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Jambura Journal of Health Sciences and Research
Published by Universitas Negeri Gorontalo
ISSN : 26230674     EISSN : 2655643X     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health
Jambura Journal of Health Sciences and Research is a health scientific journal which published original articles of public health. This articles Published Twice a year in January and July. Which Focus and Scope in public health issues, including : Epidemiology, Health Education and Promotion, Environmental Health, Occupational Health and Safety, Health Administration and Policy, Biostatistics, Reproductive Health, Hospital Management, Nutrition Science, Health Information System. Moreover, Author can submit articles on any issue relating to public health with editor consideration.
Arjuna Subject : -
Articles 352 Documents
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COMPARISON OF BONE MARROW ASPIRATION INTERPRETATION WITH IMMUNOPHENOTYPING IN CHILDREN'S LEUKEMIA DIAGNOSIS Nadirah Rasyid Ridha; Dasril Daud
Jambura Journal of Health Sciences and Research Vol 4, No 2 (2022): Jambura Journal of Health Sciences and Research
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i2.13587

Abstract

Prevalensi kanker pada anak semakin meningkat. Terdapat 90 pasien leukemia yang dirawat di RS Wahidin Sudirohusodo selama tahun 2013-2017. Diagnosis morfologi leukemia akut dibagi menjadi ALL dan AML dan kadang-kadang tidak sesuai dengan diagnosis flow cytometry, yang menunjukkan karakteristik sel ganas. Penelitian ini bertujuan untuk membandingkan hasil interpretasi aspirasi sumsum tulang dengan imunofenotip dalam mendiagnosis leukemia pada anak. Metode Data dari rekam medis digunakan dalam studi kohort retrospektif pada anak dengan leukemia (usia 1–18 tahun) yang dirawat di RS. Wahidin Sudirohusodo Makassar dari tahun 2013 hingga 2017. Semua pasien dengan diagnosis kerja leukemia diperiksa aspirasi sumsum tulangnya, diikuti oleh immunophenotyping, dan masing-masing kelompok dianalisis. Hasil Dari total 90 subjek penelitian, diagnosis akhir berdasarkan imunofenotipe adalah 60 pasien ALL dan 30 pasien AML dengan usia rata-rata 8 tahun 3 bulan. Rasio laki-laki dan perempuan adalah 1,7:1 (p = 0,353). Usia rata-rata kelompok ALL adalah 7 tahun 10 bulan, dan AML, 9 tahun (p = 0,409). Kesesuaian morfologi dan flow cytometry terhadap ALL dan AML berturut-turut adalah 92,3% dan 50%. Sebagian besar penanda berada pada kelompok ALL CD 10 dan CD 20 dengan sensitivitas masing-masing 100%, dan AML CD 117 dengan sensitivitas 92%.  Kesimpulan Diagnosis morfologi dan imunofenotipe 92,3% pada kasus ALL dan 50% pada kasus AML. Hal ini penting dalam penilaian garis keturunan dan diagnosis definitif leukemia serta deteksi dini leukemia.Kata kunci: leukemia; anak; Immunophenotyping. ABSTRACT The prevalence of cancer in children is increasing. There were 90 leukemia patients treated at Wahidin Sudirohusodo hospital during the years 2013–2017. The morphological diagnosis of acute leukemia is divided into ALL and AML and is sometimes incompatible with the diagnosis of flow cytometry, which shows the characteristics of malignant cells. This study aims to compare the results of the interpretation of bone marrow aspiration with immunophenotyping in diagnosing childhood leukemia. Methods  Data from medical records was used in a retrospective cohort study of children with leukemia (ages 1–18 years) admitted to Dr. Wahidin Sudirohusodo Makassar from 2013 to 2017. All patients with a working diagnosis of leukemia were examined for bone marrow aspiration, followed by immunophenotyping, and each group was analyzed. Results Of a total of 90 study subjects, the final diagnosis based on immunophenotyping was 60 ALL and 30 AML patients with a mean age of 8 years and 3 months. The male to female ratio was 1.7:1 (p = 0.353). The mean age of the ALL group was 7 years and 10 months, and AML, 9 years (p = 0.409). The suitability of morphology and flow cytometry to ALL and AML was 92.3% and 50%, respectively. Most markers were in the ALL CD 10 and CD 20 groups with a sensitivity of 100% each, and AML CD 117 with a sensitivity of 92%. Conclusion Morphological diagnosis and immunophenotyping of 92.3% in ALL cases and 50% in AML cases. This is important in lineage assessment and definitive diagnosis of leukemia as well as early detection of leukemia.
EFFECTIVITY OF SENGGANI LEAF EXTRACT (Melastoma candidum D.Don) ON BACTERIA Staphylococcus Epidermidis Safira Suwita; Meldawati Meldawati
Jambura Journal of Health Sciences and Research Vol 4, No 2 (2022): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i2.13832

