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Indonesian Journal of Medicine

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Published by Universitas Sebelas Maret

ISSN : - EISSN : 25490265 DOI : -

Core Subject : Health,

Medicine & Pharmacology Public Health

Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.

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Articles 273 Documents

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Multiple Segments Thoracal Spinal Canal Stenosis Caused by Ossification of Ligamentum Flavum: A Case Report Wiguna, I Gusti Lanang Ngurah Artha; Raditya, I Nyoman Yuda; Arimbawa, Ida Bagus Gede
Indonesian Journal of Medicine Vol. 7 No. 3 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Thoracal spinal canal stenosis (SCS) that refers to multiple segments of the thoracic spine is a peculiar clinical condition. Various factors can cause thoracic SCS, including ossification of the ligamentum flavum (OLF). The aim of this study is to explain about the diagnosis for multiple segment thoracal spinal canal stenosis and management properly to prevent further complications.Case Presentation: A 58-year-old male came to Orthopaedic Outpatient Clinic in Prof. I.G.N.G Ngoerah Hospital, complaining back pain since one year prior to admission. Pain aggravated when he was bending his back. The patient was diagnosed with Thoracal Spinal Canal Stenosis Th 8-9, Th9-10, Th10-11. Patient underwent decompression, stabilization, fusion and biopsy surgery.Results: Patient underwent decompression, stabilization, fusion and biopsy surgery at RSUP Prof. I.G.N.G Ngoerah. In durante operation, already done laminectomy and eight pieces of pedicle screw was applied in Th8-Th11 (55mm x 40 mm Monoaxial on right side Th8, 55mm x 40 mm Polyaxial on left side Th8; 55mm x 40 mm Monoaxial on right side Th9, 55mm x 35 mm Monoaxial on left side Th9; 55mm x 40 mm Monoaxial on right and left side Th10; 55mm x 40 mm Monoaxial on right and left side Th11). There were no complications found in this patient after 4th day following surgery.Conclusion: The goal of surgical intervention for SCS is decompression by removing the calciﬁc areas that are responsible for the spinal canal narrowing and subsequent cord compression. Although the diagnosis and choice of intervention can be difﬁcult, early detection and management are critical to postoperative success. Postoperative results are variable and often unsatisfactory.Keywords: Spinal canal stenosis, ligamentum flavum, spine, surgeryCorrespondence: I Gusti Lanang Ngurah Artha Wiguna. Division of Spine, Department of Orthopaedic and Traumatology, Prof. I.G.N.G Ngoerah Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia. Email:lanangwiguna20021979@gmail.com. Mobile: 0811388859.Indonesian Journal of Medicine (2022), 07(03): 278-288https://doi.org/10.26911/theijmed.2022.07.03.04

Effect of Date Palm (Phoenix dactylifera) Fruits Consumption on Birth Delivery Outcome: Meta-Analysis Ratna Purwani Siwi; Bhisma Murti; Didik Tamtomo
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: The choice of cesarean section continues to increase in the world and is expected to continue to increase over the coming decades, which is almost a third of all deliveries in 2030. The benefits of dates for improving labor processes are considered to increase vaginal deliveries and also reduce the frequency of cesarean sections with the aim of reducing bigger complications. This study aims to analyze and estimate the influence of the consumption of dates on labor outcomes.Subjects and Method: This study is a systematic review and meta-analysis with PICO, P: Pregnant women, I: consumption of dates, C: No consumption dates, O: Bishop's score, length of labor, and postpartum hemorrhage. Data collection was obtained from databases, namely: PubMed, Science Direct, Springer Link, and Google Scholar. Keywords used “date fruit” OR “date palm” OR “phoenix dactylifera” AND “labor” AND “delivery”, AND “oxytocin” AND “hemorrhage”. The inclusion criteria used were full papers in English with the design of randomized controlled trials in 20002022. This study was analyzed using RevMan 5.3 software.Results: Meta-analysis was conducted on 4 primary studies from several countries such as Iran, Malaysia, and Saudi Arabia with a sample size of 603 pregnant women. The meta-analysis concluded that there was an effect of date consumption on cervical dilatation upon admission to the hospital (SMD= 0.73; CI 95%= 0.09 to 1.38; p=0.030). Consumption of dates also has an effect on the duration of active 1st stage labor (SMD= 0.46; CI 95%= 0.82 to 0.09; p= 0.010). Consumption of dates has a weak effect on the length of stage II labor (SMD= 0.05; 95% CI= 0.88 to 0.78; p= 0.910). In addition, the consumption of dates also has a weak effect on the length of stage III labor (SMD=0.16; CI95%=0.46 to 0.79; p=0.610).Conclusion: Consumption of dates has an influence on labor outcomes.Keywords: phoenix dactylifera, dates, labor, postpartum hemorrhage, Bishop scoreCorrespondence: Ratna Purwani Siwi. Masters Program in Public Health, Universitas Sebelas Maret. Jalan Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: ratnapsiwi@yahoo.com. Mobile: 085602389598.Indonesian Journal of Medicine (2023), 08(01): 79-91https://doi.org/10.26911/theijmed.2023.08.01.08

