cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Syafira Dwi Cahyani
Contact Email
adminjifi@univpancasila.ac.id
Phone
+6287780957284
Journal Mail Official
syafira.ffup@univpancasila.ac.id
Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.
Location
Kota adm. jakarta selatan,
Dki jakarta
INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 20 Documents
 1   2 
Search results for , issue "Vol. 23 No. 1 (2025): JIFI" : 20 Documents clear
Characteristic and therapeutic effect of lemongrass leaf encapsulation with a different ratio of chitosan and NaTPP Kurniawan, Florencia Livia; Komariah, Komariah; Octarina, Octarina; Anggreani, Febry; Annisa, Fauziah Rahma; Nurlidar, Farah
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1570

Abstract

The lemongrass plant (Cymbopogon citratus) in Indonesia has great potential as a natural ingredient for medicines because it contains various compounds such as neral, citral, geranial acetate, flavonoids, and tannins. Previous research has demonstrated various pharmacological activities of kitchen lemongrass leaves, including antibacterial, antifungal, and anti-inflammatory properties. Encapsulation technology in the form of chitosan-NaTPP nanoparticles is used to maintain the activity of kitchen lemongrass leaf compounds. This research aims to determine the physical characteristics of the encapsulation of kitchen lemongrass leaf extract with several comparisons of chitosan and NaTPP by testing PSA (particle size analysis test), FTIR (functional group analysis test), viscosity, and stability, including pH and turbidity tests. Encapsulation with a 1:1 ratio of chitosan and NaTPP has a particle size of 524 nm and a PdI value of 0.481, classified as monodisperse (PdI <0.7). The pH value ranges from 6.46 to 7.30, and the viscosity value was 2.134–2.169 cP, which is still within mouthwash standards. The turbidity test showed stable encapsulation results. Therefore, encapsulation with a 1:1 ratio of chitosan and NaTPP is the most optimal choice and has potential for developing the therapeutic effect of mouthwash.
Assessment on the antioxidant, photoprotective, and antimicrobial properties of Siraitia grosvenorii Figo, Figo; Candra, Tasya Mariska; Novia, Jessica; Sugata, Marcelia
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1588

Abstract

Exogenous antioxidants from plant-based sources, such as polyphenols, show potential in maintaining a balance of cellular oxidation in biological systems. Additionally, the rise of antimicrobial resistance and the harmful effects of UV radiation on skin necessitate the exploration of medicinal plants for drug development and photoprotective agents. This study specifically focused on Siraitia grosvenorii or Luo Han Guo, and aimed to assess its phenolic and flavonoid content, as well as its antioxidant, antimicrobial, and photoprotective properties. The study involved the preparation of Siraitia grosvenorii extracts from seeds and fruit peels, determination of total phenolic and flavonoid content using Folin-Ciocalteu reagent and AlCl3, evaluation of antioxidant activity using the DPPH method, and analysis of antimicrobial activity against Escherichia coli using turbidity assays. Photoprotective activity was examined by calculating the Sun Protection Factor (SPF) using a UV spectrophotometer and a normalized function. The results showed that fruit peel of Siraitia grosvenorii had a higher total phenolic content than the seed, and no significant difference in flavonoid content between seed and fruit peel extract. Additionally, Siraitia grosvenorii fruit peel and seed had low SPF value and DPPH reduction. Both fruit peel and seed showed highest antimicrobial activity at the concentration of 100 ppm.
Statin prescribing pattern and the outcomes for acute coronary syndrome as primary and secondary prevention: a comprehensive review Dewi, Pramitha Esha Nirmala; Chairani, Farahdina; Himawan, Wahyu
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1604

Abstract

Cardiovascular disease is the highest rate of total burden non-communicable disease worldwide in these 5 recent years. Reducing the LDL-c level is closely related to reducing the risk of cardiovascular events recurrences among Acute Coronary Syndrome (ACS) patients. This study aims to explore the statin prescribing pattern among the ACS population and population at risk of ACS and to sum up the reported clinical outcomes, cost-effectiveness, or quality of life-related to statin utilization. The literature searching was conducted by using PubMed and Scopus databases from January 2020 to December 2021. Ten eligible studies were included, examining outcomes such as Major Adverse Cardiovascular Events (MACE), quality of life, and cost-effectiveness. Atorvastatin emerged as the most frequently prescribed statin for both primary and secondary prevention. In high-risk ACS populations, the delayed or underutilization of high-intensity statins led to suboptimal cardiovascular outcomes. Conversely, early administration, particularly within 48 hours post-event or post-PCI, significantly reduced MACE. Importantly, low to moderate intensity statin regimens showed cost-effectiveness primarily among low-risk ACS groups only when treatment was fully subsidized. In settings without government coverage, statin inaccessibility may affect the increased of recurrent events and elevated healthcare costs. The strategic use of statins—especially timely initiation and risk-based intensity selection—offers measurable benefits in reducing cardiovascular events. However, the lack of universal healthcare coverage for statin therapy in low- to middle-income settings presents a substantial barrier to cost-effective care, particularly for high-risk individuals. These findings underscore the need for policy interventions and expanded access to guideline-directed statin therapy.
Formulation of a peel-off gel mask containing mundu fruit extract (Garcinia dulcis (roxb.) kurz) for antioxidant and anti-elastase activity Ambarwati, Neneng Siti Silfi; Desmiaty, Yesi; Chandra, Amelia; Noviani, Yuslia; Triyani, Yulia; Hakim, Ratu Mayra; Amanda, Reistha Fazlia; Wahyudi, Dion
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1607

