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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 680 Documents
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Analisis Ramuan Obat Tradisional untuk Wasir di Pulau Jawa; Studi Etnofarmakologi RISTOJA 2015 Peristiwan R Widhi Astana; Ulfatun Nisa
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (484.674 KB) | DOI: 10.35814/jifi.v16i2.562

Abstract

The using of traditional medicine among community has being accepted and become huge potency to be developed by our country. One of disease which is often treated with traditional medicine is hemorrhoid or in bahasa as known as “wasir”. According to the result of ethopharmacology research of traditional medicine and jamu (RISTOJA) 2015 in java island, there are several formulas used by traditional healers to treat hemorrhoid. In order to fi nd potential formulas to be developed, a descriptive study was conducted involving identifi cation of medicinal plant and also literature study about its benefi t and toxicity evidences. The plants which named in formula’s ingredient were analized to see how important and utility value for hemorrhoid treatment. Literature study was conducted to assess potential benefi t and toxicity. The result said there were 37 species of medicinal plant in 25 family used in traditional medicine formula for hemorrhoid. Based on Frequency Citation(FC), Utility Value (UC) and literature study, Graptophyllum pictum (L.) Griff ., Curcuma longa L., Aloe vera (L.) Burm.F, and Musa balbisiana have enough scientifi c evidence to be studied further development.
Aplikasi Metode Aktivasi Netron untuk Penetapan Mineral Selenium dalam Produk Suplemen Kesehatan Titiek Martati; June Mellawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Recently, there are some health supplement products that are useful as an antioxidant in the market, and one of them is Selenium (Se) tablet. Therefore issue of falsification of drug due to the control of health supplement product become very important. In this research the determination of Se in health supplement tablet using neutron activation analysis has been carried out. Sample was irradiated using thermal neutron with 1013 neutron cm-?secondfluxes within 15 minutes, and based on n, y reaction 75Se isotope would be formed that could identified using Gamma spectrometer on 136, 264, and 279 keV energies. The result showed that neutron activation analysis method can analysis Se mineral that contained in health supplement tablet with accuracy ranged between 101.81 – 102.29 % and precision 99.02 -99.37%. The recovery test of Se mineral concentration to the labeled attached showed 105.79 - 116.66%, and this value was still in the recommended range according to the USP 28 (90 – 125%).
Sintesis Analog 3-0-Benzylstentorin sebagai Prekursor untuk Kerangka Dasar Blepharismin TENI ERNAWATI; YOSHINOSUKE USUKI; HIDEO IIO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

