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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
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Articles 443 Documents
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PENGETAHUAN PASIEN TENTANG DIABETES DAN OBAT ANTIDIABETES ORAL Nita, Yunita; Yuda, Ana; Nugraheni, Gesnita
Jurnal Farmasi Indonesia Vol 6, No 1 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v6i1.97

Abstract

The objective of this work was to determine patient knowledge regarding diabetes mellitusand oral antidiabetics drugs (OAD). Six pharmacies in Surabaya were chosen purposively inAugust 2009. The sample was DM patients who obtained OAD with prescription. Interviewswere conducted using validated questionnaires. Result showed that 95.8% (69/72) ofpatients knew the aim of DM therapy. More than 90% of patients knew that medicine,exercise and diet are the therapy for DM. The correct time of taking the medication wasknown by 57.9% (22), 43.3% (13) and 0% of patients who received 1, 2 and 3 OADrespectively. A total of 64 patients received insulin secretagogues or sulfonylureas whichhave side effects of hypoglycemia. Only 9.5% (6) of patients knew the definition ofhypoglycemia, and less than 21% of patients knew the signs of hypoglycemia. If forget totake medication, 95.8% (69/72) of patients knew that the OAD should not be taken double.To conclude, patientsâ?? knowledge about diabetes and OAD must be improved. ABSTRAKTujuan penelitian ini adalah untuk mengetahui pengetahuan pasien Diabetes Mellitustentang obat antidiabetes oral (OAD). Dilakukan di 7 apotek di Surabaya secara purposivesampling pada bulan Agustus 2009. Sampel adalah pasien DM yang menebus OAD denganresep di apotek terpilih. Data diperoleh dari interview menggunakan daftar pertanyaanterstruktur yang telah divalidasi. Diperoleh 72 pasien sebagai responden dari penelitian ini.Dari hasil penelitian diperoleh 95,8% (69) responden mengetahui tujuan terapi DM. Lebihdari 90% responden mengetahui bahwa OAD, olah raga dan pengaturan diet adalah terapiuntuk DM. Waktu yang benar dalam menggunakan obat diketahui oleh 57.9% (22), 43.3%(13) dan 0% responden yang mendapat 1, 2 dan 3 OAD. Sejumlah 64 respondenmemperoleh golongan insulin secretagogue atau sulfonylurea yang memiliki efek sampinghipoglikemia. Hanya 9.5% (6) responden yang mengetahui definisi hipoglikemia, dan kurangdari 21% mengetahui tanda-tanda hipoglikemia. Sementara 70,8 % (51/72) mengetahuibahwa apabila mereka mengalami lemas, berkeringat dan akan pingsan sebaiknyamengkonsumsi gula. Dapat disimpulkan bahwa pengetahuan pasien tentang DM dan OADmasih harus ditingkatkan.
Formulasi Effervescent Rumput Laut sebagai Antihipertensi Mandiricha, Tara; Inassani, Lustyafa; Malik, Ibnu; Harum, Zahrotul Hasanah; Setiawan, Meddy
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (318.588 KB) | DOI: 10.35617/jfi.v7i1.154

Abstract

Eucheuma spinosum belongs to rhodophyceae seaweed that comprises bioactive peptides. Those peptides worked by decreasing blood pressure, i.e. ACE inhibitor drugs. These studies are conducted to determine reaction of Eucheuma spinosum distribution as natural ACE inhibitor in form of effervescent formulation. These study were true experimental wiith pre-post test only control group. Sample consists of 28 Wistar rats, divided into 4 groups; a group of control (K) and 3 groups of experiment (P1, P2, P3) were given Eucheuma spinosum, dose 200 mg/kgBW/day, 400 mg/kgBW/day, & 600 mg/kgBW/day. The result shows that there is an effect of Eucheuma spinosum distribution to the blood pressure of hypertensive rats.Keywords : Effervescent Eucheuma spinosum, hypertension, bioactive peptide, ACE Inhibitor
Preparation and Characterization of Ba-Alginate Microspheres Containing Ovalbumin Hariyadi, Dewi Melani; Hendradi, Esti; Irawan, Mukhlis Bayu
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.701 KB) | DOI: 10.35617/jfi.v8i1.204