Abstract

The skin serves as a protective barrier against ultraviolet (UV) radiation. However, exposure to UV radiation can lead to various skin problems, including changes in the dermis. To prevent UV-induced damage, antioxidants and anti-elastase agents are needed to protect the skin from oxidative stress. This study aims to evaluate the antioxidant and anti-elastase activities of Mundu fruit extract (Garcinia dulcis (Roxb.) Kurz) and to formulate a peel-off gel mask using the concentrated extract. Antioxidant activity was assessed using the FRAP and ABTS methods, while anti-elastase activity was determined by measuring the release of p-nitroaniline from a substrate degraded by the elastase enzyme. The results showed that the IC50 value for antioxidant activity using the ABTS method is 29.57 ppm 0.72, and the FRAP value was 185.02 10.23 AAE/g. The anti-elastase activity showed IC50 of 82.21 ppm. Three peel-off gel mask formulations were developed, with Formula 3 (containing extract at 200 x IC50). showing the best performance. These findings suggest that the thick Mundu fruit extract, which tested positive for phenolic compounds, exhibits promising antioxidant and anti-elastase activities and is suitable for use in topical formulations.
Evaluation of drug services based on prescription indicators and patient care according to who at the hospital general practitioner (GP) outpatient clinic in Depok, Indonesia Syafhan, Nadia Farhanah; Risni, Hindun Wilda; Salsabila, Azzahra Fahira; Purnama Putri, Raden Jacinda Yasmin; Prasetyaningrum, Marchen
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1609

Abstract

The World Health Organization (WHO) has developed prescription and patient care indicators, accompanied by optimal benchmarks, aimed at promoting the rational and optimal medicine use. This study aims to evaluate drug services utilizing WHO prescription and patient care indicators at the hospital General Practitioner (GP) outpatient clinic. The research was conducted retrospectively for prescription indicators, consisting of 1505 prescriptions totaling 4647 medication items administered for 804 individuals between January and December 2022. Prospective data collection to evaluate patient care was conducted from April to May 2023. Evaluation of WHO prescription indicators yielded the following results: the average number of drugs prescribed per patient was 3.09 ± 2.00; the percentage of drug prescribed by generic drug names was 47.47%; the percentage of antibiotic prescriptions was 5.46%; the percentage of injectable drug prescriptions was 6.80%; and the percentage of prescriptions in accordance with the national formulary was 75.91%. The percentages of antibiotic and injectable drug prescriptions met the optimal WHO prescription values. In terms of patient care, the results showed that the average duration of a medical consultation was 12.44±8.1 minutes, the average duration of a drug dispensing was 45.65±28.8 minutes, 96.25% of the drugs were dispensed appropriately, 100% of the drugs were labeled adequately, and 78.78% of the patients were knowledgeable. Age (p=0.111) and gender (p=0.075) showed no significant correlation with patient knowledge. There was a significant relationship between education level (p=0.014) and patient knowledge. Prescription and patient care indicators are aspects of improvement to meet the optimal benchmarks according to WHO standards.
Bibliometric analysis on pharmaceutical care publications in Southeast Asia: prospective research trends Riyadi, Rahmat; Alfian, Sofa Dewi
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1621

