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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Perkembangan Anak Tikus (F1) Asal Induk Penerima Asam Valproat sebagai Model Diabetes Mellitus HADI SUNARYO; WASMEN MANALU; ADI WINARTO; BAMBANG KIRANADI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 2 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

To do research and development of antidiabetic drugs, animal models of diabetes in accordance with the conditions is required. The aim of this research was to develop a diabetic model that is fit to the pathophysiology of diabetic condition. The pregnant female rats were divided into 2 groups, one group was orally treated by a single dose of valproic acid (250 mg/kg bw) on day 9th of pregnancy and the other was a control. At the ages of 8, 16 and 24 weeks the blood samples of litters (F1) were taken for glucose, insulin and triglyceride determination. At the same time, pancreatic tissues were collected under deep anesthetic condition for immunohistological study. Results of blood glucose concentrations and histological finding of litters (F1) indicated that at the age of 8 weeks both had showed a similar pattern as compared to control. At the ages of 16 and 24 weeks, blood glucose and insulin level showed a significant increase, while positive insulin cells slightly decreased in number. It can be concluded that treating rat with valproic acid on days 9 of gestation will inhibit pancreatic β cells function. There is an indication that F1 of valproic acid treated pregnant mother start showing a metabolic syndrome at 16 weeks and being pronounce by aging.
¬Potensi Biduri [Calotropis gigantea (L.) W.T. Aiton] sebagai Tanaman Obat Meutia Faradilla; Hilda Maysarah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Calotropis gigantea (L.) W.T. Aiton or known as Biduri in Indonesia has been used in traditional medicine as an anti-inflammatory, antitoxin and antipyretic. This plant is often found in hot and arid climates. Research on the potential of this plant has not been done much in Indonesia. This article aims to examine the potential of Biduri as a source of medicinal plants. The study was carried out by reviewing research literatures of the botanical plants both sourced from international and national journals. The results of the study indicate that various types of extracts from the biduri plant have therapeutic activities for further development. The phytochemical testing and isolation has also been carried out to look for active substances that play a role in the pharmacological activity being tested. Based on the studies that have been carried out, biduri plants have great potential to be researched and further developed to become one of the sources of medicinal plants in Indonesia.
APLIKASI REAKTOR SISTEM SINAMBUNG DAN TEKNOLOGI MEMBRAN PADA PRODUKSI ENZIM A-AMILASE OLEH Bacillus subtilis Mahyudin AR; Sumaryanto Sumaryanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 1 No 2 (2003): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

