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Journal of Pharmaceutical and Medicinal Research Sekolah Tinggi Ilmu Farmasi Makassar Perintis Kemerdekaan Street KM 13.7 90242 Makassar-Indonesia
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Journal of Pharmaceutical and Medicinal Sciences
Published by Sekolah Tinggi Ilmu Farmasi Makassar
ISSN : 25282824     EISSN : 2580328X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Journal of Pharmaceutical and Medicinal Sciences (JPMS) pISSN 2528-2824; eISSN 2580-328X dedicated to publish original research papers, original research notes, invited topical reviews, mini-reviews, editorial commentary and news. Medicinal resources about exchange of information and understandings about people's use of plants, fungi, animals, microorganisms, minerals, their biological and pharmacological effects based on the principles established through international conventions. Pharmaceutical including drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology and targeted drug delivery.
Arjuna Subject : -
Articles 90 Documents
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FORMULASI PEMBUATAN KRIM JERAWAT EKSTRAK ETANOL DAUN SAWO MANILA (Manilkara zapota L.) DI DESA BATARA KABUPATEN PANGKAJENE Nurhidaya Nurhidaya; Indah Astuti Pratiwi Paerah; Fajrul Fhalaq Baso
Jurnal Farmasi dan Ilmu Pengobatan Vol 6 No 2 (2021): JPMS Volume 6 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v6i2.127

Abstract

Daun sawo manila (Manilkara zapota L.) mengandung golongan senyawa alkaloid, flavonoid, saponin, tanin, terpenoid, dan glikosida (Islam dkk, 2013) yang memiliki potensi sebagai anti jerawat. Penelitian ini bertujuan untuk membentuk formula krim dari ekstrak etanol daun sawo manila (Manilkara zapota L) dan mengevaluasi karakteristik mutu fisik krim. Formulasi krim dari ekstrak daun sawo manila (Manilkara zapota L.) dibuat dengan konsentrasi ekstrak FI (0,25 g) FII (0,5 g) FIII (1 g), setil alkohol dan trietanolamin sebagai emulgator. Konsentrasi setil alkohol dan trietanolamin yang digunakan yaitu FI (0,2% : 0,2%), FII (0,2% : 0,2%), FIII (0,2% : 0,2%). Krim yang dihasilkan dievaluasi karakteristik mutu fisiknya, yaitu organoleptis, homogenitas, daya sebar, pH, tipe krim. Dari evaluasi karakteristik mutu fisik dapat disimpulkan Formula I merupakan formula terbaik yang memenuhi syarat mutu krim yang baik. Krim ekstrak etanol daun sawo manila (Manilkara zapota L.) merupakan krim dengan tipe M/A menghasilkan organoleptis bentuk sediaan semi padat, warna merah bata, dan bau khas daun sawo manila (Manilkara zapota L.). Pada uji homogenitas tidak adanya penggumpalan pada sediaan krim sehingga sediaan homogen. Pada uji daya sebar pada FI yaitu 8,5 cm, daya sebarnya memenuhi syarat daya sebar krim yang baik. Nilai pH yang dihasilkan yaitu 6, sehingga krim termasuk kategori aman untuk wajah.
Anthocyanin From Rosella Petals (Hibiscus sabdariffa L.) as Anion Chemosensory Syamsu Nur; Imrawati Imrawati; Fitriyanti Jumaetri Sami; Alfat Fadri; Megawati Megawati
Jurnal Farmasi dan Ilmu Pengobatan Vol 6 No 2 (2021): JPMS Volume 6 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v6i2.132

