Garuda - Garba Rujukan Digital

All

JSFK (Jurnal Sains Farmasi & Klinis)

jsfk
Website

Published by Universitas Andalas

ISSN : 24077062 EISSN : 24425435 DOI : 10.25077

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.

Arjuna Subject : -

Articles 509 Documents

11 12 13 14 15

Evaluasi Terapi Adjuvant Hormonal Dan Hubungannya Terhadap Outcome Klinis Pasien Kanker Payudara Stadium Dini Di Kota Padang wessi windrasari; Fatma Sri Wahyuni; Daan Khambri
Jurnal Sains Farmasi & Klinis Vol 5, No 3 (2018): J Sains Farm Klin 5(3), Desember 2018
Publisher : Fakultas Farmasi Universitas Andalas

Terapi adjuvant hormonal merupakan pilihan terapi yang efektif bagi pasien kanker payudara stadium dini dengan hormonal responsif dan Her-2 negatif. Outcome klinis dari terapi kanker payudara adalah Disease Free Survival (DFS), Overall Survival (OS). Penelitian ini bertujuan mengevaluasi terapi adjuvant hormonal dan pengaruhnya terhadap outcome klinis pasien. Penelitian ini merupakan penelitian deskriptif dengan desain cross sectional study menggunakan data retrospektif registrasi kanker payudara Persatuan Ahli Bedah Onkologi Indonesia (PERABOI) Kota Padang selama periode 2008-2017. Analisis data menggunakan Kaplan Meier Analysis dengan Log rank. Diperoleh sebanyak 58 orang pasien yang memenuhi kriteri inklusi, dengan rerata umur yaitu 49,41 ± 8,69 tahun, kejadian relaps 22,4% dan sebanyak 6,9% pasien mengalami kematian. Terapi terbanyak pada pasien premenopause adalah tamoxifen (58,3%), pada pasien pascamenopause adalah Aromatase Inhibitor (54,5%). Secara statistik pada pasien premenopause tidak ada pengaruh terapi adjuvant hormonal yang berbeda terhadap DFS (P log rank test 0,243 dan HR = 0.513) dan OS (P log rank test 0,545 dan HR = 0.314). Pada pasien pascamenopause tidak ada pengaruh terapi yang berbeda terhadap DFS (P log rank test 0,586 dan HR = 0,10) dan OS (P log rank test 0,594 dan HR = 0,12).

Uji Aktifitas Analgetik Ekstrak Etanol Daun Pepaya (Carica papaya L.) pada Mencit Putih Jantan yang di Induksi Asam Asetat 1% Ria Afrianti; Revi Yenti; Dewi Meustika
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Analgesic activity of extract of papaya leaves (Carica papaya L.) to male mice has been evaluated. Twenty five of mice (20-30 g, 2-3 months old) were divided randomly into five groups. The first group was given sodium CMC as negative control, the second until fourth groups received ethanolic extract of Carica papaya leaves in the doses of 100, 300, and 600 mg/kgBW, respectively and the fifth group was given paracetamol 65 mg/kg BW. All interventions were administered as single dose by oral route on given day. Acetic acid 1% (w/v) was used as the pain inductor. Analgesic activity was measured by counting the percentage of writhing movements as a measure of the analgesic effect produced by each intervention. Data were analyzed with one way ANOVA to compare analgesic activity between treatment groups. The results showed that the analgesic effect of the extract on the doses of 100, 300, and 600 mg/kg BW was significantly different with control group (P

Formulasi Sabun Transparan Minyak Ylang-Ylang dan Uji Efektivitas terhadap Bakteri Penyebab Jerawat Febriyenti F.; Lisa Indah Sari; Rahmi Nofita
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Ylang-ylang oil transparent soaps in three concentration i.e. 3.1 %, 3.85 % and 4.58 % have been formulated using virgin coconut oil (VCO), olive oil and stearic acid as a base soap reacted with NaOH as alkalin base. Transparent soap were tested for its identification, pH, wetting test, the foam on distilled water, the foam on hard water, skin irritation consumen preference test and micobiology test using the agar diffusion technique against bacterium cause of acnes like Staphylococcus epidermidis. The results showed that all formulas were stable for six weeks during storage conditions. Ylang-ylang transparent soap had medium antimicrobial activity (12-16 mm) against S. epidermidis. Statistical evaluation of pH, wetting test and micobiology test from formulas against control by using one way ANOVA had significant difference (p<0,05).

