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Jurnal Ilmu Kefarmasian Indonesia

jifi
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Published by Universitas Pancasila

ISSN : 16931831 EISSN : 26146495 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 19 Documents

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Search results for , issue "Vol 17 No 1 (2019): JIFI" : 19 Documents clear

Skrining Fitokimia dan Potensi AktivitaS Antioksidan Ekstrak Etanol Daun Hijau dan Daun Merah Kastuba Baiq Sopiah; Handa Muliasari; Emmy Yuanita
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Free radicals are an atom or molecule that has unpaired electron in its outer orbital that causes maked this reactive and unstable molecule. Free radicals when exposed continuously in the body are believed to cause several diseases include atherosclorosis, ischemia, cancer and premature aging therefore, antioxidant compounds is needed to inhibit the formation of free radicals. Kastuba (Euphorbia Pulcherrima Willd.) is one of the plants that has the potential as a natural antioxidant. The aim of this study was determining the content of active chemical compounds and free radical inhibitory potential of kastuba leaves ethanol ekstract.The procedures of this study were material collection, plant determination, simplicia production, extraction, phytochemical screening and qualitative free radical inhibition test with TLC (Thin Layer Chromatography). Phytochemical screening aim to determine the chemical compounds component of kastuba leaves ethanol extract including flavonoids, tannins and terpenoid test. The potential of free radical inhibition was carried out qualitatively with the TLC, DPPH (1,1-diphenyl-2-picrylhydrazyl) spray reagent. The results showed that kastuba leaves ethanol extract for both green leaves and red leaves contained flavonoids, tannins and terpenoids, and both leaves had the potential as free radical inhibition that indicated by yellow spots on TLC after DPPH reaction spray.

Konsentrasi Kreatinin dan Urea dalam Darah Tikus Putih (Rattus norvegicus) Galur Wistar Akibat Pemberian Natrium Nitrit Dyah Ayu Widyastuti; Maria Asih Ristianti; Ika Maya Sari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Sodium nitrite is one of common food addition in most meat product. This kind of food preservative is allowed by Permenkes No. 722/Menkes/Per/IX/88 only in minimum doses due to its carcinogenic effect. The most targeted organ is kidney which is sensitive to chemical matter as nefrotoxin. When the kidney is damaged, the erytropoietin secretion to form erytrocite is disturbed. Physiological damage in kidney can be identified by the concentration of blood creatinin and urea. The objective of this research is to study about blood creatinin and urea concentration of Wistar rats which is induced by sodium nitrite. Two groups of Wistar rats were induced by two doses of sodium nitrite (11.25 and 22.50 mg/kg body weight, respectively) a day with one group of control. Blood serum of those three groups were then be analyzed for creatinin and urea concentration each week for three months. The result showed that creatinin concertration is fluctuative during the day one to day ninety. The average of creatinin concentration for two treated groups is not significantly lower than control group. Generally, the urea concentration is increasing for day fourteen to seventy seven then decreasing in day eighty four to ninety. However, there are no significant differences among three groups.

Optimasi Formula Sediaan Krim Sunflower (Helianthus annuus L.) Oil Eva Husein; Agatha Budi Susiana lestari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Sunflower oil is one of the components of moisturizing cream that keeps the moisture of the skin. To produce a good quality cream, it is necessary to select appropriate emulsifying agent. This study aims to find the optimum composition between Tween 80 and Span 80 as an emulsifying agent in the preparation of sunflower oil cream, to meet physical properties and physical stability in terms of viscosity, spread ability and viscosity shift for 30 days. The ability of the cream to maintain skin moisture was tested using the Transepidermal Water Loss (TEWL) method. This study used a 22 experimental research design with the Simplex Lattice Design. The results showed there are 3 formulas of Tween 80 and Span 80 in proportion (6:4)%, (7;3)% and (8:2)% that fulfill the requirements with 143,3-153,3 dPas in viscosity, spread ability in range 5,0-5,3 cm, and viscosity shift between 4,3-6,8%. Based on TEWL test, the optimum formula obtained has a moisturizing effect with a TEWL value 17,9-38,0%. It conclude, sunflower oil could be formulated into moisturizing cream using combination of Tween 80 and Span 80 in proportion (6:4)%, (7;3)% and (8:2)% to fulfill the requirements for 30 days and could keep the skin moisture.