Abstract

Abstrak Tanaman Senggani (Melastom Candidum D.Don) merupakan salah satu tanaman liar yang terdapat diseluruh Indonesia dan memiliki banyak khasiat. Kebaruan dalam penelitian ini karena meneliti  efektivitas ekstrak daun senggani (melastoma candidum d.don) terhadap bakteri staphylococcus epidermidis. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak daun senggani (Melastoma Candidum D.Don) terhadap bakteri Staphylococcus Epidermidis. Dalam pengujian antibakteri menggunakan konsentrasi ekstrak 20%, 40%, 60%, 80%, 100%. Sebagai kontrol positif menggunakan Clindamycin dan sebagai kontrol negatif menggunakan DMSO. Metode penelitian menggunakan metode difusi cakram. Hasil uji skrining fitokimia membuktikan bahwa daun senggani memiliki kandungan senyawa flavonoid, fenol, saponin, tannin, steroid dan terpenoid, hasil penelitian menunjukkan zona hambat terbesar pada konsentrasi 100% yaitu 18,37 mm, dan untuk zona hambat terkecil didapatkan pada konsentrasi 20% yaitu 14,76 mm. Kesimpulan ekstrak daun senggani memiliki aktivitas antibakteri terhadap staphylococcus epidermidis dengan kategori kuat. Kata kunci: Antibakteri; Eksrak; Melastoma candidum D.Don; Staphylococcus epidermidis.  Abstract Senggani Plant (Melastom Candidum D.Don) is one of the wild plants found throughout Indonesia and has many properties. The novelty in this research is the effectiveness of senggani leaf extract (Melastoma candidum d.don) against Staphylococcus epidermidis bacteria. This study aims to determine the effectiveness of senggani leaf extract (Melastoma Candidum D.Don) against Staphylococcus Epidermidis bacteria. In antibacterial testing using extract concentration 20%, 40%, 60%, 80%, 100%. As a positive control using Clindamycin and as a negative control using DMSO. The research method uses the disc diffusion method. Phytochemical screening test results prove that senggani leaves contain flavonoid compounds, phenols, saponins, tannins, steroids and terpenoids, the results showed the largest inhibition zone at 100% concentration of 18.37 mm, and for the smallest inhibition zone obtained at a concentration of 20% is 14.76 mm. Conclusion Senggani leaf extract has antibacterial activity against staphylococcus epidermidis with a strong Category. Keywords: Antibacterial; Extract; Melastoma candidum D.Don; Staphylococcus epidermidis.
THE IMPACT OF BABY MASSAGE ON BABY WEIGHT GAIN IN THE VILLAGE OF REMBAH HILIR Elvira Junita; Heny Sepduwiana; Yuyun Bewelli Fahmi; Andriana Andriana; Rika Herawati
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.12836