Association between Troponin I and Mortality in COVID-19 Patients: Meta-Analysis Study Krisnawati, Hesthi; Dewi, Yulia Lanti Retno; Murti, Bhisma
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: COVID-19 is a new disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 became a pandemic disease that killed 4 million people for almost 2 years. COVID-19 patients with comorbidities or risk factors are more prone to have a worse prognosis, one of which is heart disease which can be checked through troponin I values. This study aimed to determine the relationship between troponin I levels and mortality in patients with COVID-19.Subjects and Method: This was a systematic review and meta-analysis by searching for articles from databases such as Science Direct, Springer, Google Scholar, and PubMed using the keywords: troponin I, cohort, fatality, cardiac biomarker, death, coronavirus, COVID-19 mortality, and COVID-19. Ten accredited articles published between 2019-2021 were included for meta-analysis. The subjects of this study were 10,499 COVID-19 patients. The intervention in this study was high troponin I levels, while the comparison was normal troponin I levels. The outcome of this study is mortality in COVID-19 patients. Data processing using Review Manager software version 5.3 for the relationship between troponin I levels and mortality in COVID-19 patients.Results: From a meta-analysis of 10 primary research articles in China, Spain, New York (United States), France, Turkey, and Philadelphia (United States) showed an association between high troponin I levels and an increased risk of mortality in COVID-19 patients (aOR= 3.07; 95% CI= 1.68 to 5.61; p<0.003).Conclusion: High troponin I levels increase the risk of mortality in COVID-19 patients.Keywords: troponin I, heart disease, mortality, COVID-19.Correspondence: Hesthi Krisnawati. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: hesthikrisna86@gmail.com. Mobile: +6285278067840.Indonesian Journal of Medicine (2021), 06(03): 347-353https://doi.org/10.26911/theijmed.2021.06.03.12

Mortality of TB-HIV Co-Infection Patients Based on CD4 Level: Meta-Analysis Victoria Husadani Permata Sari; Setyo Sri Rahardjo; Bhisma Murti
Indonesian Journal of Medicine Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Tuberculosis (TB) is the most common cause of death in patients with the Human Immunodeficiency Virus (HIV). Understanding CD4 as a predictor of mortality from TBHIV coinfection is critical to improving disease management and minimizing mortality. This study aims to examine the mortality risk of TBHIV-coinfected patients based on CD4 values.Subjects and Method: Metaanalysis was performed according to the PRISMA flow chart and the PICO model (Population: TBHIV coinfected patients, Intervention: CD4 value <200 cells/µL, Comparison: CD4≥200 cells/µL, Outcome: mortality). The databases used are Google Scholar, PubMed, Scopus, Proquest, and Science Direct. Keywords used (coinfection OR "mixed infection") AND (HIV OR "Human Immunodeficiency Virus") AND (TB OR “tuberculosis”) AND ("CD4 count" OR "T4 lymphocyte") AND “mortality”. The inclusion criteria were full-text articles with cohort studies published in 20122022, articles in English, and multivariate analysis using the adjusted hazard ratio. Analysis was performed with Revman 5.3.Results: 17 articles with cohort design originating from Ethiopia, Khayelitsha, Kenya, Cape Town, Uganda, Brazil, Suriname, Sao Paulo, Guinea Bissau, Myanmar, Durban, Ireland, China, and multicountry studies between Europe and Latin America totaling 24,514 research sample. A meta-analysis of 10 study cohorts concluded that CD4<200 cells/µL had a 2.00 times risk of mortality compared with CD4 values ≥200 cells/µL (aHR=2.00; 95% CI 1.44 to 2.78; p<0.001). A meta-analysis of 7 study cohorts concluded that CD4<100 cells/µL had a 2.40 time risk of mortality compared with CD4 values≥200 cells/µL (aHR=2.40; 95% CI 1.61 to 3.57; p<0.001). A meta-analysis of 7 study cohorts concluded that CD4<50 cells/µL had a 3.12 times risk of mortality compared with CD4 values≥200 cells/μL (aHR=3.12; 95% CI 1.51 to 6.46; p<0.001).Conclusion: Decreased CD4 values increase the risk of mortality.Keywords: tuberculosis, HIV, CD4, mortality, meta-analysisCorrespondence: Victoria Husadani Permata Sari. Master’s Program in Public Health, Universitas Sebelas Maret. Jl. Ir Sutami 36A, Surakarta 57126, Jawa Tengah. Email: victoriahusadani@gmail.com. Mobile: 081393539020.Indonesian Journal of Medicine (2022), 07(04): 456470https://doi.org/10.26911/theijmed.2022.07.04.11

