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Oto Rhino Laryngologica Indonesiana
Published by Perhimpunan Dokter Spesialis Telinga Hidung dan Tenggorok Bedah Kepala Leher Indonesia
ISSN : 02163667     EISSN : 25983970     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Journal Othorhinolaryngologica Indonesiana is a peer-reviewed and open access journal that focuses on promoting otorhinolaryngology-head and neck surgery that publishes research reports, case reports, and literature reviews, to increase knowledge and updating diagnostics procedurs on otorhinolaryngology-head and neck surgery.
Arjuna Subject : -
Articles 493 Documents
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Correlation between duration of chronic renal failure patients undergoing hemodialysis and sensorineural hearing loss Primadewi, Novi; Pratiwi, Dewi; Dewi, Taufani
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 2 (2022): VOLUME 52, NO. 2 JULY - DECEMBER 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i2.453

Abstract

ABSTRACTBackground: Along with the increasing incidence of chronic renal failure patients receiving hemodialysis, recently, the incidence of sensorineural hearing loss (SNHL) among patients with end-stage kidney disease undergoing hemodialysis had also increased. The cochlea and kidney have many anatomical, physiological, pharmacological and pathological similarities. Dialysis sometimes causes worsening of hearing function. Objective: To determine the correlation between the duration of renal failure patients undergoing hemodialysis and the degree of sensorineural hearing loss. Method: A retrospective study using cross sectional method, conducted from August–September 2018. The study began by identifying patients with chronic renal failure and then continued with Oto Acoustic Emission (OAE) examination and pure tone audiometry. Result: The results of the Spearman rank statistical test for the correlation between duration of hemodialysis and the degree of SNHL in the right and left ears in patients with chronic renal failure found a significant positive correlation r= 0.498 and p=0.001 (right) , and r= 0.400 and p=0.006 (left). Conclusion: There was a significant correlation between the length of hemodialysis and the degree of sensorineural hearing loss. ABSTRAKLatar belakang: Seiring dengan peningkatan angka kejadian pasien gagal ginjal kronik yang mendapatkan hemodialisa, akhir-akhir ini didapati peningkatan angka kejadian Sensorineural Hearing Loss (SNHL) di antara pasien dengan penyakit ginjal stadium akhir yang menjalani hemodialisa. Koklea dan ginjal memiliki banyak kesamaan anatomis, fisiologis, farmakologis dan patologis. Dialisa terkadang menyebabkan memburuknya fungsi pendengaran. Tujuan: Untuk mengetahui hubungan lama pasien gagal ginjal yang menjalani hemodialisa dengan derajat gangguan pendengaran tuli sensorineural. Metode: Penelitian retrospektif dengan metode potong lintang, dilakukan dari Agustus-September 2018. Penelitian dimulai dengan mengidentifikasi pasien gagal ginjal kronik kemudian dilanjutkan dengan pemeriksaan tes Oto Acoustic Emission (OAE) dan audiometri nada murni. Hasil: Hasil uji statistik Spearman rank untuk korelasi lama hemodialisa dengan derajat SNHL telinga kanan dan kiri pada pasien gagal ginjal kronik didapatkan korelasi positif yang signifikan: r= 0,498 dan p=0,001 (kanan) dan r= 0,400 dan p=0,006 (kiri). Kesimpulan: Terdapat korelasi yang bermakna antara lama hemodialisis dengan derajat tuli sensorineural.
Relationship mastoid pneumatization and eustachian tube shape with tympanic cavity in chronic otitis media Herjanto, Ferry; Naftali, Zulfikar; Santosa, Yanuar Iman; Hendaraningrum, Farah
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 2 (2022): VOLUME 52, NO. 2 JULY - DECEMBER 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i2.457