Analisis Profil Protein dan Asam Amino Sarang Burung Walet (Collocalia fuchiphaga) Asal Painan Lina Elfita
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

This study was aimed to analyze protein profile and amino acid composition of bird nest from Painan, Pesisir Selatan Distric, West Sumatra. Protein analysis was performed by Sodium Dodecyl Sulphate Polyacrilamide Gel Electrophoresis (SDS-PAGE), meanwhile High Performance Liquid Chromatography (HPLC) was used for analysis of amino acid. Analysis on water extract of bird nest by SDS-PAGE showed six bands which correspond to molecular protein which had molecular weight of 147.2; 142.6; 133.4; 73.3; 66.2; and 37.7 kDa, respectively. HPLC analysis demonstrated that bird nest was composed of 16 amino acids. Seven of them were essential amino acids; histidine (2.31%), leucine (3.84%), threonine (3.82%), valine (3.93%), methionine (0.48%), isoleucine (1.80%), phenylalanine (4.49%), and nine of them were non-essential amino acids; serine (4.56%), aspartic acid (4.48%), arginine (3.93%), lysine (2.34%), proline (3.64%), glutamic acid (3.65%), glycine (1.87%), alanine (1.31%), and tyrosine (3.92%). Serine was the highest percentage of amino acid in the bird nest (4.56%), followed by phenylalanine (4.49%) and aspartic acid (4.48%). The study also showed that composition of amino acid in this bird nest was slightly different with composition of amino acid in bird nest from other area.

Persepsi, Pengetahuan, dan Sikap tentang Obat pada Siswa Sekolah Menengah Atas (SMA) di Kota Pariaman, Sumatera Barat Syofyan Syofyan; Habibie Deswilyaz Ghiffari; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

The irrational use of drug and drug abuse are some of the impacts of low public knowledge about medicine, including in high school students. The purpose of this study was to assess perceptions, knowledge and attitudes about medicine among senior high school students in Pariaman City, West Sumatera. The research was conducted by descriptive and analytical method with cross-sectional by using questionnaire instrument. Data were analyzed using univariate and bivariate analysis. The results showed that students’ perception on medicine was categorized as high (95.5%), student attitude was positive (60.3%) but had less knowledge (74.8%). Students living in the city had higher knowledge than those living in the village. There was a significant correlation between perception and attitude (P <0.05), however, there was no correlation between knowledge and perception level (P> 0.05) and attitude (P> 0.05). Low perceptions and knowledge can encourage students to do more fatal errors such as medications or irrational drug use. Efforts such as education about medication in schools are very important steps to improve students’ knowledge about medicine.

Efek Analgetik Ekstrak Etanol Daun Tampa Badak (Voacanga foetida (Bl.) K. Schum) Pada Mencit Putih Jantan Adriani Susanty; Armon Fernando; Ivona Adelin
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

A study on the analgesic activity ethanolic extract of Voacanga foetida leaves has been conducted on male mice by using Writhing test. The mice were induced with 0.1 mL of glacial acetic acid 1%. The extract was administered orally in the doses of 250, 500, and 1000 mg/kg, suspended with NaCMC 1%, while 65 mg/kg acetosal was used as positive control. The data was analyzed with two way ANOVA. The study revealed that the extract exhibited analgesic effect insignificantly different with acetosal at the doses of 250, 500, and 1000 mg/kg. This effect was different with negative control (p<0.05).