Abstract

Berat badan bayi merupakan salah satu indikator dalam penilaian status gizi bayi, Status gizi adalah parameter tercukupi atau tidaknya nutrisi bayi dalam proses pertumbuhan dan perkembangan. Secara nasional di Indonesia presentase status gizi buruk dan gizi kurang balita pada tahun 2018 adalah 17,7% dan di provinsi Riau pada tahun 2018 adalah 18,9%. Data Dinas Kesehatan Rokan Hulu Prevalensi gizi buruk pada Balita Tahun 2019 sebanyak 121 balita. Kebaruan dalam penelitian ini yaitu meneliti pengaruh pijat bayi terhadap peningkatan berat bayi di desa Rembah hilir. Penelitian bertujuan untuk mengetahui pengaruh pijat bayi terhadap kenaikan berat badan bayi, Dalam penelitian ini menggunakan desain one group pre-post test design. Analisa data menggunakan Dependent T-Test. Hasil penelitian yang didapatkan rata-rata berat badan bayi sebelum pijat adalah 4,86 Kg dan rata-rata berat badan bayi sesudah pijat adalah 5,72 Kg dengan nilai Pvalue 0,000 (α=0,05). Kesimpulan ada pengaruh pijat bayi terhadap peningkatan berat badan pada bayi.Kata kunci: Bayi; Benaikan Berat Badan; PijatAbstractInfant weight is one of the markers used to determine a child's nutritional status. The nutritional status of a baby is a criterion for determining whether or not the baby's nutritional needs are met during the growth and development process. In 2018, 17.7% of Indonesian children under the age of five were malnourished or undernourished, while 18.9% of children in Riau province were malnourished or undernourished. The Rokan Hulu Health Service provided the data. In 2019, there were 121 toddlers who were malnourished. The novelty of this study is to examine the effect of infant massage on increasing infant weight in the downstream village of Rembah. The goal of this study is to see how newborn massage affects weight gain. A one-group pre-post test was employed in this investigation. The Dependent T-Test was used to analyze the data. With a P-value of 0.000 (=0.05), the average baby weight before massage was 4.86 kg, while the average baby weight after massage was 5.72 kg. The result is that newborn massage has an influence on weight gain in infants.
META ANALYSIS: EFFICACY OF SHORT TERM WEIGHT-LOSS MAINTENANCE WITH FINANCIAL INCENTIVES INTERVENTION Siti Fazzaura Putri Sarahdeaz; Ardesy Melizah Kurniati; Fiona Widyasari; Karolin Adhisty; Ari Martino; Rifani Akbar Sulbahri; Yuni Adinda Putri
Jambura Journal of Health Sciences and Research Vol 4, No 2 (2022): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i2.13932

Abstract

Obesitas telah menjadi penyebab utama meningkatnya penyakit tidak menular. Penggunaan insentif finansial (FI) sangat mendorong gaya hidup sehat. Pola intervensi ini digunakan untuk mendorong perilaku hidup sehat yang bertujuan untuk mencegah dan mengelola penyakit kronis. Kebaruan penelitian ini yaitu meneliti secara meta analisis tentang kemanjuran pemeliharaan penurunan berat badan jangka pendek dengan intervensi insentif keuangan. Tujuan dari penelitian ini adalah untuk mengkonfirmasi perbedaan hasil antara studi, penelitian ini dilakukan untuk menguji efek keseluruhan dari studi menggunakan intervensi FI pada program penurunan berat badan. Metode yang digunakan adalah Database PubMed untuk mencari data. Data diambil dari studi yang melaporkan perubahan intervensi FI dengan hasil perubahan berat badan. Hasilnya menemukan bahwa 4 studi dengan obesitas dimasukkan. Hasil gabungan menunjukkan bahwa FI berpengaruh signifikan terhadap perubahan berat badan. Terdapat perbedaan peningkatan berat badan yang signifikan pada kelompok intervensi FI dibandingkan dengan kelompok kontrol (SMD: -3,37; CI 95%). Heterogenitas statistik ditemukan (I2 = 99,92%, P = 0,00). Kesimpulan hasil belum menunjukkan efek menguntungkan dari FI jangka pendek selama 3 bulan pada penurunan berat badan pada pasien obesitas. Namun, heterogenitas statistik ditemukan sehingga analisis subkelompok diperlukan.Kata kunci: penurunan berat badan; obesitas; insentif finansial. AbstractObesity has become a major etiology of the increase in non-communicable diseases. The use of financial incentives (FI) has greatly encouraged a healthy lifestyle. This intervention pattern is used to encourage healthy lifestyle behaviors aimed at preventing and managing chronic diseases. The novelty of this study is to examine the meta-analysis of the efficacy of maintaining short-term weight loss with financial incentive interventions. The aim of this study was to confirm differences in results between studies, this study was conducted to examine the overall effect of studies using FI interventions on weight loss programs. The method used is the PubMed Database to search for data. Data were drawn from studies reporting changes in the FI intervention with outcome changes in body weight. The results found that 4 studies with obesity were included. The combined results show that FI has a significant effect on changes in body weight. There was a significant difference in weight gain in the FI intervention group compared to the control group (SMD: -3.37; 95% CI). Statistical heterogeneity was found (I2 = 99.92%, P = 0.00). Conclusion the results have not shown a beneficial effect of short-term FI for 3 months on weight loss in obese patients. However, statistical heterogeneity was found so that a subgroup analysis was needed.
TOXICITY TEST OF THE CROWN OF GOD STEMPS (Phaleria macrocarpa (Scheff.) Boerl.) AGAINST Culex sp. Larvae Ali Napiah Nasution; Yunike Yessica Ulina
Jambura Journal of Health Sciences and Research Vol 4, No 2 (2022): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i2.13943

