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The Effect of Physical Exercise on Quality of Life of Breast Cancer Survivors: A Systematic Review Jadmiko, Arief Wahyudi; Kristina, Tri Nur; Sujianto, Untung; Prajoko, Yan Wisnu; Dwiantoro, Luky; Widodo, Aris Puji
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Exercise generally improves the quality of life (QoL) in adult populations especially for patients with chronic health problems such as breast cancer. The purpose of this study was to investigate the effect of physical exercise/activity on the quality of life of breast cancer survivors. Subjects and Method: This was a systematic review study that used articles from online databases, such as PubMed, Science Direct, ProQuest dan Medline, which was published from 2000 to 2021. The author used keywords of “physical exercise”, “physical activity”, “quality of life”, “breast cancer survivor”. The dependent variable was quality of life. The independent variable was physical exercise/ activity. As many as 5 articles were selected for this study from 837 articles located in South Korea, Iran, Malaysia, and China.Results: Moderate or high levels of physical activity had positive relationship on the quality of life related to overall physical health among breast cancer survivors.Conclusion: Moderate to high physical activity improve the quality of life among breast cancer survivors.Keywords: physical exercise, physical activity, quality of life, breast cancer survivor Correspondence: Arief Wahyudi Jadmiko. Nursing Department, Faculty of Health, Universitas Pembangunan Nasional Veteran Jakarta. Jl. Raya Limo Depok 16515 West Java, Indonesia Email: ariefwjadmiko@gmail.com. Mobile: 085647213628. ORCID ID https://orcid.org/0000-0002-9691-0986.Indonesian Journal of Medicine (2021), 06(04): 377-386https://doi.org/10.26911/theijmed.2021.06.04.03

Meta-Analysis: The Effect of Acupuncture Therapy in Reducing Migraine Recurrence Elsa Tursina; Hanung Prasetya; Bhisma Murti
Indonesian Journal of Medicine Vol. 8 No. 1 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Acupuncture therapy is an effective treatment for reducing headache intensity, migraine recurrence, and improving quality of life. This study aims to analyze and estimate the effect of acupuncture therapy on reducing migraine recurrence.Subjects and Method: This study used a systematic review and meta-analysis by following PICO, Population: migraine patients. Intervention: acupuncture therapy. Comparison: no acupuncture therapy. Result: reduction in migraine recurrence. The data used were obtained from scientific research articles from the Pubmed, Google Scholar, Science Direct, and SpringerLink electronic databases with a Randomized Control Trial (RCT) design from 2011 to 2022 which reports effect sizes with Mean and SD. The keywords used in the search for scientific articles are “Acupuncture” AND “Profilaxis Migraine” AND “Migraine Frequency”. The selection of articles was carried out using the PRISMA flowchart. Data were analyzed using Review Manager software version 5.4.1.Results: A total of 9 articles with qualified RCT designs from Asia, America, Australia, and Europe were selected for the systematic review and meta-analysis. The results of the meta-analysis showed that patients with migraine who received acupuncture therapy experienced migraine recurrence 0.31 units lower than those who were not treated with acupuncture (SMD= -0.31; 95% CI= -0.61 to -0.01; p=0.040).Conclusion: Acupuncture therapy reduces migraine recurrence.Keywords: acupuncture, relapse, migraine.Correspondence: Elsa Tursina. Master’s Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah. Email: elsa090798@gmail.com. Mobile: +6285655751077.Indonesian Journal of Medicine (2023), 08(01): 47-58https://doi.org/10.26911/theijmed.2023.08.01.05

