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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Penapisan Fitokimia dan Uji Hayati secara BSLT dari Daun, Buah dan Biji Phaleria macrocarpa Suci Eka Lestari; Ratna Djamil
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Mahkota Dewa (Phaleria macrocarpa [Scheff] Boerl), is Indonesian herb that famous for its medicinal activity. The chemical constituens of the leaves, fruits and seeds have been examined, and BSLT (brine shrimp lethality test) have been carried out. On phytochemical screening, the leaves showed the existence of: volatile oil, sterol, triterpene, higher fatty acid, alkaloid, flavon aglycon, coumarine, tannin, steroid glycoside, flavonoid, polyuronide and triterpene, the fruits contain: volatile oil, sterol, triterpene, higher fatty acid, alkaloid, flavon aglycon, coumarine, tannin, reducing compound, steroid glycoside, flavonoside, polyuronide and saponine; while the seeds contain: steroid, triterpene, higher fatty acid, alkaloid, flavon aglycon, coumarine, tannin, reducing compound, steroid glycoside and flavonoid. Brine shrimp lethality test showed that the LCs of the n-hexane fraction of the leaves, fruits and seeds are 2.34 ppm, 32.62 ppm and 4.33 10-28 ppm respectively; the aethyl acetate fraction of the leaves, fruits and seeds are 10.55 ppm, 29,12 ppm and 4.71 ppm respectively; while the methanol fraction of the leaves, fruits and seeds are 1.46.10-5ppm, 39.32 ppm, and 53.31 ppm respectively. From this study it may be concluded that the n-hexane and aethyl acetate fraction of the seeds have the most active compounds, while the leaves have the most active compounds in the ethyl acetate fraction.
Analisis Masalah Terkait Obat di Lima Rumah Sakit Tahun 2010 MAX JOSEPH HERMAN; IDA DIANA SARI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 2 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Drug prescribing and drug use become more complex, as the number and potency of available drugs increase, leading to a variety of Drug Related Problems (DRPs). From 15 studies conducted in several countries, 7.1% of the overall hospital admissions were related to DRPs and 59% of them might be prevented. For the last few decades, attention to DRPs in some countries like USA, Australia and England have increased. A study on pediatric inpatients was carried out in 2007 by monitoring medical records detected nearly 60% DRPs with an average of 3 DRPs per patient and other study done showed that more than 78% of geriatric patients had in average 3 DRPs. A retrospective study to identify morbidities related to DRPs has been conducted in 2010 in 5 hospitals having clinical pharmacy unit. Data were collected from medical records or clinical pharmacy documents and interviews with the head of pharmacy unit and clinical pharmacist. DRPs data were then analyzed and categorized according to a combination of American Society of Hospital Pharmacists (ASHP) and Pharmaceutical Care Network of Europe (PCNE) classifications. Results of the study revealed that there were 266 DRPs identified with an average of two DRPs per patient and anti-infection drugs were mostly involved. Duration of a treatment longer than necessary was found in 17.3% cases and had resulted in high cost drug treatment (32.7%), whilst poly-pharmacy, inappropriate drug form and new indication for drug treatment presented were hardly found. Pharmacist was the most likely who made intervention in DRPs (61.3%) and 48,9% intervention was proposed, but was rejected by prescriber.
Uji Sitotoksisitas Fraksi Aktif dan Senyawa Murninya yang Dihasilkan oleh Kapang Endoiit Tanaman Obat dari Lombok Timur terhadap Sel MCF-7 ERWAHYUNI ENDANG PRABANDARI; TUN TEDJA IRAWADI; WAHONO SUMARYONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Screening for citotoxicity has been conducted on 36 endophytic fungi isolated from medicinal plants in East Lombok. Isolates were cultivated in 100 mL potato dextrose yeast extract medium in 250 mL Erlenmeyer, incubated at 28°C and shaked in 150 rpm for 10 days. Broth was extracted with buthanol, ethyl acetate and dichloromethane. Extracts were concentrated under vacuum concentrator and assayed for citotoxicity against Artemia salina using the BSLT method. Screening using 100 mg/L of crude extract showed that 9 extracts were active out of 108 extracts assayed. Further screening based on LC50 showed that the ethyl acetate extract from fungus ENLT 74.3d.2 was the most active with LC 50=30.21 mg/L. Fungus was isolated from Cibotium barometz and described as Curvularia lunata. The most active extract was fractionated by column silica gel 60 and eluted using hexane, ethyl acetate, and methanol. These fractions showed that the ethyl acetate fraction was the most active fraction (LC50 = 4.69 mg/L). Purification was conducted by HPLC using column C18 and eluted by gradient system of acetonitril water 15% to 100% in 25 minutes. The active compound retention time was 14-16 min, λmax = 233 nm, and at 5 mg/L could inhibit 28% MCF-7 cell proliferation.
Free Radical Scavenger Activity of Green Algae Ethanolic Extract Spirogyra sp. and Ulva lactuca Using DPPH Method NINA SALAMAH; WAHYU WIDYANINGSIH; INNAYAH IZATI; HARI SUSANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Antioksidan merupakan senyawa yang dapat menghambat reaksi oksidasi dengan mengikat radikal bebas dan molekul yang sangat reaktif. Spirogyra sp. merupakan contoh spesies yang hidup di perairan tawar, sedangkan Ulva lactuca di perairan laut. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan sebagai penangkap radikal bebas ekstrak etanol ganggang hijau Spirogyra sp. dan Ulva lactuca dengan metode DPPH (1,1-difenil-2-pikrilhidrazil). Ekstrak etanol serbuk ganggang hijau Spirogyra sp. dan Ulva lactuca dibuat dengan dengan metode maserasi. Uji aktivitas antioksidan dilakukan dengan metode DPPH secara spektrofotometri visibel. Asam galat digunakan sebagai kontrol positif. Aktivitas penangkapan radikal bebas dinyatakan dalam ES50. Hasil penelitian menunjukkan bahwa ekstrak etanol Spirogyra sp. dan Ulva lactuca memiliki aktivitas sebagai penangkap radikal bebas. Nilai ES50 Spirogyra sp. sebesar (92,83±0,58) μg/mL dan Ulva lactuca sebesar (1376,65±7,80) μg/mL, sedangkan asam galat memiliki harga ES50 sebesar (0,73 ± 0,04) μg/mL
Pengaruh Lupene-ol dan Lupene-on dari Aegle marmelos Correa terhadap Pelepasan Enzim β-hexoaminidase dari Sel Mast AGUNG ENDRO NUGROHO; SUGENG RIYANTO; MOHAMAD ASPOLLAH SUKARI; KAZUTAKA MAEYAMA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