Abstract

AbstrakMahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.) mampu tumbuh dan berkembang di negara beriklim tropis seperti Indonesia. Beberapa penelitian sebelumnya dikatakan mahkota dewa memiliki banyak kandungan senyawa kimia salah satunya adalah minyak atsiri yang berpotensi membunuh nyamuk. Kebaruan dalam penelitian ini karena melakukan uji toksisitas batang tumbuhan mahkota dewa (phaleria macrocarpa (scheff.) boerl.) terhadap larva nyamuk culex sp. Populasi Culex sp. lebih banyak dari jenis nyamuk lainnya. Penelitian ini bertujuan melihat efek toksik dari ekstrak batang mahkota dewa terhadap larva nyamuk Culex sp. dalam konsentrasi 5%, 10%, 15% dan 25%  berdasarkan waktu pengamatan (0 detik, 30 detik, 1 menit, 5 menit, 15 menit, 30 menit, 1 jam dan 2 jam). Rancangan penelitian the post test only controlled group design dengan subjek penelitian yang digunakan larva nyamuk Culex sp. kedalam cawan petri yang berisi ekstrak batang mahkota dewa dengan berbagai tingkat konsentrasi (0%, 5%, 10%, 15% dan 25%) ditambahkan larva nyamuk Culex sp.. Metode Mann-Whitney digunakan untuk menganalisa data penelitian, hasilnya mengatakan bahwa perbedaan persentase larva nyamuk Culex sp. yang mati setelah diberi perlakuan ekstrak batang mahkota dewa setelah waktu pengamatan 1 jam (Nilai P = 0,001) dan 2 jam (Nilai P = 0,002). Kesimpulan esktrak batang tumbuhan mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.) mempunyai efek toksik untuk membunuh larva nyamuk Culex sp.Kata Kunci : Larva Nyamuk Culex sp;  Mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.); Toksisitas. AbstractThe crown of the god (Phaleria macrocarpa (Scheff.) Boerl.) able to grow and develop in tropical countries such as Indonesia. Several previous studies have said that the crown of god has many chemical compounds, one of which is essential oils that have the potential to kill mosquitoes. The novelty in this study was due to conducting toxicity tests of the trunk of the god's crown plant (phaleria macrocarpa (scheff.) boerl.) against the larvae of the culex sp mosquito. Population of Culex sp. more than other types of mosquitoes. This study aims to see the toxic effect of the extract of the crown of god on the larvae of the Culex sp mosquito. in concentrations of 5%, 10%, 15% and 25% based on the observation time (0 seconds, 30 seconds, 1 minute, 5 minutes, 15 minutes, 30 minutes, 1 hour and 2 hours). The post test only controlled group design with the research subjects used by Culex sp mosquito larvae. into a petri dish containing extracts of the crown of god with varying degrees of concentration (0%, 5%, 10%, 15% and 25%) added Culex sp. mosquito larvae. The Mann-Whitney method was used to analyze the research data, the results said that the difference in the percentage of larvae of the Culex sp mosquito. who died after being treated with extract of the crown of god after an observation time of 1 hour (P Value = 0.001) and 2 hours (P Value = 0.002). Conclusion of the stem of the god's crown plant (Phaleria macrocarpa (Scheff.) Boerl.) has a toxic effect to kill the larvae of the Culex sp mosquito.Keyword : Culex sp. Larvae; The crown of god (Phaleria macrocarpa (Scheff.) Boerl.);  Toxicity.
INFLUENCE OF DRUG COUNSELING ON COMPLIANCE OF PATIENTS WITH DYSLIPIDEMIA Elfia Neswita; Afriliani Br Sitepu; Razoki Razoki
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.14330