Abstract

Studies related to bibliometric analysis have been conducted globally to determine the development of pharmaceutical care. However, the prospective trends of scientific research associated with pharmaceutical care in Southeast Asia remain unclear. This study sets out to analyze and compare the results of pharmaceutical care research in Southeast Asian countries in terms of bibliometric indices. An investigation on the main electronic database Scopus was conducted for research purposes on pharmacy care in Southeast Asia until August 6, 2023. The analysis derived from the investigation included an evaluation of published document by year; lead author; country or territory, institutional affiliation, document type, subject area analysis; citation and co-citation analysis; journals that published the most articles, and the most researched topics. Microsoft Excel and VOSviewer were utilized to conduct a qualitative analysis on this dataset. This study adopted the co-authorship analysis, co-citation analysis and keyword analysis in order to gain an insight onto the research prospects and trends in pharmaceutical care. A total of 1,261 studies correlating to pharmaceutical care in Southeast Asia met the criteria for qualitative analysis. The top three countries with the highest number of publications were Malaysia, Thailand and Indonesia. Malaysia had the highest citation count (n=4670, 27.45%), followed by Thailand (n=3292, 19.35%), and Vietnam (n=3096, 18.20%). From networks of co-authorship analysis of authors, there were no collaborations found among authors in Southeast Asia. Prospective research analyzing keywords related to the theme of pharmaceutical care includes pharmacy practice, medication adherence, and qualitative research. Bibliometric analysis provides a comprehensive view of the field and status of pharmaceutical care research to develop prospective future trends and collaborations in Southeast Asia. A bibliometric analysis suggests that stronger teamwork among Southeast Asian researchers is crucial for future advancements.
Tyrosinase inhibitory activity and physicochemical properties of microalgae extract (Spirulina platensis)-loaded nanostructured lipid carriers gel Faizatun, Faizatun; Abdullah, Abdullah
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1622

Abstract

Microalgae (Spirulina platensis) belongs to the family Cyanobacteria contains phycocyanin which is efficacious as a tyrosinase inhibitor. The purpose of the study was to make gel of Nanostructured Lipid Carriers (NLC) from the Microalgae extract (Spirulina platensis). Extracts were made by maceration with 70% ethanol solvent and evaluation of the enzyme tyrosinase inhibitory activity. The extract was made by NLC with solvent evaporation method and characterized which included particle size, polydispersity index, zeta potential and Transmission Electron Microscope (TEM). NLC extract was made into gel preparations by adding gelling agent, and evaluation included organoleptic homogeneity, viscosity and flow properties, pH, and the enzyme tyrosinase inhibitory activity. The enzyme tyrosinase inhibitory activity of Microalgae extract (Spirulina platensis) with the result IC50 in the amount of 150.22 µg/mL. Five of NLC formulas was made based on the characterization obtained the best formula is NLC formula 2, which includes particle size of 119.6 nm, polydispersity index of 0.356, zeta potential of -37.8 mV, and spherical shape. The evaluation results of the gel were semi-solid, brown, typical smell, homogeneous, viscosity of 19500 cPs, plastic thixotropic flow properties, and pH 5.06. The enzyme tyrosinase inhibitory activity of NLC gel Microalgae extract (Spirulina platensis) with the result IC50 in the amount of 173.38 µg/mL. It can be formulated into a physically and chemically stable gel preparation and has activity as a tyrosinase inhibitor.
Anticancer activity of Stichopus vastus extract against MCF-7 and HeLa cells from Natuna waters Sukmiwati, Mery; Nurjanah, Nurjanah; Diharmi, Andarini; Putri, Indah Prasetya
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1631

Abstract

Sea cucumbers (Stichopus vastus) contain bioactive compounds with potential anticancer properties, making them a promising alternative raw material for pharmaceutical development. This study aimed to isolate and fractionate bioactive compounds from S. vastus and evaluate their anticancer activity against MCF-7 and HeLa cell lines. Isolation was performed using Thin Layer Chromatography (TLC), and cytotoxic activity was assessed in vitro using the MTT assay. Phytochemical screening revealed the presence of steroids, terpenoids, and saponins. IC₅₀ values were calculated through linear regression analysis. The methanol extract exhibited IC₅₀ values of 13.50 µg/mL (HeLa) and 17.25 µg/mL (MCF-7), indicating active anticancer potential. The n-hexane fraction showed IC₅₀ values of 10.09 µg/mL (HeLa) and 15.11 µg/mL (MCF-7), also categorized as active. Notably, the ethyl acetate fraction demonstrated superior activity, with an IC₅₀ of 7.00 µg/mL against HeLa (very active) and 13.32 µg/mL against MCF-7 (active). These findings suggest that the ethyl acetate fraction of S. vastus holds significant promise as an anticancer agent, particularly against HeLa cells.
Evaluation of antipsychotic utilization among outpatient schizoprenia patients at the mental health facility in West Java Sutrisno, Entris; Selifiana, Nita; Sodik, Jajang Japar; Fajarrini, Uvika Nurul
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1632

