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Yan Hendrika
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JOPS (Journal Of Pharmacy and Science)
Published by Universitas Abdurrab
ISSN : 26229919     EISSN : 26151006     DOI : https://doi.org/10.36341/jops
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JOPS is Journal Of Pharmacy and Science with Scopes of Science : 1) Pharmacy 2) Food Chemistry 3) Biotechnology 4) Pharmacology 5) Microbiology 6) Food Analysis JOPS adalah Jurnal Farmasi dan Sains dengan Ruang Lingkup keilmuan : 1) Farmasi 2) Kimia makanan 3) Bioteknologi 4) Farmakologi 5) Mikrobiologi 6) Analisa Makanan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 220 Documents
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Analisis Kepatuhan Minum Obat dan Outcome Terapi pada Pasien Hipertensi di Puskesmas Se-Kabupaten Bengkalis : Analysis of Medication Adherence and Therapeutic Outcome in Hypertension Patients at Public Health Centers in Bengkalis Regency Husnawati - Husnawati; Syilfia Hasti; Rizki Abi Rahman
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.5872

Abstract

Hypertension is a chronic disease and cannot be cured, but it can be controlled. One of the determining factors for the success of hypertension treatment is medication adherence to avoid complications. The level of adherence to antihypertensive varies among patients. The aim of this study is to analyze medication adherence and therapeutic outcome in hypertensive patients at health centers throughout Bengkalis Regency. This observational study uses a cross-sectional design with a descriptive-analytic method. The sample in this study consisted of 120 respondents who met the inclusion criteria, and the sampling technique was conducted using non-probability purposive sampling. This study was conducted at health centers across Bengkalis Regency, with five health centers serving as data collection sites. Based on this study, it was found that the majority of respondents (43.3%) had low adherence and only 37.5% achieved desired outcome. Based on the results of the Chi-Square test, it can be concluded that there is a relationship between medication adherence and therapeutic outcome in hypertensive patients at health centers throughout Bengkalis Regency, with a p-value of 0.001.
The Effect of Nigella sativa Extract on the Growth of Pseudomonas aeruginosa Isolated from Patients with Chronic Suppurative Otitis Media Zihazia Leumita; Harry Agoestaf Asroel; Devira Zahara; Ziza Putri Aisyia Fauzi
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.5988

Abstract

Chronic Suppurative Otitis Media (CSOM) is a persistent middle ear infection often associated with Pseudomonas aeruginosa, a multidrug-resistant bacterium. Nigella sativa, commonly known as black seed, is known to have antimicrobial properties and is traditionally used in alternative medicine. This study aims to evaluate the inhibitory effect of Nigella sativa extract on the growth of Pseudomonas aeruginosa isolated from ear secretions of CSOM patients. A laboratory experimental study was conducted using ear discharge specimens from patients diagnosed with CSOM. The bacteria were cultured and identified as P. aeruginosa. Ethanol extract of Nigella sativa was prepared in various concentrations (25%, 50%, 75%, and 100%). The antibacterial activity was measured using the disc diffusion method by assessing the inhibition zone diameters. The Nigella sativa extract demonstrated a concentration-dependent antibacterial effect. The largest inhibition zone was observed at 100% concentration, with a mean diameter of 16.1 mm, indicating vigorous antibacterial activity against P. aeruginosa. Statistical analysis showed significant differences in inhibition zone diameters across concentrations (p < 0.05). Nigella sativa extract exhibits promising antibacterial activity against Pseudomonas aeruginosa isolated from CSOM patients. It has potential as a natural therapeutic alternative for treating infections associated with CSOM.
Validasi Metode Analisis Niasinamid dan Asam Kojic Menggunakan Kromatografi Cair Kinerja Tinggi dan Aplikasinya dalam Sediaan Kosmetika: Validasi Metode Analisis Niasinamid dan Asam Kojic Menggunakan Kromatografi Cair Kinerja Tinggi dan Aplikasinya dalam Sediaan Kosmetika Aqnes Budiarti; Ninda Ariyanti; A Khoirul Anwar
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.5995