The Effectiveness of Ethanol Extract Chayote (Sechium Edule (Jacq.) Swartz) Fraction and Juice on Pancreatic β-Cell Diameter of Male White Rats Wistar Strain with Type 2 Diabetes Mellitus Hutagalung, Sanggam Bangun; Siahaan, Jekson Martiar; Silitonga, Hendrika Andriana
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Diabetes Mellitus is characterrized by metabolic disturbances due to prolonged hyperglycemia, causing oxidative stress, which destroys pancreatic β cells. Adjuvant therapy that has antihyperglycemic effectiveness and is required to improve the diameter of pancreatic beta cells, one of which comes from Sechium edule (Jacq.) Swartz has potential as an antihyperglycemic, antioxidant, antiapoptosis, cardioprotective, insulin resistance. This study aimed to examine the effectiveness of ethanol extract, Chayote (Sechium Edule (Jacq.) Swartz) fraction, and juice on the pancreatic β-cell diameter of white male rats Wistar strain with type 2 diabetes mellitus.Subjects and Method: This was a randomized controlled trial. Sample was Rattus novergius sp. 54 tails. The dependent variable was the diameter of the pancreatic β cells. The independent variables were ethanol extract, Sechium edule (Jacq.) Swartz fraction and juice, at a dose of 50 mg/kg BW, 100 mg/ kg BW, 150 mg/kg BW. The data were analyzed by the ANOVA test.Results: The group of mice induced by Streptozotocin 50 mg/kg BW + nicotinamide (120 mg/ kg BW) + HFD and obtained ethanol extract of chayote fruit 150 mg/ kg BW, orally, had the highest pancreatic β cell diameter compared to the other groups (Mean= 284.03; SD= 5.15).Conclusion: Sechium edule (Jacq.) Swartz has potential as an anti-apoptosis that can inhibit pancreatic β cell damageKeywords: pancreatic β cells, anti-apoptosisCorrespondence: Sanggam Bangun Hutagalung. Department of Anatomical Pathology, Faculty of Medicine, Universitas Methodist Indonesia, Medan. Jl. Setia Budi Pasar II Tj. Sari, Medan 20132, North Sumatera. Email: sanggam1973@gmail.com.Indonesian Journal of Medicine (2021), 06(03): 239-245https://doi.org/10.26911/theijmed.2021.06.03.01

Meta-Analysis the Effect of Aquatic Therapy on Functional Ability in Patients with Knee Osteoarthritis Puspita, Wita Hana; Tamtomo, Didik Gunawan; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Knee OA can affect mobility in the elderly causing pain and impaired functional ability. This study aims to analyze the effect of aquatic therapy on functional ability in knee osteoarthritis patients based on the results of a number of previous primary studies..Subject and Method: This study was conducted using a meta-analysis method with articles searched using the search keywords "knee osteoarthritis" OR "osteoarthritis genu" AND "aquatic therapy" OR "hydrotherapy" OR "water exercise" AND "functional ability" OR "WOMAC" AND "Randomized Controlled Trial” OR “RCT” from PubMed, google scholar and science direct and processed using RevMan 5.3.Results: 9 RCT articles that fit into the inclusion criteria, with a total of 573 samples. Knee OA patients receiving aquatic therapy had a mean WOMAC score of 1.22 units lower than those without aquatic therapy, and the effect was statistically significant (SMD = -1.22; 95% CI -2.03 to -0.41; p = 0.003). In other words, aquatic therapy is effective in improving functional ability in knee OA patients.Conclusion: Aquatic therapy has an effect on increasing functional ability in knee osteoarthritis patients.Keywords: Osteoarthritis, aquatic therapy, WOMAC indexCorrespondence: Wita Hana Puspita. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: wita.tj0408@gmail.com. Mobile: +628164837959.Indonesian Journal of Medicine (2022), 07(02): 138-149https://doi.org/10.26911/theijmed.2022.07.02.03

