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FITOFARMAKA: Jurnal Ilmiah Farmasi
Published by Universitas Pakuan
ISSN : 20879164     EISSN : 2622755X     DOI : https://doi.org/10.33751/jf
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
FITOFARMAKA mempublikasikan artikel yang berkaitan dengan farmasi, Kimia Farmasi, dan bidang Fitokimia serta akan dipublikasikan secara online. Publikasi secara elektronik akan menambah kekayaan informasi dan pengetahuan ilmiah terutama dari penelitian. Jurnal ini diterbitkan dua kali setahun, didokumentasikan dengan baik dalam bentuk elektronik dan cetak.
Arjuna Subject : -
Articles 268 Documents
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The Potential of Phytotherapy In Managing Dyspepsia: A Narrative Review Pratidina, Malfa Laila; Levita, Jutti
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.8255

Abstract

Dyspepsia, commonly known as indigestion, is delineated as suffering the manifestations of epigastric pain, nausea, burning, or after-meal fullness. The common therapy for dyspepsia, e.g., proton pump inhibitors or histamine-H2 receptor antagonists, has shown some adverse effects, thus, phytotherapy is currently becoming the drug of interest. Phytotherapy, additionally known as herbal medicine or botanical medicinal drug, includes the use of plant-derived compounds to prevent, alleviate, or therapy for diverse ailments. Most medications commonly used in Chinese traditional medicine or Asian folklore drugs contain mixtures of several plant extracts. Twelve clinical trials reported the effect and safety of phytotherapy on gastrointestinal disorders. Taken together, phytotherapy may be considered safe for the management of dyspepsia with close monitoring of the dose and duration of therapy.
The Potential Activity of Kecombrang (Etlingera elatior) Leaf, Flower, and Stem Extracts on the Duration of Wound Healing in Mice (Mus musculus) Zunnita, Oktaviana; Moerfiah, .; Apriana, Rinal
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 14, No 1 (2024): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v14i1.10046

Abstract

Wound is skin tissue damage due to trauma from a sharp object.  Kecombrang flower extract is known to be effective in speeding up the healing of wounds because it contains flavonoids, saponins, tannins and steroids. The leaves and stems also contain these compounds, so this research was conducted to see the difference in the potential activity of the wound healing process of the kecombrang plant on the time of wound healing. Natural ingredient extracts are wound healing agents that can fight infection and speed up wound healing. This study used 5 treatment groups consisting of control (-) distilled water, control (+) Povidone Iodine 10 %, leaf extract 10 %, flower extract 10 %, and stem extract 10 %. The parameters observed were the length of the wound and the condition of the wound until the wound healed. The obtained data were analyzed statistically using ANOVA for complately randomized factorial designed. The results of the research show that extracts of kecombrang leaves, flowers, and stems have activity in accelerating the healing process of cut wounds and produce different effects on healing time. Wound healing time for leaf extract is 12 days, flower extract and stem extract is 10 days. The conclusion of this study shows that there is a very real difference in wound healing from treatment with the best treatment for wound healing is the flower extract with highest healing score of 6.42.
Preparation of Single Garlic, Red Ginger, Lemon and Apple Vinegar Combination Tablets By Wet Granulation Method Wiendarlina, Ike Yulia; Fatmi, Mindiya; Indriati, Dwi; Novadin, Raraseta P
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.9320

Abstract

Garlic, red ginger, lemon, and apple cider vinegar are spices in Indonesia that can be useful for increasing the body's resistance and preventing degenerative diseases. Tablet preparations are preferred because they are practical, easy to use, and easy to carry anywhere. The aim of this research is to see the effect of differences in the concentration of internal and external disintegrants, binders, gliders, and lubricants in each formula. Tablets are made with the single active ingredients of garlic, red ginger, apple cider vinegar, and lemon. The wet granulation method was chosen because natural materials have poor flow properties, so by using the wet granulation method, the flow rate, compressibility, and binding capacity of the granules can be improved for the better so that they can be molded into tablet preparations. The research results showed that all tablet formulas met the tablet evaluation requirements. The concentration of external and internal disintegrants, binders, gliders, and anti-adherents does not make a difference in flow time or angle of repose but provides different water content values in formula 3.There is an influence of differences in the concentration of additional ingredients on the quality of the tablets produced. The greater the concentration, the better the weight uniformity, the harder the resulting tablet, and the longer the disintegration time. Tablet fragility on F2 is high than formula 1 and 3, but still meets tablet quality requirements.
The Antioxidant Activity of Avocado (Persea americana Mill) Seed Extract and Lotion Preparation Fatmi, Mindiya; Wulandari, Asri; Sari, Bina Lohita; Honifa, .; Widjaya, Andrea Palleva
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 14, No 1 (2024): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v14i1.9860

