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INDONESIA
The Indonesian Journal of Infectious Diseases
Published by RSPI Prof. Dr. Sulianti Saroso
ISSN : 23546077     EISSN : 25991698     DOI : https://doi.org/10.32667/ijid.v10i1
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
The Indonesian Journal of Infectious Diseases aims to disseminate and facilitate discussions on scientific papers related to health, particularly focusing on infectious diseases including emerging diseases, new emerging disease issues, and tropical medicine. The journal serves as a communication medium for various stakeholders interested in health research, including researchers, educators, students, healthcare practitioners, the Department of Health, Public Health Service, and the general public with an interest in this field. It endeavors to address the increasing demand for studying infectious diseases.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Imunologi dan Mikrobiologi (Lain-Lain)
Articles 167 Documents
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Nutritional Aspects in Pediatric Tuberculosis Cases Among Children Aged 0-5 Years Saraswati, Amanda Dwiayu; Nafisah, Lu'lu; Sistiarani, Colti
The Indonesian Journal of Infectious Diseases Vol. 11 No. 2 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i2.370

Abstract

Background: Children aged 0-5 years are the age group at the highest risk of contracting tuberculosis. This infectious disease is closely related to nutritional aspects in children. These aspects include nutritional intake, exclusive breastfeeding, nutritional status, and history of infectious diseases. This study aims to explore the nutritional aspects of pediatric tuberculosis cases among children aged 0-5 Years. Methods: This study employed a qualitative case-study approach, involving in-depth interviews with informants and document analysis. The study included five primary informants, namely mothers of children aged 0-5 years diagnosed with tuberculosis, and three supporting informants, comprising two village midwives and one tuberculosis program officer at Sumbang I Public Health Center, Sumbang Dist. Data analysis was conducted using thematic analysis. Results: Loss of appetite and weight loss were observed in toddlers after tuberculosis infection, which gradually improved with treatment. There was a balanced distribution between good and poor nutritional status among the toddlers. Tuberculosis bacteria can infect children regardless of nutritional status if the immune system is suboptimal. Children who received exclusive breastfeeding were still susceptible to tuberculosis infection. Conclusion: Mothers fulfilled the nutritional needs of toddlers. Nutritional status and exclusive breastfeeding did not directly influence the infection.  
Neglected Surgical Site Infection due to Multi-Drug Resistant Acinetobacter baumannii and Klebsiella pneumoniae Kevin, Kevin; Sihotang, Lenni Evalena; Saragih, Restuti Hidayani
The Indonesian Journal of Infectious Diseases Vol. 11 No. 2 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i2.371

Abstract

Background: Surgical Site Infections (SSI) are post-operative infections often caused by ESKAPE pathogens. These multidrug-resistant bacteria, identified by the WHO as a critical threat, typically result in severe wound infections and extended hospital stays. Case Presentation: A case of a 26-year-old male with an incisional surgical site infection (SSI) in the suprapubic area that worsened due to various management errors, prolonging the patient's wound healing, but was successfully managed with a holistic approach by a multidisciplinary team, including nutritional improvement, wound care, and rational antibiotic use, which were crucial for the success of the therapy. Conclucion:  Effective management of ESKAPE-related SSIs requires targeted diagnostics, a holistic multidisciplinary strategy, and robust antimicrobial stewardship programs to improve outcomes.  
Supplementation of Pumpkin Seed Oil and SCFASs as a Prospective Biotherapeutic to Preserve Gut Natural Microbiota of Colitis Mice Tania, Putu Oky Ari; Simamora, Dorta; Widjaja, Jimmy Hadi; Purbowati, Rini
The Indonesian Journal of Infectious Diseases Vol. 11 No. 2 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i2.399