Abstract

Rosella plants are a type of hibiscus plant and can be used as a health drink for various diseases. Rosella flowers have the potential to be used as a source of natural dyes in food. The purpose of this study is to determine the anthocyanin of rosella petals as a chemosensory anion compound. To be used as a chemosensory anion compound, testing needs to be done. The ethanol extract of rosella flower petals was extracted by sonication and the filtrate was evaporated to obtain a red extract. From the results of the extract obtained a rendition of 2.9%. Then the extract was tested as an anion chemosensory with the stages of determining the total anthocyanin content, solvatochromic test, and chemosensory test for saturated anions. The total anthocyanin content obtained was 7.648 grams / 100 grams and the chemosensor test results for saturated anions showed a significant change with the addition of KSCN from pink to clear color. Anthocyanin contained in rosella petals can be used as a chemosensor cyanide anion compound.
Antibacterial Activity of Artocarpus altilis L by Thin Layer Chromatography (TLC)-Bioautography Herlina Rante; Yasnidar Yasir; Kaltum Kaltum
Jurnal Farmasi dan Ilmu Pengobatan Vol 7 No 1 (2022): JPMS Volume 7 Issue 1
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v7i1.130

Abstract

This study aims to determine the antibacterial activity of breadfruit leaf extract (Artocarpus altilis L.) by TLC-Bioautography. Breadfruit leaves were extracted by maceration using ethanol as a solvent. The initial antibacterial test was carried out using the agar diffusion method using Staphylococcus aureus and Escherichia coli bacteria and then continued with the separation of compounds by TLC with n-hexane: ethyl acetate (1:1) eluent and activity test by TLC-Bioautography. The results showed that the ethanol extract of breadfruit leaves was able to inhibit E. coli and S. aureus up to a concentration of 1.25%. TLC-Bioautography test results of the ethanolic extract of breadfruit leaves (Artocarpus altilis L.) which has antibacterial activity on E. coli at an Rf value of 0.18; 0.45; 0.27 and 0.18, and S. aureus at Rf values ​​of 0.45 and 0.27.
Isolasi dan karakterisasi karagenan dari rumput laut merah Kappaphycus alvarezii varietas hijau dan cokelat Nursamsiar Nursamsiar; Anugerah Sukmayanti; Mubarak Mubarak; Andi Nur Aisyah; Megawati Megawati
Jurnal Farmasi dan Ilmu Pengobatan Vol 6 No 2 (2021): JPMS Volume 6 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v6i2.131

Abstract

Carrageenan is a polysaccharide obtained from the extraction of red seaweed using hot water or alkaline solutions at high temperatures. Seaweed is a large commodity in South Sulawesi and is potential to be developed into a source of carrageenan. The purpose of this study was to determine the levels of carrageenan contained in red seaweed Kappaphycus alverazii. Carrageenan extraction method from red seaweed Kappaphycus alverazii green and brown varieties using gravimetric method with 96% ethanol as precipitating material which is then characterized using FTIR spectrophotometer. The results of the study showed that carrageenan levels in red seaweed Kappaphycus alvarezii green and brown varieties were 41.37% and 36.34% respectively. Carrageenan levels of green varieties are higher than brown varieties.
Formulasi Sediaan Sabun Cuci Tangan Ekstrak Daun Kelor (Moringa Oleifera L.) dan Efektivitasnya Sebagai Antiseptik Amriani Sapra; Nur Khairi; Margaretha Margaretha; Andi Nur Aisyah; Maulita Indrisari; Fitriyanti Jumaetri; Noer Fauziah; Marwati Marwati
Jurnal Farmasi dan Ilmu Pengobatan Vol 6 No 2 (2021): JPMS Volume 6 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v6i2.133

Abstract

Aim: The present research to formulate ethanol extract of Moringa oleifera leaf as a stable hand wash with required characteristics and evaluate it is effectivity against Escherichia coli and Staphylococcus aureus. Method: Moringa oleifera was extracted using 96% of ethanol. The obtained extract was formulated into hand wash in concentration 2.5; 5; and 7.5% w/v using surfactant sodium dodecyl sulfate and cocamide DEA. Obtained hand wash then evaluated the physical characteristics including organoleptic, pH, viscosity, relative mass, and foaming level. Hand wash effectivity evaluated against Escherichia coli and Staphylococcus aureus using diffusion method. Result: Hand wash of Moringa oleifera leaf extract fulfill the physical characteristics requirement and showing strong activity against E. coli. and S. aureus with average inhibition zone 13.1 mm; 13.8 mm; 14.5 mm; 12.9 mm; 15.16 mm; and 15.46 mm respectively for 2.5; 5; and 7.5% each. Conclusion: Overall, the experimental results revealed strong inhibition activity of M. oleifera hand wash to E. coli and S. aureus, but increasing the concentration of the extract has no significant different to inhibition activity.
Application Chemometrics-Assisted Fingerprinting Profiling of Extract Variation from Mangosteen (Garcinia mangostana L.) Using FTIR Method Budiman Yasir; Dewi Purwaningsih; Nur Rahma Rumata; Nurzadrina Wahyuddin; Muh Azwar AR; Nurul Hikmah; Noer Fauziah Rahman
Jurnal Farmasi dan Ilmu Pengobatan Vol 6 No 2 (2021): JPMS Volume 6 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v6i2.134