Abstract

The combination of niacinamide and kojic acid is widely used in skin lightening cosmetics. Although the combination is effective, the safety was limited by its levels in the preparation. The levels of both are relatively small, so required sensitive and simultaneous analysis methods. This study aims to develop an analysis method of niacinamide and kojic acid and apply validated method to cosmetics. The study used an isocratic type HPLC (Jazco) with UV-Vis detector at 268 nm. The stationary phase was C18 and the optimized mobile phase was acetonitrile: aquabides (20:80, v/v) with flow rate 1.0 mL/min. Validation tests of linearity, accuracy, precision, selectivity, and sensitivity (LOD and LOQ). The results showed that the developed method can be validated and applied. The linearity tests resulted a value of r=0.999; niacinamide accuracy 99.78-100.75% and kojic acid 99.79-100.69%, precision of both produced a %RSD value≤ 2%; The LOD and LOQ of niasinamide 0.026 μg/mL and 0.086 μg/mL; The LOD and LOQ of kojic acid 0.462 μg/mL and 1.540 μg/mL, selectivity was good. The niacinamide content in samples A, B, and C were 0.052%, 0.100%, and 0.138%. The kojic acid content in samples A, B and C were 0.610%; 1.127% and 1.531%, w/w.
Penentuan Nilai Konsentrasi Hambat Minimum (KHM) dan Konsentrasi Bunuh Minimum Minyak Daun Cengkeh (Syzygium Aromaticum) terhadap Propionibacterium acnes: Determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Clove Leaf Oil (Syzygium Aromaticum) against Propionibacterium acnes Yoan Dasawanti; Candrika Candrika
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.6001

Abstract

Infectious diseases are conditions caused by the entry of microorganisms into the body, leading to illness. One of the causes of infection is the bacterium Propionibacterium acnes. Continuous use of antibiotics can lead to resistance, thus alternative treatments such as the use of natural substances are needed. One of these alternatives is clove leaf. Clove leaves contain essential oil ranging from 1-4%, with eugenol as the main component. Eugenol has pharmacological activity as both an antimicrobial and anti-inflammatory agent. This study aims to determine the antibacterial activity of clove leaf oil against Propionibacterium acnes, specifically in determining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Clove leaf oil was obtained through water distillation with a yield of 2.88%. The MIC test was performed using the agar diffusion method, while the MBC test was conducted using the streaking method. The results showed that clove leaf oil exhibits antibacterial activity that increases with increasing concentration. The MIC was obtained at a concentration of 5 mg/mL with a zone of inhibition diameter of 8.13 mm, while the MBC was at a concentration of 20 mg/mL. This antibacterial activity is attributed to the eugenol content in clove leaf oil, which can damage bacterial cell membranes and increase intracellular protein leakage. These findings indicate that clove leaf oil has potential as an effective natural antibacterial agent against Propionibacterium acnes and could serve as an alternative herbal treatment. Keywords: Clove leaf oil , KHM, KBM, Propionibacterium acnes
Potential Antibiotic-Drug Interactions in Hospitalized Patients : A Retrospective Cross Sectional Study Syilvi Rinda Sari; Kiki Rawitri; Hindri Syahputri; Muhammad Amin Nasution; Nia Novranda Pertiwi
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.6018

Abstract

 Infectious diseases are frequently seen in hospitalized patients, and antibiotics are among the most commonly prescribed drugs. Patients in the hospital frequently experience drug interactions because their severe conditions frequently necessitate the simultaneous administration of many medications. This study aims to determine the frequency of potential drug interactions between antibiotics and other drugs in hospitalized patients at Dr. Pirngadi Hospital, Medan, Indonesia. This study uses an observational method with a retrospective cross-sectional study design on 300 patients who met the inclusion criteria in January-December 2023. Potential antibiotic drug interactions seen from the Medscape application. The results showed that only 20.33% of the total sample experienced potential interactions between antibiotics and other drugs in patients at Dr. Pirngadi Hospital in the period January-December 2023, namely only 61 patients from a total sample of 300 patients with 84 cases of potential interactions between antibiotics and other drugs. The potential drug interactions that occur are pharmaceutically as much as 5.26%, pharmacokinetically as much as 10.53%, and the majority, pharmacodynamically, as much as 84.21%.
Pengaruh Aplikasi Pengingat Minum Obat (APMO) Terhadap Tingkat Kepatuhan Pasien Diabetes Melitus (DM) di UPTD Puskesmas Simpang Tiga Pekanbaru: The Effect of Medication Reminder Application (APMO) on the Level of Compliance of Diabetes Mellitus (DM) Patients in Community Health Center Simpang Tiga Pekanbaru Denia Pratiwi; Erni Susanti; Adrian Mulya; Nadya Putri Auliya Serawaidi
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.6089