Abstract

The use of microspheres nowadays is important in the pharmaceuticals formulation. The aim of the present research was to evaluate physical characteristics of ovalbumin-loaded alginate microspheres using aerosolisation technique at various concentrations of alginate and BaCl2. Alginate microspheres were characterized in terms of encapsulation efficiency, yield, particle size, surface morphology and protein integrity. The comparative study between concentrations of BaCl2 and alginate polymer was investigated. Increasing concentration of alginate polymer from 2.5 to 3.5% reduced their particle size and formed smoother and spherical microspheres. Increasing Ba2+ concentration, simultaneous increased the encapsulation efficiency and yield. Scanning electron microscope (SEM) photomicrographs revealed that with the increase in the electrolyte concentration the density of the cross link is also increased. Smoother surface was demonstrated when the electrolyte concentration is increased from 0.5M to 0.75M. Formula prepared using 0.75M BaCl2 and 3.5% alginate polymer resulted the highest encapsulation efficiency (92%), the highest microspheres yield (73%) and the smallest microspheres size (3.73µm). Most of the formulations maintain the integrity of ovalbumin after 2 hours incubation in pH 1.2 followed by 8 hours incubation in pH 7.4. The different formulations produced different physical characteristics of ovalbumin-loaded alginate microspheres.
ANALISIS FAKTOR YANG MEMPENGARUHI KEPATUHAN PENGAMBILAN OBAT PESERTA PROGRAM RUJUK BALIK DI BANDAR LAMPUNG Setyaningrum, Ndaru; Pramantara, I Dewa Putu
Jurnal Farmasi Indonesia Vol 9, No 1 (2017)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4801.067 KB) | DOI: 10.35617/jfi.v9i1.552

Abstract

ABSTRACT : Program (Program Rujuk Balik = PRB) through a health care program for the participants of the National Health Insurance with chronic diseases. Barriers to success of therapeutic treatment for patients with chronic diseases is non-adherence  related to the patient's treatment regimen. Taking medication adherence for patients with chronic illness is the first adherence can be assessed on how a person decides to get medicines for themselves. Analyzing factors affecting medication adherence taking participants PRB is important, cause non-adherence adverse effects appear in the treatment.  Participants adherence taking the drug on a PRB can be obtained from the data prescription claims to calculate the medication possession ratio (MPR), which MPR � 80% declared adherence. Data obtained from  prescription claim by participants PRB for  September 2015 until December 2015 in Bandar Lampung. Sample case study 82 people with diabetes. The calculation result MPR explains that 62.2% of respondents declared adherence taking medication, while 37.8% of respondents declared non-adherence. The results of the  logistic regression analysis, stating that there are influences together of factors respondents' knowledge, respondents belief, attitudes of personnel pharmacy services, pharmacy facilities, cost, availability of medication PRB, family support, and accessibility affect to respondent adherence of  taking medication. However, factors that significantly influence medication adherence refer the decision back is knowledge of respondents with sig = 0,028 (sig <0.05), belief of respondents with sig = 0,003 (sig <0.05), and accessibility sig = 0,044 (sig < 0.05) significantly affect to adherence  of taking medication.
PENGARUH EKSTRAK AKAR SENGGANI (Melastoma affine D.Don) TERHADAP MOTILITAS DAN JUMLAH SPERMA TIKUS Bachri, Moch. Saiful; Donatus, Imono Argo; Wahyuono, Subagus
Jurnal Farmasi Indonesia Vol 4, No 2 (2008)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i2.15

