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JSFK (Jurnal Sains Farmasi & Klinis)
Published by Universitas Andalas
ISSN : 24077062     EISSN : 24425435     DOI : 10.25077
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.
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Articles 509 Documents
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Total Flavonoid Content and Antioxidant Properties of Different Extraction Methods of Red Spinach Leaf (Amaranthus tricolor L.) Permanasari, Etin Diah; Amalia, Mega Putri Rizky; Susilo, Susilo; Prastiwi, Rini
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.17-24.2024

Abstract

Red spinach leaf (Amaranthus tricolor L.) has been well-proven to contain flavonoids that exhibit antioxidant activities. In this study, a comparison between maceration and ultrasonic methods has been carried out to evaluate the effect of these two methods on the level of red spinach leaf flavonoid. In this study, for maceration 1, 2, and 3 days while for the ultrasonic method 10-, 20-, and 30-minutes time duration have been used. The ratios of material and solvent were 1:5 and 1:10. The flavonoid content was determined with the help of a spectrophotometer at a maximum wavelength of 436.80 nm. The antioxidant activity was evaluated by the DPPH method to obtain the IC50. The result of the study revealed that the highest flavonoid content of 4.27 mgQE/g and antioxidant activity (IC50) of 110.47 ppm were obtained by an ultrasonic under conditions of 1:10 ratio and 30-minute extraction time. Results of the study suggested a significant difference (p<0,05) in the isolation of total flavonoid contents and antioxidant activities in the maceration and ultrasonic. In these two methods, ultrasonic was found to be more efficient than maceration because of minimum time, the highest flavonoid content and antioxidant activity could be obtained.
Development of Oil Vehicle Screening Method for Bromo Acid Dye-Based Color-Changing Cosmetic Formulation Susanto, Eriwan; Cita, Juang Arwafa; Sujilah, Ajeng Rana Wulan; Satrialdi, Satrialdi; Suciati, Tri; Nugraha, Yuda Prasetya
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.67-79.2024

Abstract

Bromo acid dye (Red 21) recently gained attention in the production of color-changing cosmetics. The critical aspect in the development of cosmetic products using this dye group is the compatibility of its oil vehicles. The compatibility of bromo acid dyes with oil vehicles is determined by several parameters such as the dye solubility in the oils, clarity of the mixture, and the ability to change color when the pH of the solution is adjusted to match the skin’s pH. Therefore, this study conducted the compatibility study by examining the ability of 27 oil samples to dissolve Red 21. The ability of a vehicle to dissolve a compound is influenced by the polarity of the vehicle. Hence, a correlation was established between the relative polarity of oils and their ability to dissolve Red 21. The results showed that the water-oil interfacial tension was negatively correlated (r = -0.64) with Red 21 solubility in the oil. From this research, the water-oil interfacial tension represented the relative polarity of the oil and was considered sufficient to predict the compatibility of the oil with Red 21. In addition, hydrocarbon and silicone oils are not compatible with Red 21.
Integrating Computational Methods into Antibacterial Drug Discovery and Development from Natural Products Yuliandra, Yori; Syafni, Nova
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.80-85.2024

Abstract

Natural products have long been pivotal in sustaining civilizations due to their medicinal properties and have served as a rich source of bioactive compounds for drug discovery. With the rise of antibiotic-resistant bacteria, there is an urgent need for new antibacterial agents. Natural products, with their diverse chemical structures, provide a promising reservoir for identifying new lead compounds. Historically, the discovery of bioactive natural products often relied on serendipity, but modern advancements in computational approaches, particularly computer-aided drug design (CADD), have revolutionized this process. In the modern era, vast data from advanced technologies can provide valuable insights through computational methods. These approaches enable the structural analysis of molecules and the prediction of their biological activities, accelerating drug discovery. Advances in molecular sciences have identified more antibacterial targets, further facilitating this process. Integrating computational drug design with the study of natural products allows for the efficient identification and optimization of potential antibacterial agents. Moreover, many medicinal plants harbor mechanisms of action that remain unexplored by conventional methods. By employing computational techniques, researchers can uncover these mechanisms and develop novel antibacterial drugs. This combined approach not only enhances our understanding of natural products but also addresses the critical need for new treatments in the fight against bacterial infections.
Evaluasi Penggunaan Insulin pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan di Rumah Sakit X di Jakarta Periode 2016-2017 Anggriani, Yusi; Rianti, Alfina; Pratiwi, Annisa Nadya; Puspitasari, Wulan
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 1 (2020): J Sains Farm Klin 7(1), April 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.1.52-59.2020