Abstract

Diabetes Melitus therapy can uses more than one type of drug preparation over a long period of time and has the potential to reduce the level of patient compliance in undergoing therapy. Non-compliance with planned therapy will cause therapy failure which can cause complications in DM patients. Some interventions that can be used to help improve compliance in DM patients include the Medication Reminder Application (APMO) via smartphone with two different applications. The purpose of this study was to determine the effect of the Medication Reminder Application (APMO) on the level of compliance of Diabetes Mellitus (DM) patients in the Community Health Center Simpang Tiga Pekanbaru. This study used a non-experimental method with a cross-sectional approach. The total population was 1358 patients and a sample of 93 patients who met the inclusion criteria. The sample of 93 people was divided into three groups, namely group APMO A of 31 people, group APMO B of 31 people and a group not given APMO of 31 people. The results of this study indicate that the Kruskal-Wallis analysis p-value = <0.001 (α <0.05) so that there are differences in the 3 groups, while the Chi-Square analysis p-value = <0.001 (α <0.05), thus indicating that the provision of APMO has a significant effect on the level of compliance of DM patients at the UPTD Puskesmas Simpang Tiga Pekanbaru.
Identifikasi Fungi Endofit Pada Tanaman Binahong (Andredera cordifolia) Serta Potensinya Sebagai Antibakteri Terhadap Staphylococcus aureus: Identification of Endophytic Fungi in Binahong Plants (Andredera cordifolia) and Their Potential as Antibacterials Against Staphylococcus aureus Hamtini; Ghani Nurfaizi; Aminah Aminah; Nining Kurniati; Mardyana Nizar
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.6109

Abstract

Indonesia is known as a mega biodiversity country rich in biodiversity, animals and their ecosystems. The parts of the binahong plant (Andredera cordifolia) that can be utilized come from flowers, leaves, stems, roots, and tubers that have metabolite compounds such as flavonoids, tannins, alkaloids, terpenoids and saponins. This can be used as a basis for utilizing binahong leaves from which endophytic fungi are taken to determine the potential for secondary metabolites from endophytic fungi in binahong leaves by means of isolation, identification and antibacterial potential against Staphylococcus aureus bacteria. The purpose of the study was to determine the presence or absence of endophytic fungi in binahong plants and to determine their potential as antibacterials in endophytic fungi isolated from binahong plants against Staphylococcus aureus. The methods in this study were isolation, purification of endophytic fungi, preparation of Staphylococcus aureus test bacteria, antibacterial test using the agar diffusion method. The results showed that there were 5 isolates of endophytic fungi, with isolate codes AK. H, AK. M, BT 1.1, BT 2.1, and DA 1, microscopically the fungi obtained were Penicillium sp, and Mucor sp. And have the ability to inhibit the growth of Staphylococcus aureus bacteria included in the strong category, with an average inhibition zone of 20 mm, 20.5 mm, 15.5 mm, 21 mm, 22.5 mm respectively. The conclusion of this study is that endophytic fungal isolates in binahong plants have the potential as antibacterials against Staphylococcus aureus.
Efek Analgetik Ekstrak Etanol Daun Afrika (Vernonia Amygdalina Del.) pada Mencit Putih Jantan dengan Metode Writhing Reflex Test: Analgetic Effect of Etanol Extract African Leaves (Vernonia Amygdalina Del.) on White Rats Using Writhing Reflex Test Method Relin Yesika; Miming Andika; Eka Desnita; Elsa Marsellinda
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.6111