Pengaruh Crude Fukoidan dari Ekstrak Sargassum crassifolium terhadap Kadar ICAM-1 dan VCAM-1 pada Sel Raw 264.7 yang Diinduksi Lipopolisakarida Ayu Werawati; Esti Mumpuni; Kusmardi Kusmardi; Dian Ratih Laksmitawati; Syamsudin Abdillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Inflammation is the response of vascular tissue to infection and damaged tissue to remove agents that cause inflammation. Macrophages are the dominant cells in the inflammatory reaction. Adhesion of leukocytes to vascular endothelium is a main feature of the inflammatory process. The presence of adhesion molecules, such as ICAM-1 and VCAM-1, can lead to adhesion of monocytes and lymphocytes to endothelial cells via bonding adhesion molecules to endothelial cells. Crude fukoidan derived from Sargassum crassifolium taken from Garut waters and extracted with dilute HCl, tested for anti-inflammatory activity through inhibition of ICAM-1 and VCAM-1 using lipopolysaccharide-induced RAW 264.7 cell models. The viability test was carried out in the concentration range of 0.49-1000 µg / mL. The pattern of inhibition of cell proliferation is influenced by concentration. The highest concentration that caused cell viability of 80% was the concentration of 86.46μg / ml. Crude fukoidan reduced ICAM-1 and VCAM-1 levels at concentrations of 50 and 25 μg / ml.. Percent inhibition of ICAM-1 at 50 µg / mL concentration was 61.04% compared to control and 74.26% at 25 µg / mL concentration. While the percent inhibition of VCAM-1 a

Aktivitas Senyawa Sargassum sp. sebagai Anti-aterosklerosis dengan Pembandingan Ligan-Reseptor HMG-CoA Reduktase- Simvastatin (1HW9) dan Uji Toksisitas secara In-Silico Sarah Zaidan; Syamsudin Abdillah; Deni Rahmat; Ratna Djamil; Esti Mumpuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Introduction:Sargassum.sp is one of the marine biota published as antiaterosclerosis, but compound toxicity data need to be explored for safety. Method: Virtual screening has been done with MVD software from active compounds contained in sargassum where has activity as antiaterosclerosis with the mechanism of hypolipidemic effects. Test compounds in sargassum include: fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol, phlorotannin, with HMG-COA Reductase-Simvastatin adenosine receptors with a 1HW9 /PDB code. Its toxicity is predicted using pkCSM (online). Results: The value RS, RMSD value as a result of the docking simulation carried out on said compounds, the following results are obtained: fucoidan (-110,420; 1,478), rhamnose (-72,081; 1,629), fucose (-98,408; 1,546), galactose (-95,757; 5,187), fucoxantin (-106,297; 2,161), alginate (-84,674; 2,897), phlorofucofuroeckol A (-106.701; 2,809), phloroglucinol (-103,140; 2,142), phlorotannin (-48,826; 7,750). The prediction results of toxicity showed fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol and phlorotannin not toxic with LD50 0.95-2.482g / kg. Conclusion:Based on RS values, fucoidan, fucoxantin and phlorofucofuroeckol A compounds contained in brown seaweed were predicted to have activity as antiaterosclerosis. Compounds in brown seaweed can also be predicted to be relatively non-toxic with a value of LD50 0.95-2.482g / kg.