Abstract

ABSTRACTBackground: Chronic suppurative otitis media (CSOM) is one of the causes of morbidity and mortality in developing countries. The worldwide prevalence of CSOM according to WHO is estimated at 330 million people. Pneumatic type mastoid pneumatization, narrow Eustachian tube angle, and narrow Eustachian tube diameter in the diseased ear can result in cholesteatoma formation. Objective: This study aimed to determine the relationship between mastoid pneumatization, Eustachian tube angle and diameter with tympanic cavity abnormalities in CSOM patients. Methods: This was a retrospective analysis study using cross sectional method. The data were taken from the patient’s medical records at Dr. Kariadi Hospital, Semarang, from January 2020 to June 2021. Subjects were CSOM sufferers. Mastoid multisliced computed tomography (MSCT) scan examination was carried out in the Radiology Section, using the AW Volume Share 5 application, to assess the type of mastoid pneumatization, Eustachian tube angle, Eustachian tube diameter, and tympanic cavity abnormalities in the form of cholesteatoma, granulation, and erosion of the ossicles. Statistical analysis using Chi Square test, and multivariate test. Result: There were 90 subjects with CSOM, 44 (48.9%) had tympanic cavity abnormalities and 46 (51.1%) without tympanic cavity abnormalities. Sclerotic mastoid pneumatization was more than pneumatic (p=0.001), narrow Eustachian tube angle (p=0.041), and narrow Eustachian tube diameter (p=<0.001). Logistic regression results showed that mastoid pneumatization had a dominant relationship to abnormalities in the tympanic cavity. Conclusion: There was a relationship between sclerotic mastoid pneumatization, narrow Eustachian tube angle, and narrow Eustachian tube diameter with abnormalities in the tympanic cavity. ABSTRAKLatar belakang: Otitis media supuratif kronik (OMSK) merupakan salah satu penyebab morbiditas serta mortalitas di negara berkembang. Prevalensi OMSK menurut WHO di seluruh dunia diperkirakan 330 juta orang. Pneumatisasi mastoid tipe pneumatik, sudut tuba Eustachius yang sempit, dan diameter tuba Eustachius yang lebih sempit pada telinga yang sakit dapat menyebabkan terjadinya kolesteatoma. Tujuan: Penelitian bertujuan untuk mengetahui hubungan pneumatisasi mastoid, sudut dan diameter tuba Eustachius dengan kelainan kavum timpani pada penderita OMSK. Metode: Merupakan penelitian analisis retrospektif menggunakan metode cross sectional. Data diambil dari rekam medis pasien di RSUP Dr.Kariadi Semarang, dari Januari 2020 sampai Juni 2021. Subjek adalah penderita OMSK. Pemeriksaan multisliced computed tomography (MSCT) scan mastoid dilakukan di Bagian Radiologi, dengan aplikasi AW Volume Share 5, untuk menilai jenis pneumatisasi mastoid, sudut tuba Eustachius, diameter tuba Eustachius, dan kelainan kavum timpani berupa kolesteatoma, granulasi, dan erosi pada osikula. Analisis statistik menggunakan uji Chi Square, dan uji multivariat. Hasil: Didapatkan 90 subjek penderita OMSK, adanya kelainan kavum timpani 44 (48,9%) dan yang tidak adanya kelainan kavum timpani 46 (51,1%). Pneumatisasi mastoid sklerotik lebih banyak daripada pneumatik (p=0,001), sudut tuba Eustachius sempit (p=0,041), dan diameter tuba Eustachius pendek (p=<0,001. Hasil regresi logistik menunjukan bahwa pneumatisasi mastoid memiliki hubungan yang dominan terhadap kelainan pada kavum timpani. Kesimpulan: Terdapat hubungan antara pneumatisasi mastoid sklerotik, sudut tuba Eustachius sempit, dan diameter tuba Eustachius kecil dengan kelainan pada kavum timpani.  
Factors associated with the length of stay of deep neck abscess patients Yanti, Lisa Apri; Lubis, Friska Meutia; Bahar, Erial; Ghanie, Abla
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 1 (2022): VOLUME 52, NO. 1 JANUARY - JUNE 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i1.473

