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Jambura Journal of Chemistry
Published by Universitas Negeri Gorontalo
ISSN : 26563665     EISSN : 26566834     DOI : 10.34312/jambchem
Core Subject : Science,
Chemistry
Jambura Journal of Chemistry is peer-reviewed and open access journal published by Chemistry Depertment, Faculty Mathematic and Natural Science. Jam.J.Chem that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. Jambura Journal of Chemistry publish two issues (numbers) annually (February and August).
Arjuna Subject : -
Articles 102 Documents
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Unsur Kelumit Esensial (Mn Dan Zn) dalam Biji Kakao (Theobroma Cacao L.) dari Daerah Perkebunan Ransiki Papua Barat Sabir Sumarna; Yunita Pare Rombe; Murtihapsari Murtihapsari; Apriani Sulu Parubak; Christiana Niken Larasati; Putri Sarera Surbakti; Arniana Anwar
Jambura Journal of Chemistry Vol 4, No 2 (2022): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i2.14595

Abstract

Cocoa is a rich source of essential minerals and contributes a significant amount of minerals in the human diet. Processed products from cocoa in the form of chocolate are in great demand by almost everyone from various statuses and social groups. The high consumption of chocolate is also not a fact that chocolate is beneficial to human health. The essential minerals (Mn and Zn) in cocoa beans are needed by the human body as a source of minerals, but if excess can be harmful to the body. The purpose of this study was to determine the content of essential trace elements in cocoa beans and their potential as raw materials for food products. The analysis method uses AAS (Atomic Absorption Spectrophotometry). The results showed the content of micronutrients (Mn and Zn) in cocoa beans at five location points with an average value of 0.8976 mg/100 g and 5.7534 mg/100 g.
Characteristics of Organic and Inorganic Substances in Leachate Wastewater Talumelito Regional Waste Final Disposal Site Zikran Abdullah; Sahrial Lakasim; Siti Hairunisa Kandusu; Mahdi Kilo; Wiwin Rewini Kunusa
Jambura Journal of Chemistry Vol 4, No 1 (2022): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i1.17513

Abstract

Leachate or leachate is a solution that occurs as a result of mixing rain runoff with decomposed trash and containing very fine suspended substances and pathogenic microbes that can cause potential contamination of surface water and groundwater. This study aims to analyze organic and inorganic substances (Pb, Cd, Mn, Fe and Cu metals) in leachate waste. Leachate water sampling was carried out at the Talumelito Waste Disposal Site, Gorontalo District by composite sampling at 5 location points, namely A1, A2, A3, A4, A5. The research procedure was divided into 4 stages, namely the preparation phase, the sampling stage, the sample analysis stage and the data analysis stage. Metal analysis using the AAS method. The results of the analysis at 5 location points showed the highest Lead (Pb) metal reached 0.0248 ppm, Cadmium (Cd) ˂ 0.0009 ppm and Copper (Cu) ± 0.02 ppm. For iron (Fe) the highest reaches 3.1029. For Manganese metal (Mn), they are 1.2779 ppm, 1.1441 ppm and 1.2779 ppm. Heavy metal parameter, the value is still far below the quality standard for leachate in samples A1, A2, A3, A4, and A5. As for the analysis of organic substances, nitrates and nitrites using the Uv-Vis spectrophotometry method showed the highest levels of organic matter were 40.97, nitrates 5.77 and nitrites 0.0065. However, the pH value is above the leachate quality standard of 6.9 at 3 location points, 7.8 - 8.2. And turbidity level of leachate for sample A1 reaches 135.5. From these results it can be seen that the function of the leachate control pool in the Talumelito landfill is still ineffective.
Karakterisasi Mineral dengan Analisis Sayatan Mineragrafi untuk Penentuan Mineralisasi Sphalerite (ZnS) Kostiawan Sukamto; Mohammad Zaki Mubarok; Ayub Pratama Aris; Ninasafitri Ninasafitri
Jambura Journal of Chemistry Vol 4, No 2 (2022): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i2.17508

