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Yan Hendrika
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JOPS (Journal Of Pharmacy and Science)
Published by Universitas Abdurrab
ISSN : 26229919     EISSN : 26151006     DOI : https://doi.org/10.36341/jops
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JOPS is Journal Of Pharmacy and Science with Scopes of Science : 1) Pharmacy 2) Food Chemistry 3) Biotechnology 4) Pharmacology 5) Microbiology 6) Food Analysis JOPS adalah Jurnal Farmasi dan Sains dengan Ruang Lingkup keilmuan : 1) Farmasi 2) Kimia makanan 3) Bioteknologi 4) Farmakologi 5) Mikrobiologi 6) Analisa Makanan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 220 Documents
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Pengaruh Metode Ekstraksi Maserasi dan Ultrasonik Terhadap Aktivitas Antioksidan Daun Beluntas (Pluchea indica L) Ernoviya Ernoviya; Zulfikri Zulfikri
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5324

Abstract

The antioxidant activity of the ethanol extract of beluntas leaves (Pluchea indica L.) was tested using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. This method is simple, easy to use and short in time. Several plants have used the ultrasonic extraction method for a short time and produced a higher yield than the maceration method. The aim of this research was to determine the effect of extraction methods on the antioxidant activity of beluntas leaves (Pluchea indica L.). This research method is an experimental method that uses beluntas leaves (Pluchea indica L.), extracted using the maceration method for 24 hours and ultrasonics for 30 minutes, 60 minutes. The extraction results were measured for their antioxidant activity using a UV-Vis Spectrophotometer. The results showed that extraction of beluntas leaves (Pluchea indica L.) using the maceration method produced an IC50 of 79.99 μg/ml and sonication for 60 minutes produced an IC50 of 54.29 ug/ml, including the strong category, while the ultrasonic method for 30 minutes produced an IC50 of 48.81 ug/ml. ml is in the very strong category. The conclusion of this research is that the ultrasonic extraction method produces higher antioxidant activity than the maceration method.
Uji Efektivitas Salep Ekstrak Etanol Daun Mahkota Dewa (Phaleria Macrocarpa) Terhadap Luka Sayat pada Tikus Putih Zulfikri Zulfikri; Zulfa Ismaniar Fauzi; Masrah Masrah; Khadizah Khadizah
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5327

Abstract

Mahkota Dewa is a medicinal plant that contains several active substances such as alkaloids, sapoins, tannins which can be used to affect collagen by inhibiting the production of wound tissue. The purpose of this study was to determine the effectiveness of the ethanol extract ointment from the leaves of Mahkota Dewa as a healer for cuts in white rats. This research is an experimental study, designed with a posttest Only Control Group design, where this study used the ethanol extract of Mahkota Dewa leaf ointment in three different concentrations: 5%, 10%, 15%, Povidone Iodine Ointment and Ointment Base. A number of 15 white rats were used as experimental animals. Mahkota Dewa Leaf Ethanol Extract Ointment with a concentration of 5%, 10%, 15% can heal cuts within 8 days, 7 days and 5 days respectively. Ointment with a concentration of 15% had almost the same healing time as the positive control, and the group given the ointment base (negative control) recovered on the 12th day. The conclusion of this study is that the ethanol extract of the leaves of Mahkota Dewa is effective in healing cuts in white rats.
Uji Aktivitas Ekstrak Etanol Okra Hijau (Abelmoschus esculentus L.) sebagai Penumbuh Rambut Pada Kelinci Jantan Naimatul Retno Faizah; Tresa tyas Margaretha
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5438

