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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Uji Aktivitas Antiinflamasi Nanopartikel Ekstrak Etanol Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) dengan Metode Penghambatan Denaturasi Protein Yunahara Farida; Deni Rahmat; Agi Widia Amanda
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (597.943 KB) | DOI: 10.35814/jifi.v16i2.569

Abstract

Javanese turmeric rhizome (Curcuma xanthorrhiza Roxb.) has been known to have many health benefits as antibacterial, anti-inflammatory, antidiabetic and anticancer. The purpose of this study was to compare the anti-inflammatory activity of temulawak rhizome extract with its nanoparticles. Temulawak rhizome extract was obatained by maceration using 96% (v/v) ethanol as a solvent. The extracts were made into nanoparticles by ionic gelation method which used chitosan and tripolyphosphate. The results of antiinflammatory activity test using a method of inhibiting protein denaturation showed the persentage of inhibition of protein denaturation (IC50) of the extract of temulawak rhizome of 521.67±5.80 ppm while the IC50 of the nanoparticles was 398.02±1.78 ppm. Accordingly, the antiinflammatory activity of the nanoparticles was better than the extract of temulawak rhizome.
Identifikasi Senyawa Flavonoid dalam Fraksi n-Butanol Taraxacum officinale, Asteraceae Wiwi Winarti; Ratna Djamil; Indah Yuniasari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 2 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Herbs of Taraxacum officinale, a native of Europe, contain a flavonoid, steroid/triterpenoid, saponin, tanin, and a volatile oil. The purpose of this research was to determine the flavonoid substances, after partitioning of the methanolic extract by the Charaux-Paris method with n-butanol. Identification by uv-visible spectrophotometry confirmed that flavonoid from isolate la was a flavonol with an OH at 3, 7 position, oxygen at 6 or 8, while isolate III, also a flavonol, showed an OH at 3, 7 position, oxygen at 6 or 8, and besides that an additional o-diOH attached to ring B.
Pengaruh Pemberian Ekstrak Etanol Buah Makasar (Brucea javanica [L.] Merr) terhadap Aktivitas dan Kapasitas Fagositosis serta Produksi ROI Sel Fagosit Mencit secara In vivo ROS SUMARNY; SILVI RISDIYANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

One way to prevent of disease through increased endurance by increasing the effectiveness of the immune system to light the causes of disease. Macassar fruit (Brucea javanica [L.] Merr) of Simambaceae is known containing quasinoid which has cytotoxic activity against cancer, antiplasmodium, and improving the effectiveness of humoral immun system. The work is to investigate the effect of Macassar fruit ethanol extract on the activity and phagocytic capacity, as well as phagocyte ROI production of mice phagocyte cells. Five groups consisted of 12 mice per group were prepared. Group I, a normal control was given distilled water, Group II was given orally with Macassar fruit ethanol extract dose of 100 mg/ kg, Group III a dose of 200 mg/kg, Group IV a dose of 300 mg/kg, and positive control group V was given Stimuno. Results showed that the phagocytic activity of phagocyte cells increased with increasing doses. The highest phagocytic activity was achieved by the 300 mg/kg dose, observed either at 8th and 15th days after the treatment, with an increase in phagocytic activity of 65 .60% and 70.5%. ROI production of phagocytic cells has different response after 7 days or 14 days treatment with Macassar fruit extract. The ROI production increased by 43% after 14 days treatment with Maccasar fruit ethanol extract with the dose of 300 mg/kg BW.
Analisis Kandungan Residu Sulfametazin dalam Daging dan Hati Ayam secara Kromatografi Cair Kinerja Tinggi Zuhelmi Aziz; Yulvian Sari; Raphaela Widiastuti; Lydia Septa Desiyana
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 2 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Sulfamethazine is an antimicrobial and anticoccidiocis which usually used in poultry farm. The using of sulfamethazine to cattle has an accumulated residue effect on cattle products. An experiment of the decreasing motive of sulfamethazine residue concentration in chicken meat and liver has been carried out. One day old broiler chicken classified into 4 groups which are negative control, the positive control, the 7 days (7 days before the slaughtering day which on 36th day), and 5 days group (5 days before the slaughtering day which on 36th day). The last three groups are given sulfamethazine solution in oral 3 times a week with 0.2 ml/kg BW or 50 mg/kg BW dosage. After the giving of sulfamethazine stopped, each of those 4 groups slaughtered on 1st, 2nd, 3rd, 4th, 5th, 7th, 24th, 48th, 120th, 168th, 240th hour and then each of chicken meat and liver extracted and analyzed with high performance liquid chromatography (HPLC). The Sulfamethazine residue decreasing along with the increasing of time can be noticed from the experiment. In common, the decreasing of Sulfamethazine can be seen starting form 24th hour, then at 48th hour the sulfamethazine concentration stay at lower state and decrease along with the increasing of time.
