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Yan Hendrika
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JOPS (Journal Of Pharmacy and Science)
Published by Universitas Abdurrab
ISSN : 26229919     EISSN : 26151006     DOI : https://doi.org/10.36341/jops
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JOPS is Journal Of Pharmacy and Science with Scopes of Science : 1) Pharmacy 2) Food Chemistry 3) Biotechnology 4) Pharmacology 5) Microbiology 6) Food Analysis JOPS adalah Jurnal Farmasi dan Sains dengan Ruang Lingkup keilmuan : 1) Farmasi 2) Kimia makanan 3) Bioteknologi 4) Farmakologi 5) Mikrobiologi 6) Analisa Makanan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 220 Documents
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Kadar Zat Besi dan Uji Hedonik pada Cookies Berbahan Tepung Kelakai dan Kacang Hijau Lamia Diang Mahalia; Grace Abigail Larongge; Harlyanti Muthma’innah Mashar
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.4790

Abstract

Background: To promote local food security, food diversification efforts can be made by utilizing local food sources such as kelakai and mung beans that can be processed into flour as a substitute for wheat flour in making cookies. Objectives: Analyze the iron content and determine the characteristics, organoleptic quality, and acceptability of cookies made from kelakai bean flour and mung bean flour. Methods: Completely Randomized Design with 3 treatments, F1 with a ratio of 40 g mung bean flour and 10 g kelakai flour, F2=40 g : 15 g, and F3=40 g: 20 g. Characteristics and acceptability testing using hedonic test; Fe content using atomic absorption spectophotometry. Results: The cookies produced have the characteristics of brownish green color, unpleasant odor (langu), less sweet taste, and very crunchy texture. The largest Fe content is in formula F3 which is 1.305 mg per piece of cookies (± 45 grams). The results of the acceptability test on aroma, taste, color, and texture show that the most preferred cookies are in formula F1. Conclusion: Cookies formula F1 has the potential to be developed into functional food because it has a fairly high iron content and good acceptability.
Sociodemographic Factors Associated with Chronic Obstructive Pulmonary Disease Comorbidities: Based on Indonesia Family Life Survey-5 Wardatul Jannah; Adi Nurmesa
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.4911

Abstract

COPD is still one of the major health problems in Indonesia. The aim of this study was to look at the relationship between sociodemographics and the incidence of comorbidities in COPD patients. Cross-sectional study design, using IFLS-5 data. Inclusion criteria were patients with a diagnosis of COPD by self-report, and at least 15 years old. Results: Of 34,252 people filling out household health questionnaires in IFLS 5, 618 subjects had COPD. Based on multivariate test, gender (aOR: 1.792 (1.282-2.506); p-value: 0.001), age 36-45 years (aOR: 1.259 (0.764-2.074); p-value: 0.028), age 46-55 years (aOR: 2.418 (1.365-4.282); p-value: 0.002), age 56-65 years (aOR: 2.418 (1.365-4.282); p-value: 0.002), and age >65 years (aOR: 3.502 (1.884-6.510); p-value: 0.000). 002), age 56-65 years (aOR: 3.502 (1.884-6.510); p-value: 0.000), and age >65 years (aOR: 6.508 (3.338-12.690); p-value: 0.000) had a significant association with the incidence of comorbidities in COPD patients in Indonesia.
ISOLASI DAN KARAKTERISASI BAKTERI DARI IKAN FERMENTASI BEKASAM (RASBORA SP.) SERTA EVALUASI POTENSI ANTIBAKTERINYA M. Rifqi Efendi; Yunita Safitri; Rustini Rustini; Mesa Sukmadani Rusdi
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bekasam is a traditional fermented fish product. This study aimed to isolate and identify the bacteria involved in the fermentation of Bekasam from Riau and evaluate the antibacterial potential of their ethyl acetate extracts. Bacterial isolation was conducted using the pour plate method with selective media (MRS agar-CaCO3 0.5%). Antibacterial activity was tested against Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) using the agar diffusion method, with chloramphenicol as a positive control. Four bacterial isolates were identified: Lactobacillus sp1 (BAC1), Lactobacillus sp2 (BAC2), Bacillus sp1 (BAC3), and Bacillus sp2 (BAC4). All ethyl acetate extracts from these isolates demonstrated antibacterial activity. The highest activity was observed from the Lactobacillus sp1 extract against E. coli, with an inhibition zone diameter of 16.1 mm.
The Immuno candies; Formulation, Characterization and Antioxidant Activity of Gotu Kola (Centella asiatica (L.) Urb) Herbal Hard Candy Rafita Yuniarti; Minda Sari; Misna Rosalinda Hutabarat; Nurul Hasanah; Zulmai Rani
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5185

