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Acta Biochimica Indonesiana
Published by Perhimpunan Biokimia dan Biologi Molekuler Indonesia
ISSN : 26546108     EISSN : 26543222     DOI : https://doi.org/10.32889
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
Acta Biochimica Indonesiana (ActaBiolna) is a peer-reviewed and open-access journal that disseminates original research articles and review articles covering diverse topics in Biochemistry and Molecular Biology. The journal is published biannually by Indonesian Society for Biochemistry and Molecular Biology.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 114 Documents
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Association between vitamin D receptor FokI polymorphism and hypertension in Indonesian ischemic stroke patients: a cross-sectional study Arrizal, Rizki; Arina, Cut Aria; Siregar, Yahwardiah
Acta Biochimica Indonesiana Vol. 9 No. 1 (2026): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.237

Abstract

Background: Vitamin D receptor (VDR) FokI polymorphism (rs2228570) affects VDR protein transcriptional activity and may influence hypertension risk through renin-angiotensin system modulation. However, evidence in Southeast Asian stroke populations remains limited. Objective: To investigate the association between VDR FokI polymorphism and hypertension in Indonesian ischemic stroke patients. Methods: This cross-sectional study enrolled 85 ischemic stroke patients (50 hypertensive, 35 normotensive) from Medan, Indonesia. VDR FokI genotypes (CC, CT, TT) were determined using PCR-RFLP. Association with hypertension was analyzed using chi-square test. Results: Genotype distribution showed CC and CT at equal frequency (44.7% each) and TT at 10.6%, with corresponding C and T allele frequencies of 67.1% and 32.9%, respectively. Among hypertensive stroke patients, CT genotype predominated (52.0%), whereas CC genotype was most prevalent in normotensive patients (57.1%). Despite these distributional differences, no significant association was observed between VDR FokI polymorphism and hypertension (χ² = 3.732, p = 0.155). Conclusion: VDR FokI polymorphism was not significantly associated with hypertension in Indonesian ischemic stroke patients, suggesting that genetic predisposition via this single polymorphism may be overshadowed by established stroke pathophysiology or complex gene-environment interactions in this specific clinical context.
Efficacy of liposomal amphotericin B eye drops at two concentrations in experimental aspergillus keratomycosis in rabbits Amalia, Husnun; Ridwan, Rahmawati; Estuningtyas, Ari; Sitompul, Ratna; Adawiyah, Robiatul; Freisleben, Hans-Joachim
Acta Biochimica Indonesiana Vol. 9 No. 1 (2026): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.240

Abstract

Background: Keratomycosis, a fungal corneal infection prevalent in tropical regions, frequently leads to visual impairment and blindness. Liposomal amphotericin B (L-AmB) offers improved efficacy and reduced toxicity compared to conventional amphotericin B deoxycholate and represents a promising option for topical ophthalmic use. Objective: To evaluate and compare the therapeutic efficacy of L-AmB eye drops at 0.15% and 0.5% concentrations in experimental Aspergillus keratomycosis in New Zealand White rabbits. Methods: Four rabbits received midstromal corneal inoculation with a mixed suspension of Aspergillus flavus, A. fumigatus, A. niger, and A. terreus (2 x 10⁴ CFU/0.05 mL). L-AmB eye drops were applied hourly from day 8 post-inoculation until corneal cultures became negative. Antifungal susceptibility was assessed by disc diffusion. Clinical response was monitored by slit lamp examination using a modified scoring system. Results: Negative corneal cultures were achieved in all treated eyes within 10 to 18 days (mean 15 days, L-AmB 0.15%) and 11 to 15 days (mean 14 days, L-AmB 0.5%). No toxic effects were observed. Complete corneal transparency without cicatrix was achieved in one eye treated with L-AmB 0.15%. Conclusion: Both concentrations were effective and safe. Liposomal AmB 0.15% appears as efficacious as 0.5% for experimental Aspergillus keratomycosis. Clinical studies in humans are warranted.
Dose-dependent anticholesterol effects of Fuji apple simplicia in a rat model of metabolic syndrome Himawan Pramudana Amiruddin; R. Prihandjojo Andri Putranto; Amalina Shabrina; Veronika Ika Budiastuti
Acta Biochimica Indonesiana Vol. 9 No. 1 (2026): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.233

Abstract

Background: Metabolic syndrome-associated dyslipidemia increases cardiovascular disease risk. Fuji apples (Malus domestica) contain bioactive compounds that may modulate cholesterol metabolism. Objective: To evaluate dose-dependent anticholesterol effects of Fuji apple simplicia in metabolic syndrome rats. Methods: Thirty male Wistar rats were allocated into five groups (n=6): negative control, positive control (metabolic syndrome without treatment), and three treatment groups receiving simplicia at 150, 300, or 450 mg/200 g body weight/day for 28 days. Metabolic syndrome was induced using high-fat diet and streptozotocin-nicotinamide injection. Total cholesterol was measured using enzymatic colorimetric assay and analyzed using mixed ANOVA. Results: Simplicia produced significant dose-dependent cholesterol reductions compared to positive control (p<0.001). Reductions were 71.77 mg/dL (34.09%), 100.53 mg/dL (47.78%), and 112.02 mg/dL (52.75%) at doses of 150, 300, and 450 mg/200 g body weight/day, respectively. Conclusion: Fuji apple simplicia exhibits significant anticholesterol activity in metabolic syndrome rats through a dose-dependent mechanism, supporting its potential as a complementary intervention for hypercholesterolemia management in metabolic syndrome.
Sustainable bromelain extraction from pineapple waste: ATPS purification, freeze-drying, and cosmetic safety evaluation Parcon, Ma. Rachel V.; Bautista, Gladys Ann B.; Jose, Chelsea Kate F.; Ysulat, Jan Anthony N.; Cortez, Geaver Nicolei C.; Abarcar, Andrea Nicole Y.; Morales, Pauline Yarah H.; Alfaro, John Cyrus O.; Bidol, Aileen C.
Acta Biochimica Indonesiana Vol. 9 No. 1 (2026): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.236

Abstract

Background: Pineapple processing generates substantial waste; peels represent a rich source of bromelain, aproteolytic enzyme with dermatological applications. Objective: To develop sustainable bromelain extraction from pineapple peels using aqueous two-phase system(ATPS), evaluate freeze-dried extract, and assess safety for topical cosmetic use. Methods: Bromelain was extracted using PEG-4000/MgSO₄ ATPS and freeze-dried. Proteolytic activity was quantified by tyrosine release and gelatin digestion assays. Purified bromelain was incorporated into gel cleanser and serum formulations (2-5%, pH 4.5-7.0) and evaluated for physicochemical properties, microbial safety, and skin compatibility through human repeat insult patch testing (HRIPT). Results: The 10% PEG-4000/30% MgSO₄ system achieved optimal balance (37.64% yield, 2.80 U/mL activity). Freezedrying produced free-flowing powder. Formulations met ASEAN microbial limits (<1,000 cfu/g) and demonstrated non-irritating properties with low hypersensitivity risk in HRIPT. Conclusion: ATPS extraction combined with freeze-drying produces stable, bioactive bromelain suitable for safe

Page 12 of 12 | Total Record : 114

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