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INDONESIA
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Published by Universitas Muhammadiyah Purwokerto
ISSN : 16933591     EISSN : 2579910X     DOI : -
Core Subject : Science,
Materials Science & Nanotechnology
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) is a scientific journal publishing original articles research in pharmaceutical science such as Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, and Pharmaceutical Care.
Arjuna Subject : -
Articles 475 Documents
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Formulation of Aromatherapy Balm from Essential Oil of Lemongrass (Cymbopogon citratus (DC.) Stapf) La Ode Akbar Rasydy; Alasya Sihotang
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.9345

Abstract

Lemongrass kitchen (Cymbopogon citratus (DC.) Stapf) is one type of spice native to Indonesia containing essential oil that can be used as perfumes, cosmetics, food additives and medicines. The study aims to formulate essential oils of lemongrass kitchen to aromatherapy balm preparations. Essential oils were obtained by steam distillation. The aromatherapy balm preparations were formulated by paraffin liquid, methanol, cera alba and vaseline album, and varying concentrations of essential oil of 0% (F1), 3% (F2), 6% (F3) and 12% (F4). The aromatherapy balms ware evaluated their physical quality with organoleptic tests, homogeneity tests, pH tests, GC-MS tests, and hedonic tests. Data were analyzed using one way ANOVA. The results showed that all aromatherapy balm formulas produced an organoleptic test that was yellowish white with a semi-solid form, smell like aromatherapy types. Homogeneity test showed F1-F4 did not change shape during storage. The pH test of the four formulas ranging from 5.27 to 6.89 met the skin neutral pH requirements. The preference test of 40 panelists showed that the panelists preferred the F4 which had a sharper aroma of aromatherapy essential oils. The results show that essential oil of lemongrass kitchen can be formulated to aromatherapy balm preparations with concentration of 12% of lemongrass, the best among the four formulas.
Kandungan Fenol, Flavonoid Total, dan Aktivitas Antioksidan Sediaan Infusa dan Freeze-dried Infusa Tanaman Plocoglottis lowii Rchb.f. Pratiwi Apridamayanti; Sigit Normagiat
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.8777

Abstract

Keragaman spesies anggrek di hutan tropis Indonesia sangat melimpah, salah satunya tanaman Plocoglottis lowii Rchb.f. yang terdapat di daerah Sanggau, Kalimantan Barat. Penggunaan oleh masyarakat lokal sebagai minuman obat tradisional. Penelitian ini bertujuan untuk mengetahui kandungan fenol dan flavonoid total serta aktivitas antioksidan pada tanaman tersebut. Sejumlah 10 ml infusa dilakukan uji senyawa fenol dan flavonoid total menggunakan metode Chun, diukur secara spektrofotometer UV/Vis, kemudian dilanjutkan dengan uji aktivitas antioksidan (IC50) dengan menggunakan metode DPPH dan sebanyak 10 mg freeze dried infusa (FDI) dilakukan uji senyawa fenol dan flavonoid total menggunakan metode Chun, diukur secara spektrofotometer UV/Vis, kemudian dilanjutkan dengan uji aktivitas antioksidan (IC50) dengan menggunakan metode DPPH. Hasil yang diperoleh kandungan flavonoid total infusa sebesar 2,462±0,05%b/b Quarcetin Equivalent (QE), 19,220±0,38%b/b Rutin Equivalent (RE) Freeze-dried infusa (FDI) sebesar 1,389±0,44%b/b QE, 15,024±3,26% RE. Kandungan fenol total infusa sebesar 19,578±0,42%b/b Asam Galat Equivalent (AGE) dan Freeze-dried infusa (FDI) sebesar 38,538±1,25%b/b AGE. Aktivitas antioksidan (IC50) yang dimiliki oleh infusa dan FDI adalah 59,493±0,42 ppm dan 27,310±1,25 ppm dan  termasuk dalam kategori kuat dan sangat kuat.
Indeks dan Panduan Penulis Pharmacy Vol. 17 No. 02 Desember 2020 PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal Of Indonesia)
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.12359

Abstract

Indeks dan Panduan Penulis Pharmacy Vol. 17 No. 02 Desember 2020
Formulation and Antibacterial Activities of Chewable Lozenges of Celery (Apium graveolens L.) Leaf Ethanolic Extract against Dental Caries Causing Streptococcus mutans Vella Lailli Damarwati; Rizka Wahyu Septiasih; Zaki Tiffani Lazuardian; Annisa Krisridwany
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.9346