Perbandingan Profil Lipid pada Tikus Putih yang diberi Crude Fucoidan dari Rumput Laut Coklat (Sargassum polycystum) yang Diinduksi Diet Tinggi Lemak Juliana Irem Adriana Purukan; Kusmardi Kusmardi; Dian Ratih Laksmitawati; Syamsudin Abdillah; Bambang Ponco Priosoeryanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

: Brown seaweed (Sargassum polycystum) is one of the plants that produces pharmacological activity which is as anti-atherosclerotic with the potential chemical content is fucoidan. The aim of this research is to know the effectiveness of crude fucoidan in decreasing total cholesterol, LDL, TG, increasing HDL levels and atherogenic index. In the optimization phase, 5 rat test animals were used to see the effect of the composition of a high-fat diet given on lipid profiles. While in the testing phase 30 test animals were divided into 6 groups to see the effect of a high-fat and crude fucoidan diet given to lipid profiles. Examination of lipid profiles was carried out three times, namely on the 0th, 14th and 36th days, after that the atherogenic index is calculated. On the 36th day the test, rats were anesthetized and necropsy for subsequent blood collection through the heart organ.The results showed that 200 mg crude fucoidan dose could significantly decreasing total cholesterol, LDL, TG, increased HDL levels and significantly decreased the atherogenic index of rat serum compared to the dosages of 100 mg and 50 mg, but did not differ significantly from the positive control at 10 mg atorvastatin.

Aktivitas Anti Obesitas Ekstrak Daun Tin (Ficus carica Linn) pada Tikus yang diberi Diet Lemak Tinggi Errol Rakhmad Noordam; Swasono R. Tamat; Syamsudin Abdillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Obesity is a health problem in the community because it can cause a risk of degenerative diseases such as type 2 diabetes mellitus, high blood pressure, heart disease, cancer, and atherosclerosis. Unhealthy lifestyles such as lack of physical activity by exercising, a diet high in carbohydrates and fats, can cause fat deposits in the body, especially in the abdomen. The use of chemical drugs such as Orlistat as a weight loss or to help reduce the risk of regaining lost weight, is less effective because it requires a long consumption time and the presence of side effects. Tin leaf content (Ficus carica Linn) is flavonoids, alkaloids, tannins and steroids, tin leaf extract has IC50 150mg/L antioxidant activity. This study was to determine the anti-obesity activity of tin leaf extract in male Sprague-Dawley rats given a high fat diet. 30 Sprague-Dawley rats were classified into 6 groups. The results obtained, in the group dose of 100 mg / kg obtained an average body weight of 381.8 grams, the test group 200 mg / kg obtained an average body weight of 414.5 grams, in the test group 400 mg / kg obtained 387 grams. The conclusion of this study is that the activity of Tin leaf extract (Ficus carica Linn) can be used as an anti-obesity.

Uji Aktivitas Antioksidan dan Anti Aging Body Butter dengan Bahan Aktif Ekstrak Daun Kelor Nunuk Aries Nurulita; Elza Sundhani; Irma Amalia; Fifi Rahmawati; Nina Nurhayati Dian Utami
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Moringa leaf (Moringa oleifera) was one of plants that containt phenol compounds such as alkaloid, tannin, saponin and flavonoid that were useful as a antioxidant and anti aging. The aim of this research was to prove antioxidant and anti aging’s activity of Moringa leaf. The extraction process of Moringa leaf using Maseration method with ethanol solvent 70 % ratio 1:10, then the antioxidant properties determinate using beta carotene bleaching (BCB) and anti aging’s activity test was done, after that formulated the body butter with activeingredient of Moringa leaf extract 0,5 %. Moringa extract contains total phenolic 10,45 mg GAE/g extract and 5,53 % of total flavonoid. The result showed that Moringa leaf extract had inhibition of beta carotene bleaching properties as shown by BCB results. Moringa leaf extract inhibit the collagenase activity until 47,25 % at concentration of 1600 ppm. Moringa leaf extract body butter has high potency of antiaging through antioxidant and collagenase inhibitor mechanism. Moringa body butter had good organoleptic properties. However the physical properties of moringa body butter should be optimozed its composition to get the better one.

