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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Uji Aktivitas Ekstrak Etanol 70% Daun Kaliandra Merah (Calliandra calothyrsus Meisn.) sebagai Penurun Kadar Glukosa Darah pada Tikus Hiperglikemia Dwitiyanti Dwitiyanti; Hayati Hayati; Sindi Anggraeni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.916

Abstract

Diabetes mellitus (DM) is an increase in blood glucose levels due to impaired metabolism of carbohydrates, fats, and proteins. Red kaliandra leaf (Calliandra calothyrsus Meisn.) contains tocopherol, carotenoid, flavonoid, saponin, and tannin compounds are natural sources of non-enzymatic antioxidants. The active compound has inhibitory activity against the α-glucosidase enzyme so that it can be potential as an antidiabetic. This study aims to determine the activity of 70% ethanol extract of red calliandra leaves on the decrease in blood glucose levels in male white rats Sprague Dawley hyperglycemia strain. Test animals were divided into 6 groups consisting of normal controls (standard feed), negative controls (alloxan induction), positive controls (metformin HCL dose 51.38 mg/kg), group I dose (50 mg/kg), dose II (100 mg/kg), and dose III (200 mg/kg). Data were analyzed using one way ANOVA and continued by Tukey test. The results showed that doses 1, 2, and 3 can reduce blood glucose. Dose 3 had a decrease in the percentage of 58.08% which was comparable to a positive control (metformin HCl dose 51.38 mg/kg) of 63.85%.
Efek Ekstrak Daun Sambung Nyawa (Gynura procumbens) untuk Mengurangi Ketombe pada Kulit Kepala Neneng Siti Silfi Ambarwati; Rita Susesty; Devi Sulastiowati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.942

Abstract

Gynura procumbens is a medicinal plant commonly used in Asian countries such as China, Thailand, Indonesia, Malaysia, and Vietnam. G. procumbens content flavonoids and glycosides and have bacteria activity and anti-fungal activity such as Candida albicans and Aspergillus niger. The purpose of this study was to obtain empirical data about the effect of using the G. procumbens leaves extract on reducing dandruff on the scalp. The extract was obtained by the maceration method using 70% ethanol solvent. The phytochemical compound content is determined with spectrophotometry ultraviolet. Two observers observe the scalp by using observation sheets and grating instruments assisted by a skin and hair analyzer. The reduction of scalp dandruff was the difference between the initial the results and the final test (after treatment). The sample was selected using a purposive sampling technique totaling ten people and divided into two groups (experimental and control groups). The results showed that the calculation of hypothesis testing after analyzing the data obtained a value of t count (5.817)>t table (1.86). This showed an effect of using the G. procumbens leaves extract as a shampoo for reducing dandruff on the scalp. The use of G. procumbens leaves extract as shampoo can reduce dandruff.
Formulasi dan Uji Inhibitor Tirosinase Masker Peel-Off Ekstrak Etanol 96% Kulit Buah Jeruk Nipis (Citrus aurantifolia) Ari Widayanti; Rini Prastiwi; Kartika Tiara Wijayanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.764

Abstract

Tyrosinase is an enzyme that is widely distributed in microorganisms, plants and animals. Tyrosinaseis the main enzyme involved in the biosynthesis of melanin. Melanin has a very important role in skin protection, especially against exposure to ultraviolet rays which are harmful to the skin. This study aims to test the tyrosinase inhibitor in the peel-off mask of lime peel extract (Citrus aurantifolia). Lime peel extract is formulated into a peel-off mask with extract content of 0% (F1), 15% (F2) and 25% (F3) respectively and with the gelling agent PVA (Polyvinyl alcohol). The physical stability test was carried out by measuring the pH, the results obtained were F2 pH 6.85 and F3 pH 6.78. The analysis of tyrosinase inhibitor activity was carried out using a UV-Vis spectrophotometer and seen from the percent inhibition value obtained. The percent inhibition results obtained from the peel-off mask of lime extract were 17.89% (F2) and 18.86% (F3). Lime peel has the potential as a tyrosinase inhibitor.
Formulasi Self Nano Emulsifying Drug Delivery System (SNEDDS) Minyak Biji Jinten Hitam dengan Surfaktan Tween 80 dan Kosurfaktan Sorbitol Iis Wahyuningsih; Yenni Latief
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.945