Abstract

Sphalerite is a mineral rich in Zinc and Iron is the main source of zinc metal production in the world. The purpose of this study was to determine the mineralization in the Cigudeg area, Bogor Regency, West Java, especially the mineralization of Zinc (Zn) by using mineragraphic analysis. Mineragraphic incision analysis is performed to describe the structure and composition of a mineral, the Physico-chemical properties of the mineral, and the presence of associated minerals in the sample. Based on the test results, the mineral component of sphalerite (ZnS) 40-45% as the most dominant component, often contains inclusions of very fine copper grains measuring less than 1 m to 5 m and quartz (SiO2) 10-15% is granular, as for sulfide ore minerals. Others such as chalcopyrite (CuFeS2), pyrite (FeS2), cuprite (Cu2O), and galena (PbS) are present in small amounts.
Uji Efektivitas Ekstrak Etanol Kulit Batang Kersen (Muntingia calabura L.) Sebagai Antidiabetes Pada Mencit Jantan Endah Nurrohwinta Djuwarno; Widy Susanti Abdulkadir; Febriyaningsi Radjak
Jambura Journal of Chemistry Vol 4, No 2 (2022): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i2.17510

Abstract

Diabetes is a degenerative disease characterized by high levels of glucose in the blood. Diabetes can lead to complications if left untreated. Treatment of diabetes can be done pharmacologically (using traditional medicines or synthetic) or non- pharmacologically (accustoming a healthy lifestyle). The use of traditional medicines is relatively cheap compared to synthetic drigs so that can be used as an anti-diabetic is the Jamaica Cherry (Muntingia calabura L.), as it contains secondary metabolites tha act as antidiabetics. Therefore, this present research aimed to determine the as an antidiabetic in male mice. The research methods used were maceration, phytochemical screening, anti-diabetic test with pre test and post test control design methods to determine if there was a decrease after the administration of the extract. The finding depicted that in the phytochemical screening test, it was observable that Jamaica Cherry (Muntingia calabura L.) bark contained secondary metabolites, incluiding alkaloids, flavonoids, and tannins, while the antidiabetic test indicated that all four extract with concentration of 50 mg, 100 mg, 200 mg and 400 mg were effective to reduce the blood sugar level with each percentage of 9%, 16%, 26%, and 42%. In brief, the antidiabetic compounds that play a role in the ethanol extract of Jamaica Cherry (Muntingia calabura L.) bark were flavonoids and tannins.
Isolasi dan Identifikasi Senyawa Fenil Pentanoat dari Fraksi Etil Asetat Sarang Semut (Myrmecodia pendans.) Emma J. Pongoh; Rymond J Rumampuk; Sofia S. Krisen; Hutri C. Werfete; Arfiani Rizki Paramata
Jambura Journal of Chemistry Vol 4, No 2 (2022): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i2.18945

Abstract

Ants nest (Myrmecodia pendans.) is an epiphytic plant from Papua which is used as herbal medicine. The reseacrh to isolate and identification the ethyl acetate fraction of phenyl penatnoate compounds from ant nests(myrmecodia pendans.). The isolaton process was carried out using the maceration technique, fro the purifcation and separation of compounds the thin layer chromatographic and gravity column chromathographic were used F1 isolated were obtained weighing up to 180 mg in liquid. Identification using spectroscopy Nuclear Magnetic Resonance Proton (1H-NMR) and Nuclear Magnetic Resonance Carbon (13-NMR). The result of identification of isolated F1 indicated the posibillity of a phenyl derivative compound with the proposed name 6-hydroxy-5,5-dimethyl-phenyl-pentanoate.
SENYAWA SITOTOKSIK DARI FRAKSI DIKLOROMETANA DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) TERHADAP SEL KANKER PAYUDARA MCF-7 Ari Widiyantoro
Jambura Journal of Chemistry Vol 5, No 1 (2023): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v5i1.16539