Penilaian Kualitas Hidup Terkait Kesehatan Pasien Kanker Payudara di RSUP dr. M. Djamil Padang, Indonesia Dian Ayu Juwita; Almahdy Almahdy; Rizka Afdila
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Health related quality of life is a feeling of comfort and patient satisfaction with the function of controlling diseases including psychological, social, and physical health. Measurement of quality of life needs to be done because therapeutic interventions such as drugs potentialy to increase or decrease the quality of life. The purpose of this study to determine the effect of chemotherapy on the quality of life of breast cancer patients in Dr. M. Djamil Hospital Padang. Assessment of the quality of life of breast cancer patients was performed using an EORTC QLC-30 questionnaire. The sample of the study was breast cancer patients in surgical polyclinic of Dr. M. Djamil Hospital Padang during the period of March to May 2018 meeting the inclusion criteria. The data is rated in the range 0-100 using a linear transformation formula, then presented as a mean value. The quality of life of breast cancer patients based on the functional scale group of cognitive function domain (71,09 ± 21,05), role function (66,65 ± 26,52), physical function (61,97 ± 22,22), emotional function 60,91 ± 18,24), and social function (51,47 ± 15,24), whereas in symptom scale group from diarrhea domain (24,41 ± 23,69), constipation (26,38 ± 29,36) , dyspnea (31.35 ± 31.80), insomnia (42.24 ± 34.26), financial difficulties (48.03 ± 22.24), decreased appetite (53.00 ± 26.28), pain ( 55,41 ± 20,11), fatigue (58,59 ± 17,58), and nausea and vomiting (68,00 ± 28,82), last for general health status / QoL obtained 65,03 ± 14,83.

Natrium Alginat sebagai Polimer Mukoadhesif terhadap Daya Lekat serta Pelepasan Granul Mukoadhesif Amoksisilin Yudi Srifiana; Ari Widayanti; Nopriadi Nopriadi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Mucoadhesive is a bioadhesive dosage form which forms a bond with mucous membranes. Mucoadhesive dosage forms stayed on mucous membranes in prolonged time so can increase bioavailability. This study intended to determine the effect of sodium alginate as bioadhesive polymer to mucoadhesive strength of granules. The granules prepared using amoxicillin as active agent and sodium alginate as bioadhesive polymer by wet granulation method. Granule evaluation are moisture content, particle size, wash off test using rat stomach and dissolution test. Test results of total recovery F1, F2, F3, F4, F5, 540 mg, 560 mg, 580 mg, 600 mg, 620 mg. Test results of flow rate 10,78-11,75 g/second, and angle of repose 33,50-35,15°, test of particle size distribution in the range of 1410-1680 µm, moisture content from 11.07 to 13.57%, wash off test of F1, F2, F3, F4 and F5 as consecutively 12.67, 14.00, 18.67, 26.00 and 33.33%. 2-way ANOVA test to % dissolution and wash-off test results sig. <0.05, so there is a significant difference between formulas. Based on the results showed that increasing concentration of sodium alginate increase mucoadhesive strength of granules but less able to resist of drug release, and the best formula is F3 that containing sodium alginate 580 mg.

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Home Page

OAI Link

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Contact Name Syafira Dwi Cahyani

Contact Email adminjifi@univpancasila.ac.id

Phone +6287780957284

Journal Mail Official syafira.ffup@univpancasila.ac.id

Editorial Address Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location Kota adm. jakarta selatan, Dki jakarta INDONESIA

Abstract

Abstract

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Abstract

Abstract

Abstract

Abstract

Abstract

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Abstract

Contact Name
Syafira Dwi Cahyani

Contact Email
adminjifi@univpancasila.ac.id

Phone
+6287780957284

Journal Mail Official
syafira.ffup@univpancasila.ac.id

Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location
Kota adm. jakarta selatan,

Dki jakarta

INDONESIA