Abstract

Black cumin seed oil has many benefits. One of which is as an anticancer, it can be used as an opportunity to develop drugs that utilizes the black cumin seed oil. A method to improve the stability and absorption of the drug in the body is within the formulation of Self Nano Emulsifying Drug Delivery System (SNEDDS). This study aims to determine whether the black cumin seed oil can be made into SNEDDS formula with tween 80 and sorbitol as a surfactant and cosurfactant along with the establishment for the optimal formula. SNEDDS formula of black cumin seed oil was optimized using SLD method by DX.10 software. SNEDDS formula was made using tween 80 as surfactant and sorbitol as cosurfactant. Previously carried out with the manufacturing of a trial formula to determine the lower and upper value of each component, then 14 formulas were made based on DX.10. The formula were evaluated for transmittance percentage in 650 nm wavelength and emulsification time of 37oC. Results of the tests included in DX10 is to obtain the optimal formula. The optimal formula was validated by t-test and evaluated for droplet size, zeta potential, and stability test of nanoemulsion in artificial gastric fluid (AGF) and artificial intestinal fluid (AIF) for 4 hours. The results showed that the proportion of 13% black cumin seed oil, 60% tween 80 and 27% sorbitol is able to establish the optimal SNEDDS formula of black cumin seed oil. Transmittan value of the optimal formula was 92% with the emulsification time of 56 seconds, SNEDDS black cumin seed oil droplet size of 21.5 nm, zeta potential value -31.5 mV and nanoemulsion stable in the AIF and AGF.
Potensi Daun Tembelekan (Lantana Camara Linn.) Sebagai Anti-Agregasi Platelet dan Anti-Infl amasi Secara In Vivo Ni Made Dwi Sandhiutami; Yesi Desmiaty; Nattika Sari Darmastuti; Fahri Muhammad
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.707

Abstract

Atherosclerosis is chronic inflammatory disease that can be prevented with anti-inflammatoryactivity agents and reduce thrombus formation in blood vessels. Tembelekan leaves (Lantana camaraLinn.) contain fl avonoids, saponins, and essential oils which potential to inhibit platelet aggregation andbe anti-inflammatory. This study aimed to test the in vivo anti-platelet aggregation and anti-inflammatoryactivity of tembelekan leaves. Platelet anti-aggregation test was carried out on mice by assessing thedecrease in plasma absorbance after addition of ADP. Mice were divided into normal group, positivecontrol group which was given clopidogrel and 3 test groups which were given Tembelekan leaf extractat a dose of 2.5, 5, 10 g/kgBW. In vivo anti-inflammatory test used the Winter method with intraplantar1% carrageenan as inducer. There was a signifi cant decrease in plasma absorbance after addition ofADP at doses of 2.5 and 5 g/kgBW of tembelekan leaves i.e 5.47% and 12.28% compared to thenormal group. Positive control and dose of 10 g/kgBW gave the same eff ect. In anti-inflammatorytest, the doses of 3.2 and 6.4 g/kgBW of tembelekan leaves gave percentage value of inhibition whichwas not signifi cantly diff erent with diclofenac sodium. Tembelekan leaves potentially as anti-plateletaggregation and anti-inflammatory properties.
Preparasi dan Karakterisasi Mikrokapsul Asam Mefenamat Menggunakan Polimer Natrium Alginat dengan Metode Gelasi Ionik Sandra Aulia Mardikasari; Suryani Suryani; Marwah Puspitasari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.797

