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Jurnal Ilmu Kefarmasian Indonesia

jifi
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Published by Universitas Pancasila

ISSN : 16931831 EISSN : 26146495 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 721 Documents

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Isolasi dan Identifikasi Senyawa Antioksidan dari Ekstrak Benalu Teh (Scurrula oortiana (Korth) Danser) Partomuan Simanjuntak; Titi Parwati; Lisya Evy Lenny; Swasono R. Tamat; Retno Murwani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 2 No 1 (2004): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (615.865 KB)

The leaves of tea benalu (Scurrula oortiana (Korth) Danser) were extracted with nhexane, ethyl acetate, methanol, and water respectively. The antioxidant activities were measured using 1,1-diphenyl-2-picrylhidrazyl (DPPH) methods. The result showed that the isolated compound has scavenging effect with IC50 92.22 ppm. Identification by interpretation of ultraviolet, infrared, and nuclear magnetic resonance spectra showed that the isolated compound was cathecin.

Analisis Kualitatif Uji Strip Sildenafi l Sitrat dengan Kombinasi Beberapa Reagen dalam Membran Kertas Selulosa Yessy Gladiani Sutrisno; Siska Khoirunnisa; Diani Sri Agustien; Eva Karyati; Nabila Fasya; Hendri Wasito
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Sildenafi l citrate was widely used to treat erectile dysfunction in men. The high demand of this drug, infl uence of counterfeit drugs. Therefore, it is required an analytical method to determine the authenticity of this drug. The aims of this research were to develop and evaluate of strip test for sildenafi l sitrat identifi cation. Research was conducted by preparation of solution and choosing the appropriate reagent for sildenafi l citrate. The optimum reagents were immobilized in cellulose paper followed by manufactured into strip test. Product performance was evaluated by evaluating several test in termed of qualitative, reproducibility, specifi city and response time. The results showed that the optimum membrane product was consisted of copper sulfate and sodium bicarbonate (2:1); ammonium ferric sulfate hexahydrate and copper acetat (1:3); sodium sulfate, copper acetate and ammonium ferrite sulfate (2:1:1) and mercury acetate and copper sulfate (2:1) reagents. The strip test had a capability in specifi c identify of sildenafi l citrate with a good reproducibility and less than ten seconds for time response. The strip test developed could be used as an early detection tool for the authenticity of a sildenafi l citrate tablet which more rapid.

Toksisitas dan Anti-inflamasi Senyawa 1,5-Bis(3’-Etoksi-4’-Hidroksifenil)-1,4- Pentadien-3-on (EHP) ESTI MUMPUNI; LESTARI RAHAYU; ARIEF NURROCHMAD
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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The 1,5-bis(3’-ethoxy-4’-hydroxyphenyl)-1,4-pentadiene -3-one (EHP) is a curcumin analogue. The structure has also been identified before. EHP is obtained, which has been pharmacologically proven to have higher antioxidant activity than curcumin. The objectives of this research were to determine the acute toxicity (LD50) of EHP compound by Weil C.S. method using male mice as experimental animals and to determine its antiinflammatory activity. The LD50 value of the synthesized EHP compound is 6,8675 g/kg body weight (bw) with the criteria of mild toxic, so it is assumed to be safe as drug substance candidate. The anti-inflammatory activity of the compound was determined by obeserved legs swelling index of the mouse. Anti-inflammatory activity of EHP with doses of 137.35 mg, 274.70 mg and 549.40 mg were equal to aspirin with the dose of 90 mg/200 g bw

Aktivitas Antioksidan Ekstrak Tunggal dan Kombinasinya dari Tanaman Curcuma spp. FAUZY RACHMAN; EMELIA DEVI LOGAWA; HARUMI HERGATIKA; PARTOMUAN SIMANJUNTAK
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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The aim of this research is to investigate the antioxidant activity of the simple extract and its combination from the rhizome of temulawak (Curcuma xanthorriza), temu giring (Curcuma heyneana), temu ireng (Curcuma aeruginosa), and kunyit (Curcuma Zonga) using the free radical scavenging effect methode namely DPPH (1,1-difenil-2-pikrilhidrazil). The use of combination extract is to explore, wether the antioxidant activity are sinergistic or antagonistic. The rhizomes of each plants were extracted With methanol, then partionated to n-hexane. The result indicated that the single methanol extract of kunyit(Curcuma Ionga) at 100 ppm showed the biggest activity (90.04%), While the combination extract of temulawak (Curcuma xanthorriza) and kunyit (Curcuma Zonga) performed the biggest scavenging activity (98.75%) by ratio 1:1.