Abstract

Type 2 Diabetes Mellitus (DMT2) is a metabolic disease with the characteristics of hyperglycemia that occurs due to abnormal insulin secretion. One of the treatments of DM is insulin therapy. Based on its provenance, insulin consists of human insulin and analogue insulin. This study was conducted to identify profiles of insulin used in DMT2 patients at RSUP X hospital in Jakarta. This was an observational study conducted retrospectively on data from 2016 to 2017. The total sample numbers of DMT2 outpatients using insulin were 218 in 2016, and 225 in 2017. Data on insulin therapy regimens were obtained from medical records and drug use reports. The results obtained from this study indicated that the type of insulin that was widely used by DMT2 outpatients was analogue insulin with a percentage of 99%. The human insulin was rarely used in outpatients. The highest use of analogue insulin was analog premixed insulin (35%).
Efektivitas Ekstrak Etanol Kulit Buah Terung Ungu (Solanum melongena L.) sebagai Antimalaria terhadap Jumlah Eosinofil pada Mencit (Mus musculus) yang Diinduksi Plasmodium berghei Haris, Muhammad Faisal; Kahtan, Muhammad Ibnu; Widiyantoro, Ari
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.107-114.2020

Abstract

Malaria is a disease caused by Plasmodium that is transmitted to humans through female Anopheles mosquito bite. Many cases of antimalarial drug resistance such as chloroquine led to the need for new antimalarial discoveries. Eggplant contains many secondary metabolites that are potential as antimalarial. This study aimed to determine the effectivity of ethanol extract of eggplant peels as antimalarial towards eosinophil in mice induced by Plasmodium berghei. Eggplant peels were extracted by maceration method using 70% ethanol. The analysis of secondary metabolites from the ethanol extract of eggplant peels was conducted using tube test and thin layer chromatography. The percentage of parasitemia and eosinophil were calculated from peripheral blood smear of mice which were treated with extracts at the doses of 0.075, 0.15, and 0.30 mg/20 g of body weight. Dihydroartemisinin-piperaquin (3.744 mg/20 g of body weight) was used as positive control, while distilled water was used as negative control. The study showed that ethanolic extract of the eggplant peels contained alkaloids, flavonoids, terpenoids, steroids, phenolic, and saponins. The extract effectively reduced parasitemia at a dose of 0.075 mg/20 g, but it was not effective in increasing the number of eosinophil in mice. There was no correlation between the number of parasitemia and eosinophil. The study concludes that ethanolic extract of the eggplant peels exhibits antimalarial activity, but does not show immunomodulatory activity in increasing eosinophil.
Gambaran Perilaku Keluarga dalam Menyimpan dan Membuang Obat Antibiotik di Kecamatan Pariangan, Kabupaten Tanah Datar Zulkarni, Zulkarni; Syofyan, Syofyan; Triyanda, Zola
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.172-179.2020

Abstract

Risk factors for drug-related incidents can begins from problems in getting, using, storing and disposing of inappropriate drugs including antibiotics. The problem of antibiotic drugs has become a global problem that needs serious attention, including in Indonesia. The purpose of this study was to describe the behavior of families in storing and disposing of antibiotic drugs in Pariangan Subdistrict, Tanah Datar, Indonesia. The study used a cross sectional design with a purposive sampling technique. Based on the calculation of the number of samples by using Slovin formula, there were 100 families in Pariangan Subdistrict, Tanah Datar District that met the inclusion and exclusion criteria. This study used an instrument in the form of a questionnaire that met the validity and reliability test requirements. The data were analyzed by SPSS. The results showed that the family’s behavior in storing and disposing of antibiotics was sufficient with mean values of 6.07 and 6.90, respectively. Based on the correlation test, it can be concluded that there is no relationship between knowledge of families regarding of pharmacist profession and antibiotic drugs with family behavior in storing and disposing of antibiotics as indicated by a value of r = 0.163.
Penentuan Aktivitas Antioksidan dan Antidiabetes Ekstrak Daun Kepundung (Baccaurea racemosa Muell.Arg.) secara In Vitro Wulandari, Lestyo; Nugraha, Ari Satia; Azhari, Nuri Putri
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 1 (2020): J Sains Farm Klin 7(1), April 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.1.60-66.2020