Abstract

Background: Ulcerative Colitis (UC) is an inflammatory disease in the colon, due to the disruption of the interaction between the immune response and the intestinal microbiota in a genetically susceptible host. The imbalance between commensal and pathogenic intestinal microbiota promotes inflammation. This study aims to explore the efficacy of pumpkin seed oil and SCFAs in maintaining the intestinal microbiota in UC model mice. Methods: Four groups, K1, K2, K3, and K4, as health control given distilled water (K1); K2, K3, and K4 induced UC with 2% DSS, followed by administration of Short Chain Fatty Acids (SCFAs) (K3), supplementation of SCFAs and pumpkin seed oil (K4). The number of colonies measured microbiota diversity (log CFU/mL/g) in NA, EMB, MRSA, and McConkey media. Hemoglobin and hematocrit were also measured to assess anemia. Results: The average number of bacterial colonies that grew on NA, EMB, MRSA, and McConkey media in K4 was 7.65, 5.78, 7.85, and 6.20, respectively, and the average HB and hematocrit levels were 14.2 g/dL and 42%, respectively. There was greater microbiota diversity and lactobacillus bacteria in UC rats given pumpkin seed oil and SCFAs, with fewer Enterobacteriaceae and E. coli than in the UC model. The increase in HB and hematocrit levels also showed the same trend. Conclusion: Pumpkin seed oil at a dose of 100 mg/kg and SCFAs can be a prospective biotherapy for maintaining the balance of the natural microbiota and increasing HB levels.
The Effect of Propolis (Bee Glue) on Sepsis: A Systematic Review Jesslyn, Stephanie; Malisie, Ririe Fachrina
The Indonesian Journal of Infectious Diseases Vol. 11 No. 2 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i2.408

Abstract

Background: With pathogenic resistance and risk of dysbiosis, antimicrobial therapy for sepsis becomes less effective. Therefore, there is a need for an additional therapy, such as immunomodulation, either directly or through modulation of the gut microbiota. Propolis, or bee glue, has immunomodulatory properties and positive effects on the gut microbiota. This systematic review aims to assess the potential of propolis as an adjunctive therapy in alleviating sepsis through pathways associated with gut microbiota, such as inflammation and oxidative stress. Methods: This study was made in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The keywords for the literature search and study relevance were determined with the Population, Intervention, Comparison, and Outcome (PICO) formula: Population (P): Septic human or animal; Intervention (I): Propolis administration; Comparison (C): Septic human or animal without propolis administration; Outcome (O): Gut microbiota and inflammatory as well as oxidative stress biomarkers. A literature search was conducted in PubMed, ScienceDirect, and Google Scholar to obtain relevant studies with a download period from January 2015 to March 2025. Results: The literature search yielded 3,189 articles, with four articles eligible for inclusion in this literature review. The four studies were animal studies and reported that propolis administration improved sepsis by reducing inflammatory and oxidative stress biomarkers and mitigating organ damage. None of the studies reported the outcome on gut microbiota in sepsis. Conclusion: Propolis showed potential as an adjunctive therapy for sepsis through its anti-inflammatory and antioxidative effects, but there is no evidence from human studies.  
Diagnostic Challenges of Weil’s Disease with Acute Kidney Injury: A Case Report and Clinical Review Agustini, Made Priska Arya; Dewi, Putu Itta Sandi lesmana; Lestari, I Dewa Ayu Made Dian; Sunaka, I Wayan
The Indonesian Journal of Infectious Diseases Vol. 11 No. 2 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i2.409

Abstract

Background: Severe leptospirosis or Weil’s disease can cause multi-organ failure, which is characterized by jaundice and acute kidney injury in approximately 10% of cases. Its nonspecific symptoms often lead to misdiagnosis with other acute febrile illnesses, resulting in delayed diagnosis. Case Presentation: A 48-year-old male construction worker presented with fever, headache, myalgia, epigastric pain, nausea, and vomiting for four days without any signs of bleeding. The patient lived and worked at a project site adjacent to rice fields. Physical examination revealed fever, icteric sclera, conjunctival suffusion, and tenderness of the gastrocnemius muscle. Laboratory tests showed leukocytosis, thrombocytopenia, impaired renal function, elevated liver enzymes, hyponatremia, and hypokalemia. The patient was diagnosed with Weill’s disease. He was treated with antibiotics and supportive therapy. Sixteen days after discharge, the patient reported gradual improvement and had resumed normal activities. Discussion:  Patients presenting with acute febrile illness should undergo a comprehensive evaluation, and leptospirosis should be considered when leukocytosis, neutrophilia, and thrombocytopenia are observed in a complete blood count. A detailed history focusing on risk factors and associated symptoms, along with additional diagnostic tests based on the criteria, can help guide the diagnosis. Antibiotic therapy should be initiated immediately in patients with suspected or probable leptospirosis without waiting for serological confirmation. Conclusion: This case highlights the diagnostic challenges of leptospirosis, particularly in resource-limited healthcare settings. Enhancing clinical awareness, improving access to rapid diagnostic tools, and optimizing preventive measures are crucial to reducing morbidity and mortality rates
Cost-Effectiveness Analysis of Antibiotics in Pneumonia Patients with Diabetes Mellitus Type 2 Victoria, Brigita; Piter, Piter; Aviatin, Memy; Siahaan, Selma Arsit Selto; Maylinda, Tashya Dhela
The Indonesian Journal of Infectious Diseases Vol. 11 No. 2 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i2.553