Efek Proteksi Fraksi Etil Asetat Daun Surian (Toona sureni (Blume) Merr. ) terhadap Aterosklerosis Suhatri Suhatri; Netty Marusin; Delva Yeni; Rahmi Yosmar
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

A study of the protection effect of ethyl acetate fraction of toona leaves (Toona sureni (Blume) Merr.) to the atherosclerotic blood vessel on the hypercholesterolemic quails has been carried out. The observation was conducted for histopathology of the blood vessel. The hypercholesterolemic quails were obtained through high-fat diet and propylthiouracil (PTU) induction. Aortic wall thickness, changes on the aortic lumen are, and visual endothelial cell dysfunction were determined. The study showed that the ethyl acetate fraction of toona leaves on the dose of 50 mg/kg body weight exhibited the best protection effect, indicated by aortic wall thickness and lumen area, and the degree of endothelial cell dysfunction which were not significantly different with the negative control group (p>0.05), but significantly different with positive control group (p<0.05).

Formulasi Granul Mukoadhesif Ketoprofen Menggunakan Polimer Kitosan Salman Umar; Wida Ningsih; Monalisa Meliana
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

The aim of this research was to formulate of mucoadhesive ketoprofen granules using chitosan polymer. Ketoprofen granules were prepared by wet granulation method with several concentrations of chitosan polymer 0%, 10%, 20%, and 30% (w/v). Granules were evaluated physically and chemically. In vitro dissolution test was carried out for 6 hours using a basket method in buffer phosphate medium pH 7.4. General evaluation of granules showed the yield was relatively good. In vitro mucoadhesive test exhibited that mucoadhesive ketoprofen granules using chitosan polymer could provide mucoadhesive properties to stomach and intestinal of rabbits. The statistics tests for dissolution efficiency with one ways ANOVA (SPSS 17) showed a significant different among F0, F1, F2 and F3 (P0.05). All the formulas followed Langenbucher kinetic release model.

Efektifitas Propolis Toothpaste sebagai Initial Therapy pada Mild Gingivitis Nila Kasuma
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Characteristics of mild gingivitis are change in the color of the gums, slight edema, and no bleeding and painless. If it does not receive the proper treatment, gingivitis can become periodontitis which cause alveolar jaw bone tissue damage, resulting in further tissue damage locally and systemically through the blood vessels. The selection of appropriate therapy is essential to reduce the prevalence of the disease. In addition to scaling and plaque control, the propolis toothpaste can be used as initial therapy. The toothpaste contains propolis known for anti-inflammatory effects that is useful as one of the initial teraphy to treat mild gingivitis. Gingival index of 15 patients were measured before and after use of propolis toothpaste. Data analysis was performed by means of univariate to describe each variabel using Kolmogorov Smirnof Test. Gingival Index difference between before and after brushing with toothpaste containing propolis by paired t-test. Toothpaste contains propolis which proved effective in the initial therapy of mild gingivitis with an average difference of reduction in Gingival Index scores before and after was 0.40 ± 0.04 There are significant differences (p <0.05) difference between the average reduction in Gingival Index scores before and after the use of toothpaste containing propolis.

Formulasi dan Evaluasi Losion Tabir Surya Ekstrak Daun Stevia (Stevia rebaudiana Bertoni M) Yola Desnera Putri; Haruman Kartamihardja; Intan Lisna
Jurnal Sains Farmasi & Klinis Vol 6, No 1 (2019): J Sains Farm Klin 6(1), April 2019
Publisher : Fakultas Farmasi Universitas Andalas

Daun stevia (Stevia rebaudiana Bertoni M) selain digunakan sebagai bahan dasar gula juga memiliki senyawa alami yang dapat digunakan sebagai tabir surya seperti flavonoid dan fenolat. Flavonoid dalam tanaman memiliki potensi sebagai tabir surya karena adanya gugus kromofor, gugus kromofor tersebut merupakan sistem aromatik terkonjugasi yang menyebabkan kemampuan untuk menyerap kuat sinar pada kisaran panjang gelombang sinar UV, sehingga senyawa flavonoid dapat digunakan sebagai senyawa berkhasiat dalam sediaan tabir surya. Losion merupakan salah satu bentuk sediaan tabir surya yang banyak tersebar dipasaran dan sering digunakan oleh masyarakat. Tujuan dari penelitian ini yaitu menentukan konsentrasi dari ekstrak daun stevia yang memiliki aktivitas sebagai tabir surya dan membuat sediaan losion tabir surya dari daun stevia. Hasil nilai SPF dari ekstrak etanol daun stevia dengan konsentrasi 0,05% sebesar 15,247, sedangkan hasil nilai SPF losion tabir surya yang mengandung ekstrak etanol daun stevia 0,05% untuk F1 11,052; F2 10,363; F3 10,175; dan F4 8,315. Hasil evaluasi losion tabir surya ini losion memiliki warna hijau, pH losion 7,21-8,11, viskositas losion 2000-8000cps, dan uji sentrifugasi losion tidak terjadi pemisahan. Nilai SPF keempat formulasi losion tersebut termasuk kedalam rentang nilai tabir surya proteksi maksimal.