Skrining Fitokimia dan Potensi AktivitaS Antioksidan Ekstrak Etanol Daun Hijau dan Daun Merah Kastuba Baiq Sopiah; Handa Muliasari; Emmy Yuanita
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Free radicals are an atom or molecule that has unpaired electron in its outer orbital that causes maked this reactive and unstable molecule. Free radicals when exposed continuously in the body are believed to cause several diseases include atherosclorosis, ischemia, cancer and premature aging therefore, antioxidant compounds is needed to inhibit the formation of free radicals. Kastuba (Euphorbia Pulcherrima Willd.) is one of the plants that has the potential as a natural antioxidant. The aim of this study was determining the content of active chemical compounds and free radical inhibitory potential of kastuba leaves ethanol ekstract.The procedures of this study were material collection, plant determination, simplicia production, extraction, phytochemical screening and qualitative free radical inhibition test with TLC (Thin Layer Chromatography). Phytochemical screening aim to determine the chemical compounds component of kastuba leaves ethanol extract including flavonoids, tannins and terpenoid test. The potential of free radical inhibition was carried out qualitatively with the TLC, DPPH (1,1-diphenyl-2-picrylhydrazyl) spray reagent. The results showed that kastuba leaves ethanol extract for both green leaves and red leaves contained flavonoids, tannins and terpenoids, and both leaves had the potential as free radical inhibition that indicated by yellow spots on TLC after DPPH reaction spray.

Konsentrasi Kreatinin dan Urea dalam Darah Tikus Putih (Rattus norvegicus) Galur Wistar Akibat Pemberian Natrium Nitrit Dyah Ayu Widyastuti; Maria Asih Ristianti; Ika Maya Sari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Sodium nitrite is one of common food addition in most meat product. This kind of food preservative is allowed by Permenkes No. 722/Menkes/Per/IX/88 only in minimum doses due to its carcinogenic effect. The most targeted organ is kidney which is sensitive to chemical matter as nefrotoxin. When the kidney is damaged, the erytropoietin secretion to form erytrocite is disturbed. Physiological damage in kidney can be identified by the concentration of blood creatinin and urea. The objective of this research is to study about blood creatinin and urea concentration of Wistar rats which is induced by sodium nitrite. Two groups of Wistar rats were induced by two doses of sodium nitrite (11.25 and 22.50 mg/kg body weight, respectively) a day with one group of control. Blood serum of those three groups were then be analyzed for creatinin and urea concentration each week for three months. The result showed that creatinin concertration is fluctuative during the day one to day ninety. The average of creatinin concentration for two treated groups is not significantly lower than control group. Generally, the urea concentration is increasing for day fourteen to seventy seven then decreasing in day eighty four to ninety. However, there are no significant differences among three groups.

Optimasi Formula Sediaan Krim Sunflower (Helianthus annuus L.) Oil Eva Husein; Agatha Budi Susiana lestari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Sunflower oil is one of the components of moisturizing cream that keeps the moisture of the skin. To produce a good quality cream, it is necessary to select appropriate emulsifying agent. This study aims to find the optimum composition between Tween 80 and Span 80 as an emulsifying agent in the preparation of sunflower oil cream, to meet physical properties and physical stability in terms of viscosity, spread ability and viscosity shift for 30 days. The ability of the cream to maintain skin moisture was tested using the Transepidermal Water Loss (TEWL) method. This study used a 22 experimental research design with the Simplex Lattice Design. The results showed there are 3 formulas of Tween 80 and Span 80 in proportion (6:4)%, (7;3)% and (8:2)% that fulfill the requirements with 143,3-153,3 dPas in viscosity, spread ability in range 5,0-5,3 cm, and viscosity shift between 4,3-6,8%. Based on TEWL test, the optimum formula obtained has a moisturizing effect with a TEWL value 17,9-38,0%. It conclude, sunflower oil could be formulated into moisturizing cream using combination of Tween 80 and Span 80 in proportion (6:4)%, (7;3)% and (8:2)% to fulfill the requirements for 30 days and could keep the skin moisture.