Abstract

Celery (Apium graveolens L.) is an herbal plant that has the chemical content flavonoid, saponin and tannin. The antibacterial activity of them have been investigated for many years. However, the antibacterial activity has not been evaluated in oral formulations. This study aims to formulate chewable lozenges celery leaf ethanolic extract, evaluate physical characterized and antibacterial activity of chewable lozenges. Celery leaf ethanolic extract is formulated into chewable lozenges using molded method with concentration of 20 g and 25 g. This formulation was characterized for organoleptic test, weigh uniformity, dissolution testing, thickness testing and pH determination. Antibacterial activity of chewable lozenges was carried out by diffusion method using Streptococcus mutans. From the chewable lozenges formula there are no significant physical differences between formulas and can be organoleptically acceptable. The results of the antibacterial activity test showed the value of inhibition zone diameters of Streptococcus mutans bacteria in F1, F2, F3, F4, F6 respectively 8,8 mm, 9 mm, 8,16 mm, 9,33 mm, 8 mm dan 9,13 mm. Formulation F4 shown better antibacterial activity as compared to its other formulations.
Kapasitas Daya Hambat Antibakteri Minyak Atsiri Nilam Aceh (Pogostemon cablin Benth.) terhadap Methicillin-Resistant Staphylococcus aureus (MRSA) Layli Adhayani; Rasistia Ramadhani; Rima Ristianti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.8938

Abstract

Minyak nilam Aceh mengandung senyawa yang aktif sebagai antibakteri seperti patchouli alcohol, eugenol, beta-caryophyllene, seychellene, gurjunene, alpha-guaiene, beta-patchoulene, bulnesene, dan gamma-guaiene.  Kajian ini akan menguraikan daya hambat minyak nilam Aceh yang telah diredistilasi di Atsiri Research Center (ARC) Universitas Syiah Kuala. Minyak atsiri nilam diambil dari Kabupaten Aceh Jaya dan diuji daya hambatnya terhadap bakteri Methicillin-resistant Staphylococcus aureus (MRSA). Bahan yang digunakan adalah isolat bakteri MRSA, minyak nilam dengan berbagai konsentrasi. Pembuatan konsentrasi minyak nilam dilakukan dengan mencampurkan minyak nilam dengan larutan etanol. Konsentrasi minyak nilam yang diuji dalam penelitian ini adalah 80, 40, 20, dan 10%. Pengujian antimikroba dilakukan berdasarkan metode difusi cakram Kirby-Bauer, masing-masing tiga ulangan setiap perlakuan. Hasil penelitian menunjukkan bahwa konsentrasi nilam terbaik untuk daya hambat bakteri adalah 80% dengan diameter zona hambat terhadap MRSA sebesar 11,78 mm. Penelitian ini juga membuktikan bahwa semakin tinggi konsentrasi minyak nilam maka semakin besar daya hambat bakterinya.
Pengaruh Penambahan Fucoidan Pada Omeprazol Terhadap Perbaikan Gejala Dispepsia dan Kualitas Hidup Pada Pasien Dispepsia Fungsional Khaerani Khaerani; Suharjono Suharjono; Bambang Eko Wahyono
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.7568

Abstract

Dispepsia Fungsional merupakan salah satu gangguan fungsi pada gastrointestinal dan dapat berpengaruh terhadap kualitas hidup pasien. Fucoidan memiliki banyak efek farmakologi, salah satunya sebagai mukoprotektor dan bersifat sebagai anti ulcer pada gastrointestinal yang diduga dapat memperbaiki gejala dispepsia. Tujuan dari penelitian ini yaitu menganalisis efek penambahan fucoidan pada omeprazol terhadap perbaikan gejala dispepsia dan kualitas hidup pasien pada pasien dispepsia fungsional. Hasil yang diperoleh adanya perbaikan gejala dan kualitas hidup sebelum dan setelah menerima penambahan terapi fucoidan dengan nilai p < 0,05. Pada perbandingan perbaikan yang dilakukan pada kedua kelompok tidak terjadi perbaikan yang signifikan secara statistik dengan nilai p > 0,05 untuk beberapa domain kuesioner. Akan tetapi dalam perbaikan gejala klinik yang diobservasi terdapat perbaikan gejala dispepsia dan kualitas hidup yang lebih baik pada penambahan fucoidan.
Formulation of Cassava (Manihot esculenta Crantz) Tuber Extract Gel and Effectiveness Test on Burns in Rabbit (Oryctolagus cuniculus) Julia Megawati Djamal; Zaenal Fanani; Noor Hidayah; Noor Cholifah
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.9347

Abstract

Burn is heat transfer in which the source can be direct or indirect contact with fire, electricity, friction chemicals or radiation. It can cause damage of skin tissue even in a state of multisystem injury leading to serious disorders. Systemic effects and mortality caused by burn is generally determined by the extent and depth of affected skin. Cassava (Manihot esculenta Crantz) contains carbohydrates, phosphorus, calcium, vitamin C, vitamin B1, protein and iron. Furthermore, substances contained in cassava are able to give effect to the re-epithelialization of skin damaged cell tissue due to burns. The aim of this study was to find out the cassava tuber extract in gel preparation formulation and the effectiveness of burn healing in rabbits. This study was an experimental study to examine the concentration of cassava tuber extract gel formula which is the most effective in healing superficial burns of degree 4 in male rabbits. From the observations of giving gel preparations once a day by using positive control comparison (Bioplaceton) could be concluded that the extract of cassava provided healing which was not significantly different from the positive control.
Pengaruh Penggunaan Obat On-Label dan Off-Label dengan Munculnya Reaksi Obat Tidak Dikehendaki pada Pasien Pediatrik Irsalina Nurul Putri; Anton Bahtiar; Retnosari Andrajati
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.9105