Abstract

Spermatogenesis effect of  ethanol extract senggani root (Melastoma affine D. Don) was proved. Furthermore, the extract was fractionated with ethyl acetate and was investigated toward spermatogenesis effect to explore natural product  as male  contraception. The subject of this research were five groups of thirty two fertile male Wistar rat,. Four groups were treated with ethyl acetate fraction of senggani root in gradually 500; 250; 125; and 62,5 mg/kg body weight dose. The fifth group as negative control was treated by CMC Na 0,5 %. Every groups was treated by orally administration for twenty two days period of time, once a day. In twenty third day, the rats were killed then observed toward the motility, sperm count, and testis histopathology. Results of the research indicated that there were influence toward spermatogenesis effect from ethyl acetate fraction of senggani root, especially at sperm motility and sperm count. Decrease of sperm motility after treatment was compared with negative control group. The percentage of the sperm count decreased at 500; 250 mg/kg body weight dose from ethyl acetate fraction was 49,74 % and 48,21.This decreased probably were caused by seminiferous tubules necrotic.   ABSTRAK Pemberian ekstrak etanol akar senggani (Melastoma affine D. Don) telah terbukti dapat menyebabkan berkurangnya jumlah dan motilitas sperma tikus. Berdasarkan hasil penelitian tersebut dilakukan fraksinasi ekstrak etanol akar senggani dengan etil asetat kemudian fraksi itu di uji cobakan pada tikus dengan tujuan untuk eksplorasi bahan alam yang dapat dipakai sebagai bahan kontrasepsi pria. Penelitian ini menggunakan 32 ekor tikus jantan fertil galur Wistar, umur 2,5-4 bulan dengan bobot 145-350 g dan dibagi menjadi 5 kelompok. Empat kelompok merupakan kelompok perlakuan fraksi etil asetat akar senggani dengan dosis 500; 250; 125; dan 62,5 mg/kgBB. Kelompok V merupakan kelompok kontrol negatif dengan perlakuan CMC Na 0,5 %. Semua kelompok diberi perlakuan secara per oral selama 22  hari dengan frekuensi pemberian sekali sehari. Pada hari ke-23 tikus dikorbankan dan diamati motilitas, dan jumlah atau angka sperma. Dilakukan juga pengamatan histopatologi organ testis. Hasil penelitian menunjukkan ada pengaruh pemberian fraksi etil asetat akar senggani terhadap motilitas dan jumlah (angka) sperma. Motilitas sperma menjadi berkurang pada semua dosis perlakuan jika dibandingkan dengan kelompok kontrol. Penurunan motilitas sperma terbesar pada dosis 250 mg/kgBB. Jumlah sperma juga mengalami penurunan untuk semua dosis perlakuan. Persentase penurunan jumlah sperma terbesar pada dosis 500 ; 250 mg/kgBB sebesar 49,74 % , dan 48,21 %. Penurunan ini kemungkinan diakibatkan oleh rusaknya tubulus seminiferus testis yang mengalami nekrosis
Free Radical Scavenging and α-Glucosidase Inhibitor Activity of Ethanolic Extract of Mucuna pruriens L. Widowati, Wahyu; Ratnawati, Hana; Retnaningsih, Ch.; Lindayani, .; Rusdi, Udju D.; Winarno, Wahyu
Jurnal Farmasi Indonesia Vol 5, No 3 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i3.46

Abstract

Biji kacang â??koro bengukâ? atau velvet bean sudah sangat dikenal tetapi dasar ilmiah penggunaannya sebagai obat tradisional terutama sebagai antioksidan dan antidiabetik masih belum diketahui. Oleh sebab itu dalam penelitian ini dilakukan percobaan untuk mengevaluasi aktivitas antioksidan dan antidiabetik dari ekstrak biji koro benguk, serta fraksi heksana, etil asetat, butanol dan air menggunakan uji in vitro menggunakan DPPH (1,1-difenil-2-pikril-hidrazil) dengan pembanding positif kuersetin dan BHA. Hasil penelitian menunjukkan bahwa IC50 DPPH untuk ekstrak biji koro benguk, fraksi heksana, etil asetat, butanol dan air berturut-turut sebesar 22,17; 152,60; 113,03; 4,93; dan 9,14 μg/mL, sedangkan untuk kuersetin dan BHA masing masing sebesar  4,28 dan 22,587 μg/mL. Aktivitas antidiabetik ditentukan menggunakan metode penghambatan α-glukosidase dengan glucobay sebagai kontrol positif. Hasil penelitian menunjukkan bahwa IC50 antidiabetik untuk ekstrak biji koro benguk, fraksi heksana, etil asetat, butanol, air, dan glucobay berturut-turut sebesar 24,44; 19,55; 8,40; 80,98; 48.97; dan 16,23 μg/mL. ABSTRACT Velvet bean seeds are ubiquitous but the scientific basis for its medicinal use especially as antioxidant and antidiabetic remains unknown. Therefore, a study was designed to evaluate  antioxidant and antidiabetic activities of the  extract, hexane, ethyl acetate, butanol and water fractions of velvet bean seeds. In order to evaluate antioxidant activity of extract and fractions  using  quercetin,  butylated hydroxyanisole (BHA) as positive control and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging activity was determined. The results showed that IC50 of DPPH were 22.17; 152.60; 113.03; 4.93; 9.14 μg/mL respectevily;  quercetin 4.28 and BHA 22.587 μg/mL.  Antidiabetic activity was determined by using  of α-glucosidase inhibition assay of  extract, four fractions and glucobay as positive control. The results showed that antidiabetic IC50 were24.44; 19.55; 8.40; 80.98; 48.97μg/mL respectively and glucobay as positive control  16.23 μg/mL.
STUDI PENGARUH KOMPLEK SIKLODEKSTRIN TERHADAP PENETRASI PERKUTAN PIROKSIKAM Agustin, Rini; Agoes, Goeswin; T, Sasanti
Jurnal Farmasi Indonesia Vol 3, No 3 (2007)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i3.78