Abstract

Garcinia mangostana L. (mangosteen) is a plant that comes from the tropics and is very loved by the public because of its pleasant taste. It has anti-diabetic effects, wound treatment, diarrhea, skin anti-infection, antioxidant, anticancer, anti-inflammatory, antimicrobial, antioxidant, and anti-tumorigenic effects. This study aims to determine the fingerprint profile of mangosteen seed extract and peel using variations of ethanol using FTIR and combined chemometrics with multivariate analysis methods. Mangosteen seeds and peels were extracted with a variety of solvents (ethanol 70%, and ethanol 96%) by maceration obtained 8 types of extracts. All extracts were analyzed through FTIR spectroscopy with KBr pellets and solvent methanol PA at wavelengths 400-4000 cm-1. Mangosteen peel and seed extracts have functional groups with fingerprint markers at wavelength positions 3414 cm-1 (O-H), 2964.59 cm-1 (C-H3), 2920.23 cm-1 (C-H2), and 2856.58 cm-1 (C-H2). Multivariate analysis showed loading plot of extract had normally distributed and 96% seed Bulukumba extract had a major effect on PC1 (0.424) and 96% ethanol peel Bulukumba extract (0.439). The plot score affected PC1 (20.1%) and PC2 (57.4%) with a similarity between 31.57-99.89% in the extracts. The correlation of each extract showed a very positive correlation with the equation (y = 0.9805x + 65.177; R² = 0.9926). The use of FTIR spectra in observing the fingerprint profile of mangosteen peel and seed extracts with ethanol variations and chemometric combinations is highly applicable and can be applied in the validation and study of the chemical components of plant extracts.
Activity Test of Ethyl Acetate Fraction and N-Hexane Fraction of Tamarind Leaf Extract (Tamarindus indica L.) Against Healing Burns and Incision Wounds in Rabbits (Oryctolagus cuniculus) Sitti Rahimah; Suwahyuni Mus; Zulkifli Zulkifli; Nurzadrina Nurzadrina; Nurhikmah Nurhikmah; Ismail Ismail; Rahmad Aksa; Nur Rahma Rumata
Jurnal Farmasi dan Ilmu Pengobatan Vol 7 No 1 (2022): JPMS Volume 7 Issue 1
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v7i1.135

Abstract

Tamarind leaf (Tamarindus indica L.) is one of the forgotten plants that has potential as a medicine for burns based on its chemical compounds such as alkaloids, flavonoids, saponins and tannins. This study aims to determine the effect of giving the ethyl acetate fraction and the n-hexane fraction of tamarind leaves on the healing of burns in rabbits (Oryctolagus cuniculus). The test was carried out using 3 rabbits for each type of treatment, namely burns and incision wounds. Each experimental animal was induced as many as 6 wounds on each back of the rabbit with the following treatments: Wound I (negative control), Wound II (bioplacenton gel), Wound III (1% n-hexane fraction), Wound IV (n-hexane fraction). 3% hexane, Wound V (1% ethyl acetate fraction) and Wound Vl (3% ethyl acetate fraction). The macroscopic observations observed included color, edema, wound diameter, scab formation and opening and epitalization. Both hexane and ethyl acetate fraction of tamarind leaf extract had activity as a burn healer at concentrations of 1% and 3%.The conclusion was that the ethyl acetate fraction of 3% tamarind leaf extract had the best activity among other treatments.
Validity and reliability test for the questionnaire: The role of the existence of pharmacists on pharmaceutical services in public perceptions Asrul Ismail
Jurnal Farmasi dan Ilmu Pengobatan Vol 7 No 1 (2022): JPMS Volume 7 Issue 1
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v7i1.138