Abstract

Background: Pagagan is a plant that has antioxidant properties. The benefits of antioxidants are essential for everyone because they can prevent cell damage due to the bad influence of free radicals. Formulating gotu kola in the form of candy is one effort so that the antioxidant effects of gotu kola can always be obtained easily because candy is a snack everyone likes and can be obtained easily anywhere. Objective: Formulate, physical characterization and antioxidant activity of hard candy immuno candies. Method: Hard candy formulation with varying concentrations of gotu kola herbal essence (0%, 1%, 5%, 10%, and 15%), physical characterization using organoleptic tests, water content, weight uniformity and stability, and antioxidant activity using the DPPH method. Results: Hard candy made with concentrations of 0%, 1%, 5%, 10%, and 15% has a sweet and slightly bitter taste (typical of gotu kola) at a concentration of 5%-15%, has a typical weak sugar aroma, and highwater content. respectively 0.72%, 0.77%, 0.84%, 0.8%, 0.89%, 0.95%, and is stable at a storage temperature of 8ºC-15ºC with closed packaging, has good weight uniformity, and IC50 values ​​were 32552.69 µg/mL, 12992.589 µg/mL, 12077.09 µg/mL 9669.15 µg/mL, 9484.519 µg/mL Conclusion: Gotu kola herbal juice can be formulated into hard candy up to a concentration of 15 %, has good physical characteristics as well as inactive antioxidant activity.
Aktivitas Antioksidan Polen Lebah Tetragonula testacetarsis Asal Kalimantan Timur Bambang Mego Hantoro; Paula Mariana Kustiawan
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5223

Abstract

Bee pollen is known for its various therapeutic activities, one of which is as an antioxidant. The utilization of Tetragonula testacetarsisbee pollen from East Kalimantan is still limited, and there is little scientific information available about its antioxidant activity. This study aims to determine the compound content in Tetragonula testacetarsis bee pollen and to evaluate its antioxidant activity. The pollen was macerated using 70% ethanol to obtain a thick ethanol extract. The extract was then tested using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method with UV-Vis spectrophotometry, and the antioxidant activity was determined using the % inhibition parameter. The test results showed that the % inhibition of Tetragonula testacetarsis bee pollen was 94.77% at a concentration of 100 ppm, indicating that Tetragonula testacetarsisbee pollen has antioxidant activity.
Uji Validasi Metode Penetapan Kadar Ibuprofen dalam Sediaan Tablet dengan Nama Dagang dan Generik Secara Spektrofotometri UV Wirda Tulljannah; Rahma Dona; Tilar Eka Widia Ningrum; Meiriza Djohari
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5247

Abstract

This study aims to determine the levels of ibuprofen in tablet preparations using the UV spectrophotometric method and determine the suitability of ibuprofen tablets with trade and generic names that meet the requirements according to the Indonesian Pharmacopoeia Edition VI. The determination of ibuprofen levels in tablet preparations was tested for validity based on linearity, limit of detection (LOD) and limit of quantitation (LOQ) parameters, accuracy with the spiked-placebo recovery method and precision. Based on the results obtained linearity value of r = 0.9993 with limit of detection (LOD) 0.2825 ppm and limit of quantitation (LOQ) 0.9418 ppm, accuracy obtained at 3 concentrations of 8, 10 and 12 ppm respectively 99.59%; 99.29%; and 99.99% and on precision obtained RSD results of 0.77%; 0.49%; 1.48%. The results of the determination of levels in the four samples of generic tablet preparations and trade names are 100.91%; 104.02%; 100.91%; and 100.99%. From the results of the study, it is concluded that the UV spectrophotometric method used has met the parameters set in the validation test and the ibuprofen levels obtained also meet the requirements set in the Indonesian Pharmacopoeia VI Edition, which is not less than 90% and not more than 110%.
Cost-Effectiveness Analysis of Erythropoietin in Anemia Therapy Strategies for Chronic Kidney Disease Patients Undergoing Hemodialysis: A Systematic Review Rosi Ami Sari; Seftika Sari; Dwi Endarti; Neni Frimayanti
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

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Abstract

Chronic kidney disease is a significant health issue, with increasing case numbers leading to higher treatment costs. This condition causes decreased kidney function and can result in anemia due to impaired red blood cell production. This study aims to analyze the cost-effectiveness of anemia treatment using Erythropoietin, either as a single therapy or in combination, for patients with chronic kidney failure undergoing hemodialysis. The methods employed include conducting a systematic review to identify problems, establish inclusion and exclusion criteria, and search various databases for relevant studies. The results show that cost-effectiveness varies depending on the Hemoglobin target and the type of Erythropoietin used. In conclusion, setting an appropriate Hemoglobin target and selecting the correct type of Erythropoietin are crucial for effective anemia treatment. This systematic review recommends a Hemoglobin target of >10–11 g/dL and the use of Erythropoietin is adjusted to the patient's condition so that the choice is more cost effective.
Anticonvulsant Activity of Flower Extract from Telang Plant (Clitoria ternatea L) in Male Albino Mice Induced Strychnine Erjon Erjon; Luluk Hasanah; Ensiwi Munarsih
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5279