Abstract

ABSTRACTBackground: Deep neck abscess is an accumulation of pus in one or more potential spaces of the deep neck fascia. Complications of deep neck abscesses are considered as an emergency in the Ear Nose Throat–Head and Neck field. One determining factor of prognosis in deep neck abscess patients is the length of stay in the hospital.  Objective: To find out the factors associated with the hospital length of stay of deep neck abscess patients. Method: Observational research using a cross sectional design. Data collection was carried out using medical record data on 91 subjects diagnosed with deep neck abscess at Dr. Mohammad Hoesin Hospital Palembang from July 2018 to May 2021. Result: From the 91 samples studied, the average hospital length of stay for deep neck abscess patients was 11.26 days. The study found factors related to the length of stay in the hospital, namely comorbidities (p=0.005), location of the abscess (p=0.004), pus culture (p=0.003), and the number of deep-neck spaces involved (p=0.005). Linear regression found that the most significant factors on the hospital length of stay were the involvement of abscess in 2 or more deep neck spaces (p = 0.002) and the presence of comorbidities (p = 0.005). Conclusion: Abscess involvement in 2 deep neck spaces or more and the presence of comorbidities were the most influential factors associated with the hospital length of stay in deep-neck abscess patients.ABSTRAKLatar Belakang: Abses leher dalam adalah akumulasi pus pada satu atau lebih ruang potensial fasia leher dalam sebagai akibat penjalaran infeksi. Komplikasi abses leher dalam masih merupakan keadaan darurat di bidang THT-KL. Salah satu faktor penentu prognosis adalah lama rawat di rumah sakit. Banyak faktor yang dapat mempengaruhi lama rawat pasien abses leher dalam di rumah sakit. Tujuan: Untuk mengetahui faktor-faktor yang berhubungan dengan lama rawat pasien abses leher dalam di RSUP Dr. Mohammad Hoesin Palembang. Metode: Penelitian observasional yang menggunakan rancangan potong lintang. Pengumpulan data dilakukan dengan menggunakan data rekam medis pada 91 subjek dengan diagnosis abses leher dalam di RSUP Dr. Mohammad Hoesin Palembang periode Juli 2018 sampai dengan Mei 2021. Hasil: Dari 91 sampel yang dilakukan penelitian, rerata lama rawat di rumah sakit pada pasien abses leher dalam adalah 11,26 hari. Penelitian mendapatkan faktor yang berhubungan dengan lama rawat di rumah sakit yaitu komorbid (p=0,005), lokasi abses (p=0,004), kultur pus (p=0,003), dan jumlah ruang leher dalam yang terlibat (p=0,005). Dari uji regresi linier didapatkan faktor yang paling memengaruhi lama rawat di rumah sakit adalah keterlibatan abses ³ 2 ruang leher dalam (p=0,002) dan terdapat komorbid (p=0,005). Kesimpulan: Keterlibatan abses pada 2 ruang leher dalam atau lebih, dan terdapatnya komorbid adalah faktor yang paling berpengaruh terhadap lama rawat pasien abses leher dalam.
Clinicopathological profile of nasopharyngeal carcinoma in 2016-2019 at Dr. Soetomo General Hospital Susetiyo, Karindra Amadea; Kusumastuti, Etty Hary; Yusuf, Muhtarum; Falerina, Rosa
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 1 (2022): VOLUME 52, NO. 1 JANUARY - JUNE 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i1.474

Abstract

ABSTRACTBackground:.The number of nasopharyngeal carcinoma (NPC) cases is increasing and causing death, placing this cancer in fifth place as the cause of death in Indonesia. The initial clinical symptoms that are less specific often cause patients coming with advanced stage conditions. Therefore, the study of clinical and pathological profiles of NPC patients are required. Objective: To find out the clinicopathological profile of  NPC patients in Dr. Soetomo General Hospital in 2016-2019. Methods: This study was descriptive research with a retrospective study using medical records of NPC patients in Dr. Soetomo General Hospital from 2016 to 2019. Results:  192 NPC patients that meet the criteria were divided according to their age, gender, histopathological classification, stage, and post-therapy response. Out of 192 patients, 22 patients had post-therapy response based on histopathological data. Conclusion: NPC patients in Dr. Soetomo General Hospital in 2016-2019 were found in the range of 14-77 years old, most patients were in the age group 41-≤50 years old (66 patients, 34%). There were more male than female patients (73%). The most common clinical symptoms experienced by patients were a lump on the neck (82%), local ear complaints (79%), and local nasal complaints (75%). The most common histopathological subtype was non-keratinizing squamous cell carcinoma undifferentiated in 181 patients (94%). The highest stage of patients was IV A in 122 patients (64%). In 18 (82%) from 22 patients, based on histopathology examination had good criteria on therapy response. ABSTRAKLatar belakang: Angka kasus karsinoma nasofaring yang (KNF) kian meningkat dan dapat menyebabkan kematian, menempatkan kanker ini pada urutan ke lima di Indonesia. Gejala klinis awalnya yang kurang spesifik seringkali menyebabkan penderita datang dengan kondisi stadium lanjut. Oleh karena itu, profil penderita KNF secara klinis dan gambaran histopatologinya perlu diteliti lebih lanjut. Tujuan: Mengetahui profil klinikopatologi penderita KNF di RSUD Dr. Soetomo tahun 2016-2019. Metode: Penelitian secara deskriptif dengan studi retrospektif menggunakan rekam medis penderita KNF di RSUD Dr. Soetomo tahun 2016-2019. Hasil:  Sebanyak 192 penderita KNF yang memenuhi kriteria dibagi berdasarkan kategori usia, jenis kelamin, klasifikasi histopatologi, stadium, dan respon pasca terapi. Dari 192 penderita ditemukan sebanyak 22 penderita memiliki data respon pasca terapi berdasarkan histopatologi. Kesimpulan: Penderita KNF di RSUD Dr.Soetomo tahun 2016-2019 ditemukan pada rentang usia 14-77 tahun dengan penderita terbanyak pada rentang usia 41- 50 yaitu 66 (34%) serta lebih banyak terjadi jenis kelamin laki-laki yaitu 140 (73%). Gejala klinis yang paling banyak dialami penderita adalah benjolan pada leher 158 (82%), keluhan lokal telinga 151 (79%), dan lokal hidung 144 (75%). Subtipe histopatologi terbanyak adalah nonkeratinizing squamous cell carcinoma undifferentiated yaitu 181 (94%) penderita. Stadium terbanyak penderita adalah IV A yaitu 122 (64%) penderita. Sebanyak 18 (82%) dari 22 penderita berkriteria baik pada respon terapi berdasarkan histopatologi.
Comparison of fiberoptic endoscopic examination of swallowing findings between neurogenic and non-neurogenic dysphagia patients Zuleika, Puspa; Jalili, Melania; Bahar, Erial; Ghanie, Abla
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 1 (2022): VOLUME 52, NO. 1 JANUARY - JUNE 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i1.475