Abstract

Excessive exposure to free radicals can cause skin to look dry and thin. Avocado seeds are a part of the fruit that is very rarely used and is even considered waste by society. Avocado seeds are known to contain good antioxidant activity to ward off free radicals. Topical preparations that are widely used to protect the skin from exposure to free radicals, one of which is lotion preparations with natural ingredients that contain antioxidants. This research aims to determine the antioxidant activity of avocado seed extract with different concentrations, formulate avocado seed extract lotion, distribute avocado seed extract lotion preparations, and determine the antioxidant activity of avocado seed extract lotion. The method used in this research is the in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Each avocado seed was extracted with ethanol 50 %; 70 %; and 96 %. The best antioxidant results are made into cream preparations in 3 formulas, namely F1 0.01 %; F2 0.05 %; and F3 0.1 %. The best antioxidant test results were obtained from avocado seed extract with ethanol 70 % and an IC50 of 20.68 ppm with very strong antioxidant intensity. The three lotion formulations met the evaluation requirements for topical preparations and provided an antioxidant value of F1 of 128 ppm, F2 of 72 ppm, and F3 of 55 ppm. The conclusion of this research is that the highest antioxidants in avocado seed extract are found in the 70 % ethanol extract and in the formula 3 lotion preparation.
Prebiotic Activity of Ambon Banana (Musa acuminata (AAA Group) ‘Ambon’) Peel Starch Against Lactobacillus. acidophilus and Escherichia coli In Vitro Rusdi, Bertha; Yuniarni, Umi
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.9237

Abstract

Prebiotics are compounds with the ability to specifically enhance the population of advantageous bacteria in the gastrointestinal tract. Starch is a polysaccharide which has prebiotic activity. Agricultural waste like banana peel contains prebiotic polysaccharides including starch. The prebiotic effect of starch from many varieties of banana peel has been explored by researchers. Although Ambon banana is a variety that is commonly consumed in Indonesia, the prebiotic activity of its peel, particularly the peel starch,  has not been studied yet. Thus, this study aims to research the prebiotic activity of Ambon banana peel starch against probiotic bacteria of the Lactobacillus acidophilus and the opportunistic pathogen bacteria of Eschericia coli. In this research, starch was extracted from banana peel (var. pisang Ambon) and prebiotic activity of the starch was tested on L. acidophilus and E. coli.  The number of bacteria was calculated at 0 and 24 hours of incubation using plate count methods.The result showed that at the concentration of 1% w/v, Ambon banana peel starch increases the number of L. acidophilus while inhibiting the growth of E. coli. The L. acidophilus culture in the starch-containing media had SCFAs (acetic, butyric and propionic acid) that were  known to have good impact to human health.
Effect of Sappan Wood Ethanol Extract in CRP Level and Phagocytic Index Between Group of Mice Infected with S. aureus and E. coli Rohmah, Martina Kurnia; Hisbiyah, A'yunil; Octivani, Amellya; Anwari, Farida
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 14, No 1 (2024): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v14i1.10040