Abstract

Masih rendahnya tingkat kepatuhan dalam meminum obat menyebabkan tingkat kesembuhan pasien rendah. Kebaruan dalam penelitian ini adalah pengaruh konseling obat terhadap kepatuhan pasien dislipidemia. Penelitian ini bertujuan untuk melihat apakah ada pengaruh dari pemberian konseling obat terhadap kepatuhan pasien dalam meminum obat sebelum dan sesudah diberi konseling obat. Metode penelitian ini menggunakan kuesioner Morisky MMAS-8 dan dilakukan secara prospektif quasi-eksperimental secara one group pretest-posttest design dan data dianalisis dengan Paired-sample T-test, regresi linier sederhana menggunakan SPSS versi 28. Hasil penelitian menunjukkan adanya pengaruh konseling obat pada pasien Dislipidemia sebelum dan sesudah diberi konseling obat dengan nilai signifikansi sebesar 0,01 dengan arti bahwa tingkat kepercayaan pada penelitian ini sebesar 99%.  Kesimpulan penelitian ini diperlukan peranan farmasi dalam memberikan konseling obat di setiap unit kesehatan.Kata Kunci: Kepatuhan; Pasien dislipidemia; Konseling obat                   AbstractThe low level of adherence to taking medication causes the patient's recovery rate to be low. This study aims to be low. The novelty in this study is the effect of drug counseling on the adherence of dyslipidemic patients. This study aims to see whether there is an effect of counseling on patient compliance in taking medication before and before being given drug counseling. This study aims to see whether there is an effect of giving drug counseling on treatment adherence in people taking medication before and after being given drug counseling. This research method uses the Morisky MMAS-8 questionnaire and is carried out in a prosective quasi-experimental one group pretest-posttest design, with data analyzed using the Paired Sample T-Test and Simple Linear Regression in SPSS version 28. The results showed that there was an effect of drug counseling on dyslipidemic patients before and after being counseled, with a significance value 0.01, which means that the confidence level in this study is 99%. The conclusion of this study is that the role of pharmacy is needed in providing drug counseling in every health unit.Keywords: Treatment Adherence; Dyslipidemia; Drug Counseling
THE EFFECT OF DRUG COUNSELING ON HYPERTENSION PATIENT'S COMPLIANCE IN A HOSPITAL IN MEDAN CITY etha tesalonika tamba; Reh Malem Br Karo; Razoki Razoki; Elfia Neswita; Erida Novriani
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.15100

Abstract

Pemahaman pasien terhadap pengobatan merupakan faktor kunci untuk terjadinya kepatuhan dalam pengobatan sehingga didapatkan terapi yang optimal dan efektif. Namun kenyataannya masih banyaknya pasien yang tidak patuh dalam pengobatan terutama pada penyakit hipertensi. Hipertensi dapat memicu penyakit lainnya / komplikasi sehingga dapat merusak organ-organ vital dan mengancam kualitas hidup seseorang. Untuk mencegah hal tersebut maka dibutuhkan kepatuhan pasien hipertensi dalam meminum obat dimana konseling menjadi sektor penerapan konsep asuhan kefarmasian dengan tujuan menambah ilmu perihal obat, penyakit serta harapannya mampu memahamkan penderita perihal peran obat untuk kesembuhan penyakit. Kebaruan penelitian ini karena meneliti tentang pengaruh konseling obat terhadap kepatuhan pasien  hipertensi di salah satu rumah sakit. Tujuan penelitian ini adalah untuk mengetahui apakah ada pengaruh konseling obat terhadap kepatuhan pasien hipertensi rawat jalan di salah satu rumah sakit di Kota Medan. Metode Penelitian dilakukan secara eksperimental dengan menggunakan pra- eksperimental (Pre-Experimental) dan rancangan The One Group Pretest – Posttest Design. Penelitian ini dilakukan di salah satu rumah sakit kota medan selama bulan April 2022. Populasi adalah Pasien di salah satu rumah sakit di Kota Medan yang memenuhi kriteria inklusi dan ekslusi. Sebanyak 39 pasien yang memenuhi kriteria diberikan kueisioner MMAS-8 lalu dilakukan analisa data menggunakan Uji Normalitas, Paired T-Test, Regresi Linear Sederhana dan Pengujian Hipotesis Parsial. Hasil penelitian ini didapatkan nilai Uji Normalitas, paired T-Test, Regresi linear dan pengujian hipotesis parsial secara berturut-turt adalah 0,05; 0,05; 0,01 dan 0,00. probability 0.05. Kesimpulan ada pengaruh konseling obat terhadap kepatuhan pasien hipertensi rawat jalan di salah satu rumah sakit di Kota Medan.Kata kunci: Konseling Obat; Kepatuhan; Hipertensi AbstractPatient understanding of treatment is a key factor for adherence to treatment so that optimal and effective therapy is obtained. However, in reality there are still many patients who do not comply with treatment, especially in hypertension. Hypertension is also a trigger for complications that can damage vital organs and threaten a person's quality of life. Therefore, patient compliance is needed in taking hypertension medication. Counseling is a sector of applying the concept of pharmaceutical care with the aim of increasing knowledge about drugs, diseases and the hope of being able to understand patients about the role of drugs for healing disease. The novelty of this study is because it examines the effect of drug counseling on the adherence of hypertensive patients in one of the hospitals. The purpose of this study was to determine whether there is an effect of drug counseling on the adherence of outpatient hypertension patients at a hospital in Medan City. Methods The research was conducted experimentally using a pre- experimental (Pre-Experimental) and The One Group Pretest – Posttest Design. This research was conducted at one Medan city hospital for 1 month in April 2022. The population was patients at one Medan city hospital who met the inclusion and exclusion criteria. A total of 39 patients who met the criteria were given a MMAS-8 questionnaire and then analyzed the data using the Normality Test, Paired T-Test, Simple Linear Regression and Partial Hypothesis Testing. The results of this study obtained a significant value of 0.000. The conclusion is that there is an effect of drug counseling on the compliance of outpatient hypertension patients in a hospital in Medan City.Keywords: Drug Counseling; Adherance; Hypertension
ANTIBACTERIAL EFFECTIVENESS OF MORINGA LEAF EXTRACT GEL FORMULATION AGAINST PROPIONIBACTERIUM ACNES Miranda christy Br Tarigan; Pitri Pitri; Andre Budi; Claudia Tanamal
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.15025