Abstract

ABSTRACTBackground: Dysphagia is the difficulty or discomfort on swallowing which can affects a person’s quality of life. Based on pathophysiology, dysphagia can be classified as neurogenic and non-neurogenic. One method of diagnosis is to use a flexible endoscope called the Fiberoptic Endoscopic Examination of Swallowing (FEES). The basic findings obtained from the FEES examination were standing secretion, silent aspiration, hypopharyngeal sensitivity, leakage, residue, penetration and aspiration. Objective: To compare the findings of the FEES examination between patients with neurogenic and non-neurogenic dysphagia. Method: Observational research using cross sectional design. Data collection was carried out using medical record data on 94 subjects with dysphagia who underwent FEES examination at Dr. Mohammad Hoesin Hospital Palembang from January 2019 to January 2021. Result: The most common FEES finding in neurogenic dysphagia were filtered purée residue, milk residue, and biscuit residue. In the non-neurogenic dysphagia group, the most common FEES finding was filtered purée residue. There were significant differences in FEES findings between neurogenic dysphagia and non-neurogenic dysphagia in filtered purée residue (p=0.014), rice purée residue (p=0.017), flour purée residue (p=0.007), and biscuit puree penetration (p=0.017). Conclusion: There were significant differences in FEES findings between neurogenic dysphagia and non-neurogenic dysphagia concerning residue of filtered purée, residue of rice purée, residue of flour purée, and biscuit penetration. From regression analysis, the dominant factors found in neurogenic dysphagia were filtered purée penetration, flour purée residue, biscuit penetration, and found in non-neurogenic dysphagia were flour purée penetration and biscuit puree leakage.ABSTRAKLatar belakang: Disfagia adalah kesulitan atau gangguan proses menelan, yang dapat memengaruhi kualitas hidup seseorang. Berdasarkan patofisiologinya, disfagia dapat diklasifikasikan menjadi neurogenik dan non-neurogenik. Salah satu metode diagnosis adalah dengan menggunakan Fiberoptic Endoscopic Examination of Swallowing (FEES). Temuan dasar yang diperoleh dari pemeriksaan FEES adalah standing secretion, silent aspiration, sensitivitas hipofaring, leakage, residu, penetrasi dan aspirasi. Tujuan: Membandingkan hasil pemeriksaan FEES antara pasien disfagia neurogenik dan non-neurogenik. Metode: Penelitian observasional dengan desain potong lintang. Pengumpulan data dilakukan dengan menggunakan data rekam medis pada 94 subjek disfagia yang menjalani pemeriksaan FEES di Rumah Sakit Dr. Mohammad Hoesin Palembang dari Januari 2019 hingga Januari 2021. Hasil: Temuan FEES yang paling umum pada disfagia neurogenik adalah residu bubur saring, residu susu, dan residu biskuit. Pada kelompok disfagia non-neurogenik, temuan FEES yang paling umum adalah residu bubur saring. Terdapat perbedaan yang signifikan dalam temuan FEES antara disfagia neurogenik dan disfagia non-neurogenik pada residu bubur saring (p=0,014), residu bubur nasi (p=0,017), residu bubur tepung (p=0,007), dan penetrasi bubur biskuit (p=0,017). Kesimpulan: Terdapat perbedaan yang signifikan dalam temuan FEES antara disfagia neurogenik dan disfagia non-neurogenik pada residu bubur saring, residu bubur beras, residu bubur tepung, serta penetrasi bubur biskuit.  Dari analisis regresi ditemukan faktor dominan di disfagia neurogenik adalah penetrasi bubur saring, residu bubur tepung, penetrasi bubur biskuit, dan di disfagia non-neurogenik adalah penetrasi bubur tepung dan kebocoran bubur biskuit.
Relationship between stunting and clinical ear, nose and throat disorders Wibowo, Aryo Mandraguna; Dermawan, Arif; Anggraeni, Ratna
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 1 (2022): VOLUME 52, NO. 1 JANUARY - JUNE 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i1.486