Abstract

Mefenamic acid belongs to a class of the non-steroidal anti-infl ammatory drugs that work asan analgesic. Mefenamic acid is sensitive to the light and temperature, also has unpleasant odors andtastes. Microencapsulation technology is a technique where the active substance is coated by a thin layerso that the active substance is protected from environmental infl uences. The aim of this research was toformulate and characterize mefenamic acid in the form of microcapsule using ionic gelation methodswith sodium alginate. Preparation was done by comparing the concentrations of sodium alginatepolymers namely, 1%, 2%, and 3%. Success parameters include the entrapment effi ciency, particleshape, particle size distribution, and dissolution. The results on the entrapment effi ciency using UVVISspectrophotometer showed a concentration of 1% polymer has a high value of 94.02%, for particleshapes using the optical microscope showed that three formulas were spherical with the smallest particlesize distribution was 1266 μm. The dissolution test by type II dissolution test showed that the higherthe concentration of polymer used, the slower the drug release. This research provides an alternativeformulation of mefenamic acid microcapsule by using sodium alginate polymer.
Uji Aktivitas Antioksidan Sediaan Lip Balm Rambut Jagung (Zea mays L.) dengan Metode DPPH (1,1-Diphenyl-2-Picrylhydrazyl) Hartati Hartati; Fadli Husain; Nangsih Sulastri Slamet; Fihrina Mohamad; Zulfiayu Sapiun
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.829

Abstract

Jagung sebagai komoditas utama di Provinsi Gorontalo menghasilkan limbah yang cukupbanyak. Hal ini membuat pemerintah menawarkan peluang investasi dengan memanfaatkan limbahjagung, di antaranya rambut jagung. Studi pustaka menunjukkan bahwa rambut jagung memilikiaktivitas antioksidan yang cukup baik, sehingga dilakukan formulasi lip balm dengan memanfaatkaninfusa rambut jagung sebagai bahan aktif. Penelitian kuantitatif dengan quasi eksperimen laboratoriumdilakukan untuk mengetahui aktivitas antioksidan dari sediaan lip balm rambut jagung (Zea mays L.)yang diformulasi dengan menggunakan tiga konsentrasi infusa rambut jagung, yaitu Formula A (7,5%);Formula B (15%) dan Formula C (22,5%). Sediaan dibuat dengan mencampurkan fase air (infusa rambutjagung dan gliseril monostearat) dengan fase minyak (lanolin, beeswax, setil alkohol, paraffi n cair danminyak jagung) serta emulgator (span 60 dan tween 60). Hasil uji stabilitas organoleptik dan pH selama4 minggu pengamatan menunjukkan bahwa tidak ada perubahan, baik dari segi organoleptik maupunpH masing-masing sediaan. Aktivitas antioksidan diukur dengan menggunakan spektrofotometer UVVisibel“SHIMADZU UV-1800” dan kuersetin (1000 μg/mL) sebagai pembanding. Hasil pengujianmenunjukkan bahwa Formula B (15%) memberikan aktivitas yang lebih baik dalam meredam radikalDPPH dengan nilai IC50 sebesar 0,987 mg/mL, Formula C (22,5%) sebesar 1,857 mg/mL dan FormulaA (7,5%) sebesar 2,909 mg/mL.
Analisis Efektivitas Biaya Haloperidol-Chlorpromazine dengan Haloperidol-Risperidone pada Pasien Skizofrenia di Rumah Sakit dr. H. Marzoeki Mahdi Bogor Fitriani Putri; Delina Hasan; Ahmad Fuad Afdhal; Lahargo Kembaren
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.899

