase in ROS (reactive oxygen species) thus inducing liver pathogenesis which promotes severe inflammatory and apoptotic responses, as indicated by an increase in the SGPT enzyme. The pineapple peel contains flavonoid. It is known of having a strong antioxidant activity. With the giving of pineapple peel extract, it is expected to decrease the blood glucose level. This research to find out the the effect of pineapple peel extract (Ananas comusus L. Merr) on decreasing blood glucose levels and SGPT levels in male white rats (Rattus norvegicus) induced by streptozotocin. This research is an experimental study with a research design of pretest and posttest control group design. The samples consisted of 18 rats divided into 6 groups consisted of: normal control, negative control, and positive control group given metformin, and pineapple peel extract with dose 200mg/KgBW, 300mg/KgBW and 500mg/KgBW for 28 days and the measurement of the rats blood glucose was conducted by blood glucose test meter at day 1, day 4 (after post inductionof STZ 45mg/KgBW given by intraperitoneal), and day 29. The analysis result of One Way ANOVA showed that pineapple peel extract with dose 200mg/KgBW, 300mg/KgBW, and 500mg/KgBW decrease the blood glucose level significant (p-value<0,05) with negative control group. There was no significant difference between 200mg/KgBW, 300mg/KgBW and 500mg/KgBW compared with positive control (p>0.05). There was an effect of pineapple peel extract administration on the SGPT levels of STZ-induced rats with a dose of 200mg/kg BW, 300mg/kg BW, 500mg/kg BW (p-value <0.05). The administration of 300mg/kg BW pineapple peel extract had the highest decrease in SGPT levels compared to other groups. Pineapple peel extract (Ananas comosus L. Merr) can reduce blood glucose leveland SGPT levels in rats induced by streptozotocin with the greatest reduction at dose 300mg/KgBW.
The Demineralization Optimization for Chitosan Synthesis from Crab Shell Waste (Portunus pelagicus) Intan Permata Sari; Esti Mulatsari; Esti Mumpuni; Agus Purwanggana
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4653

Abstract

Chitosan, gelatin, albumin, and sodium alginate are examples of natural polymers that are often utilized as a basis material for polymeric nanoparticles. The deacetylation of chitin molecules produces the formation of chitosan. Chitin, protein, CaCO3, MgCO3, and astaxanthin pigment are all found in crab shells. Crab shell is an undervalued potential waste. Despite the fact that copious crab shell waste can be used to produce raw materials and industrial products. According to the findings of Mohadi et al (2014), chitosan was extracted with a yield of 70.71% and a deacetylation degree of 76.6%. Previous research on optimizing chitosan synthesis has involved changing the base reagent at the deacetylation stage. The results showed that a 50% concentration of KOH reagent produced the best chitosan properties. Another study on the synthesis of chitosan from crab shells got a yield of 70.4%, and the following analysis showed that this high yield is due to the amount of calcium. Therefore, demineralization in the synthesis of chitosan from crab shells must be optimized. The calcium content was measured after optimization with various solvent concentration variations. The best demineralization optimization results use 3 M hydrochloric acid with a decrease in calcium content of 97.75%.
The Effect of Ethanol Extract of Cherry Tomato (Solanum lycopersicum L.) on Mast Cell Degranulation in Male White Mice Invitro Relin Yesika; Meiridha Mutiara Andania; Rahmi Nurdi
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4678

Abstract

Cherry tomatoes (Solanum lycopersicum L.) belong to the Solanaceae family which contains antioxidant compounds such as carotenoid compounds, which come from the terpenoid group, for example lycopene, besides cherry tomatoes also have flavonoid compounds. Both of these compounds have many pharmacological activities, one of which is as an anti-inflammatory. Inflammation starts from the process of mast cell degranulation, which is the process of releasing mast cell granules containing inflammatory mediators such as histamine, leukotriene and prostaglandins that cause type I hypersensitivity (allergies). This study aims to determine the effect of cherry tomato ethanol extract on mast cell degranulation of male white mice in vitro. The experimental animals used were male white mice that were actively sensitized after being induced with 20% ovalbumin antigen 0.2 mL/20 g BW on the first day intraperitoneally and the 7th day subcutaneously. The results of the average percentage of mast cell degranulation by cherry tomato extract at concentrations of 25 μg/ml; 50 μg/ml; 100 μg/ml and 200 μg/ml were 54.70%; 51.71%; 46.73%; 42.65% and 38.92%. This study shows that cherry tomato extract (Solanum lycopersicum L.) can inhibit mast cell degranulation in male white mice
Evaluası Penggunaan Antıbıotık Berdasarkan Krıterıa ATC/DDD pada Anak dengan Pneumonıa dı RSI Sıtı Rahmah Padang Cindy Elvionita; Hagi Varizal; Almahdy Almahdy
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4681

Abstract

Pneumonia is inflammation or infection of the respiratory tract which causes pain and makes it difficult for sufferers to breathe because there is fluid in the form of pus in the alveoli sacs. Pneumonia is the highest cause of death in the world, especially in children under 5 years of age. Pneumonia caused by bacterial infections is treated using antibiotics. Antibiotics that are used inappropriately can cause bacterial resistance, resulting in worsening infections, an increase in infections, longer hospital stays, and increased health service costs. The aim of this research is to determine the quantitative evaluation of antibiotic use in pediatric patients with pneumonia at RSI Siti Rahmah Padang. This research is observational analytic with a retrospective design. The samples used in this study were pediatric pneumonia patients aged ≤18 years who cmet the inclusion criteria. Quantitative analysis was carried out by calculating the quantity of antibiotics used by pediatric pneumonia patients based on ATC/DDD criteria. The research results showed that the total DDD was 51.69 DDD/100 patient-days with the highest DDD value for the antibiotic ceftriaxone with a value of 19.44 DDD/100 patient-days.

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