Abstract

ABSTRACTBackground: Stunting is an impediment marker for child welfare. Based on the United Nations Nutrition report, in 2018, as many as 50.5 million children worldwide under the age of 5 years were wasting and 150.8 million were stunting. Stunting is associated with morbidity, mortality, stunted-child- development, decreased learning capacity, increased risk of infection, and decreased productivity. Until now, stunting is still a problem in many countries, including Indonesia which calls for serious solution. Stunting is associated with deficiencies of micronutrients such as vitamins A, D, zinc and iron resulting in impaired physical development and decreased immune system. In the field of ORL-HNS, stunting in toddlers could cause various disorders such as impaired hearing development, otitis media, rhinitis, and tonsillitis. Purpose: To describe the relationship between stunting and clinical abnormalities occurrence in the ORL-HNS, to increase awareness of stunting prevention and the related ORL-HNS disorders, and to be a reference for further research of ORL-HNS disorders in stunting patients. Literature review: Stunting or failure to thrive is a condition that describes a chronic undernutrition status during a child’s growth and development since the beginning of life, which is represented by a z-score of height for age less than minus two standard deviations based on the WHO growth standard curve. Conclusion: Stunting is a condition caused by an unbalanced nutritional intake during the golden period, not by growth hormone abnormalities, nor by certain diseases. Micronutrient deficiency could have a role in the occurrence of several clinical abnormalities of ORL-HNS in stunting children.ABSTRAKLatar belakang: Stunting merupakan penanda untuk kesejahteraan anak. Berdasarkan laporan United Nations Nutrition pada tahun 2018 sebanyak 50,5 juta anak di seluruh dunia yang berusia di bawah 5 tahun mengalami wasting dan sebanyak 150,8 juta mengalami stunting. Stunting berhubungan dengan morbiditas, mortalitas, terhambatnya perkembangan anak, penurunan kapasitas belajar, peningkatan risiko infeksi, dan penurunan produktivitas. Hingga saat ini, stunting masih menjadi salah satu permasalahan yang perlu diperhatikan di banyak negara, termasuk di Indonesia. Stunting berhubungan dengan defisiensi mikronutrien seperti vitamin A, D, zink dan zat besi yang berakibat terganggunya perkembangan fisik dan penurunan sistem imunitas. Di bidang THT-KL, stunting pada balita diduga dapat menimbulkan berbagai kelainan seperti gangguan perkembangan pendengaran, otitis media, rinitis, dan tonsilitis. Tujuan: Untuk menggambarkan adanya hubungan stunting dengan terjadinya kelainan klinis di bidang THT–KL, meningkatkan kewaspadaan untuk mencegah stunting dan    kelainan THT-KL yang berhubungan dengan stunting, serta dapat menjadi rujukan penelitian lebih lanjut mengenai prevalensi gangguan THT-KL pada pasien dengan stunting. Tinjauan pustaka: Stunting atau gagal tumbuh adalah suatu kondisi yang menggambarkan status gizi kurang yang memiliki sifat kronis pada masa pertumbuhan dan perkembangan anak sejak awal masa kehidupan yang dipresentasikan dengan nilai z-score tinggi badan menurut umur kurang dari minus dua standar deviasi berdasarkan kurva standar pertumbuhan WHO. Kesimpulan: Stunting merupakan kondisi yang disebabkan oleh kurang seimbangnya asupan gizi pada masa periode emas, bukan disebabkan oleh kelainan hormon  pertumbuhan maupun akibat dari penyakit tertentu. Hasil dari beberapa penelitian mengungkapkan bahwa defisiensi mikronutrien dapat berperan terhadap terjadinya beberapa kelainan klinis THT–KL pada anak dengan stunting.
The role of human leucocyte antigen in nasopharyngeal carcinoma Rahman, Sukri; Sari, Jenny Tri Yuspita; Grecwin, Debby Apri; Hafiz, Al
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 1 (2022): VOLUME 52, NO. 1 JANUARY - JUNE 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i1.487