Kombinasi Ekstrak Daun Pandan Wangi ( Pandanus amaryllifolius Roxb.) dan Buah Mengkudu (Morinda citrifolia) sebagai Antifungi terhadap Jamur Penyebab Ketombe AMBARWATI AMBARWATI; TANTI AZIZAH SUJONO; RETNO SINTOWATI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 1 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Dandruff is a scalp problem which causes itching and hair loss. It causes by microorganisms, especially fungi. Pandan Wangi (Pandanus amaryllifolius Roxb.) leaves and Noni (Morinda citrifolia) fruit are known have antifungal eff ect. The aim of this study was to determine the combination of 96% ethyl acetate extract of Pandan leaves and 96% ethanol extract of Noni fruit could inhibit fungal which isolated from dandruff . The fungi were isolated from dandruff sample on PDA (Potatoes Dextro Agar) and it was purifi ed. Based on the research, it was known the density of fungi was 9.2x108 colonies/ gram. Purifi ed from 17 types of fungal isolates in dandruff sample. The inhibition test of EPW:EP (1:1) showed that 82.4% fungal isolates inhibited, the diameter of inhibition zone ranging between 15-35 mm.There are three species of fungi: Aspergillus sp, Paecylomyces varotii, Candida sp (non albicans) and 1 isolate was yeast. The active compound in Pandan leaves extract: phenol (9.42% w/w) and fl avonoids (4.39% w/w), while in Noni fruit extract: alkaloids (1.97% w/w), phenol (12.50% w/w) and fl avonoids (8.61% w/w). It can be concluded that the combination of Pandan Wangi leaves and Noni fruit extract have potential used as anti-dandruff shampoo.
Dislipidemia sebagai Faktor Risiko Penurunan Nilai Estimasi Laju Filtrasi Glomerulus (eLFG) pada Diabetes Mellitus Tipe II DITA MARIA VIRGINIA; FENTY FENTY
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Prevalence of diabetes mellitus type II is high in the world as well as in Indonesia which is 55% patient get dyslipidemia. The risk of cardiovascular disease arises on patient DM type 2 with dyslipidemia so that it is possible to make vasoconstriction in renal artery getting worse. Renal function value can mark from estimated glomerular filtration rate (eGFR). The aim of this study is to determine dyslipidemia in DM type II as risk factor on declining renal function which is marked from decreasing eGFR. This study was analytical observational with cross sectional design. This study compared eGFR between DM type II patient with and without dyslipidemia in Hospital X, Central Java, Indonesia. A hundred subject participated in this study. Data have analyzed in descriptive and Chi-Square using SPSS. Result showed Dyslipidemia on patient Diabetes Mellitus (DM) type II was not risk factor for declining renal function based on eGFR value (OR=0,711, CI95%= 0,270 – 1,875).
Lauret-7-Sitrat sebagai Detergensia dan Peningkat Busa pada Sabun Cair Wajah Glysine soja (Sieb.) Zucc SITI UMRAH NOOR; DESY NURDYASTUTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 1 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Soya milk is an extraction product from soya bean that can be used as humectant due to its amino acids which are similar to those in our skin, such as glycine, serine, alanine, asparagine, ornithine, citruline, proline, and 17 other amino acids. ln this study, a liquid facial Wash containing soya milk using lauret-7-citrate (concentration 0, 1, 2, and 3%) was formulated that could affect the surface active characteristis, and the foam formation. The organoleptic characteristics, density, viscosity, rheology, surface tension, foam height and stability of foam height in pure and hard Water were determined at 25°C and 40°C for 8 Weeks. The results obtained showed that the best facial Wash was that contained 15% soya milk (2% lauret-7-citrate) of which had the following properties: a pseudoplastic rheology, a density of 1.076-l.079 g/cm3, a viscosity of 14,550-17,300 cPs, a surface tension of 25.41-27.18 dyne/ cm3, foam height in pure Water of 850-866.67 ml and in hard Water 466.67-600 ml, and stable at pH 4.99-5.00.