Page 13 of 51 | Total Record : 509

11 12 13 14 15

Filter by Year

2014 2025

Filter By Issues

All Issue Vol 12 No 2 (2025): J Sains Farm Klin 12(2), August 2025 Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025 Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024 Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024 Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024 Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023 Vol 10, No 2 (2023): J Sains Farm Klin 10(2), Agustus 2023 Vol 10 No 2 (2023): J Sains Farm Klin 10(2), Agustus 2023 Vol 10 No 1 (2023): J Sains Farm Klin 10(1), April 2023 Vol 10, No 1 (2023): J Sains Farm Klin 10(1), April 2023 Vol 9 No 3 (2022): J Sains Farm Klin 9(3), Desember 2022 Vol 9, No 3 (2022): J Sains Farm Klin 9(3), Desember 2022 Vol 9, No 2 (2022): J Sains Farm Klin 9(2), Agustus 2022 Vol 9 No 2 (2022): J Sains Farm Klin 9(2), Agustus 2022 Vol 9, No 1 (2022): J Sains Farm Klin 9(1), April 2022 Vol 9 No 1 (2022): J Sains Farm Klin 9(1), April 2022 Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022 Vol 8 No 3 (2021): J Sains Farm Klin 8(3), Desember 2021 Vol 8, No 3 (2021): J Sains Farm Klin 8(3), Desember 2021 Vol 8 No 2 (2021): J Sains Farm Klin 8(2), Agustus 2021 Vol 8, No 2 (2021): J Sains Farm Klin 8(2), Agustus 2021 Vol 8, No 1 (2021): J Sains Farm Klin 8(1), April 2021 Vol 8 No 1 (2021): J Sains Farm Klin 8(1), April 2021 Vol 7, No 3 (2020): J Sains Farm Klin 7(3), Desember 2020 Vol 7 No 3 (2020): J Sains Farm Klin 7(3), Desember 2020 Vol 7, No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020 Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020 Vol 7, No 1 (2020): J Sains Farm Klin 7(1), April 2020 Vol 7 No 1 (2020): J Sains Farm Klin 7(1), April 2020 Vol 6, No 3 (2019): J Sains Farm Klin 6(3), Desember 2019 Vol 6 No 3 (2019): J Sains Farm Klin 6(3), Desember 2019 Vol 6, No 2 (2019): J Sains Farm Klin 6(2), Agustus 2019 Vol 6, No 1 (2019): J Sains Farm Klin 6(1), April 2019 Vol 5, No 3 (2018): J Sains Farm Klin 5(3), Desember 2018 Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018 Vol 5, No 1 (2018): J Sains Farm Klin 5(1), April 2018 Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017 Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017 Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016 Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016 Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015 Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015 Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014 More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Yori Yuliandra

Contact Email
yoriyuliandra@gmail.com

Phone
-

Journal Mail Official
jsfkonline@gmail.com

Editorial Address
-

Location
Kota padang,

Sumatera barat

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Yori Yuliandra

Contact Email yoriyuliandra@gmail.com

Phone -

Journal Mail Official jsfkonline@gmail.com

Editorial Address -

Location Kota padang, Sumatera barat INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Yori Yuliandra

Contact Email
yoriyuliandra@gmail.com

Phone
-

Journal Mail Official
jsfkonline@gmail.com

Editorial Address
-

Location
Kota padang,

Sumatera barat

INDONESIA