cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota adm. jakarta barat,
Dki jakarta
INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
Arjuna Subject : -
Articles 443 Documents
 8   9   10   11   12 
Bioaktivitas Ekstrak n-Heksana dan Alkaloida Kasar Kulit Batang Actinodaphne macrophylla (Blume) Nees var angustifolia Koord & Valeton Rachmatiah, Tiah; Subaryanti, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 2 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.013 KB)

Abstract

Bioactivies of n-hexane extract and crude alkaloid extract from stem bark of Actinodaphne macrophylla (Blume) Nees var angustifolia Coordinator. & Valeton (Lauraceae) have been investigated. The plants of Lauraceae family are known to contain active compounds such as alkaloids, lactones, fatty acids, terpenes and essential oils. Phytochemical screening of the bark exhibited that it contains triterpenoids, alkaloids and tannins. N-hexane extract was prepared by maceration and the crude alkaloid extract was prepared by maceration in dichloromethane after the powdered bark was previously moistened with 25% NH4OH. The bioactivity assays involved the test of toxicity against brine shrimp larvas (Artemia salina Leach), cytotoxicity against Murine P-388 cells and antimalarial against Plasmodium falciparum. The results indicated that n-hexane extract was active against shrimps larvas with LC50 value of 85.11 ppm, and against P.falciparum with IC50 values of 1.824 ppm, but inactive against Murine P-388 cells with IC50 values of 43.0 ppm, while the crude alkaloid extract was active against shrimp larvas with LC50 value of 36.31 ppm, against Murine P-388 cells with IC50 values of 5.2 m ppm, and against P.falcifarum with IC50 value of 0.1 ppm.Keywords : Lauraceae, Actinodaphne, bioactivity, alkaloids, extract.
Aktivitas Senyawa Isolasi Daun Surian terhadap Disfungsi Sel Endotel Hiperkholesterolemia Suhatri, .; Yanwirasti, .; Dachriyanus, .; Ellyza, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 2 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.529 KB)

Abstract

The protective effects of isolated compounds of ethylacetate fraction of surian's leaf (Toona sureni BL Merr) towards endothelial cell dysfunction on hypercholesterolemia have been investigated. Hypercholesterolemia was induced by atherogenic cocktail for the duration of 60 days. The protective effect was determined by Endothelia Derivate Relaxing Factor 9EDRF/NO) concentration. The result showed that isolated compounds oe ethyl acetate fraction of surian's leaf was able to protect the endothelia cell damage in hypercholesterolemia that can be seenn by increasing the bioavailability of NO serum (P<0.05).Keywords : flavonoid, cocktail, hypercholesterol and nitrogen mono oxide (EDRF)
Identifikasi Senyawa Antikanker dari Fraksi Kloroform Kulit Batang Bruguiera gymnorhiza dan Aktivitas Sitotoksiknya Warsinah, .; Sismindari, .; Susidarti, Ratna Asmah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 2 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (979.176 KB)

Abstract

Bruguiera gmnorhiza is one of mangrove plant that has not been widely studied as potential anticancer compounds. Previous research noted that the methanol extract of the bark of B.gymnorhiza are cytotoxic towards HeLa cells. The purpose of this study was to determine the compounds in the chloroform fraction and cytotoxic activity in HeLa cells. Stem bark of B. gumnorhiza was extracted with methanol, further fractionation by partitioning method, using of the solvent h-hexane and chloroform. Fraction of chloroform was evaporated, the tested cytotoxic activity against HeLa cells by MTT method and apoptotic induction by double staining method. Faction levels are used for 500, 250, 125, 62.5 and 31.25 mg/mL with 24-hour incubation time. Subsequent fractions were identified by GC-MS method. The result showed that the chloroform fraction contains 21 compounds, 6 in the form of fatty acids and terpenoids that have anticancer cytotoxic activity (IC50) of 134 ug/mL with apoptotic mekanism.Keywords: Apoptosis, Bruguiera gymnorhiza, cytotoxic, Fractionation, HeLa cell
Aktivitas Antibakteri dan Antimitotik dari Fungi yang Bersimbiosis dengan Spons Maarisit, Wilmar; Minelko, Marstella; Jan, Tan Tjie
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 2 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (667.295 KB)