Abstract

Reaksi obat tidak dikehendaki (ROTD) adalah salah satu masalah kesehatan di masyarakat yang terjadi terutama pada populasi anak. ROTD pada anak dapat memiliki efek yang relatif lebih parah bila dibandingkan dengan orang dewasa. Penggunaan obat off-label merupakan faktor risiko terjadinya ROTD pada anak. Penelitian tentang penggunaan obat off-label sudah dilakukan di beberapa tempat di Indonesia tetapi sebagian besar hanya sebatas persentase penggunaan obat off-label tetapi tidak diketahui lebih lanjut tentang pengaruhnya terhadap munculnya ROTD. Tujuan dari penelitian ini adalah mengevaluasi penggunaan obat off-label dan on-label sebagai faktor risiko terjadinya reaksi obat tidak dikehendaki pada pasien pediatri.  Penelitian ini merupakan penelitian studi kohor yang membandingkan reaksi obat tidak dikehendaki antara peresepan secara on-label dan off-label selama masa rawat pasien. Studi ini meneliti 130 pasien dengan jumlah penggunaan obat sebanyak 549 obat selama 4 bulan masa penelitian. Sebanyak 141 obat digunakan secara off-label dan 408 obat digunakan secara on-label. Pemberian obat off-label memiliki risiko untuk terjadinya ROTD 5,787 (Relative Risk=5,787; 95% Confidence Interval 1,072- 31,256) atau 5 kali lebih besar dibandingkan dengan pemberian obat on-label. Peneitian ini mengindikasikan bahwa pemberian obat off-label merupakan faktor risiko terjadinya reaksi obat tidak dikehendaki. Variabel perancu yang berhubungan bermakna dengan kejadian ROTD adalah variabel umur (p< 0,05).
Evaluation of the Use of Antihypertensive Agents in Ischemic Stroke Patients Hospitalized in West Nusa Tenggara Hospital, Indonesia Baiq Leny Nopitasari; Cyntiya Rahmawati; Anna Pradiningsih; Baiq Nurbaety
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.9343

Abstract

Antihypertensive agents are one of the drugs recommended on ischemic stroke patients as a secondary therapy for prevention of occurrence repeated stroke and reduce the risk of brain edema. If the management of hypertension is incorrect on ischemic stroke patient can worsen the patient's condition and affect mortality. The use of antihypertensive drugs must be evaluated accordingly with rational use of drugs. This study aims to examine the accuracy of the use of antihypertensive drugs in ischemic stroke patients which includes right indication, right patient, right medicine, right dose and right frequency. This research is a cross sectional descriptive study using medical record data of 19 ischemic stroke patients. The inclusion criteria of the study were all ischemic stroke hospitalization patients and receiving antihypertensive drugs therapy. The evaluation of accuracy was done descriptively by comparing research data to the literature which includes JNC VII & VIII, PERDOSSI 2011, PIONAS 2015, FORNAS and Revised RSUDP Formulary 6th. The results showed the accuracy of use antihypertensive agents is 100% that is 100% precise indication; 100% right patient; 100% right dose; and 95% right frequency. The type of inaccuracy encountered is frequency imprecision drug administration, therefore the role of a pharmacist in hospital are needed as part of efforts to improve the accuracy of the use of drugs in ischemic stroke patients.
Combination of Traditional Medicine and Synthesis Medicine Therapy for Hypertension and Diabetic Patients Ersi Arviana Ihsan; Fitriwati Sovia; Erma Ewisa Oktresia; Tri Puspita Yuliana; Sulistia Ardyati; Arief Rafsanjani
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.9348

Abstract

Hypertension and diabetic are interrelated diseases affect atherosclerosis. This study aims to analyze the combination of traditional medicines and synthetic medicine with a job background for patients with hypertension and diabetic. Case-control study method retrieves patient data with medical records. Sampling was done with a purposive sampling technique of 30 respondents conducted in March-June at Labuhan Lombok Health Center. The results showed the percentage of diabetic patients was 26.67% for men and 73.33% for women with a background of 60% of traders, 20% of farmers, 13.3% of fishermen, and housewives of 6.7%. Furthermore, for hypertension patients, the percentage was 13.33% for men and 86.67% for women with a background of 40% of traders, 53.3% for farmers, 6.7% for fishermen. For traditional medicine used are Moringa oleifera L., Cucumis sativus L., jamu gendong, Averrhoa bilimbi L., Curcuma longa L., and Artocarpus camansi Blanco. Based on this, the risk factors for women are more generous than for men, and the use of a combination of drugs gives positive results in improving health.

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