Comparison of the Effectiveness of the Chemosurgery and Cryosurgery for the Treatment of Patients with Condyloma Acuminatum at Dr. Moewardi Hospital, Surakarta Mawardi, Prasetyadi; Febrianto, Bobby; Yuliarto, Danu
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Condyloma acuminatum (CA) is one of the most common sexually transmitted infections. Several therapeutic modalities that can be used are chemosurgery with trichloroacetic acid and cryosurgery with liquid nitrogen. Recurrence in CA often occurs, so selecting the right therapeutic modality and eliminating the lesion also prevents recurrence. This study aimed to compare the effectiveness of chemosurgery and cryosurgery therapy in patients with CA who are treated at Dr. Moewardi Hospital, Surakarta.Subjects and Method: A retrospective cross-sectional study was conducted at the Dermatology and Venereology Polyclinic, Dr. Moewardi Hospital, Surakarta, from January 1, 2018, to December 31, 2020. The study subjects were 78 patients diagnosed with CA based on ICD-10 criteria, while chemosurgery and cryosurgery procedures were based on ICD-9. The dependent variable was healing time in weeks. The independent variables were chemosurgery and cryosurgery therapy. The data came from the patient's medical record. Data were analyzed using an independent t-test.Results: Based on univariate analysis, most patients were male (67.9%), and the age group was 20-29 years (51.28%). Most of the CA patients work as private employees (46.15%). The most sexual orientation was heterosexual (53.8%), the most common site of lesions was genital (47.4%), and 52.6% were coinfected with HIV. Most CA patients received chemosurgery (70.5%). Bivariate analysis showed that chemosurgery therapy provided faster clinical improvement (Mean= 23.34; SD= 26.45) than cryosurgery therapy (Mean= 28.69; SD= 19.84), and the difference was statistically significant (p= 0.037).Conclusion: Treatment of CA using chemosurgery provides clinical improvement faster than cryosurgery, so that faster treatment time can reduce treatment costs and improve the patient's quality of life.Keywords: chemosurgery, cryosurgery, HPV, condyloma acuminatumCorrespondence: Prasetyadi Mawardi. Department of Dermatology and Venereology, Faculty of Medicine of Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Central Java, Indonesia. Email: prasetyadimawardi@gmail.com/ prasetyadi_m@staff.uns.ac.id. Mobile: +6281229750211.Indonesian Journal of Medicine (2021), 06(03): 290-297https://doi.org/10.26911/theijmed.2021.06.03.06

Meta-Analysis the Effectiveness of Ivermectin Use on the Length of Stay in Inpatients of COVID-19 Wijayanto, Masromi Hendria; Tamtomo, Didik; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: COVID-19 is a common problem in global health. COVID-19 is a disease that infects the respiratory tract caused by the Coronavirus virus. Symptoms range from mild to severe and life-threatening pneumonia can occur. At the beginning of the PSBB, information circulated that Ivemectin could treat COVID-19 infections. Ivermectin is an antiparasitic drug that can be used as prophylaxis and therapy for coronavirus disease 2019. Ivermectin is an alternative therapy for COVID-19 because there is a previous drug, chloroquine, which can be used to treat COVID-19. This study aims to estimate the effectiveness of Ivermectin on the duration of hospitalization of patients with COVID-19 based on the results of previous similar studies.Subjects and Method: This study is a meta-analysis with the following PICO, population: COVID-19 patients. Intervention: ivermectin. Comparison: standard therapy. Outcome: shorter duration of hospital stay. Meta-analyses and systematic studies using the PubMed, Scopus, Scholar, Springlink, Cochrane, Clinical Key, and Science Direct databases. Keywords using Ivermectin AND RCT AND COVID-19 AND “Coronavirus Disease” AND “NCOV disease” AND “COVID-19 treatment”. The article under study is a full-text article with a randomized controlled clinical trial (RCT) study design. Articles were collected using PRISMA diagrams and analyzed using Review Manager 5.3.Results A total of 9 Randomized Control Trial (RCT) studies from Europe, America, Asia and Africa were selected for systematic review and meta-analysis. COVID-19 patients receiving Ivermectin therapy decreased the duration of hospital stay by 1.52 units compared to standard therapy and this result was statistically significant (SMD= -1.52; 95% CI= -2.34 to -0.70; p= 0.003).Conclusion: Ivermectin can reduce the duration of hospital stay for COVID-19 patients.Keywords: COVID-19, ivermectin, duration hospital stayCorrespondence: Masromi Hendria Wijayanto. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah. Email: masromihendria@gmail.com. Mobile: 0895402471549.Indonesian Journal of Medicine (2022), 07(02): 200-208https://doi.org/10.26911/theijmed.2022.07.02.08