Abstract

Reduced hair density is a hallmark of hair loss, a medical condition. A deficiency in hair nourishment is one of the reasons of hair loss. The compounds in green okra include tannins, alkaloids, and flavonoids, are ingredients that may promote hair development. The purpose of this study was to study the effect of green okra ethanol extract on the hair development of male white rabbits and identify the optimal dose for this purpose is the main objective of this research. This study used a true experimental method. The hair-fertilizing activity test of green okra ethanol extract was carried out on 6 rabbits as positive control, negative control, normal control and samples with extract doses of 5%,10%, 20%. The results of the study showed that the average hair growth of rabbits with concentrations of 5%, 10% and 20% was 12.12 mm, 13.62 mm and 16.06 mm. The results of the anova test were 0.000. The conclusion of this study is that there is an effect of green okra ethanol extract on rabbit hair growth.
Pengaruh Pemberian Vitamin E terhadap Kondisi Dismenore Primer Pada Remaja Putri di Desa Sempaja Selatan Nurul Utamy; Hajrah Hajrah; Putri Anggreini
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5450

Abstract

Prevalensi dismenorea primer di Indonesia mencapai 64,5%. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian vitamin E terhadap kondisi dismenorea primer pada remaja putri di Kelurahan Sempaja Selatan. Metode penelitian adalah quasi eksperimental dengan time-series design, menggunakan pre-test dan post-test. subjek dalam penelitian ini adalah 50 remaja putri usia 10-19 tahun di Kelurahan Sempaja Selatan. Sampel yang digunakan vitamin E dikonsumsi selama 5 hari yaitu pada 2 hari sebelum menstruasi hingga 3 hari saat perdarahan. Instrumen penelitian berupa kuesioner karakteristik, kuesioner skala nyeri NRS dan WBFPRS dan kuesioner efek selain penurunan nyeri. Hasil data karakteristik remaja putri yang mengalami dismenorea primer di Kelurahan Sempaja Selatan yaitu berusia 19 tahun (38%), usia menarche >12tahun (50%), nyeri karena genetik (33%), dan status BMI underweight (56%). Selanjutnya, didapatkan hasil penurunan intensitas nyeri yang bermakna setelah mengonsumsi vitamin E jika dibandingkan pada saat responden tidak mengonsumsi vitamin E. Intensitas nyeri berdasarkan skala NRS menunjukkan penurunan pada saat responden mengonsumsi vitamin E (p = 0,000) dan berdasarkan skala WBFPRS juga menunjukkan penurunan intensitas nyeri setelah mengonsumsi vitamin E (p = 0,000). Vitamin E juga menimbulkan efek selain penurunan nyeri, yaitu nafsu makan meningkat 19%, kulit menjadi lebih cerah 12%, menjadi lebih bugar 16%, dan pandangan mata kabur 2%. Berdasarkan hasil tersebut, dapat disimpulkan bahwa vitamin E memiliki pengaruh terhadap kondisi dismenorea primer pada remaja putri di Kelurahan Sempaja SelatanKata kunci: Dismenorea primer, Efek selain penurunan nyeri, Intensitas nyeri, Vitamin E
Formulasi dan Uji Antibakteri Staphylococcus aureus Terhadap Sediaan Sabun Kertas Ekstrak Serai Dapur (Cymbopogon citratus) Dwi Retno Sari; Eno Mahmudah; Yusfia Urwatul Wutsqa
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5456

Abstract

Paper soap is a unique soap that has a thin sheet shape similar to paper. Citratus or also known as lemongrass is a well-known herbal medicine with a myriad of benefits. This study aims to evaluate the ethanol extract of lemongrass (Cymbopogon citratus Dc) as an ingredient in making paper soap. Lemongrass is known to contain various compounds such as saponins, flavonoids, and essential oils, which have the potential to inhibit bacterial growth. The experimental method was used to make paper soap from lemongrass extract with formulations I, II, and III with a percentage of 5%, 10% and 15% lemongrass extract. Then the evaluation and test of antibacterial effectiveness against staphylococcus aureus using the paper disc diffusion method. Organoleptic tests showed that the color and aroma of the soap became more intense with increasing extract concentration. The pH test revealed that the soap had a pH range of 6-11, suitable for soap. The foam height test showed all formulas, except the third, met the standard. The antibacterial test showed that the zone of inhibition of Staphylococcus aureus increased as the concentration of lemongrass extract increased. Formulations with 5%, 10%, and 15% percentages formed inhibition of 21.35 mm, 23.52 mm, and 26.6 mm, respectively. These results indicate that formulations containing higher lemongrass extract have relatively better antibacterial ability.
Skrining Fitokimia Ekstrak Herba Serai Wangi (Cymbopogon nardus) Variasi Pelarut dan Stabilitas Lotion Repellent Nyamuk Dwi Retno Sari; Moh Mukhlishin; Fawwaz Muhammad Fauzi
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5457