Abstract

Moringa oleifera Lam, lebih sering disebut sebagai tanaman kelor di Indonesia, adalah contoh tanaman yang memiliki potensi signifikan yang belum dimanfaatkan untuk digunakan dalam industri farmasi. Daun pohon kelor menyediakan berbagai nutrisi penting, termasuk energi, protein, lemak, karbohidrat, serat makanan, dan berbagai vitamin dan mineral. Bubuk daun kelor memiliki konsentrasi sitokinin yang tinggi, salah satunya adalah zeatin, molekul dengan sifat anti-oksidan yang kuat serta sifat anti-penuaan dan anti-inflamasi. Jerawat disebabkan oleh bakteri Propionibacterium acnes, yang dapat ditemukan di kulit (acne vulgaris). Tujuan dari penelitian ini adalah untuk melihat apakah gel ekstrak etanolik yang terdapat pada kelor mengandung sifat antibakteri yang dapat membantu menghentikan pertumbuhan bakteri Propionibacterium acnes.  Model in vitro digunakan dalam jenis penelitian ini, yang dilakukan di laboratorium. Desain penelitian adalah True Experimental Post-Test Group Design, dan jumlah hewan uji sebanyak 28 ekor. Hewan uji dibagi menjadi tujuh kelompok, dengan masing-masing kelompok menerima terapi yang berbeda. SPSS digunakan untuk menganalisis informasi yang diperoleh. Hasil penelitian menunjukkan bahwa formulasi gel ekstrak daun kelor berpengaruh konsisten terhadap pertumbuhan bakteri Propionibacterium acnes, dengan rata-rata diameter zona hambat 14,5 mm (efektifitas kuat) pada metode sumuran dan 13,0 mm (efektifitas kuat) pada metode sumuran. difusi cakram metode sumur. Temuan menunjukkan bahwa formulasi gel mengurangi pertumbuhan bakteri Propionibacterium acnes secara konsisten. Jika dibandingkan dengan konsentrasi lain, aksi antibakteri ekstrak etanol gel daun kelor memiliki daya hambat paling tinggi saat menggunakan teknik sumuran pada konsentrasi 20%, dan saat menggunakan metode difusi cakram pada konsentrasi 40%. Kata Kunci :  gel ekstrak daun kelor; Propionicacterium acnes AbstractMoringa oleifera Lam, more commonly referred to as Moringa plant in Indonesia, is an example of a plant that has significant untapped potential for use in the pharmaceutical industry. Moringa leaves are the most widely used plant parts by the community. Moringa tree leaves provide a variety of essential nutrients, including energy, protein, fat, carbohydrates, dietary fiber, and various vitamins and minerals. Moringa leaf powder has a high concentration of cytokinins, one of which is zeatin, a molecule with strong anti-oxidant properties as well as anti-aging and anti-inflammatory properties. Cytokinins are also found in Moringa leaf powder. Acne is caused by the bacterium Propionibacterium acnes, which can be found on the skin (acne vulgaris). Propionibacterium acnes is a strain of bacteria that can cause infection. The purpose of this study was to see whether the ethanolic extract gel contained in Moringa contains antibacterial properties that can help stop the growth of Propionibacterium acnes bacteria. In vitro models are used in this type of research, which is carried out in a laboratory. The research design was True Experimental Post-Test Group Design, and the number of test animals was 28. The test animals were divided into seven groups, with each group receiving a different therapy. SPSS is used to analyze the information obtained. The results showed that the gel formulation of Moringa leaf extract had a consistent effect on the growth of Propionibacterium acnes bacteria, with an average inhibition zone diameter of 14.5 mm (strong effectiveness) in the well method and 13.0 mm (strong effectiveness) in the well method. disc diffusion well method. The findings showed that the gel formulation reduced the growth of Propionibacterium acnes bacteria consistently. When compared with other concentrations, the antibacterial action of the ethanolic extract of Moringa leaf gel had the highest inhibition when using the well technique at a concentration of 20%, and when using the disc diffusion method at a concentration of 40%.Keywords: Moringa leaf extract gel; Propionicacterium acnes
ADMINISTRATIVE, PHARMACEUTIC AND CLINICAL STUDY OF PRESCRIPTION ANTI-DIABETES DRUGS IN ONE OF MEDAN CITY PHARMACIES Yogi Andriansyah; Elfia Neswita; Razoki Razoki
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.14252