Abstract

The telang plant (Clitoria ternatea L.) has been reported to have sedative activity and has the potential as an anticonvulsant. The purpose of this study was to test the anticonvulsant activity of the flower extract of the telang plant on male albino mice of the Swiss Webster strain. The extraction process used the maceration method. Testing parameters included seizure onset, time of death and recovery time. The doses used were 100, 200, and 400 mg/kgbw, and diazepam was used as a comparison with a dose of 5 mg/kgbw. The results of this study indicate that the flower extract ot the telang plant at doses of 100, 200, and 400 mg/kgbw has anticonvulsant activity. Increasing the dose of the flower extract of the telang plant correlated very strongly with the prolongation of seizure onset. A dose of 400 mg/kgbw can prevent the death of mice in the convulsion model. The flower extract of the telang plant has the potential to be developed as an anticonvulsant.
Correlation of Drug-Related Problems and Quality of Life in Chronic Kidney Disease (CKD) Patients Undergoing Hemodialysis Kiki Rawitri; Sri Wahyuni; Syilvi Rinda Sari; Lusi Grasia Situmorang; Zulmai Rani
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The complexity of treatment with the disease in patients with chronic kidney disease (CKD) can increase the incidence of Drug Related Problems (DRPs). Analysis of DRPs is very useful to reduce the duration of illness, death, and treatment costs. The condition of patients who require hemodialysis therapy can cause changes such as physical, psychological, lifestyle and social that have an impact on the quality of life. This study aims to determine correlation between DRPs and the quality of life of CKD patients undergoing hemodialysis at Dr. Pirngadi Hospital, Medan, Indonesia. This study uses an observational method with a retrospective and prospective cross sectional research design on 72 patients who met the inclusion criteria in February-March 2024. DRPs were analyzed applying Cipolle and quality of life was obtained using the EQ-5D-5L questionnaire. The data was analyzed using the Spearman Rho test in the SPSS program. The results showed that there were DRPs in 64 patients with the categories of needing additional drugs (3.38%), unnecessary therapy (15.54%), drug interactions (35.13%) and ineffective drugs (45.95%). Quality of life with categories of good (36.1%), adequate (41.7%), and poor (22.2%). The patient's average quality of life score was 0.657. There was a correlation between the number of DRPs and the patient's quality of life (r=-0.802) with a significance value of p=0.032 (p<0.05), which shows that the higher the incidence rate of DRPs, the lower the patient's quality of life. Based on the results of the study, it was concluded that there was a significant relationship between the number of DRPs events and the quality-of-life value of CKD patients undergoing hemodialysis.
Pengaruh Pemberian Ekstrak Etanol Daun Pepaya Jepang (Cnidoscolus aconitifolius (Mill.) I.M. Johnst) Terhadap Diferensial Leukosit Mencit Putih Jantan Relin Yesika; Irmisya Nure Firania; Fauzia Noprima Okta; Aina Fatkhil Haque; Rizki Oktarini; Yogie Andika Tri Nanda; Elisa Ayudia
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i1.5320

Abstract

Immunomodulators are medicines that alter or influence the immune system to make it work more effectively. Immunomodulators can increase (immunostimulants) or decrease immune response (immunosuppressants). Secondary metabolites that have immunomodulatory activity are polyphenols, alkaloids, and terpenoids. One of the plants that contain these secondary metabolites is Japanese papaya leaves. Japanese papaya leaves have been widely used as traditional medicine to treat various diseases. This study aims to determine the effect of the administration of Japanese papaya leaf extract on differential leukocytes of male white mice. This study used 24 male white mice with skin allergies after administering 20% ovalbumin 0.2 mL/20g BW intraperitoneally on day 1 and day 7 subcutaneously. Twenty male white mice were divided into 4 groups. Group I (control) mice weren’t given ovalbumin antigen or papaya leaf extract; groups II, III, and IV were given ovalbumin and extract (100; 200; 400 mg/kg BW). After oral administration of the extract for seven days, leukocyte differential count of white mice. Giving ethanol extract of japanese papaya leaves at doses of 100, 200, and 400 mg/kg BW can significantly affect leukocyte differentials, namely lymphocytes and monocytes (p<0.05). While basophils, eosinophils, rod-neutrophils, and segment-neutrophils are not significantly different (p>0.05).

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