Abstract

Dengue Hemorrhagic Fever (DHF) is a health problem in Indonesia. Until the 22nd week of 2024, there were 119,709 dengue cases with 777 deaths. The use of citronella (Cymbopogon nardus) repellent is done to prevent it. This study aims to determine the content of citronella extract with ethanol (polar), ethyl acetate (semi-polar), and n-hexane (non-polar) solvents as active ingredients of mosquito repellent lotion and determine the stability of the lotion. The type of this research is experimental research with true experimental design:the posttest-only control group design. Phytochemical screening was conducted to determine the saponin, flavonoid, alkaloid, phenolic, triterpenoid, and steroid content of each extract. Lotion stability is tested for 28 days by storing the lotion at room temperature. On days 0, 14, and 28, the organoleptic, homogeneity, pH, adhesion, spreadability, and emulsion type tests were carried out on the lotion. The results of phytochemical screening showed that the ethanol extract contains saponins, flavanoids, and phenolics. The ethyl acetate extract contains steroid. The n-hexane extract contains triterpenoid and steroid. The results of the stability test showed that all preparations met the requirements of the organoleptic test, homogeneity test, pH test, adhesion test, and emulsion type test which are good and stable. But it does not meet the requirements of a good spreadability test.
Evaluation of Antituberculosis Potential of N-Hexane Extract And Ethanol Extract of Soursop Leaves (Annona Muricata L.) In Vitro Muhammad Sulaiman; Cut Fatimah; Muhammad Gunawan; Safrina Safrina
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5472

Abstract

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis, primarily affecting the lungs and transmitted through droplets. Indonesia ranks second in the world for pulmonary TB cases. Due to increasing resistance to synthetic TB drugs, alternative treatments are needed, such as soursop leaves, which are known to treat symptoms like coughing and bleeding. This study aims to evaluate the potential of soursop leaf extract against TB. The method used in this study is the Lowenstein-Jensen method with varying concentrations. Sputum samples from TB-positive patients were identified using Zheil-Nelsen staining, while soursop leaf extract was obtained through percolation using n-hexane and ethanol fractions. The results showed that the moisture content of soursop leaf powder was 5%, meeting the simplisia standard. The antituberculosis test revealed resistance to synthetic drugs starting from the second week, while the n-hexane extract showed resistance from the first week. The ethanol fraction inhibited bacterial growth until the third week, but positive growth occurred in the fourth week. Therefore, soursop leaf extract, particularly the ethanol fraction, shows potential as an alternative TB treatment, which warrants further investigation.
Uji Efektivitas Fraksi Etil Asetat Rambut Jagung (Zea mays L) Sebagai Antihipertensi Pada Tikus Putih Jantan Miming Andika; Asra Laila; Rizqa Hasanah; Fajrian Aulia Putra; Oryza i Sativa Fitrian; Nola Rahmadasmi
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Corn hair is a group of stigmas that are smooth, soft, and look like threads or yellowish hair. The use of corn hair, which is a waste from corn cultivation, is still limited to its use as a traditional medicine. Hypertension or high blood pressure is a chronic condition characterized by increased blood pressure on the walls of arteries. This study aims to determine the effect of the effectiveness of the ethyl acetate fraction of corn hair (Zea mays L) on the reduction of blood pressure in male white rats of the Wistar strain. This type of study is an experimental pre-test and post-test control group design, using Wistar male white rat test animals, the inducing used is NaCl 8%. Blood pressure measurements are carried out using the CODA®. Data analysis using the One Way Anova Statistical test followed by the Duncan test obtained the result that the administration of the ethyl acetate fraction of corn hair with doses of 250 mg/kgBB, 500 mg/kgBB, and 1000 mg/kgBB had a significant effect on reducing blood pressure (p<0.05). It can be concluded that the variation in the dose of the ethyl acetate fraction of corn hair (Zea mays L) has a significant difference in the reduction of blood pressure and affects histological improvement. The effective dose of the ethyl acetate fraction of corn hair in lowering blood pressure is a dose of 1000 mg/kgBB.
Test of Collagen-Chitosan Scaffold Activity on Healing Artificial Wounds on Rat (Rattus Norvegicus) Skin Alfrit Rahmatu Retra; Muhammad Gunawan; Muhammad Bagas Fahriansyah; Cut Fatimah
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5498