Abstract

Pandan Wangi (Pandanus amaryllifolius Roxb.) is the plant that contains secondary metabolites with high antioxidant activity. These various activities include antibacterial, antidiabetic and hepatoprotective. This research was conducted to determine the cytotoxic activity and to determine the characteristics of isolates from dichloromethane fraction. This research was conducted in several stages including maceration, partitioning, and chromatography. The results showed that the isolate from dichloromethane fraction of pandan leaves had moderate cytotoxic activity against MCF-7 breast cancer cells with an IC50 of 155.0551 g/mL. The isolate from dichloromethane fraction was characterized 1H-NMR analysis (DMSO, 500 MHz), predicted as alkaloid group with a pyrrolidin skeleton. The chemical shift showed H 8.08 ppm (1H, s), 7.68 ppm (6H, m), 7.31 ppm (10H, m), 7.10 ppm (5H, s), 4.22 ppm (7H, m), 3.54 ppm (13H, s ), 3.36 ppm (11H, s), 3.16 ppm (2H, s), 2.64 ppm (2H, s), 2.36 ppm (2H, s), 1.98 ppm (1H, s), 1.65 ppm (12H, m), 1.45 ppm (12H, m), 1.29 ppm (19H, m), 1.17 ppm (5H, t), 1.10 ppm (4H, m), 1.06 ppm (3H, d), 0.99 ppm (6H, m), 0.79 ppm (24H, m) dan 0.51 ppm (17H, m).
Evaluation of Nitrogen, Phosphorus, and Potassium Levels in Rice Straw Compost for Sweet Corn Growth in Gorontalo La Kilo, Akram; Djafar, Yuliyanti Wahab; Iyabu, Hendri
Jambura Journal of Chemistry Vol 5, No 2 (2023): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v5i2.14720

Abstract

This study aims to determine the NPK nutrient content of a mixture of soil and straw compost. -The determination of nitrogen, phosphorus, and potassium levels was carried out using the Kjeldahl method, UV-Vis, and AAS instrument, respectively.The results of the analysis showed that the levels of NPK in the mixture of soil and straw compost, the levels of N 1.6-3.6%, P 0.39-44%, and Potassium 0.14-0.16%, the results obtained that levels of nitrogen, phosphorus met the minimum standard of SNI 19-7030-2004, the potassium content is only slightly or does not meet the standard of SNI/19/7030/2004. The results of the analysis of variance (ANOVA) showed that a mixture of soil and straw compost was suitable as a planting medium for sweet corn which had a significant effect on plant height, stem diameter, stem circumference, and number of leaves.
Analisis Mutu Minyak Zaitun Yang Diperoleh Dari Buah Zaitun (Olea eurofaea) Dan Aplikasinya Sebagai Antikolesterol Duwi Cahyadi, Kadek; Dewi Lestari, Gusti Ayu; Esati, Ni Ketut
Jambura Journal of Chemistry Vol 5, No 1 (2023): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v5i1.16767

Abstract

Olive oil is oil obtained from olives (Olea europaea L.). Olive oil contains high in oleic acid so it can be used as an anticholesterol. This study aims to determine the quality of olive oil according to SNI 01-4474-1998 and its anticholesterol activity by UV-Vis spectrophotometry. In this research, olive oil quality test was conducted, namely water content test using the thermogravimetric method, fatty acid content test using an alkalimetric titration method based on an acid-base reaction, saponification test using the acidimetric method, and iodine number test using the iodometric titration method. The method of testing the anticholesterol activity of olive oil was carried out in vitro using Lieberman-Burchard reagent. The results of the quality test on olive oil obtained water content of 0.03%, free fatty acids 1.73%, saponification number 190.90 mgKOH/g, iodine number 91.25g iodine/100g, where these results have met the SNI 01-4474-1998 standard. The results of the anticholesterol test showed a decrease in free cholesterol levels by 39.76%. Olive oil shows anticholesterol activity due to the presence of oleic acid or MUFA (Mono Unsaturated Fatty Acids)
Studi Molecular Docking dan Prediksi ADME Senyawa Metabolit Sekunder Tumbuhan Obat Tradisional Gorontalo Terhadap Reseptor HER-2 Sebagai Antikanker Payudara Ischak, Netty Ino; Musa, Weny J.A; Aman, La Ode; Alio, La; Kilo, Akram La; Saleh, Sri Deltalia
Jambura Journal of Chemistry Vol 5, No 2 (2023): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v5i2.20544