Abstract

ABSTRACTBackground: The cause of Nasopharungeal Carcinoma (NPC) is an interaction of multiple factors. The main etiologic factors are Epstein-Barr virus (EBV) infection which interacts with genetic susceptibility, and environmental factors. The growth of malignancy due to the virus is largely determined by the host immune response. Human leukocyte antigen (HLA) plays a significant role in presenting viral antigens, which is the key in determining the impact of the host immune response against this viral infection. Purpose: To discuss the role of HLA in NPC. Literature review: Individuals with specific HLA alleles may experience a decreased ability to present viral antigens and be less efficient in triggering an immune response against EBV-infected cells resulting in increased susceptibility to NPC and vice versa, so those specific HLA alleles may be protective. Various studies have reported the association of HLA alleles with NPC. The results of these studies are not always consistent. In the study of HLA class I, HLA-A2 and HLA-B46 alleles were the most consistently increasing frequency in NPC, while HLA-A11, HLA-B13, and HLA-B27 alleles were associated with a decreased risk of NPC. The HLA-DRB1*03, *08, *09, and *10 alleles contributed to susceptibility to NPC, while the HLA-DRB1*11 and *12 alleles were protective factors against NPC. Conclusion: Genetic factors are important risk factors for NPC, many studies have consistently reported the role of HLA in the pathogenesis of NPC, where specific HLA alleles cause susceptibility to NPC growth, but several HLA alleles are also associated with a reduced risk of NPC.ABSTRAKLatar belakang: Penyebab terjadinya Karsinoma Nasofaring (KNF) merupakan interaksi dari beberapa faktor. Faktor etiologi utama adalah infeksi virus Epstein-Barr (EBV) yang berinteraksi dengan kerentanan genetik, dan faktor lingkungan. Pertumbuhan keganasan akibat virus sangat ditentukan oleh respon imun host. Human Leucocyte Antigen (HLA) berperan penting dalam penyajian antigen virus, yang merupakan kunci dalam menentukan dampak respon imun host terhadap infeksi virus ini. Tujuan: Membahas peran HLA pada KNF. Tinjauan pustaka: Individu dengan alel HLA spesifik dapat mengalami penurunan kemampuan untuk mempresentasikan antigen virus dan kurang efisien dalam memicu respon imun terhadap sel yang terinfeksi EBV yang mengakibatkan peningkatan kerentanan terhadap KNF dan sebaliknya, sehingga alel HLA tertentu mungkin bersifat protektif. Berbagai penelitian telah melaporkan hubungan alel HLA dengan KNF. Hasil dari berbagai penelitian tersebut tidak selalu konsisten. Pada studi HLA kelas I, alel HLA-A2 dan HLA-B46 adalah yang paling konsisten frekuensinya meningkat pada KNF, sedangkan alel HLA-A11, HLA-B13 dan HLA-B27 dikaitkan dengan penurunan risiko KNF. Alel HLA-DRB1*03, *08, *09 dan *10 berkontribusi terhadap kerentanan terhadap KNF, sedangkan alel HLA-DRB1*11 dan *12 merupakan faktor protektif terhadap KNF. Kesimpulan: Faktor genetik merupakan faktor risiko penting pada KNF, berbagai penelitian konsisten melaporkan peran HLA dalam patogenesis KNF, di mana alel HLA tertentu menyebabkan kerentanan terhadap pertumbuhan KNF, sementara beberapa alel HLA juga terkait dengan penurunan risiko KNF.
The effect of neutrophil-lymphocyte ratio on neck nodule size in nasopharyngeal carcinoma chemotherapy -, Soehartono; Novitasari, Dwi; Maharani, Iriana
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 2 (2022): VOLUME 52, NO. 2 JULY - DECEMBER 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i2.490