Abstract

Wounds are disorders of the skin's protective function characterized by the loss of epithelial tissue continuity, either with or without damage to other tissues such as muscles, bones, and nerves. Scaffolds with porous structures play an important role in supporting cell function and helping the formation of new tissues or organs. The design of scaffolds for tissue engineering must meet several criteria, such as having a surface that supports cell adhesion, stimulates cell growth, and maintains differentiated cells. In this study, scaffolds were made using chitosan and collagen. Chitosan is known to stimulate cell proliferation, increase collagen formation, and accelerate epithelial cell regeneration in injured skin. Meanwhile, collagen is considered a very promising material in tissue engineering because of its biocompatible, biodegradable, and low antigenicity properties. The results showed that collagen-chitosan scaffolds with added glycerol were able to accelerate wound healing in mouse skin. On the 16th day, the wound healing process was already visible in the scaffold group with a ratio of 80:20:20, while on the 17th day there was no significant difference between the comparison group and the 70:30:20 (F2) and 80:20:20 (F3) scaffold groups. This shows that the better the combination of collagen and chitosan, the faster the wound healing process. Higher collagen concentrations in chitosan scaffolds have been shown to be effective in increasing regeneration and accelerating wound healing.
Karakterisistik Ekstrak Etanol 96% Kulit Jeruk Purut, Analisa GCMS dan Penetapan Nilai SPF (Sun Protection Factor) Dewi Rahma Fitri; Nespi Leo Renzi; Triana Triana; In Rahmi Fatria Fajar; Iin Hardiyati
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5534

Abstract

Exposure to high intensity ultraviolet light can cause sunburn, erythema, and tanning. In addition, ultraviolet radiation encourages the formation of ROS (reactive oxygen species) and nitrogen species (RNS), resulting in skin damage. To prevent this, antioxidants are needed which function to protect the skin from the bad effects of ultraviolet rays. Kaffir lime or what is commonly called kaffir lime has the potential to be a rich source of bioactive compounds. Kaffir lime peel contains essential oil components such as linalool, citronellol, geraniol, citronellal, and other components that have antioxidant activity. The aim of this research was to determine the characteristics of 96% ethanol extract of kaffir lime peel, chemical content and determine the SPF value. Kaffir lime peel was extracted using 96% ethanol and tested for extract characteristics, GCMS analysis and SPF value tested using the Mansur method. The results of the extract characteristics test showed a yield of 8.22%, air content of 8.74%, ash content of 2.17% and drying loss of 1.3%. Phytochemical screening showed results containing tannins, alkaloids and flavonoids and secondary metabolite compounds, GC-MS analysis showed the compounds beta-mycrene, gamma terpinene, linalool, terpinen-4-ol, geraniol, caryophyllene, nerolidol, sphatulenol, citronellal and Neral. SPF test results at a wavelength of 290-320nm with a concentration of 100 ppm: 23.096271, 150 ppm: 35.833618, 200 ppm: 45.047732, 250 ppm: 56.55952, 300 ppm: 68.919985

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