Aktivitas Gastroprotektif Kombinasi Ekstrak Kulit Batang Mimba (Azadirachta indica A. Juss) dan Rimpang Kunyit (Curcuma domestica Linn.) pada Tikus Putih yang Diinduksi Asetosal SANTI PUMA SARI; ABDUL MUN’IM; DINI KUSUMANINGTYAS
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Some pre-clinical and clinical studies reported that neem (Azadirachta indica A. Juss) bark and turmeric (Curcuma domestica Linn.) rhizome extracts demonstrated strong gastroprotective activities. In this studies, the effect of combination of neem bark and turmeric rhizome extracts were investigated on acetosal-induced gastric ulcer in rats.The combination is expected to produce synergic effect on the gastric ulcer. The combination of extracts was administered orally in various doses for 7 days prior to the ulcer induction. On the 8th-day rats were given asetosal 400 mg/kg bw to induce gastric ulcer. All rats were sacrificed 8 hours after asetosal induction for the determination of ulcer index, total acidity, mucus thickness and histophatological examination. The combination of neem bark extract (250 mg/kg bw) and turmeric rhizome extract (50 mg/kg bw) was significantly reduced the ulcer index (a = 0.05). This result was substantiated by histophatological examinations. Results of this study showed that combination of neem bark and turmeric rhizome extracts have synergic gastroprotective activities.
Respon Galur Leuconostoc mesenteroides dan Weissella confusa terhadap pH Kondisi Pertumbuhan Menggunakan Antibiotik sebagai Indikator AMARILA MALIK; DEWI PUSPITA; RIZKI AYU AMALIA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Lactic acid bacteria is known to contribute to human health as exopolysaccharide producer, bacteriocin producer, live vaccins, starter in fermentation process and as probiotics. This study aimed to observe Leuconostoc mesenteroides and Weisella confusa strains response under manipulated growth condition for carbon source composition and on pH as a model, using various antibiotics as indicator. MRS and modified MRS (50% normal dextrose concentration) were used. Modification of pH representing acidic and alkaline condition were 4.6 and 9.0. Disc diffusion method was employed using six different antibiotics. Result showed that all strains grown in acidic standard MRS tend to be more sensitive to amoxicillin (Am), chloramphenicol (Ch) and polymyxin B (PoB), but more resistant to ciprofloxacin (Ci), while in the acidic modified MRS, the strains respond more sensitive to Am, Ch, Ci and PoB. When grown in alkaline standard MRS, all strains respond more sensitive to Am, Ci and PoB, but more resistant to Ch, while in alkaline modified MRS, they respond more resistant to Am and Ch but more sensitive to Ci and PoB. Most of the strains did not show inhibition against vancomycin and none of strains showed inhibition against sulphamethoxazole-trimethoprim under conditions applied.
Aktivitas Antikanker Ekstrak Daun Aglaia elliptica Blume pada Tikus Betina yang Diinduksi 7,12 dimethylbenz[a] antracene AGUNG ERU WIBOWO; FRANS D. SUYATNA; WAHONO SUMARYONO; NURYATI CHAIRANI SIREGAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Aglaia elliptica Blume is one of plants that contain cyclopenta[b] tetrahydrobenzofuran compound with strong cytotoxic effect on various types of cancer cell lines. The objective of this study is to determine the inhibition effect of ethanol extract of A. elliptica leaves on mammary tumor growth in Sprague Dawley female rats induced by 7.12-dimethylbenz[a]anthracene (DMBA). The study was conducted with induction of 50 female rats with DMBA at a dose of 20 mg/kg orally for 11 times. Twenty-five female rats suffering mammary tumor were divided into 5 groups. Three groups were treated with ethanol extract at a dose of 50, 100 and 200 mg/200 g BW one day after the tumor appeared for 30 days, 1 group as a negative control and 1 group as a positive control (doxorubicin 2 μg/200 g BW). The results showed that the induction of DMBA resulting tumor incidence by 74% and tumor multiplicity of 2 nodules/rat. Histopathological analysis of mammary tumor, suggested that the carcinogenesis has reached the level of ductal carcinoma invasive (DCIV). The administration of ethanol extract at dose of 50, 100 and 200 mg/200 g BW suppressed the growth of mammary tumor volume by 30 %, 33.5% and 37.4%, respectively.

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