Abstract

ABSTRACTBackground: Nasopharyngeal carcinoma (NPC) is a cancer of the head and neck, that ranks as the 4th most malignant cancer in Indonesia. The prognosis of NPC patients is determined from the clinical stage based on the Tumor, Nodule, Metastatic (TNM) classification system. These prognosis factors are not entirely reliable for predicting treatment outcomes. The Neutrophil Lymphocyte Ratio (NLR) represents an index of pro-tumor and anti-tumor activity, that can be used to predict the outcome of neoadjuvant chemotherapy and the patient’s well-being as assessed by Karnofsky status, Body Mass Index (BMI), and neck nodule size (NNS). Purpose: To study the effect of NLR on Karnofsky status, BMI, and NNS in WHO type III NPC patients who underwent 3 cycles of neoadjuvant chemotherapy. Method: Analytical observational research with a cohort-retrospective approach on WHO type III NPC subjects who underwent platinum-based regimen neoadjuvant chemotherapy. NLR pre-chemotherapy was analyzed for its effect on Karnofsky status, BMI, and NNS. Result: NLR had no significant effect on Karnofsky status pre- and post-chemotherapy, BMI pre- and post-chemotherapy, NNS pre-chemotherapy, changes in Karnofsky status and BMI pre-and post-chemotherapy, but had significant effect on the size of neck nodules post-chemotherapy, and changes in the size of neck nodules. Conclusion: NLR has no significant effect on Karnofsky status, on BMI pre- and post-chemotherapy, and neck nodule size pre-chemotherapy. However, NLR had a significant effect on neck nodule size post-chemotherapy and neck nodule size changes. ABSTRAKLatar belakang: Karsinoma Nasofaring (KNF) merupakan keganasan dalam bidang THT yang menempati urutan ke-4 keganasan di Indonesia. Prognosis pasien KNF terutama ditentukan dari stadium klinis berdasarkan sistem klasifikasi Tumor, Nodul, Metastasis (TNM) yang tidak sepenuhnya dapat diandalkan untuk memprediksi hasil pengobatan. Sedangkan Ratio Netrofil-Limfosit (RNL) mempresentasikan indeks aktivitas protumor dan antitumor sehingga dapat digunakan sebagai pelengkap stadium klinis untuk memprediksi hasil kemoterapi neoadjuvan dan kesejahteraan subjek melalui status Karnofsky, Index Massa Tubuh (IMT) dan ukuran nodul leher. Tujuan: Mempelajari efek Rasio Netrofil-Limfosit (RNL), Index Massa Tubuh (IMT), dan ukuran nodul leher pada subjek dengan KNF WHO tipe III yang telah menjalani 3 siklus kemoterapi neoadjuvan. Metode: Penelitian observasional analitik dengan pendekatan kohort-retrospektif menggunakan data rekam medis penderita KNF tipe III WHO yang menjalani kemoterapi neoadjuvan menggunakan regimen berbasis platinum. RNL sebelum kemoterapi dianalisis pengaruhnya terhadap status Karnofsky, IMT dan ukuran nodul leher. Hasil: RNL berpengaruh tidak signifikan terhadap status Karnofsky sebelum dan sesudah kemoterapi, IMT sebelum dan sesudah kemoterapi, ukuran nodul leher sebelum kemoterapi, perubahan status Karnofsky, perubahan IMT, namun berpengaruh signifikan terhadap ukuran nodul leher sesudah kemoterapi dan perubahan ukuran nodul leher. Kesimpulan: RNL berpengaruh tidak signifikan terhadap status Karnofsky, IMT sebelum dan sesudah kemoterapi, ukuran nodul leher sebelum kemoterapi, namun berpengaruh signifikan terhadap ukuran nodul leher sesudah kemoterapi dan perubahan ukuran nodul leher sebelum kemoterapi, namun berpengaruh signifikan terhadap ukuran nodul leher sesudah kemoterapi dan perubahan ukuran nodul leher.
Correlation of LMP-1 expression with KRAS and Cyclin-D1 expressions in WHO type III NPC patients Neri, Rizki Amelia Yurika; Soehartono, Soehartono; Surjotomo, Hendradi
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 1 (2024): VOLUME 54, NO. 1 JANUARY - JUNE 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i1.493