Correlation between Cardiorespiratory Fitness and Blood Pressure in Elderly Fitri Filmasari; Farid Rahman; Young Ari Kusworo
Indonesian Journal of Medicine Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Due to its strong association with major morbidity and mortality in the elderly, such as heart attack, stroke, kidney disease, and death, hypertension is currently one of the health problems associated with non-communicable diseases. It is certainly influenced by various vari¬ables, one of which is one’s cardiorespiratory fitness which can affect blood pressure. The study aims to find out if there is a correlation between cardiorespiratory fitness and blood pressure in the elderly.Subjects and Method: The cross-sectional study was conducted in Pepe Village, Kwarasan, Juwiring, Klaten, Central Java. A sample of 31 elderly people was selected by using purposive sampling. The dependent variable was blood pressure. The independent variable was cardiorespiratory fitness. Cardiorespiratory fitness was measured by the Six Minute Walking Test (SMWT). Blood pressure was measured with a sphygmomanometer. The correlation between cardiorespiratory fitness and blood pressure was tested using Pearson correlation and Spearman rho with a 95% confidence interval and p<0.050 statistical meaningfulness.Results: Cardiorespiratory fitness lowered systolic blood pressure by 0.14 mmHg (r= -0.14; p= 0.442) and diastolic blood pressure by 0.55 mmHg (r= -0.55; p= 0.771), but both were statistically insignificant.Conclusion: There was no relationship between blood pressure and physical fitness in the elderly.Keywords: hypertension, blood pressure, cardiorespiratory fitness, six-minute walking test, elderly.Correspondence: Farid Rahman. Study Program of Physiotherapy, Faculty of Health Sciences, Universitas Muhammadiyah Surakarta. Jl. Ahmad Yani, Pabelan, Kartasura, Surakarta, Central Java 57162, Indonesia. Email: Fr280@ums.ac.id. Mobile: 085223333141.Indonesian Journal of Medicine (2022), 07(04): 379-386https://doi.org/10.26911/theijmed.2022.07.04.03

Meta-Analysis the Effect of Acupressure in Lowering Pain of Dysmenorrhea Rahmawati, Anisya Fajar; Prasetya, Hanung; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Dysmenorrhea is the most common cause of lower abdominal pain and has a negative impact on women's quality of life resulting in activity limitations. Non-pharmacological management can be used as an intervention in the management of dysmenorrhea. Acupressure is a therapy that is given by massaging or pressing certain points. The purpose of this study was to analyze the effect of acupressure therapy on reducing dysmenorrhea pain.Subject and Method: This study was a meta-analysis with the following PICO, population: Women aged 16-30 years old with primary dysmenorrhea. Intervention: administration of Acupressure Therapy. Comparison: Acupressure therapy was not performed. Results: Decreased pain in primary dysmenorrhea. The articles used in this study were obtained from three databases, namely Google Scholar, Pubmed, and Science Direct. Keywords to search for articles “Acupressure” OR “Acupressure Therapy” AND “Sanyinjiao Point (SP6)” AND “Hequ Point (LI4)” AND “Dysmenorrhea” OR “Primary Dysmenorrhea” OR “Menstrual Pain” AND “Randomized Controlled Trial”. The articles included are full-text English with a Randomized Control Trial study design from 2007 to 2022. The articles were selected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.Results: Meta-analysis of 9 randomized controlled trial articles from Asia and Europe concluded that acupressure therapy can reduce pain in primary dysmenorrhea (SMD= -0.66; 95% CI = -0.96 to -0.36; p < 0.001).Conclusion: Acupressure therapy can affect pain reduction in women with complaints of primary dysmenorrhea.Keywords: Acupressure, pain relief, primary dysmenorrheaCorrespondence: Anisya Fajar Rahmawati. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Mobile: +6285715840985. Email: anisyafajar25@gmail.com.Indonesian Journal of Medicine (2022), 07(01): 51-60https://doi.org/10.26911/theijmed.2022.07.01.06