Abstract

 Kepundung (Baccaurea racemosa Muell.Arg.) merupakan salah satu tanaman berkhasiat di Indonesia yang mengandung flavonoid, polifenol, tanin, dan terpenoid yang dapat berfungsi sebagai antioksidan. Kandungan senyawa dengan aktivitas antioksidan dapat dikaitkan dengan potensi aktivitas antidiabetes dari tanaman ini. Penelitian dilakukan untuk mengetahui aktivitas antioksidan dan antidiabetes ekstrak metanol, etanol, dan etil asetat dari daun kepundung. Ekstraksi dilakukan dengan metode ultrasonik. Pengujian aktivitas antioksidan dilakukan secara kuantitatif dengan metode DPPH, sedangkan pengujian aktivitas antidiabetes menggunakan metode penghambatan enzim α-amilase. Nilai IC50 pada penentuan aktivitas antioksidan dan antidiabetes ditentukan dengan menggunakan spektrofotometer UV-Vis pada panjang gelombang maksimum. Hasil penentuan antioksidan menunjukkan bahwa nilai IC50 ekstrak metanol, etanol, dan etil asetat masing-masing adalah 9,38 ± 0,15; 10,55 ± 0,09; dan 946,70 ± 2,31 ppm. Ini menunjukkan ekstrak metanol dan etanol memberikan hasil terbaik dalam aktivitas antioksidan. Nilai IC50 aktivitas antidiabetes in vitro ekstrak metanol, etanol, dan etil asetat masing-masing adalah 67,63 ± 0,36; 67,46 ± 0,23; dan 841,04 ± 1,52 ppm. Hasil ini juga menunjukkan bahwa ekstrak metanol dan etanol daun kepundung memiliki aktivitas antidiabetes yang hampir sama
Penentuan Kadar Fenolat Total, Uji Aktivitas Antioksidan dan Antibakteri dari Ekstrak dan Fraksi Kulit Batang Bintangor (Calophyllum soulattri Burm. F) Husni, Elidahanum; Dachriyanus, Dachriyanus; Saputri, Veny Wahyu
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 1 (2020): J Sains Farm Klin 7(1), April 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.1.92-98.2020

Abstract

Bintangor (Calophyllum soulatri Burm. F) merupakan tumbuhan dari familia Clusiaceae. Beberapa bagian dari tumbuhan ini seperti kulit batangnya telah lama digunakan sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui kadar fenolat total, aktivitas antioksidan dan antibakteri dari kulit batang bintangor dalam bentuk ekstrak dan fraksi. Ekstrak kulit batang bintangor dibuat dengan teknik maserasi dengna pelarut etanol, sedangkan fraksinasi dilakukan dengan pelarut n-heksan, etil asetat dan butanol. Kadar fenolat total dari ekstrak dan fraksi ditentukan menggunakan metode Folin-Ciaocalteau. Aktivitas antioksidan ditentukan dengan metode Ferric Reducing Antioxidan Power, sedangkan aktivitas antibakteri dievaluasi dengan metode difusi agar terhadap bakteri patogen. Hasil penelitian menunjukkan bahwa kadar fenolat total tertinggi diperoleh dari ekstrak etanol (60,481 g/100 g), demikian juga dengan aktivitas antioksidan tertinggi (4,29 mmol Fe(II)/100 g). Aktivitas antibakteri paling baik diperlihatkan oleh ekstrak etanol dengan konsentrasi hambat minimum 0,8%, menghasilkan diameter hambat 6,96 mm, diikuti oleh fraksi n-heksan (konsentrasi 0,9%, menghasilkan diameter hambat 6,63 mm), fraksi etil asetat (konsentrasi 0,625%, menghasilkan diameter hambat 6,28 mm), dan fraksi butanol (konsentrasi 0,5%, menghasilkan diameter hambat 6,03 mm).
Formulasi dan Uji Sifat Fisik Sediaan Lulur Krim dari Ekstrak Etanol Daun Sirsak (Annona muricata L.) serta Penentuan Aktivitas Antioksidannya Hakim, Zainur Rahman; Meliana, Dewi; Utami, Pri Iswati
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.135-142.2020