20(29)-lupene-3α-ol and 20(29)-lupene-3-on are pentacyclic triterpenes isolated from Aegle marmelos Correa collected in Yogyakarta, Indonesia. Their molecular structures were confirmed in Universiti Putra Malaysia. These compounds were obtained from petroleum ether extract of the plant’s stem bark. This study investigated the effects of the compounds on the β -hexoaminidase enzyme release from mast cell culture (RBL-2H3 cell line). DNP24-BSA was used as immunologic inducer for the β -hexoaminidase release from the mast cells. The enzyme release was determined by colorimetric methods with a substrate, p-nytrophenyl-2-acetamydo-2-deoxy- β -D-gluko-pyranocide, and a microplate reader at 405 nm. lt was found that treatment with 20 µg/ml DNP24-B SA could stimulate the release of β -hexoaminidase from RBL-ZH3 cells by 3O.83 ± 1.10%. Lupene-ol and lupene-on showed inhibitory effects on the β -hexoaminidase release from RBL-2H3 cells induced by DNP24-BSA in dose-dependent manner. At the dose of 100 µM, lupene-ol and lupene-on inhibited the β -hexoaminidaserelease by 35.69i4.7 5% and 39.19 9.56%, respectively. The ICN values of their effects on DNP24-BSA experiments were 59.40 µM and 72.51 µM. The results suggested that the inhibitory effect of lupene-ol and lupene-on on the β-hexoaminidase release involved mechanisms related to the interaction of IgE on the RBL-2H3 cells surface or intracellular signal transductions found in the mast cell degranulation. Key words: Aegle marmelos Correa, lupene-ol, lupene-on, mast cells, β -hexoaminidase enzyme.
Pengaruh pH dan Kekuatan Ionik terhadap Profil Kelarutan Ofloksasin BUDIPRATIWI WISUDYA NINGSIH; SUWALDI SUWALDI; AKHMAD KHARIS NUGROHO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Ofloxacin is an antibiotic and categorized as class 2 in Biopharmaceutics Classification System (BCS). Ofloxacin solubility is dependent on pH of the solvent due to its amphoteric properties. The objectives of this research was to investigate the effects of pH and ionic strength on solubility profile of ofloxacin. Ofloxacin solubilities were measured at various pH ranged from 1.5 to 12.5 and ionic strengths from 0.01 to 0.20 respectively. Solubility experiments were carried out using shaking thermostatic-waterbath for 3 hours at a temperature of 37°C ± 1°C. Results showed that ofloxacin solubility increased at pH’s below the pKa1 value (6.08) and above the pKa2 value (8.25). However, the solubility decreased at pH’s between pKa1 and pKa2. Changing the solution pH from 6.2 to 1.5 or to 12.5 affected the solubility of ofloxacin increased about 9.96 and 8.64 times higher, respectively. Ofloxacin solubility in various ionic strengths showed that stronger ionic strength solution caused an increase in ofloxacin solubility. This mean that there was a salting in phenomena. Least-Square Fitting Analysis using Henderson-Hasselbalch equation for amphoteric compound was insufficient to describe ofloxacin solubility process in a series of pH.
Isolasi Senyawa Polifenol Black garlic Dan Uji Toksisitasnya Terhadap Larva Udang (Artemia salina Leach) Santi Nur Handayani; Lidya Cahyo Bawono; Diana Pramesti Ayu; Hesti Nurrizqi Pratiwi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.801 KB) | DOI: 10.35814/jifi.v16i2.561