Abstract

Background: Pneumonia poses a high clinical and economic burden, particularly in patients with type 2 diabetes mellitus (DM). Selecting the appropriate antibiotic is essential to ensure both clinical effectiveness and cost efficiency. This study aimed to evaluate the cost-effectiveness of fluoroquinolone monotherapy compared to beta-lactam–macrolide combination therapy in BPJS inpatients with pneumonia and comorbid type 2 DM at Prof. Dr. Sulianti Saroso Infectious Diseases Hospital (RSPI) during 2023–2024. Methods: This retrospective observational study used a cost-effectiveness analysis (CEA) approach, drawing on medical record data. Effectiveness was measured based on the Pneumonia Severity Index (PSI) and length of stay, while total direct medical costs were analyzed to calculate the Average Cost-Effectiveness Ratio (ACER).   Results: There was no significant difference in effectiveness or total direct medical costs between the two regimens. However, fluoroquinolone monotherapy had lower total costs (Rp10,090,591) and a smaller ACER value than the beta-lactam–macrolide combination (Rp13,386,045), suggesting that monotherapy was more cost-effective despite similar clinical outcomes. Conclusion: Although statistical differences were not significant, fluoroquinolone monotherapy appeared more cost-effective than beta-lactam–macrolide combination therapy for pneumonia patients with comorbid type 2 DM. These findings may support pharmacoeconomic-based decision-making in antibiotic selection. The study’s limitations include a small sample size, a single-center setting, and a retrospective design, which may affect generalizability.  
Spatial Distribution and Temporal Trends of Pneumonia in Indonesia: Descriptive Analysis of Early Warning and Response System (SKDR) Data, 2022-2024 Wawang, Wawang; Tri Yunis Miko, Wahyono; Amelia, Marisa
The Indonesian Journal of Infectious Diseases Vol. 11 No. 2 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i2.580

Abstract

in Indonesia. This study aims to analyze the spatial distribution and temporal trends of pneumonia in Indonesia using data from the Early Warning and Response System (SKDR) for the period 2022–2024. Methods: This descriptive study utilized secondary aggregate data from the Indonesian Ministry of Health's SKDR, covering all 38 provinces from 2022 to 2024. Analyses were performed on the annual and cumulative distribution of pneumonia cases across provinces, visualized through ranking tables and choropleth maps, followed by a temporal analysis of quarterly trends Results: The SKDR recorded 1,204,023 pneumonia cases during the study period. Temporally, a significant yearly increase was observed, alongside a predictable seasonal pattern, with Quarter 2 consistently the period of lowest incidence. Spatially, extreme disparities were found, with the highest case hotspots concentrated predominantly on Java Island. Conversely, coldspots in Eastern Indonesia (e.g., Southwest Papua, Maluku) more likely reflect limitations in surveillance and healthcare access, indicating the presence of hidden high-risk areas. Conclusion:  Pneumonia in Indonesia exhibits dynamic temporal patterns and sharp spatial concentration. These findings underscore the necessity of differentiated control strategies: proactive interventions based on seasonal patterns, intensive resource allocation in hotspots to control transmission, and strengthened surveillance systems and healthcare access in coldspots to address hidden high-risk areas.

Page 17 of 17 | Total Record : 167

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