Abstract

Cyclodextrin was cyclic oligosakarida that can be able to form inclusion complex with drug, used for the optimasi of transdermal delivery. Based on some research that had been done, probably that cyclodextrin can improve percutan penetration of drug by modifying the nature of phsycochemistry of drug especially drug solubility in bases, distribution and partition of drug and modify permeability of stratum corneum. Based on this reason, percutan penetration of inclusion complex of piroxicam with cyclodextrin in carbopol 940 gel had been studied. The Inclusion complex was prepared by copresipitation method with b-cyclodextrin as inclusion agent. The amount of piroxicam included by -cyclodextrin was 85.28% with stability constant of inclusion complex, K1:1 = 75.86 M-1. Percutan penetration test of inclusion complex in carbopol 940 gel using modified Franz diffusion cell with abdominal skin rat as membrane diffusion, shown that the inclusion complex with -cyclodextrin gave a higher diffusion rate than piroxicam gel without cyclodextrin and gel with physical mixtures of piroxicam-cyclodextrin. ABSTRAK Siklodekstrin merupakan oligosakarida siklik berbentuk torus yang dapat membentuk komplek dengan obat yang dapat digunakan untuk optimasi penghantaran transdermal. Berdasarkan beberapa penelitian yang telah dilakukan, diduga bahwa siklodekstrin dapat meningkatkan penetrasi perkutan dengan memodifikasi sifat fisiko-kimia obat terutama kelarutan dalam basis, partisi dan distribusi obat pada kulit serta merubah permeabilitas stratum corneum. Berdasarkan hal tersebut telah diteliti penetrasi perkutan kompleks inklusi piroksikam dengan siklodekstrin dalam sediaan gel karbopol 940. Kompleks inklusi dibuat menurut metode kopresipitasi menggunakan b-siklodekstrin sebagai pengompleks. Jumlah piroksikam yang terinklusi oleh b-siklodekstrin adalah 85,28% dengan konstanta stabilitas komplek K1:1 = 75.86 M-1. Pengujian penetrasi perkutan menggunakan sel difusi Franz yang dimodifikasi dengan membran difusi kulit abdomen tikus menunjukkan bahwa kompleks inklusi piroksikam dengan b-siklodekstrin dalam sediaan gel karbopol 940 mempunyai kecepatan difusi yang lebih tinggi dibanding sediaan gel piroksikam tanpa siklodekstrin dan sediaan dengan campuran fisik piroksikam siklodekstrin.
Analisis Adverse Drug Reactions pada Pasien Asma di suatu Rumah Sakit, Surabaya Lorensia, Amelia; Canggih, Beny; Wijaya, Rizka Indra
Jurnal Farmasi Indonesia Vol 6, No 3 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.783 KB) | DOI: 10.35617/jfi.v6i3.135

Abstract

Asthma is a chronic inflammatory disease of the respiratory tract. Treatment of asthma can lead to ADRs (adverse drug reactions), which can aggravate asthma symptoms. The purpose of this study was to analyze the incidence of ADRs in patients with asthma. The study design is divided into retrospective studies, for hospitalized patients and cross-sectional with purposive sampling to outpatient. Any actual ADRs that ocured was calculated using the Naranjo probability scale. The number of hospitalized patients were 60 people and outpatients were 22 people. The number of ADRs that occur were 39 cases, consisted of 36 cases of ADRs in  hospitalized patients with asthma and 3 cases of ADRs in outpatient asthma patients. Drug groups most involved in ADRs was B2-agonist group. Naranjo scale calculations on ADRs that occured that the possibility of ADRs. The most common ADRs are in asthma therapy, so it takes the role of pharmacists in monitoring ADRs in asthma treatment to prevent and minimize the occurrence of ADRs.Keywords : asthma, naranjo scale, hospitalized patient, outpatient.
Enkapsulasi Ekstrak Daun Murbei untuk Peningkatan Absorpsi In-vitro Kandungan Rutin Aminah, Siti
Jurnal Farmasi Indonesia Vol 7, No 2 (2014)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v7i2.237