Abstract

Cancer is one of diseases caused by cell division that is uncontrollable. Cervical cancer is a cancer that suffered by many women. Alternative medicine of cancer disease is use black garlic. Black garlic is the result of processing the garlic with high temperature and humidity without addition of other substances. In that process occur Maillard reaction that cause changes in the color, smell, and taste of the original on the garlic. Such reaction also lead to an increase some bioactive compounds such as S-allyl cysteine ​​(SAC), amino acids, flavonoids, and polyphenols. To determine the toxic properties of black garlic extract, it is necessary to do isolation of polyphenolic compounds and toxicity test against Artemia salina Leach. When calculated by SPSS application, the obtained LC50 values of black garlic extract on the aging prosess time variations of 30 days and 40 days showed concentration of 682.433 and 572.403 ppm.
Studi Pengikatan Cadmium (II) pada Resin Anorganik Titanium Oksida dan Zirkonium Oksida Sunarhadijoso Soenarjo; Titiek Martati; Murti Winanti; Atmi Wirasti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 1 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Immobilization of Cd-(II) in production technology of indium medical radioisotopes (lll In or 115min) by means of 112Cd (p, 2n) 11 In or 114Cd (n,y) 115Cd 115mIn nuclear reaction is an important step regarding to the quality of the produced radioactive indium and efficiency of the utilization of the enriched targets (112Cd or 114Cd). The phenomena and capacity of Cd-(II) immobilization were studied using two kinds of inorganic oxide resins, i.e. titanium oxide and zirconium oxide. The aim of this study is gaining experimental data supporting the utilization of the resins in the production of 111In and 115min. The immobilization of Cd-(II) was proceeded by treating standard solutions of Cd-(II) with the resins followed by measurement of Cd-(II) content of the treated solution before and after treatment. The separation of the treated Cd-(II) solution from the resin was performed by means of centrifugation, while the measurement of Cd-(II) was performed by means of Ultra Violet spectrophotometry. The ready-used titanium oxide from Merck did not bind Cd-(II) even after being treated with several kinds of activating media. Zirconium oxide synthesized from the reaction of ZrOCI,. 8H,O with a basic solution of NaOH was in the form of the hydrate compound formulated as ZrO. nH,O with the value of n=(1.7034 +0.0186) and showed a capability to bind Cd-(II) higher than that of zirconium oxide synthesized with a basic solution of NH,OH or of the ready-used ZrO2. In general the Cd-(II)-binding capacity of Zro, tends to decrease with increasing of the amount of Zro.
Tanaman Transgenik dan Kebijakan Pengembangannya di Indonesia Faisal Faisal
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 1 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Transgenics plant is a plant that is produced by genetic engineering process. This product still creates polemic, because its impact still not certain yet, for human and environment. European countries seem to be careful in distributing or to importing this product, but United State actively promote and produce this plant. In order to develop and to protect it's country, US has prepared regulations, policy and institutions. Regulation should be prepared in Indonesia, as well as policies and institutions, because this product has been distributed and consumed largely. In addition, this regulations and policy are important for research activities. This review discusses about transgenic development, and government policies for the development of transgenics technology in Indonesia.
Sitotoksisitas terhadap Sel Leukemia L1210 dan Profil Kromatogram dari Serbuk Temu Putih Curcuma zedoaria (Berg) Rosc. yang Diradiasi ERMIN KATRIN W.; JOHANS RICHARD ALBERT; SWASONO R. TAMAT; SUSANTO SUSANTO; HENDIG WINARNO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

White turmeric Curcuma zedoaria (Berg) Rosc. is useful for treating cancer disease. It is very susceptible to microbial, therefore gamma irradiation technique to reduce microbial contamination is necessary in order to extend the storing period. Gamma irradiation on white tumeric was carried out by cobalt-60 source at doses of 5, 7.5, 10, and 15 kGy. Then they gradually were maeerated with n-hexane, ethyl acetate, and ethanol. The purpose of this research was to study the effect of gamma irradiation by observing parameters on the cytotoxic activity of ethyl acetate extract and active fraction of white tumeric rhizome against L1210 leukemia cells, also profiles of thin layer and HPLC chromatograms of active fraction as anticancer agent. Ethyl acetate extract of irradiated and control samples were the most active to inhibit the growth of L1210 leukemia cells with IC50 value of 4.71 ug/mL. Ethyl acetate extracts from irradiated and control samples were fractionated using column chromatography and obtained 7 fractions (Fr), respectively. Fraction 3 of control sample was the most active fraction with IC50 values 1.43 µg/ ml. The IC50 value of Fr 3 decreased with increasing irradiation doses and chromatogram profiles of radiated samples with doses of > 5 kGy were changed. The maximum radiation dose for white turmeric preservation is 7.5 kGy, at this dose its anticancer efficacy was maintained.

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