Abstract

Schizophrenia is a disease that requires a long treatment time, this will have an impact on drug use and costs in the long term. Therefore it is necessary to find an alternative drug that is eff ective and effi cient by using pharmacoeconomics methods, that is cost-eff ectiveness analysis. The purpose of this study was to determine which of the two combination drugs was eff ective and effi cient for the treatment of schizophrenic patients in hospital Marzoeki Mahdi Bogor. This research method used cross sectional design, the sample size in this study was 90 schizophrenic patients obtained from patient medical records and data collected prospectively from dr. H. Marzoeki Mahdi in 2019. Samples were divided equally into two groups, one group received haloperidol - chlorpromazine and the second group received haloperidol - risperidone. The eff ectiveness parameter used in this study is the GAF (Global Assessment of Functioning) value. The results showed that the combination of haloperidol - risperidone was more eff ective than the combination of haloperidol - risperidone, this was evidenced by an increase in the patients GAF value by 95.5% (43 patients) with an average diff erence between the initial and fi nal GAF values of 6.89, while the combination of haloperidol - chlorpromazine amounted to 93.3% (42 patients) with an average diff erence between the initial and fi nal GAF values of 5.84. The ACER value of haloperidol - chlorpromazine is Rp. 6,587,753 and the ACER value for the haloperidol – risperidone combination is Rp. 6,148,897. In conclusion, the haloperidol - risperidone combination is more cost eff ective (p < 0.05) than the haloperidol - chlorpromazine combination.
Evaluasi Fitokimia dan Antioksidan dari Piper hispidum Sw. yang dikoleksi dari Desa Gunung Malang pada Vegetasi yang Berbeda Vivi Anggia; Rindita Rindita; Fauziah Ulfa Ramadhany
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.926

Abstract

Jamaican pepper (Piper hispidum Sw.) is a wild plant, member of Piperaceae family and invasive plant species reported used to heal wounds and treat symptoms of skin leishmaniasis. This study aims to explore phytochemicals of Piper hispidum, especially phenolic content and antioxidant capacity, in two different abiotic condition of the forest, shaded and open area. Exploration of P. hispidum was conducted in Gunung Malang Village, Halimun Salak Mountain National Park (TNGHS). The sample was extracted with the ultrasonic method. The phenolic level and antioxidant activity were determined with Folin Ciocalteu and DPPH method where gallic acid was used as a standard. The total phenolic content assay showed 70% ethanol extract of P. hispidum Sw. leaves from the shaded and open forest were 17.4775 mg GAE/g and 12.6137 mg GAE/g of sample respectively. The antioxidant activity assay showed that IC50 of the sample from shaded and open forest were 94.8414 and 94.3412 ppm and gallic acid was 7.9817 ppm. This study showed that differences in vegetation and environmental abiotic factor may contributed in the amount of chemical compounds where open vegetation exposed to the sunlight had lower values than shaded but not significantly affected the antioxidant value.
Efek Penurunan Kadar Glukosa Darah Rebusan Asparagus (Asparagus offi cinalis L.) Pada Mencit yang Diinduksi Aloksan Rika Sari Dewi; Lestari Rahayu; Ni Made Dwi Sandhiutami; Sondang Khairani; Isti Atika
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.956

Abstract

Diabetes mellitus characterized by hyperglycemia whereas the condition for high blood glucose. InIndonesia, there are a lot of medicinal plants that used as antidiabetic treatment. Medicinal plants are known have relatively few side eff ects compared to chemical based drugs. Asparagus (Asparagus offi cinalis L.) was reported to have fl avonoids and saponins compounds that could be functioned as antidiabetic. The aim of this research was to fi nd out the eff ect of boiled asparagus on blood glucose level in mice induced by Alloxan. This research used 30 male DDY strained mice, which were classifi ed into 6 groups, and each group consisted of 5 mice. These 6 groups were: normal control, negative control, positive control (Acarbose), the boiled asparagus with dose of 280, 560, and 840 mg/kgBW for 14 days. Blood glucose level of mice were observed on day-0, 8, 15, and 22. The results showed that Alloxan injection increased the level of blood glucose. Another result showed that boiled asparagus with dose of 280, 560 and 840 mg/kgBW reduced the level of blood glucose and the eff ect showed treatment groups doses of 560 dan 840 mg/kgBW had no signifi cantly diff erent with positive control group (Acarbose).

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