Abstract

The ethanolic extract of soursop leaves (Annona muricata L.) is reported as an antioxidant agent with an IC50 value of 14.48 µg/mL. This research aimed to examine physical characteristics and investigate the antioxidant activity of the ethanolic extract of soursop leaves in a scrub cream. Soursop leaves powder was extracted with 70% ethanol and formulated as scrub cream at the concentration of 1.4%, 2.8%, and 4.2%, then evaluated for physical characteristics. The antioxidant activity was evaluated using DPPH (1.1-diphenyl-2 picrylhydrazyl) method. The result showed that the scrub cream at all concentrations tested fulfilled all physical characteristics required for good topical preparations. These included organoleptic, homogeneity, viscosity, pH, spreadability, and adhesion. The IC50 value of the scrub cream at the concentration of 1.4%, 2.8 %, and 4.2% were 30.72, 26.82, and 24.03 µg/mL, respectively. The IC50 values indicated that the scrub creams exhibit radical scavenging activities which categorized as strong activity antioxidants.
Analisis Outcome Klinis Berdasarkan Kualitas Hidup dan Biaya Medik Langsung Pasien Diabetes Melitus Tipe 2 Ratnasari, Pande Made Desy; Andayani, Tri Murti; Endarti, Dwi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 1 (2020): J Sains Farm Klin 7(1), April 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.1.15-22.2020

Abstract

Diabetes Melitus (DM) tipe 2 merupakan penyakit kronis yang membutuhkan terapi untuk mengontrol glukosa darah. Pengontrolan glukosa darah yang buruk berdampak pada penurunan kualitas hidup dan peningkatan biaya. Tujuan penelitian adalah menganalisis perbedaan outcome klinis yaitu kadar Glukosa Darah Sewaktu (GDS) selama 3 bulan berdasarkan kualitas hidup dan biaya medis langsung. Outcome klinis dikatakan terkontrol apabila GDS <200 mg/dL dan tidak terkontrol apabila GDS ≥200 mg/dL. Rancangan penelitian ini adalah cross sectional dengan jenis observasional. Kriteria inklusi mencakup pasien DM tipe 2 yang memperoleh antidiabetik yang sama minimal 3 bulan di Instalasi Rawat Jalan RSUD Panembahan Senopati Bantul pada September 2017. Kriteria eksklusi meliputi kondisi hamil atau menyusui. Pengambilan data dilakukan melalui pengisian kuesioner, rekam medis dan bagian keuangan. Data demografi dianalisis secara deskriptif sedangkan outcome klinis diolah menggunakan uji Kruskal Wallis. Hasil penelitian menunjukkan sebanyak 129 dari 200 pasien menunjukkan outcome klinis tidak terkontrol (64,5%) dengan rata-rata nilai kualitas hidup yang baik (65,7±7,7) serta mengeluarkan biaya medis langsung sebesar Rp 489.005. Terdapat perbedaan outcome klinis berdasarkan kualitas hidup (p=0,000) pada domain fungsi fisik (p=0,034), kepuasan pribadi (p=0,000), kepuasan pengobatan (p=0,000) dan frekuensi gejala penyakit (p=0,012) serta berdasarkan biaya medis langsung (p=0,012). Pasien dengan outcome klinis terkontrol menunjukkan kualitas hidup yang lebih tinggi dan mengeluarkan biaya lebih rendah.

Page 46 of 51 | Total Record : 509

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