Abstract

Pharmacists have a massive role in the health care system. The pharmacist's paradigm shift, which initially focused on drugs and pharmaceutical supplies, changed to patient- and community-oriented. This change has an impact on the existence of pharmacists. Many attempts have been made to measure the extent of the pharmacist's role, one of which is by using a questionnaire. Research has been conducted on the validity and reliability of the questionnaire on public perceptions of the existence and role of pharmacists in pharmaceutical services. This study aimed to determine the validity and reliability of the pharmacist's role and existence questionnaire. This study uses the Cronbach Alpha method with the Pearson bivariate test. Questionnaires were distributed to 30 patients containing 28 questions consisting of 4 domains. There are two measurement scales: the Guttman scale and the Likert scale. The study results indicate that 28 questions have a greater significance than the r-table (0.361) on each scale. This means that the 28 questions are declared valid, while the reliability test shows an R-value of 0.588 for the Guttman scale and 0.905 for the Likert scale.
Formulation and Evaluation Lozenges of Angkak Powder as supportive therapy candidate for DHF Nurul Hikma; Andi Arjuna; Radhia Riski; Jainer Pasca Siampa
Jurnal Farmasi dan Ilmu Pengobatan Vol 7 No 2 (2022): JPMS Vol 7 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v7i1.140

Abstract

Angkak contains monacolin-K compounds which are identical to lovastatin and B complex vitamins (vitamin B12 and folic acid) are believed to play a role in increasing blood platelet levels in DHF. This study aims to determine the optimum formula of angkak powder lozenges with variations of sucrose-mannitol-aspartame sweetener that meet the physical requirements. In this study lozenges were made in 5 formulas with sucrose-mannitol sweetener (F1 14%; without mannitol, F2 10;4%, F3 7;7%, F4 4;10% and F5 without sucrose;14%), while the concentration The aspartame used in the 5 formulas is 1%. The method used is the wet granulation method with the resulting tablet weight is 1000 mg. The lozenges were tested for physical properties including weight uniformity, size uniformity, catch up, and disintegration time. The results showed that the use of sucrose-mannitol-aspartame sweetener produced lozenges that met the requirements for uniformity of weight, uniformity of size, and disintegration time. So, it can be said that F5 is the optimal formula with an average value of 0.042% and a disintegration time of 20.22 minutes.
Studi Penambatan Senyawa Dari Tanaman Kembang Bulan (Tithonia Diversifolia (Hemsley) A.Gray) Terhadap Peroxisome Proliferator-Activated Receptor-Gamma (PPARɣ) Untuk Penyakit Diabetes Melitus Nur Rahma Rumata; Nursamsiar Nursamsiar; Maghfirah Putri Arifin
Jurnal Farmasi dan Ilmu Pengobatan Vol 7 No 2 (2022): JPMS Vol 7 Issue 2
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v7i2.141

Abstract

Diabetes mellitus is a disease whose prevalence continues to increase both in the world and developing countries, so it is said that diabetes mellitus is a problem for global public health. One of the receptors that play a role in stimulating insulin storage so that resistance does not occur is the PPARƔ receptor. The purpose of this study was to simulate the interaction of moonflower compounds with several proteins at the PPARƔ receptor in the design of antidiabetic drugs by molecular docking method. The docking results showed that all moonflower compounds could interact with the active site of PPARƔ. The ligands with the best interactions were indicated by compounds with the best interactions shown by compounds 27, compounds 29 and compounds 31 with binding energy values, respectively, namely, -8.03 kcal/mol, -6.85 kcal/mol, -8.20 kcal/mol. Meanwhile, Thiazolidinediones as a positive control showed G value of -9.71 kcal/mol. These results indicate that the compound T. diversifolia is predicted to have potential as antidiabetic therapy.

Page 9 of 9 | Total Record : 90

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