The Effects of Diabetes Mellitus Comorbidities on the Risk of Treatment Failure in Tuberculosis Patients: A Meta-Analysis Sri Iswahyuni; Ani Nur Fauziah; Indarto Indarto; Joko Tri Atmojo; Aris Widiyanto
Indonesian Journal of Medicine Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Tuberculosis or TB is a disease caused by the Mycobacterium tuberculosis complex. There are several comorbidities that experience severity and death when infected with tuberculosis or TB, namely hypertension, diabetes mellitus, cardiovascular disease, chronic kidney disease, cerebrovascular disease, and other diseases. This study aims to estimate the magnitude of the risk of treatment failure in Tuberculosis patients with Diabetes Mellitus comorbidity, with a meta-analysis of primary studies conducted by previous authors.Subjects and Method: This was a systematic review and meta-analysis with the following PICO, population: tuberculosis patients. Intervention: chronic comorbid diabetes mellitus. Comparison: without comorbid diabetes mellitus. Outcome: treatment failure. The articles used in this study were obtained from three databases, namely Google Scholar, PubMed, and Science Direct. Keywords to search for articles “Tuberculosis” OR “TBC” AND “Diabetes Mellitus” OR “DM” AND “Treatment failure”. The included article is a full-text English cohort study design from 2007 to 2021 and reports the adjusted odds ratio (aOR) in multivariate analysis. The selection of articles is done using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.Results: A total of 7 cohort studies involving TB patients undergoing treatment from America, Europe, Africa and Asia were selected for systematic review and meta-analysis. The data collected showed that tuberculosis patients undergoing treatment with comorbid diabetes mellitus had a 1.57 time the risk of treatment failure compared to patients without comorbid diabetes mellitus (aOR= 1.57; 95% CI= 1.08 to 2.30; p= 0.002).Conclusion: Comorbidity Diabetes mellitus increases the risk of experiencing treatment failure in tuberculosis patients.Keywords: diabetes mellitus, tuberculosis, mortality.Correspondence: Sri Iswahyuni. School of Health Sciences Mamba’ul Ulum Surakarta. Jl. Ringroad Utara, Mojosongo, Jebres, Surakarta, Central Java, Indonesia. Email: iswahyunisri@yahoo.co.id. Mobile: +62 815-6720-715.Indonesian Journal of Medicine (2022), 07(04): 417-427https://doi.org/10.26911/theijmed.2022.07.04.07

Differences in Age Estimated by the Kvaal Method on Right and Left Mandibular Canines Kusumaningrum, Sulistyani; Wasita, Brian; Wujoso, Hari; Rahayu, Rachmi Fauziah; Hermansyah, Muhamad Lukman; Lawei, Tharina
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: The radiographic method for determining the estimated age has the advantage of being non-invasive and the orthopantomogram images are digitally processed. Canines have a strong correlation with chronological age and have good resistance and large pulp space. This study aimed to determine the difference in age estimates using the Kvaal method on the right and left mandibular canines.Subjects and Method: There were 80 orthopantomogram samples from dental and oral clinic patients who had undergone orthopantomography at the Radiology Installation of Dr. Moewardi Hospital, from January 2019 to December 2020. The estimated age of right and left canines was calculated based on the Kvaal method and performed a T-test.Results: At the estimated age of the right and left mandibular canines determined by the Kvaal formula, the T-test was performed showing a mean of 38.3 years for the right mandibular canine (Mean= 38.3; SD= 6.7) and 38.2 year the left mandibular canine (Mean= 38.2; SD= 8.9), with p = 0.910. Data analysis showed that there was no difference in age estimation using the Kvaal method on the right and left mandibular canines.Conclusion: There was no difference in age estimates by the Kvaal method on the right and left mandibular canines.Keywords: Oratopantomogram, Metoday Qual, Kaninus MandibulaCorrespondence: Sulistyani Kusumaningrum. Department of Radiology Dr. Moewardi Hospital / Faculty of Medicine Universitas Sebelas Maret, Surakarta. Email: kusumasulis1@gmail.com.Indonesian Journal of Medicine (2021), 06(02): 206-211https://doi.org/10.26911/theijmed.2021.06.02.09