a-Amylase enzyme (endoamylase) is produced for hydrolysis of 1,4-glikosidic binding from starch to maltose in food and non food industries. Due to increasing production capacity, continuous of fermentation process and maintaining the enzyme activity can be achieved with CSTR (Continuous Stirred Tank Reactor), an alternative for batch process replacement. 3,51 Reactor combined with microfiltration membrane under specific conditions such as : pH, molasses-urea medium, temperature, and agitation are adjusted to 8,37° C, and 250 rpm. The result obtained showed that in 1 vv m aeration Bacillus subtilis ATCC 6633 reached an enzyme specific activity of 93 Unit/mg protein during 20 hours fermentation. By continuous fermentation using a medium containing 3 % molasses - 0,6 % urea, these bacteria excrete an enzyme with a specific activity of 60 U/mg protein during 22 hours fermentation. It was shown that a production during 96 hours gave an enzyme production with a specific activity of 90 U/mg protein.
Mikroenkapsulasi Controlled Release Lansoprazol dengan Kombinasi Hydroxy Propyl Methyl Cellulose Phthalate dan Natrium Alginat secara Gelasi Ionotropik RICKY KURNIAWAN; DENI RAHMAT
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Lansoprazol adalah obat anti ulkus peptikum golongan penghambat pompa proton yang memiliki absorpsi efektif di usus tetapi terurai oleh asam lambung sehingga perlu menggunakan sistem controlled release untuk meningkatkan ketersediaan hayatinya. Polimer yang digunakan untuk sistem controlled release yaitu natrium alginat 2% dengan penambahan kalsium laktat dalam konsentrasi 5% (Formula I), 7,5% (Formula II) dan 10% (Formula III). Mikrokapsul dibuat dengan metode gelasi ionotropik. Natrium alginat dan lansoprazol dicampur dengan rasio 3:1, kemudian diteteskan ke dalam larutan kalsium laktat dengan kecepatan pengadukan 100 putaran per menit. Mikrokapsul yang dihasilkan dicuci dengan air suling dan dikeringkan selama 4 jam pada suhu 60 oC. Hasil kemudian dikarakterisasi diantaranya organoleptik, kadar air, distribusi ukuran mikrokapsul, perolehan kembali dan penjeratan, indeks pengembangan dan pelepasan zat aktif. Mikrokapsul yang dihasilkan memiliki indeks pengembangan tertinggi pada Formula II yaitu 256,89%. Formula I memiliki rata-rata distribusi ukuran mikrokapsul terkecil sekitar 925-1000 μm dan terbesar pada Formula III sekitar 1075-1150 μm. Formula III memiliki nilai perolehan kembali tertinggi yaitu 86,5%. Penjeratan zat tertinggi pada Formula III yaitu 64,46%. Persen pelepasan lansoprazol pada jam ke-8 dari Formula I, II dan II berturut-turut adalah 87,89%, 68,09% dan 57,09%. Mikrokapsul menunjukkan sifat gastroresisten setelah disalut dengan larutan HPMCP 5% dan 10%.
Kombinasi Ekstrak Etanol Buah Mengkudu (Morinda citrifolia L.) dan Daun Pepaya (Carica papaya L.) sebagai Hepatoprotektif selama Pengobatan Tuberkulosis TITIK SUNARNI; RINI PRASTIWI; MARDIYONO MARDIYONO; YUDI RINANTO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Hepatoprotective activity of Morinda citrifolia L. fruits and Carica papaya L. leaves ethanolic extract have been investigated in antituberculosis-induced rats. Forty rats were divided into following eight groups: normal control group was treated with normal feed and water; negative control group was treated with isoniazid and rifampicin, positive control group was treated with isoniazid, rifampicin and Methicol®, and the last five groups were treated with isoniazid, rifampicin and combination of M. citrifolia L. fruits and C. papaya L. leaves extract on various doses. All groups were treated daily for 27 days. Serum levels of bilirubin, alanine aminotransferase (ALT) as well as aspartate aminotransferase (AST) were determined on day -0, 14, 21 and 28 to monitor the liver function. All rats were sacrified on day-28 for liver histology observation. Combination of M. citrifolia extract 20 mg/200 g bw and C. papaya extract 120 mg/200 g bw significantly decreased the serum level of ALT, AST as well as bilirubin. The histology study showed that this combination could prevent the liver damaged based on the lower percentage of necrosis (27.83%), as compared to that of negative control (47.47%).
Penapisan Kapang Endofit Ranting Kayu Meranti Merah (Shorea balangeran Korth.) sebagai Penghasil Enzim Xilanase SHIRLY KUMALA; NUR ANNISA FITRI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 1 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Endophytic microbes are microorganisms that live in the plant. These microbes, are able to produce secondary metabolites, such as oligosaccharide degrading enzymes, growth factors, antibacterial substances and Xylanaze enzyme, an enzyme that can reduce the use of chlorine as bleaching agent in paper industries. This study Was aimed to isolate endophytic fungi that can produce extracellular xylanaze. Isolation of endophytic fungi from red memnti (Shorea balangeran Korth.) branches was carried out using surface sterilization and direct seeding methods on CMM (Corn Meal Malt) medium. Xylanaze was produced by using shaking fermentation methods on PDY (Potato Dextrose Yeast) for 12 days. Enzyme activity was assessed by using DNS (Dinitro salicylic acid) method. The results showed that of nine endophytic fungi isolates, eight have xylanaze enzyme activity, ranging from 1.279 µ/ml (highest) to 0.12 µ /ml (lowest).
Aktivitas Anti Obesitas Ekstrak Daun Tin (Ficus carica Linn) pada Tikus yang diberi Diet Lemak Tinggi Errol Rakhmad Noordam; Swasono R. Tamat; Syamsudin Abdillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (423.482 KB) | DOI: 10.35814/jifi.v17i1.700

Abstract

Obesity is a health problem in the community because it can cause a risk of degenerative diseases such as type 2 diabetes mellitus, high blood pressure, heart disease, cancer, and atherosclerosis. Unhealthy lifestyles such as lack of physical activity by exercising, a diet high in carbohydrates and fats, can cause fat deposits in the body, especially in the abdomen. The use of chemical drugs such as Orlistat as a weight loss or to help reduce the risk of regaining lost weight, is less effective because it requires a long consumption time and the presence of side effects. Tin leaf content (Ficus carica Linn) is flavonoids, alkaloids, tannins and steroids, tin leaf extract has IC50 150mg/L antioxidant activity. This study was to determine the anti-obesity activity of tin leaf extract in male Sprague-Dawley rats given a high fat diet. 30 Sprague-Dawley rats were classified into 6 groups. The results obtained, in the group dose of 100 mg / kg obtained an average body weight of 381.8 grams, the test group 200 mg / kg obtained an average body weight of 414.5 grams, in the test group 400 mg / kg obtained 387 grams. The conclusion of this study is that the activity of Tin leaf extract (Ficus carica Linn) can be used as an anti-obesity.
Uji Aktivitas Antioksidan dan Anti Aging Body Butter dengan Bahan Aktif Ekstrak Daun Kelor Nunuk Aries Nurulita; Elza Sundhani; Irma Amalia; Fifi Rahmawati; Nina Nurhayati Dian Utami
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (741.227 KB) | DOI: 10.35814/jifi.v17i1.543