Pengaruh Crude Fukoidan dari Ekstrak Sargassum crassifolium terhadap Kadar ICAM-1 dan VCAM-1 pada Sel Raw 264.7 yang Diinduksi Lipopolisakarida Ayu Werawati; Esti Mumpuni; Kusmardi Kusmardi; Dian Ratih Laksmitawati; Syamsudin Abdillah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Inflammation is the response of vascular tissue to infection and damaged tissue to remove agents that cause inflammation. Macrophages are the dominant cells in the inflammatory reaction. Adhesion of leukocytes to vascular endothelium is a main feature of the inflammatory process. The presence of adhesion molecules, such as ICAM-1 and VCAM-1, can lead to adhesion of monocytes and lymphocytes to endothelial cells via bonding adhesion molecules to endothelial cells. Crude fukoidan derived from Sargassum crassifolium taken from Garut waters and extracted with dilute HCl, tested for anti-inflammatory activity through inhibition of ICAM-1 and VCAM-1 using lipopolysaccharide-induced RAW 264.7 cell models. The viability test was carried out in the concentration range of 0.49-1000 µg / mL. The pattern of inhibition of cell proliferation is influenced by concentration. The highest concentration that caused cell viability of 80% was the concentration of 86.46μg / ml. Crude fukoidan reduced ICAM-1 and VCAM-1 levels at concentrations of 50 and 25 μg / ml.. Percent inhibition of ICAM-1 at 50 µg / mL concentration was 61.04% compared to control and 74.26% at 25 µg / mL concentration. While the percent inhibition of VCAM-1 a

Aktivitas Senyawa Sargassum sp. sebagai Anti-aterosklerosis dengan Pembandingan Ligan-Reseptor HMG-CoA Reduktase- Simvastatin (1HW9) dan Uji Toksisitas secara In-Silico Sarah Zaidan; Syamsudin Abdillah; Deni Rahmat; Ratna Djamil; Esti Mumpuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Introduction:Sargassum.sp is one of the marine biota published as antiaterosclerosis, but compound toxicity data need to be explored for safety. Method: Virtual screening has been done with MVD software from active compounds contained in sargassum where has activity as antiaterosclerosis with the mechanism of hypolipidemic effects. Test compounds in sargassum include: fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol, phlorotannin, with HMG-COA Reductase-Simvastatin adenosine receptors with a 1HW9 /PDB code. Its toxicity is predicted using pkCSM (online). Results: The value RS, RMSD value as a result of the docking simulation carried out on said compounds, the following results are obtained: fucoidan (-110,420; 1,478), rhamnose (-72,081; 1,629), fucose (-98,408; 1,546), galactose (-95,757; 5,187), fucoxantin (-106,297; 2,161), alginate (-84,674; 2,897), phlorofucofuroeckol A (-106.701; 2,809), phloroglucinol (-103,140; 2,142), phlorotannin (-48,826; 7,750). The prediction results of toxicity showed fucoidan, rhamnose, fucose, galactose, fucoxantin, alginate, phlorofucofuroeckol A, phloroglucinol and phlorotannin not toxic with LD50 0.95-2.482g / kg. Conclusion:Based on RS values, fucoidan, fucoxantin and phlorofucofuroeckol A compounds contained in brown seaweed were predicted to have activity as antiaterosclerosis. Compounds in brown seaweed can also be predicted to be relatively non-toxic with a value of LD50 0.95-2.482g / kg.

Perbandingan Profil Lipid pada Tikus Putih yang diberi Crude Fucoidan dari Rumput Laut Coklat (Sargassum polycystum) yang Diinduksi Diet Tinggi Lemak Juliana Irem Adriana Purukan; Kusmardi Kusmardi; Dian Ratih Laksmitawati; Syamsudin Abdillah; Bambang Ponco Priosoeryanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

: Brown seaweed (Sargassum polycystum) is one of the plants that produces pharmacological activity which is as anti-atherosclerotic with the potential chemical content is fucoidan. The aim of this research is to know the effectiveness of crude fucoidan in decreasing total cholesterol, LDL, TG, increasing HDL levels and atherogenic index. In the optimization phase, 5 rat test animals were used to see the effect of the composition of a high-fat diet given on lipid profiles. While in the testing phase 30 test animals were divided into 6 groups to see the effect of a high-fat and crude fucoidan diet given to lipid profiles. Examination of lipid profiles was carried out three times, namely on the 0th, 14th and 36th days, after that the atherogenic index is calculated. On the 36th day the test, rats were anesthetized and necropsy for subsequent blood collection through the heart organ.The results showed that 200 mg crude fucoidan dose could significantly decreasing total cholesterol, LDL, TG, increased HDL levels and significantly decreased the atherogenic index of rat serum compared to the dosages of 100 mg and 50 mg, but did not differ significantly from the positive control at 10 mg atorvastatin.

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Editorial Address Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

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Contact Name
Syafira Dwi Cahyani

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adminjifi@univpancasila.ac.id

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+6287780957284

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syafira.ffup@univpancasila.ac.id

Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

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Kota adm. jakarta selatan,

Dki jakarta

INDONESIA