Profile of Cognitive Impairement in Patients with Brain Tumors in Dr. Moewardi Hospital, Surakarta Hapsari, Maria Yosita Ayu; Ilyas, Muhana Fawwazy; Ristinawati, Ira; Stepvia, Stepvia; Novika, Revi Gama Hatta
Indonesian Journal of Medicine Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Brain tumor is a disease that is difficult to treat and causes high morbidity and morta¬lity. One of the clinical manifestations of brain tumors is cognitive impairment which is the most common neurological problem. The aim of this study is to determine the profile of cognitive impairment in patients with brain tumors.Subjects and Method: The design of this study was a retrospective cross-sectional using secondary data from the Neurology Polyclinic of RSUD Dr. Moewardi in January 2021-March 2022. The subject was diagnosed with a brain tumor based on anamnesis, physical examination, and neuroimaging. Cognitive impairment was inferred through the MoCA-Ina test. The analysis used was univariate descriptive analysis, independent T test, Mann-Whitney test, and Pearson correlation test.Results: There were 29 subjects with a mean MoCA-Ina score (17.97). Primary brain tumors (79.3%), more than metastatic tumors. The majority of patients were diagnosed with meningioma (55.2%). This study showed that there were differences in abstraction scores (p=0.015) and total MoCA-Ina scores (p=0.042) between patients with tumors located in the temporal lobe and non- temporal lobe; differences in abstraction scores (p=0.034) and orientation scores (p=0.042) between patients with supratentorial and infratentorial tumors; and differences in memory scores (p=0.028) between patients with and without radiation history. In addition, this study also found an association between the number of lobes affected by brain tumors with attention score (p=0.027; r=-0.409), abstraction score (p=0.004; r=-0.524), orientation score (p=0.021; r=-0.426), and the total score of MoCA-Ina (p=0.018, r=-0.435).Conclusion: There is an association between brain tumors and cognitive impairment which is concluded through the MoCA-Ina test. The clinical manifestations of cognitive impairment in the patient are in accordance with the neuroanatomical function of the brain affected by the lesion.Keywords: Cognitive, Tumor, MoCA-InaCorrespondence: Maria Yosita Ayu Hapsari. Department of Neurology, Faculty of Medicine, Universitas Sebelas Maret/ Moewardi Hospital, Indonesia. Email: ayositahapsari@gmail.com. Phone: 0813 3155 5412.Indonesian Journal of Medicine (2022), 07(02): 242-250https://doi.org/10.26911/theijmed.2022.07.02.12

Association between Community Perception and Willingness to Vaccinated Againts COVID-19 in Surakarta, Central Java, Indonesia Dewi, Annita Viesta Nirmala; Kharisma, Alya Ayu; Inas, Nailah Salma; Habiba, Chusna; Indriyani, Okti; Dharmawan, Caroline; Jihadillah, Syarifah; Mujahidah, Hibah; Trisiadewi, Kharisma; Ramadhani, Nabila; Wahidah, Nurul Jannatul; Novika, Revi Gama Hatta
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Covid-19 has been declared a pandemic since March 2020 until now, so the government requires the provision of a covid-19 vaccine for all people. The government's vaccination campaign has received various responses from the public, some people accept and some reject the Covid-19 vaccine. This study aims to determine the relationship between public perception of the acceptance of the COVID-19 vaccine in Surakarta.Subjects and Methods: The cross sectional study was conducted in Surakarta. A sample of 65 people aged >12 years was selected by random sampling. The dependent variable was the willingness to receive the covid-19 vaccine. Tthe independent variable was perception. Data was collected by online questionnaire (google form). Data were analyzed by chi square test.Results: There is a relationship between public perception of vaccination and acceptance of the covid-19 vaccine (OR=5.45 ; 95% CI= 2.57 to 11.53 ; p<0.001)Conclusion: There is a significant relationship between perceptions related to vaccines and people's willingness to receive the COVID-19 vaccine.Keywords: covid-19, acceptance, knowledge, rejection, vaccinationCorrespondence: Annita Viesta Nirmala Dewi. Midwifery Study Program, Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir Sutami 36 Surakarta, Central Java. Email: contact.anitaviee@gmail.com. Mobile: +6285103027268.Indonesian Journal of Medicine (2021), 06(04): 430-438https://doi.org/10.26911/theijmed.2021.06.04.09

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