Abstract

Rational use of drugs aims to give therapy according to patient’s clinical needs. Based on Ni komang's research (2021) there are still inaccuracies in the use of antipsychotic drugs. The purpose of this study was to determine the evaluation of the use of Antipsychotics based on the parameters of right indications, drugs, dosage, and frequency in outpatient schizophrenia patients at the West Java Provincial Mental Hospital. The study used a method with descriptive presentation of data and retrospective data collection. Data obtained period October-December 2022 from 130 patients, this study evaluated the use of Antipsychotics with the parameters of right indications, drugs, dosage, and frequency then the data will be analyzed based on the criteria for drug use from Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS. The results of the study on the use of Antipsychotics in schizophrenic patients at the Java Provincial Mental Hospital based on Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS obtained the right indications as much as (100%), the right drugs (100%), the right dose (98%), and the right frequency (98%).
Effectiveness of Artocarpus heterophyllus lamk. serum in eliminating dark spot in the guinea pig melasma model due to UV-a exposure Mas Tiari, Ida Ayu Dwi Putri; Mardiyanti Putri, Ni Putu Kania; Marliani, Ni Luh Setia; Sari, Ni Made Elma Agustini; Malelak, Julia Eva; Adrianta, Ketut Agus
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1639

Abstract

Indonesia's high UV-A exposure significantly contributes to skin hyperpigmentation conditions such as melasma. This study investigated the effectiveness of Jackfruit (Artocarpus heterophyllus Lamk.) leaf serum in reducing dark spots in a guinea pig model of melasma induced by UV-A radiation. Crude extracts were prepared and purified from Jackfruit (Artocarpus heterophyllus Lamk.) leaves, then formulated into serums at 4% and 5% concentrations. These formulations underwent physical quality evaluations, including organoleptic properties, pH, homogeneity, spread ability, adhesion, and viscosity. Anti-hyperpigmentation effects were assessed using Masson Fontana staining on UV-A-exposed guinea pigs treated for 14 days. The results demonstrated a reduction in melanin content, with mean values of 17.97±1.68 (negative control), 1.17±0.28 (positive control), 3.56±2.77 (4% serum), and 2.56±1.25 (5% serum). Histological analysis showed that fibroblast proliferation and epidermal hyperplasia were significantly reduced with serum treatment. These effects are attributed to the flavonoid content in Jackfruit (Artocarpus heterophyllus Lamk.) leaves, which exhibit antioxidant and anti-melanogenesis properties. In conclusion, Jackfruit (Artocarpus heterophyllus Lamk.) leaf serum, particularly at 5% concentration, is effective in reducing melasma-related hyperpigmentation and may offer a safer alternative to synthetic treatments.

Page 1 of 2 | Total Record : 20

 1   2 

Filter by Year

2025 2025


Reset
Filter By Issues
All Issue Vol 23 No 2 (2025): JIFI Vol. 23 No. 2 (2025): JIFI Vol 23 No 1 (2025): JIFI Vol. 23 No. 1 (2025): JIFI Vol 22 No 2 (2024): JIFI Vol 22 No 1 (2024): JIFI Vol 21 No 2 (2023): JIFI Vol 21 No 1 (2023): JIFI Vol 20 No 2 (2022): JIFI Vol 20 No 1 (2022): JIFI Vol 19 No 2 (2021): JIFI Vol 19 No 1 (2021): JIFI Vol 18 No 2 (2020): JIFI Vol. 18 No. 2 (2020): JIFI Vol 18 No 1 (2020): JIFI Vol 17 No 2 (2019): JIFI Vol 17 No 1 (2019): JIFI Vol 16 No 2 (2018): JIFI Vol 16 No 1 (2018): JIFI Vol 15 No 2 (2017): JIFI Vol 15 No 1 (2017): JIFI Vol 14 No 2 (2016): JIFI Vol 14 No 1 (2016): JIFI Vol 13 No 2 (2015): JIFI Vol 13 No 1 (2015): JIFI Vol 12 No 2 (2014): JIFI Vol 12 No 1 (2014): JIFI Vol 11 No 2 (2013): JIFI Vol 11 No 1 (2013): JIFI Vol 10 No 2 (2012): JIFI Vol 10 No 1 (2012): JIFI Vol 9 No 2 (2011): JIFI Vol 9 No 1 (2011): JIFI Vol 8 No 2 (2010): JIFI Vol 8 No 1 (2010): JIFI Vol 7 No 2 (2009): JIFI Vol 7 No 1 (2009): JIFI Vol 6 No 2 (2008): JIFI Vol 6 No 1 (2008): JIFI Vol 5 No 2 (2007): JIFI Vol 5 No 1 (2007): JIFI Vol 4 No 2 (2006): JIFI Vol 4 No 1 (2006): JIFI Vol 3 No 2 (2005): JIFI Vol 3 No 1 (2005): JIFI Vol 2 No 2 (2004): JIFI Vol 2 No 1 (2004): JIFI Vol 1 No 2 (2003): JIFI Vol 1 No 1 (2003): JIFI More Issue