Abstract

The extract is a preparation that widely used of  medicinal purposed plants. Rutin is an  ingredient contained in the extract of mulberry leaves (Morus alba L.)   and has very low solubility in water. Drugs with a low solubili ty will have difô???iculty in the process of absorption.  In this study, chitosan is used for encapsulation formation of mulberry extract; furthermore, the encapsulated extract was then   investigated the in- vitro absorption of the rutin.  The extract was made using 95% ethanol by remaceration method. The encapsulation formulas consist of 0.25 % w/v mulberry extract, chitosan TPP mass ratio of 0.5:1 and of 1:1.  The content of rutin in the extract was determined by using HPLC.   Characterization was done on the particle size, zeta potential, encapsu-lation efô???iciency and FTIR. In-vitro absorptions of rutin in the  mulberry leaves extract and of rutin in the encapsulated extract were carried out by Everted Small Intestine Sac Technique. The results showed that mulberry extract contains rutin as much as 0.879 ± 0.138 mg/g.  Formulation with chitosan-TPP mass ratio of  0.5:1 and 1:1 formed par-ticles with sizes of  99.23±16.74 nm and 420.13± 30.52 nm, zeta potentials of 47.94±6.28 mV and -8.78± -1.36 mV, encapsulation efô???iciency of  76.14 ± 2.29 %  and 59.06 ± 12.24 % respectively. Rutin  absorption of the formulation with chitosan-TPP increased sig-niô???icantly (p< 0.05) as shown by increased their permeabilities. The absorption rate of rutin in the extract increased by encapsulation (p< 0.05).
Validasi Metode Penetapan Kadar Lisinopril dalam Spiked Plasma Secara Ultra Performance Liquid Chromatography Melalui Derivatisasi dengan 1-Fluoro 2,4 Dinitrobenzen Sumiyani, Ririn; Martono, Sudibyo; Sugiyanto, .
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.293 KB) | DOI: 10.35617/jfi.v8i1.417

Abstract

ABSTRACT: A rapid, accurate, and sensitive method for determining lisinopril in spiked plasma was developed by means using an Ultra Performance Liquid Chromatography (UPLC) with 1-fluoro 2,4 dinitrobenzen (FDNB) derivatization. Lisinopril was precolumn derivatized with FDNB at optimum condition, i.e. room temperature and borate buffer at pH 11, subsequently analyzed with UPLC. Isocratic condition of acetate buffer (0.01 M, pH 3.50) : acetonitrile : metanol = 70 : 10 : 20 (v/v/v) as mobile phase, 0.3 mL/min of flow rate at λ 296 nm were applied at Acquity BEH C18 column, resulting a linearity of lisinopril at range of concentration of 5,0-100 ng/mL (Y = 410,59x + 211,91, r = 0.93). The accuration of the established method was achieved by 88,59±6,01 to 101,70± 2,56% recovery, while the precision was shown with RSD value of 2,57- 8,16 %, limit of detection (LOD) instrument of 0,73 ng/mL and limit of quatification (LOQ) 2,44 ng/mL, dwith R2 = 0,9987 dan r = 0,9993. In addition, the resulted LOD and LOQ more or less similar with the published HPLC-MS-MS method (1.03-10.0 ng/mL). Hence, it could be concluded that the developed UPLC method can be used as an alternative method for determining lisinopril in plasma.Keywords: Lisinopril, FDNB, derivatization, UPLCABSTRAK: Penetapan kadar lisinopril dalam spiked plasma secara Ultra Performance Liquid Chromatography (UPLC) melalui derivatisasi dengan 1-fluoro 2,4 dinitrobenzen (FDNB) merupakan metode yang cepat, sensitif dan akurat. Derivatisasi precolumn lisinopril dan FDNB optimum pada suhu kamar, suasana dapar borat pH 11,0, dilanjutkan analisis secara UPLC isokratis menggunakan kolom Acquity BEH C dan fase gerak dapar asetat (0,01 M pH 3,50): asetonitril:metanol (70: 10: 20, v/v/v), laju alir 0,3 mL/menit pada λ 296 nm, menghasilkan linieritas kadar lisinopril dalam spiked plasma pada rentang 5,0 -100 ng/mL terhadap luas area lisinopril-DNB dengan persamaan Y = 410,59x + 211,91 dengan R2 = 0,9987 dan r = 0,9993 Akurasi metode ditunjukkan dengan nilai % rekoveri sebesar 88,59±6,01 smpai dengan 101,70± 2,56 %. Ketelitian ditunjukkan dengan nilai RSD 2,57- 8,16 %, sedangkan Batas Deteksi Instrumen = 0,73 ng/ mL dan Batas Kuantitasi = 2,44 ng/mL. Hasil Batas Deteksi penelitian ini relatif sama dengan Batas Deteksi penetapan kadar lisinopril secara HPLC-MS (1,03- 10,0 ng/mL). Dengan demikian dapat disimpulkan bahwa metode ini berpotensi dikembangkan sebagai metode alternatif pengganti HPLC-MS untuk penetapan lisinopril dalam plasma.Kata kunci: Lisinopril, FDNB, derivatisasi, UPLC

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