Abstract

S.aureusand E.coli are pathogenic bacterial that cause many infectious disease in the world. Immunomodulator is needed to prepare the immune system to be able against the infection. Some parameters usually used to assess the immunomodulatory activity such as C-Reactive Protein (CRP) and phagocytic index. This study aims to investigate the difference effect of sappan1wood extract  in CRP level and phagocytic index between group mice infected with S. aureus and E. coli.  Two treatment groups of mice were prepared for S. aureus and E. coli test. Each group subjected to 7 treatments i.e. (1) Normal mice1(CMC-Na 1 %- Merck® 217277), 1(2) Negative Control (bacterial infection + CMC-Na 1 %),11(3) Positive Control (bacterial infection + Imboost force®1treatment, PT SOHO Industri Pharmasi), (4) Bacterial infection and EESW treatment 25 mg/kg BW, (5) 50 mg/kg BW, (6) 100 mg/kg BW, and (7) 200 mg/kg BW. Mice blood was taken to detect the CRP and phagocytic index after treatment. The T test showed that there was a significant difference between CRP levels (p0.05) and phagocytic index (p0.05) of S. aureus and E. coli group. EESW 200 mg/kg BW reduced CRP level to 11 mg/dL (S. aureus) and 6 mg/dL in (E. coli). EESW 200 mg/kg BW increased phagocytosis to 1.54 folds (S. aureus) and 4.62 folds (E. coli). Sappan wood ethanol extract effect to CRP level and phagocytic index1in mice group infected with E. coli is better than S. aureus1infection group.
The Effectiveness of Flavonoids in Pigeon Pea (Cajanus cajan) as Inhibitors of α-Glucosidase Enzyme in Anti-diabetes Ginaris, Rifkarosita Putri; Fauzah, Na’imatul Retno
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.9311

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia, due to relative and absolute insulin deficiency of the body. Acarbose is a drug that can be used to treat diabetes mellitus, especially type II diabetes mellitus. Type II diabetes mellitus is an endocrine disease that causes 95 % of deaths worldwide. Gude bean extract (Cajanus cajan) is one alternative to the use of natural anti-diabetic medicine, containing saponins, flavonoids, phenolics, and tannins. Flavonoids are antioxidant compounds that have a hypoglycemia effect in people with diabetes mellitus. This study aimed to test the inhibitory activity of alpha-glucosidase enzyme from gude bean extract. The enzyme α-glucosidase activity was quantified by measuring the quantity of para-nitrophenol generated at a wavelength of 405 nm. The inhibitory power of the α-glucosidase enzyme was seen from the IC50 value. Gude Bean Extract has the ability to inhibit the enzyme α-glucosidase resulting in an IC50 value of 69.67 ppm strong level activity. Gude Bean Extract has the ability to inhibit the enzyme α-glucosidase resulting in an IC50 value of 69.67 ppm with a strong strength level
Variations of Tween Surfactant and Propylene Glycol Cosurfactant in Topical Microemulsion Formulation on The Penetration of Ibuprofen Fitrianingsih, Sri; Widodo, Gunawan Pamudji; Marlina, Dian
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.5785

Abstract

ABSTRACTIbuprofen is a derivative of propionic acid, a class of non-steroidal anti-inflammatory drugs (NSAIDs). Ibuprofen has side effects on the gastrointestinal tract. So that topical use can be a solution to reduce the side effects of oral use because of the release of topical drugs through the stratum corneum which makes it selective in certain places. The preparation chosen was a topical microemulsion because it is more thermodynamically stable and has no effect on the gastrointestinal tract. This study aims to determine the effect of the ratio of surfactant concentrations of various ratios of tween 20:tween 80 and cosurfactant propylene glycol to the penetration rate of ibuprofen across the membrane and to determine the physical characteristics of topical microemulsions. Selection of tween surfactant and propylene glycol cosurfactant because it has high physical stability. This research is an experimental study, namely by making four formulations with various ratios of surfactant and cosurfactant with a difference of 2.5% in each formulation of topical ibuprofen microemulsion with a concentration of 5% ibuprofen using variations of surfactant tween 20 and tween 80, cosurfactant propylene glycol with black cumin oil phase. Evaluation of the preparation by organoleptic test, pH test of the preparation, examination of the type of emulsion, particle size measurement, microemulsion release test in vitro using the Franz diffusion method. The results show that the concentration ratio of surfactant tween 20:tween 80 and cosurfactant propylene glycol can affect particle size, pH and penetration velocity (flux) in Franz diffusion. The results of the study showed that in F1 using surfactant tween 20:tween 80 with a concentration of 71.6% (6:4) had the smallest particle size of 11.5 nm and the largest flux value was 128.45 g.cm-2.H- 1. In conclusion, variations in surfactant and cosurfactant concentrations can affect the pH of the preparation, particle size, penetration speed (flux). The results obtained that the cumulative percent and penetration speed of all formulas had significant differences (p0.05).

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