Abstract

Diabetes melitus adalah penyakit kronis yang diakibatkan oleh resistensi insulin ditandai dengan kadar gula darah semakin tinggi. Diabetes mellitus memiliki angka kejadian yang cukup tinggi hampir di setiap negara. Kebaruan penelitian ini karena meneliti tentang kajian administratif, farmasetis dan klinis resep obat anti diabetes di salah satu apotek. Penelitian ini bertujuan untuk melihat kesesuaian pelayanan resep antidiabetik di apotek pada aspek kesesuaian adminstratif,farmasetis dan klinis resep dengan PMK No. 35 tentang Standar Pelayanan Kefarmasian di Apotek Kebaruan penelitian ini meneliti kajian administratif, farmasetis dan klinis resep obat anti diabetes. Jenis penelitian yang digunakan ialah metode penelitian deskriptif dengan pendekatan cross sectional. Data diperoleh dari resep periode Oktober – Desember 2020. Peneliti melakukan pengecekan didalam resep adakah obat yang berinteraksi antara obat satu dengan obat lain sehingga tidak menghasilkan efek terapi yang maksimal. Hasil penelitian menunjukkan bahwa tidak satupun resep yang secara keseluruhan memenuhi Kriteria Aspek Administrasi, Farmasetis dan klinis, namun terdapat 38 resep dari 53 resep  memenuhi aspek Farmasetis, terdapat 15 resep yang tidak memenuhi Kriteria Aspek Administrasi, Farmasetis dan klinis. Kesimpulan bahwa tidak satupun resep memenuhi PMK No.35 tahun 2014.Kata kunci: Resep; Administratif;  Farmasetis; Klinis; Obat Anti Diabetes AbstractDiabetes mellitus is a chronic disease caused by insulin resistance which is characterized by increased blood sugar levels. Diabetes mellitus has a fairly high incidence rate in almost every country. The novelty of this study is due to researching about administrative, pharmaceutic and clinical studies of prescription anti-diabetic drugs in one of the pharmacies. This study aims to determine the suitability of antidiabetic prescription services in pharmacies on aspects of administrative, pharmaceutical and clinical compliance with prescriptions with PMK No. 35 concerning Standards of Pharmaceutical Services in Pharmacies. The novelty of this study examines administrative, pharmaceutical and clinical studies of antidiabetic drug prescriptions. The type of research used is descriptive research method with a cross sectional approach. The data was obtained from prescriptions for the period October – December 2020. Researchers checked in the prescription whether there were drugs that interacted with each other so that they did not produce a maximum therapeutic effect. The results showed that none of the prescriptions met the administrative, pharmaceutical and clinical criteria, but 38 of the 53 prescriptions met the pharmaceutical aspects, there were 15 prescriptions that did not meet the criteria for administrative, pharmaceutical and clinical aspects. The conclusion is that there is no prescription to fulfill PMK No. 35 of 2014.Keywords: Recipe; Administrative; Pharmacy; Clinic;  Anti-Diabetes Medicine
THE EFFECT OF THE USE OF ANTI-DIABETES INSULIN ON THE LONG OF CARE OF CORONA VIRUS DISEASE - 2019 (COVID - 19) PATIENTS IN PRIMA MEDAN ROYAL HOSPITAL setia wati br sitepu; irza Haicha Pratama; Andre Budi; Duwina Puspita Sari
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.15178