Osteochondroma of the Distal Femur in Young Patient: An Oncology Case Report Sandiwidayat, Komang Septian
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Osteochondroma is the most common primary bone tumor manifested as a painless, slow-growing mass. Apart from its asymptomatic manifestations, the tumor is malignant potential so appropriate management needs to be acknowledged. The aim of this study is to discuss the possible clinical findings for diagnosing with managing this rare case properly, which may provide a good outcome for this patient.Case Presentation: A 17-year-old male presented with a chief complaint of a slow-growing lump on the back of his right thigh. On physical examination, a 7 cm x 6 cm mass with mild tenderness was found during palpation. Based on these clinical and imaging findings, we informed and gained consent from the patient for surgery followed by a histopathology examination. The histopathology examination confirmed osteochondroma in the right distal femur.Results: Surgery was performed to curatively remove the tumor, followed by a histopathological examination which confirmed the diagnosis of osteochondroma. One week after the surgery, the post-surgical wound care was performed showing an excellent result, without any signs of infection or complications.Conclusion: Typical manifestation of painful osteochondromas may be associated with mechanical compression to the surrounding nerve and vascular structures. Surgical excision is an appropriate management approach to provide consistent relief of pain and deformity in osteochondroma case.Keywords: arteriovenous malformations, CT scan, rare case, embolizationCorrespondence: Komang Septian Sandiwidayat. Oncology Division, Department of Orthopaedic & Traumatology, Sanglah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia. Email: drseptianortho@gmail.com. +62-821-4725-2042.Indonesian Journal of Medicine (2022), 07(01): 82-88https://doi.org/10.26911/theijmed.2022.07.01.09

Effect of Ethanolic Extract in Moringa oleifera, Lam. Leaf on Uric Acid Levels and Body Surface Area of Kidney Glomerulus in Wistar Rats (Rattus novergicus) Induced Metabolic Syndrome Model Darmawan, Muhammad Dzaki; Subandono, Jarot; Setyawan, Novan Adi; Budiani, Dyah Ratna
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: There has been an increasing prevalence of metabolic syndrome (MS) caused by life style such as sedentary behavior and western diet. Metabolic syndrome causes degeneration in ren’s structure and processes the elimination of by product in metabolism, which is uric acid. Moringa oleifera Lam. leaves contain antioxidant that can repair damages caused by MS. Studies about improvement of ren’s structure and uric acid level related to Moringa oleifera Lam. leaves’ consumption has not been found yet. Therefore, this study was intended to examine the effects of ethanolic extract in Moringa oleifera Lam. leaves to uric acid and glomerular surface area in male wistar rat (Rattus norvegicus) with induced metabolic syndrome model.Method: This study is an experimental laboratory study. The subjects of this study consisted of 30 rats which were divided into 5 groups with 6 in each group. K1 is control group, K2 is MS group, and K3, K4, and K5 are MS groups given variety of ethanolic extract doses. The induction of MS was done by giving high-fat diet in 28 days and injection of streptozotocin-nicotinamide (STZ-NA) in the 25th day. Rats in group K3, K4, and K5 were given doses of 150, 250, and 350 mg/kgBW in 28 days.Results: The administration of high-fat diet for 28 days and injection of STZ-NA caused MS condition in rats. Repeated ANOVA and One-Way Anova test showed that the administration of ethanolic extract in Moringa oleifera Lam. leaves with doses of 150, 250, and 350 mg/kgBW in 28 days decreased uric acid significantly (p= 0.001; p=0.001; p= 0.001). Another result also found that ethanolic extract from Moringa oleifera Lam. leaves with doses of 250 and 350 mg/kgBW increased area of glomerular surface area in rats significantly.Conclusion: The administration of ethanolic extract from Moringa oleifera Lam. leaves with doses of 150, 250, and 350 mg/kgBW for 28 days decreased uric acid level in rats. Ethanolic extract of Moringa oleifera Lam. leaves 250 and 350 mg/kgBw doses increase glomerular surface area.Keywords: Moringa Oleifera, uric acid, glomerular cross-sectional area, metabolic syndrome, kidneyCorrespondence: Muhammad Dzaki Darmawan. Study Program of Medical Doctor Education, Faculty of Medicine, Universitas Sebelas Maret. Email: mdddzaki@student.uns.ac.id.Indonesian Journal of Medicine (2021), 06(04): 412-422https://doi.org/10.26911/theijmed.2021.06.04.07