Abstract

Moringa leaf (Moringa oleifera) was one of plants that containt phenol compounds such as alkaloid, tannin, saponin and flavonoid that were useful as a antioxidant and anti aging. The aim of this research was to prove antioxidant and anti aging’s activity of Moringa leaf. The extraction process of Moringa leaf using Maseration method with ethanol solvent 70 % ratio 1:10, then the antioxidant properties determinate using beta carotene bleaching (BCB) and anti aging’s activity test was done, after that formulated the body butter with activeingredient of Moringa leaf extract 0,5 %. Moringa extract contains total phenolic 10,45 mg GAE/g extract and 5,53 % of total flavonoid. The result showed that Moringa leaf extract had inhibition of beta carotene bleaching properties as shown by BCB results. Moringa leaf extract inhibit the collagenase activity until 47,25 % at concentration of 1600 ppm. Moringa leaf extract body butter has high potency of antiaging through antioxidant and collagenase inhibitor mechanism. Moringa body butter had good organoleptic properties. However the physical properties of moringa body butter should be optimozed its composition to get the better one.
Penilaian Kualitas Hidup Terkait Kesehatan Pasien Kanker Payudara di RSUP dr. M. Djamil Padang, Indonesia Dian Ayu Juwita; Almahdy Almahdy; Rizka Afdila
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (360.774 KB) | DOI: 10.35814/jifi.v17i1.682

Abstract

Health related quality of life is a feeling of comfort and patient satisfaction with the function of controlling diseases including psychological, social, and physical health. Measurement of quality of life needs to be done because therapeutic interventions such as drugs potentialy to increase or decrease the quality of life. The purpose of this study to determine the effect of chemotherapy on the quality of life of breast cancer patients in Dr. M. Djamil Hospital Padang. Assessment of the quality of life of breast cancer patients was performed using an EORTC QLC-30 questionnaire. The sample of the study was breast cancer patients in surgical polyclinic of Dr. M. Djamil Hospital Padang during the period of March to May 2018 meeting the inclusion criteria. The data is rated in the range 0-100 using a linear transformation formula, then presented as a mean value. The quality of life of breast cancer patients based on the functional scale group of cognitive function domain (71,09 ± 21,05), role function (66,65 ± 26,52), physical function (61,97 ± 22,22), emotional function 60,91 ± 18,24), and social function (51,47 ± 15,24), whereas in symptom scale group from diarrhea domain (24,41 ± 23,69), constipation (26,38 ± 29,36) , dyspnea (31.35 ± 31.80), insomnia (42.24 ± 34.26), financial difficulties (48.03 ± 22.24), decreased appetite (53.00 ± 26.28), pain ( 55,41 ± 20,11), fatigue (58,59 ± 17,58), and nausea and vomiting (68,00 ± 28,82), last for general health status / QoL obtained 65,03 ± 14,83.
Hewan Model Kanker Ovarium untuk Studi Preklinik dan Pengembangan Obat Kanker Ovarium Ni Made Dwi Sandhiutami; Puspita Eka Wuyung; Wawaimuli Arozal; Melva Louisa; Deni Rahmat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (495.923 KB) | DOI: 10.35814/jifi.v17i2.734

Abstract

Treatment for ovarian carcinoma is still far from optimal, animal models are still needed to study human epithelial ovarian cancer. Animal models of ovarian cancer are very important for understanding the pathogenesis of the disease and for testing new treatment strategies. Ovarian carcinogenesis models in mice have been modified and repaired to produce preneoplastic lesions and neoplastic ovaries that are pathogens resembling human ovarian cancer. Although spontaneous ovarian tumors in mice have been reported, some of the shortcomings of existing studies preclude their use as animal models of ovarian cancer. Because of this, many efforts have been made to develop animal models that are relevant for ovarian cancer. Experimental animal models are developed accurately to represent cellular and molecular changes associated with the initiation and development of human ovarian cancer. Accurate experimental models have significant potential in facilitating the development of better methods for early detection and treatment of ovarian cancer. Several animal models of ovarian cancer have been reported, including manipulation of various reproductive factors or exposure to carcinogens. The latest advance in ovarian cancer modeling is using genetically engineered mice.

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