Abstract

Secondary metabolites of medicinal plants, including polyphenols, flavonoids, terpenoids, and alkaloids, serve as crucial sources for the development of anti-inflammatory and analgesic drugs. One of the plants with a high concentration of secondary metabolites is African leaves, which contain a variety of secondary metabolites, including alkaloids, glycosides, steroids, flavonoids, tannins, terpenoids. Whithing reflex test, which used intraperitoneal injection of acetic acid 0.5% to induce the reflex. The mice, which were divided into six groups: Group I (normal animals): not administered any treatment; Group II (negative control): only administered acetic acid; Group III (positive control/comparator): administered ibuprofen 200mg/kgBW; Group IV: administered 150mg/kgBW extract, Group V: administered 300mg/kgBW extract, group VI: administered 600mg/kgBW extract. The number of writhes should be counted every 10 minutes for a duration of 30 minutes. The percentage of analgesic protection in groups I, II, III, IV, V, and VI, respectively, was 98.84%, 0%, 97.65%, 23.52%, 76.47%, and 88.23%. The one-way ANOVA test yielded significant results (p<0.05). African leaves extract has been demonstrated to reduce the number of pain-related writhing behaviors observed in male white mice following the administration of acetic acid. The highest percentage of analgesic protection was extract with dose of 600mg/kgBW.
Analisis Fitokimia dan Analisis GCMS Ekstrak Kembang Bulan Tithonia Diversifolia (Hemsl.) A. Gray: Analisis Fitokimia Dan Analisis GC-MS Ekstrak Kembang Bulan Tithonia Diversifolia (Hemsl.) A. Gray Dewi Rahma Fitri; Dedri Syaefei; Kartika Sari
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.6123

Abstract

Extracts from plants made from simple drugs are used as active ingredients, intermediates or finished product ingredients. The extract is standardized with two parameters specific and non-specific parameters. Non-specific extract quality parameters are indirect tests related to active compounds and their pharmacological activity, but aim to ensure the quality and uniformity of the extract. Specific extract quality parameters are aspects of chemical analysis that focus on the removal and quantification of active compounds in the extract that affect its pharmacological activity. The purpose of this study was to obtain a moonflower extract that meets specific quality standards related to the content of active compounds both qualitatively and quantitatively. The research method by testing the chemical compounds contained in the moonflower extract includes phytochemical screening, GCMS analysis and phenol content and total flavonoid content. The results of the study obtained 70% ethanol extract of moonflower with a yield value of 18.19%. Organoleptically, it is reddish brown in color, with a distinctive aroma of moonflower. The results of the water content are 9.79%, ash content 11.99%, and drying loss 13.64%. Contains flavonoids, phenols and tannins. The results of GCMS analysis contain compounds Benzenetricarboxylic acid, Cyclotetrasiloxane, octamethyl, Salicic acid, diethyl bis (trimethylsilyl) ester, Cyclotetrasiloxane-octamethyl, Heptasiloxane. Total flavonoid content is 3.2 Mg / g EQ and total phenolic content is Mg / g GEA.
Uji Parameter Spesifik Ekstrak Etanol Umbi Sarang Semut Asal Kalimantan Tengah: Specific Parameter Testing of Ethanol Extract of Sarang Semut Tubers from Central Kalimantan Rezqi Handayani; Fera Sartika; Eky Agus Setiawawan
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.6128

Abstract

Standardization is a series of parameters, procedures, and measurement methods whose results constitute elements related to the pharmaceutical quality paradigm. The standardization stage begins with the preparation of sample extracts by establishing specific parameters. Based on chemical screening tests of Sarang Semut plants originating from Papua and Aceh, they contain phenolic and flavonoid compounds as antioxidants, while those from Central Kalimantan have antibacterial properties. The aim of this research is to identify and determine the pharmacognostic profile based on specific parameters of the ethanol extract of Sarang Semut tubers originating from Central Kalimantan. This research uses an experimental method with specific parameter procedures including extract identity, organoleptic examination, determination of water-soluble and ethanol-soluble compound content, and identification tests for secondary metabolite chemical compounds. The extraction of Sarang Semut tubers in this study used the Soxhlet extraction method. Based on the results of specific parameter tests, it is known that the ethanol extract of Sarang Semut tubers contains chemical compounds, namely alkaloids, flavonoids, saponins, tannins, steroids, triterpenoids, and quinones. The results of the water-soluble compound content test were 16.03%, and the ethanol-soluble compound content was 41.57%. The results obtained from this study can be concluded that the ethanol extract of Sarang Semut tubers has secondary metabolites with pharmacological effects, one of which is as an antibacterial agent, so it can be developed into a raw material for traditional medicine.

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