Effectiveness of Acupuncture Therapy to Reduce Pain in Patients with Upper Trapezius Myofascial Pain Syndrome: A Meta-Analysis Saraspuri, Niken Putri Eka; Tamtomo, Didik; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 3 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Upper trapezius myofascial pain syndrome is a muscle pain condition associated with sensory, motoric, or autonomic functions and generated by trigger point arising from hardened and stiff taut band of muscle fiber while being touched as well as palpated. One of the interventions to reduce the pain is by using acupuncture therapy. The study aims to analyze and estimate the effectiveness magnitude of acupuncture therapy toward the pain reduction in patients with upper trapezius myofascial pain syndrome.Subjects and Method: This was a systematic review and meta-analysis study using PRISMA diagrams. The article search was conducted based on the eligibility criteria using the PICO Model. population: patients with upper trapezius myofascial pain syndrome. Intervention: acupuncture therapy. Comparison: placebo acupuncture. Outcome: reduced pain. The articles used were from 6 databases, namely Pubmed, Google Scholar, Science Direct, Scopus, Spinger Link, and Hindawi Key words for article search were “acupuncture” OR “acupuncture therapy” AND “upper trapezius pain” OR “upper trapezius myofascial pain syndrome” OR “upper trapezius MPS” AND “Randomized Con¬trolled Trial” OR “RCT”. Inclusion criteria used of the study were full text articles with Randomized Controlled Trial study design, measure of association used was Mean SD. Articles were analyzed using the Review Manager 5.3 application.Results: The 9 articles reviewed were from Taiwan, China, UK, Turkey, Brazil, and Iran. The study result indicated that acupuncture therapy was effective in reducing pain in upper trapezius myofascial pain syndrome. Upper trapezius myofascial pain syndrome that obtained acupuncture therapy had average score of pain -1.16 units lower than placebo acupuncture (SMD= -1.16; CI 95%= -1.93 to -0.39; p= 0.003).Conclusion: Acupuncture therapy was effective in reducing pain in upper trapezius myofascial pain syndrome.Keywords: acupuncture, pain, upper trapezius myofascial pain syndrome, randomized controlled trial, meta-analysis.Correspondence: Niken Putri Eka Saraspuri. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: nikenputri54@gmail.com. Mobile: 081327372766.Indonesian Journal of Medicine (2022), 07(03): 326-336https://doi.org/10.26911/theijmed.2022.07.03.09

Transcutaneous Electrical Nerve Stimulation Uptake in Lowering Low Back Pain Salsabil, Husna Arwa; Prasetya, Hanung; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Low Back Pain (LBP) is a generalized pain from the second lumbar vertebra to the sacroiliac joint, and is generally a lifelong health disorder. LBP is often the cause of people feeling a decrease in ability in daily functional activities. Patients often complain of symptoms of pain, muscle spasms and impaired function. One of the interventions that can be used to reduce LBP is therapy using transcutaneous electrical nerve stimulation (TENS). TENS is a device used to relieve pain by stimulating nerves through electrodes transcutaneously. TENS is one of the modalities that can improve neuromuscular function or reduce pain and is very useful for patients with complaints of low back pain who experience pain and muscle weakness around the pelvis, trunk, and lower legs. LBP patient.Subject and Method: This study was a meta-analysis with the following PICO, population: low back pain patients. Intervention: administration of TENS. Comparison: not given TENS. Result: decreased pain. The articles used in this study were obtained from three databases, namely Google Scholar, Pubmed, and Science Direct. Keywords to search for articles “transcutaneous electrical nerve stimulation” OR “TENS” AND “reduction pain” OR “pain relief” AND “low back pain”. The articles included are full-text English with a randomized control trial study design from 2007 to 2022. Article selection was carried out using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 . application.Results: A total of 12 case studies from continental Europe, America and Asia were selected for systematic review and meta-analysis. It was found that giving TENS -0.67 times reduced pain in complaints of low back pain compared to not given TENS significantly (SMD = -0.67; 95% CI = -1.03 to -0.32; p = 0.002).Conclusion: Transcutaneous Electrical Nerve Stimulation reduces pain in low back pain patients.Keywords: Transcutaneous Electrical Nerve Stimulation, reduction pain, low back painCorrespondence: Husna Arwa Salsabil, Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Mobile: +6289611006503. Email: husna0105@gmail.com.Indonesian Journal of Medicine (2022), 07(01): 9-18https://doi.org/10.26911/theijmed.2022.07.01.02

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