Abstract

Sponge-derived fungi are source of natural bioactive compounds. The aim of this research is to test the anti-bacterial and anti-mitotic activities from marine sponge-derived fungus. The sponge-derived fungus (strain TID.24041021-2) has been successfully isolated from sponge (strain TID.24041021-2) collected from the sea around Tidung Island. The morphology of this fungus has been identified and classified in the genus Wangiella sp. This fungus was cultivated in PDA with salinity 25 ppm for 21 days at room temperature, extracted with acetone, partitioned with ethyl acetate, and tested the anti-bacterial activity against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus, and also tested the anti-mitotic activity using root tip cells of Allium cepat. The results showed that crude extract of ethyl acetate could inhibit the growth of B. subtilis 91.30-2.30 mm), E.coli (1.50-3.03 mm) dan S.aureus (2.80-5.0 mm) bacteria. Also, antimitotic activity from crude extract of ethyl acetate showed that there is chromosome abnormalities of 0.76 and 1.38 in extract concentration of 20% and 25%, respectively.Keywords : Sponge-derived fungi, anti-bacterial, anti-mitotic, chromosome abnormalities.
Kajian Biodegradasi Filem Plastik Campuran Polimer Sintetik dengan Biopolimer dalam Larutan Air Octaviani, Melzi; Zaini, Erizal; Djamaan, Akmal
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 2 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1542.725 KB)

Abstract

The degradation of a plastic film containing polymer syntheticpolystyrene (PS) and biopolymer poly(3-hydroxybutyrate)[P(3HB)] and poly (3-hydroxybutyrate-co-3-hydroxy valerat)[P(3HB-co-3HV)] in various composition in aquous solution by in-vitro and in-vivo has been carried out. The testing was conducted based on immersion test in aquadest, river water, pH 4 solution, 6,8 and 10. Rate degradation measured use linear regression equality and parameter is time degradation 50% (t 50%), time degradation 95% (t 95%) and indicated by the slope (k). The result showed that, degradation of a plastic film containing PS and P(3HB) in pH 6 solution occurred faster, followed by ratio PS/P(3HB) 95:5, PS/P(3HB) 90:10, PS/P(3HB) 85:15 and PS/P (3HB) 80:20, in contrast degradation of pure PS (100:0) not occured. It is also observed that the biodegradation plastic film containing PS/P(3HB-co-3HV) in river water ratio PS/P(3HB-co-3HV) 95:5, PS/P (3HB-co-3HV) 90:10 and PS/P (3HB-co-3HV) 85:15, in contrast degradation of pure PS (100:0) not occurred.Keywords : biodegradation, polystyrene, poly(3-hydroxybutyrate), poly (3-hydroxybutyrate-co-3-hydroxyvalerat), plastic film.
Aktivitas Antibakteri Fraksi Daun Aka Lambuang Alen, Yohannes; Rustini, .; Honesty, Resta
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 2 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.89 KB)

Abstract

Antibacterial activity tests were conducted on the leaf fraction of Aka lambuang (Merremia peltata (L.)Merr.) by dilution method and microplate reader towards Staphylococcus aureus and Escherichia coli. The results showed that activity performed at the minimum inhibitory concentration of 500 ppm and 1000 ppm respectivelyKeywords :  Merremia peltata, antibacterial, microplate reader.
Aktivitas Antioksidan dan Penghambat Xantin Oksidase dari Ekstrak Buah Andaliman (Zanthoxylum acanthopodium DC.) Kristanty, Ruth Elenora; Mun'im, Abdul; Katrin, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 3 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.683 KB)

Abstract

The fruits of andaliman (Zanthoxylum acanthopodium DC.) are well known in North Sumatera and commonly used as seasoning for Batak traditional cuisine. Aims of this study were to determine the scavenging activity of free radicals and xanthine oxidase inhibitory activity from the andaliman fruit extracts after macerated garually in petroleum ether, dichloromethane, ethyl acetate, n-butanol, and methanol. Activity assay were evaluated in vitro by using DPPH and enzyme xanthine oxidase. The result showed that n-butanol extract has medium antioxidant activity with IC50 values of 53.51 μg/mL and methanol extract has strong antioxidant activity with IC50 values of 26.39 mg/mL. Xanthine oxidase inhibitory activity of the extract given by n-butanol and methanol are very strong with IC50 values of 3.69 μg/mL and 4.03 μg/mL. Keywords : antioxidant, free radical, xanthine oxidase, Zanthoxylum acanthopodium DC.  
Penetapan Kadar Alkaloid Ekstrak dari Etanolik Bunga Kembang Sepatu (Hibiscus rosa-sinensis L.) Murrukmihadi, Mimiek; Wahyuono, Subagus; Marchaban, .; Martono, Sudibyo
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 3 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.643 KB)

Abstract

Kembang sepatu flower (Hibiscus rosa-sinensis L.) was fractionally used as expectorant. Based on Bioassay Guided fractionation, an active fraction was separated, and the fraction was identified is Alkaloid was the major compound based on TLC analysis. Viscosity value measured by viscometer was used as a Bioassay model of expectorant activity in vitro and acetyl cysteine was used as positive control. Alkaloid content determination of the ethanolic extract was measured by TLC-Densitometric compared with standard curve of isolated alkaloid as the selected marker (Y=12,1360X+2901,4474). The alkaloid content in the ethanolic extract was determined as 2.35±0,67%.Keywords : alkaloid, ethanolic extract, Hibiscus rosa-sinensis L.
Analisis Adverse Drug Reactions pada Pasien Asma di suatu Rumah Sakit, Surabaya Lorensia, Amelia; Canggih, Beny; Wijaya, Rizka Indra
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 3 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.783 KB)