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a malignancy with pathologically andepidemiologically unique characteristics. The risk factors that are often associated with NPC are chronicEBV infection, environmental factors, and epigenetic changes. EBV infection expresses Latent MembraneProtein-1 (LMP-1) in NPC. The role of LMP-1 is to activate signaling pathways, including KRAS-RAFMEK-ERK which induces transcription of cyclin D1 that contributes to cell proliferation. Purpose: Todetermine the correlation between LMP-1 expression and KRAS expression, LMP-1 expression with cyclinD1 expression, and KRAS expression with cyclin D1 expression in nasopharyngeal tissue of WHO typeIII NPC patients. Method: Analytical observational study with a cross-sectional approach involving 30paraffin blocks of biopsy tissue from NPC patients who had not received radiotherapy or chemotherapy.Expression of LMP-1, KRAS, and cyclin D1 was examined with immunohistochemical staining methodand calculated using manual counting by anatomical pathologists. Result: Statistical analysis of LMP-1expression with KRAS expression showed an insignificant positive correlation (p=0.546) with a correlationcoefficient (ρ=0.115). The LMP-1 expression with cyclin D1 expression showed an insignificant positivecorrelation (p=0.305) with a correlation coefficient (ρ=0.194). The KRAS expression with cyclin D1expression showed an insignificant positive correlation (p=0.262) with a correlation coefficient (ρ=0.212). Conclusion: In WHO type III NPC tissue in the proliferative process, an increase in LMP-1 expression(53.4%±27.35%,) was followed by an increase in KARS expression (49.83%±22.83%) and D1 expression(42.27%±31.94%) as well as an increase in KRAS expression (42.27%±31.94%) followed by an increasein cyclin D1 expression (42.27%±31.94%) although not significant.
Caldwell-Luc approach for odontogenic maxillary sinusitis Irfandy, Dolly; Budiman, Bestari Jaka; Ivanny, Putri Sari
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 2 (2022): VOLUME 52, NO. 2 JULY - DECEMBER 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i2.500

Abstract

ABSTRACTBackground: Maxillary odontogenic sinusitis is a maxillary sinusitis of dental origin. Odontogenic origin of infection must be suspected in those sinusitis patients who have symptoms of unilateral maxillary sinusitis, sinonasal symptoms such as nasal obstruction, rhinorrhea, and/or foul odour, a history of dental pain or dental/oral surgical treatment, and in those who are resistant to conventional treatment of sinusitis. Purpose: To report and analyze the result of Caldwell-Luc approach for odontogenic maxillary sinusitis. Case report: One case of odontogenic maxillary dextra sinusitis treated by Caldwell-Luc approach. After 2 months of follow-up, there was no thick and smelly discharge coming out of the nose, no complaints of pain in the nose, nor swelling and numbness of the cheeks and gums. Clinical question: “Does Caldwell-Luc approach provide good result for odontogenic maxillary sinusitis?” Review method: Literature searching was performed through Cochrane database, PubMed, ClinicalKey, and Google Scholar using keywords “Caldwell-Luc” and “odontogenic sinusitis.” Result: The search obtained 76 literatures which were related to clinical question. Afterwards filtered with eligible criteria, had resulted 21 relevant literatures. Conclusion: The choice of Caldwell-Luc approach for treating odontogenic maxillary sinusitis is a less invasive procedure and gave a satisfying result. Overlooking to identify a dental cause of maxillary sinusitis could lead to persistent symptoms, and failure of medical, as well as surgical intervention. ABSTRAKLatar belakang: Sinusitis maksilaris odontogenik adalah sinusitis maksilaris yang bersumber dari infeksi gigi. Sumber infeksi odontogenik harus dipikirkan ketika ditemukan gejala sinusitis maksila unilateral, gejala sinonasal seperti obstruksi hidung, rinorea dan bau busuk, riwayat infeksi gigi sebelumnya, trauma atau karena prosedur bedah pada tatalaksana gigi, dan pada pasien yang resisten terhadap pengobatan konvensional sinusitis. Tujuan: Melaporkan dan menganalisis hasil pendekatan Caldwell-Luc pada kasus sinusitis maksilaris odontogenik. Laporan Kasus: Satu kasus sinusitis maksilaris odontogenik dekstra yang ditatalaksana dengan pendekatan Caldwell-Luc. Setelah 2 bulan follow-up, tidak ada ingus kental dan berbau busuk yang keluar dari hidung, tidak ada keluhan nyeri di hidung, bengkak dan mati rasa pada pipi dan gusi. Pertanyaan klinis: “Apakah prosedur Caldwell-Luc memberikan hasil terbaik untuk kasus sinusitis maksilaris odontogenik?” Telaah literatur: Dilakukan pencarian melalui database Cochrane, PubMed, CinicalKey dan Google Scholar, menggunakan kata kunci “Caldwell-Luc” dan “sinusitis odontogenic”. Hasil: Diperoleh 76 literatur yang terkait dengan pertanyaan klinis. Setelah disaring dengan kriteria riset, terdapat 21 literatur yang relevan. Kesimpulan: Pemilihan tatalaksana sinusitis maksilaris odontogenik dengan pendekatan Caldwell-Luc merupakan prosedur invasif minimal, dan memberikan hasil yang memuaskan. Bila sumber infeksi dari gigi pada sinusitis maksilaris tidak terdeteksi, hal itu akan menyebabkan gejala persisten, dan kegagalan dalam tatalaksana medikamentosa maupun intervensi bedah.

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