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas dan interaksi senyawa uji dari 12 tumbuhan obat tradisional Gorontalo dengan reseptor HER-2 yang merupakan protein yang terkait dengan sel kanker payudara secara in silico melalui molecular docking. Molekul dengan hasil docking terbaik akan diprediksi menggunakan program Absobsi, Distribusi, Metabolisme, dan Eliminasi (ADME) menggunakan program SwissADME secara online. Hasil validasi situs ikatan dengan menerapkan protokol penambatan ulang (redocking) menunjukkan nilai Root Mean Square Deviation konformasi ligan standar (2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridine-3-yl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5yl]ethoxy}ethanol) menggunakan Autodock Tools dengan nilai energi bebas ikatan yang terbentuk sebesar -6,32 kkal/mol. Sedangkan nilai Root Mean Square Deviation ligan standar menggunakan Autodock Vina memiliki energi bebas ikatan sebesar -11,3 kkal/mol. Hasil energi bebas ikatan ligan uji Palmarumycin CP1 sebesar -9,2 kkal/mol. Interaksi residu aktif HER-2 pada Palmarumycin CP1 dengan kontribusi terbesar terdapat pada residu Tyr 735. Hasil prediksi ADME menunjukkan bahwa hanya ada lima senyawa yang termasuk aturan Lipinski Rule of Five yaitu senyawa Tembetarine, Palmarumycin CP1, Curcumin, Cepharadione A, dan Hexahydrocurcumin. Oleh karena itu, hasil ADME menunjukkan bahwa hanya ada satu senyawa yang memenuhi aturan Lipinski Rule of Five dan sesuai dengan hasil Molecular Docking yang memiliki energi bebas ikatan sebesar -9,2 kkal/mol adalah senyawa Palmarumycin CP1.
STUDI HKSA SENYAWA ANALOG QUINOLON-4(1H)-IMINE SEBAGAI ANTIMALARIA MENGGUNAKAN PERHITUNGAN HARTHREE-FOCK Jafar La Kilo; Akram La Kilo
Jambura Journal of Chemistry Vol 4, No 1 (2022): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i1.20008

Abstract

Penelitian ini bertujuan untuk melakukan studi hubungan kuantitatif struktur-aktivitas (HKSA) terhadap senyawa analog Quinolon-4(1H)-imine sebagai agen antimalaria. Pendekatan HKSA digunakan untuk menghubungkan aktivitas biologi molekul dengan deskriptor yang dihasilkan dari perhitungan menggunakan metode kimia kuantum Harthree-Fock Sebanyak 22 senyawa turunan Quinolon-4(1H)-imine digunakan sebagai bahan kajian, dengan perhitungan deskriptor elektronik dan molekul yang berpengaruh terhadap aktivitas antimalaria. Model HKSA dianalisis menggunakan metode regresi linear berganda (MLR) dan delapan model persamaan HKSA terbaik dihasilkan. Model-model tersebut kemudian divalidasi dan model terbaik dipilih berdasarkan parameter statistik yang signifikan. Rancangan senyawa usulan juga dilakukan berdasarkan model terbaik, dengan mengganti substituen pada senyawa turunan Quinolon-4(1H)-imine. Hasil penelitian ini dapat memberikan kontribusi dalam pengembangan obat antimalaria baru dengan pendekatan teoritik dan pemodelan, sehingga dapat mengurangi biaya dan waktu yang diperlukan dalam penemuan dan pengembangan obat antibiotik baru.

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