Abstract

Asthma is a chronic inflammatory disease of the respiratory tract. Treatment of asthma can lead to ADRs (adverse drug reactions), which can aggravate asthma symptoms. The purpose of this study was to analyze the incidence of ADRs in patients with asthma. The study design is divided into retrospective studies, for hospitalized patients and cross-sectional with purposive sampling to outpatient. Any actual ADRs that ocured was calculated using the Naranjo probability scale. The number of hospitalized patients were 60 people and outpatients were 22 people. The number of ADRs that occur were 39 cases, consisted of 36 cases of ADRs in  hospitalized patients with asthma and 3 cases of ADRs in outpatient asthma patients. Drug groups most involved in ADRs was B2-agonist group. Naranjo scale calculations on ADRs that occured that the possibility of ADRs. The most common ADRs are in asthma therapy, so it takes the role of pharmacists in monitoring ADRs in asthma treatment to prevent and minimize the occurrence of ADRs.Keywords : asthma, naranjo scale, hospitalized patient, outpatient.
Pengaruh Pemberian Ekstrak Etanol Umbi Mahakaan terhadap Waktu Perdarahan dan Pembekuan serta Jumlah Trombosit Darah Mencit Putih Betina Dharma, Surya; Dachriyanus, .; Sartika, Zikra
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 3 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.148 KB)

Abstract

The effect of aethanolic extract of mahakaan's (Gynura pseudochina (L) DC tuber on shortening bleeding and coagulation time and trombocytes cell of the white female mice has been studied. The overal doses used were 30,100 and 300 mg/kg BW. The effect was observed on 1st, 7th, 14th and 21st days by using the modified cutting tail method, slide method and using hemositometer. As a comparator used vitamin K with dose of 0,026 mg/20g BW was given. The result indicated that the extract has ability to shorten bleeding and coagulation time at all doses, and the dose of 300 mg/kg BW showed a stronger effect on shortening bleeding time compared to vitamin K 0,026 mg/20g BW (p<0,01). The doses of 100 and 300 mg/BW showed a stronger effect on shortening coagulation time. The thrombocytes was not influenced by the all doses, and neither was the lenght of the administration (p>0,01). keywords : Gynura pseudochina (L.) DC), bleeding time, coagulation time and level of thrombocyt.

Page 10 of 45 | Total Record : 443

 8   9   10   11   12 

Filter by Year

2006 2019


Reset
Filter By Issues
All Issue Vol 11, No 2 (2019) Vol 11, No 1 (2019) Vol 11, No 1 (2019) Vol 10, No 2 (2018) Vol 10, No 2 (2018) Vol 10, No 1 (2018) Vol 10, No 1 (2018) Vol 9, No 2 (2017) Vol 9, No 2 (2017) Vol 9, No 1 (2017) Vol 8, No 2 (2016) Vol 8, No 1 (2016) Vol 7, No 4 (2015) Vol 7, No 3 (2015) Vol 7, No 2 (2014) Vol 7, No 1 (2014) Vol 6, No 4 (2013) Vol 6, No 3 (2013) Vol 6, No 2 (2012) Vol 6, No 1 (2012) Vol 5, No 4 (2011) Vol 5, No 3 (2011) Vol 5, No 2 (2010) Vol 5, No 1 (2010) Vol 4, No 4 (2009) Vol 4, No 3 (2009) Vol 4, No 2 (2008) Vol 4, No 1 (2008) Vol 3, No 4 (2007) Vol 3, No 3 (2007) Vol 3, No 2 (2006) Vol 3, No 1 (2006) Vol 9, No 1 (2017): Punica Granatum Vol 8, No 2 (2016) Vol 8, No 1 (2016) Vol 7, No 4 (2015) Vol 7, No 3 (2015) Vol 7, No 2 (2014) Vol 7, No 1 (2014) Vol 6, No 4 (2013) Vol 6, No 3 (2013) Vol 6, No 2 (2012) Vol 6, No 1 (2012) Vol 5, No 4 (2011) Vol 5, No 3 (2011) Vol 5, No 2 (2010) Vol 5, No 1 (2010) Vol 4, No 4 (2009) Vol 4, No 3 (2009) Vol 4, No 2 (2008) Vol 4, No 1 (2008) Vol 3, No 4 (2007) Vol 3, No 3 (2007) Vol 3, No 2 (2006) Vol 3, No 1 (2006) More Issue