Abstract

Latar Belakang: Penyandang Diabetes Militus  memiliki risiko tinggi tertular Covid 19 dan memilik prognosis yang buruk apabila kita  terinfeksi Covid 19. Tujuan penelitian mengetahui pengaruh penggunaan obat insulin dan  terapi kombinasi terhadap lama rawatan  penyembuhan pasien Covid-19.Metode: Penelitian ini merupakan penelitian yang bersifat analitik observasional   untuk melihat pengaruh penggunaan obat anti diabetes Insulin dan Terapi Kombinasi terhadap lama rawatan pasien Covid di Rumah Sakit Umum  Royal Prima. Dengan desain penelitian cross sectional, penelitian dilakukan instalasi rekam medis  Rumah Sakit Umum  Royal Prima Medan pada bulan Desember  2020 -Juni 2021. Populasi dalam penelitian ini adalah seluruh pasien covid-19 dengan diabetes mellitus yang dirawat tercatat dalam catatan medik di RSU Royal Prima pada bulan desember-juni dengan jumlahsampel 2045, populasi sebanyak 173 dengan Teknik simple random sampling. Hasil: Dari 173 pasien Covid-19paling banyak dengan penggunaan terapi kombinasi yaitu 132 orang dengan rerata lama 9,67 hari dengan standart deviasi 4,619. Dari 23 orang dengan rapid/short acting lama rawatan rerata 6,78 dan standard deviasi 4,022 dan dari 18 orang dengan penggunaan obat Long acting lama rawatan 7,11 dengan standart deviasi 4,601 dan hasil uji Oneway-Anova menunjukkan diperoleh sig 0,003 0,05 yang berarti terdapat pengaruh penggunaan obat insulin dan  terapi kombinasi terhadap lama rawatan  penyembuhan pasien Covid-19. Kesimpulan: terdapat pengaruh penggunaan obat insulin dan  terapi kombinasi terhadap lama rawatan  penyembuhan pasien Covid-19. Kata Kunci: Covid 19; DM; Lama Rawatan; Obat Insulin  Abstract                Background: People with diabetes mellitus have a high risk of contracting Covid 19 and have a poor prognosis if they are infected with Covid 19. \-The purpose of the study was to determine the effect of using insulin and combination therapy on the length of treatment for Covid-19 patients. Methods: This type of analytic research is observational with a cross sectional research design, the study was carried out by the installation of medical records at the Royal Prima General Hospital in Medan in December 2020 -June 2021. The population in this study were all Covid-19 patients with diabetes mellitus who were treated recorded in the medical records. at RSU Royal Prima in December-June with a total population of 173 with a simple random sampling technique. Results: Of the 173 Covid-19 patients, the most used combination therapy, namely 132 people with an average duration of 9.67 days with a standard deviation of 4.619. From 23 people with rapid/short acting the average length of stay was 6.78 and the standard deviation was 4.022 and from 18 people with long-acting drugs the length of stay was 7.11 with a standard deviation of 4.601 and the results of the Oneway-Anova test showed sig 0.003 0.05. which means that there is an effect of using insulin and combination therapy on the length of treatment for Covid-19 patients. Conclusion: there is an effect of using insulin and combination therapy on the length of treatment for Covid-19 patients. Keywords: Covid 19; DM; Length of Treatment; Insulin Drugs

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