A Method for the synthesis of precursor for the basic skeleton of blepharismin and structural analog was described. Such compound is identified as potential drug for the treatment of antiviral and photodynamic therapy. Benzyl stentorin analog as the basic skeleton of blepharismin was effectively synthesized via reaction one of hydroxyl groups in bianthraquinone derivative with p-methoxybenzylchloride in the presence of potassium carbonate as base. Dimerization of bromo anthraquinone derivative produced dimmer in 55% while the formation of compounds analogous of 3-0-benzylstentorin resulted in 70% yield.
Efek Antioksidan dari Ekstrak Biji Petai Cina (Leucaena leucocephala L.) pada Tikus Putih Fatty Nurhasanah; Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 1 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The study deals with the examination of the antioxidative effect of a Leucana leucocephala L. seed extract on diabetic rats induces with streptozotosin. The rats were divided in to 6 groups, each consisting of 5 rats i.e. group 1: normal, group 2: control (chlorpropamide), group 4: low dose of Laucaena seed extract 0,5/kg BW and group 6: high dose of Laucaena seed extract 1 g/kg BW. The malon dialdehyde (MDA) and superoxid dismutase (SOD) contents were analyzed by ANOVA and continued with the ttest. The result obtained shows that an increase of SOD could be observed by a Laucaena seed extract of resp 0.25;0.5 and 1 g/kg BW.
Transformasi Plasmid pTRLI ke dalam Protoplas Aspergillus terreus dengan Penambahan Polietilenglikol DUDI HARDIANTO; MARLIA SINGGIH; AMIR MUSADAD; WAHONO SUMARYONO; TUTUS GUSDINAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Plasmid transformation is the introduction and incorporation of exogenous plasmid into cells or protoplast. The purpose of this research is transformation of pTRLI plasmid into protoplasts of Aspergillus terreus and obtain stable transformants. The research was initiated by isolation of pTRLI plasmid and determining its purity and concentration by nanodrop machine. Furthermore, protoplasts of A. terreus were isolated enzymatically by addition of chitinase, cellulase, and maserozyme enzymes. pTRLI plasmid was transformed into protoplasts of A. terreus by addition of calcium chloride and polyethyleneglycol (PEG) solutions. These transformants were grown in Czapek-Dox agar medium containing pyrithiamine 1 mg/L and the number of transformants/µg of pTRLI plasmid was calculated. The number of transformants were produced ranging from 12 to 19 transformants/µg of pTRLI plasmid. The success of the transformation was indicated by ptrA gene in transformants that could be amplified by PCR of 801 base pairs in size. It was concluded that PEG solution could be used to transform pTRLI plasmid into protoplasts of A. terreus and transformants are stable up to live generations by growing the transformants in Czapek-Dox agar medium containing pyrithiamine 1 mg/L.
Intervensi farmasis didokumentasikan untuk membandingkan intervensi aktif farmasis di bangsal berbeda di rumah sakit anak, dan untuk membandingkan faktor yang mempengaruhi penerimaan intervensi farmasis oleh dokter. Peneliti melakukan observasi intervensi HESTY UTAMI RAMADANIATI; YA PING LEE; JEFFERY DAVID HUGHES
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Pharmacists’ interventions were documented to compare pharmacists’ active interventions in different settings within a children’s hospital and identify the predictors for physician acceptance of the interventions. The investigator observed pharmacists’ interventions between 35-37 days on five study wards. The rates and types of pharmacists’ interventions on the different wards were compared. Multivariate logistic regression analysis was performed to identify the acceptance predictors of the interventions. The Hematology-Oncology Ward had a higher rate of active interventions (2.43 interventions per 100 medication orders) compared to general settings. Dose adjustment was the most frequent interventions in the general settings, whilst drug addition constituted the most common interventions on the Hematology-Oncology. The acceptance degree of intervention by physicians was high. There were three variables predicting the acceptance: patients’ age (OR = 0.893; 95%CI 0.813, 0.981), non high-risk medication (OR = 2.801; 95% CI 1.094, 7.169) and pharmacists’ experience (OR = 1.114; 95%CI 1.033, 1.200). The rate of active interventions on Hematology-Oncology Ward was higher than the general wards.The pattern of the interventions on Hematology-Oncology Ward was different compared to that of other wards. The interventions involving younger patients, non high-risk medications, recommended by more experienced pharmacists increased likelihood of acceptance by physicians.
Ekstraksi dan Identifikasi Senyawa Antimikroba Herba Meniran (Phyllanthus niruri L.) WIBOWO MANGUNWARDOYO; ENI CAHYANINGSIH; TEPY USIA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 7 No 2 (2009): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Phyllanthus niruri L. herbs was extracted using ethanol 96%, ethylacetate and n-hexane. The rendements were respectively 49.25% (for ethanol extract), 4.18% (ethylacetate extract) and0.78% (n-hexane extract). Identification of the ethanol extract using phytochemical assays resulted in alkaloid, flavonoid, saponin, and tannin compounds. Purification of the ethanol extract using thin layer chromatography (TLC) with n-hexane-ethylacetate (6:4) followed by the inhibitory activity test using bioautography TLC showed that the spot of Rf 0,46 inhibited Staphylococcus aureus and that of Rf 0,66 inhibited Candida albicans. Analysis with infra red spectrophotometer showed that the ethanol extract has hydroxyl (-OH) and carbonyl (C=O) functional groups.
Potensi Ekstrak Rimpang Kunyit Sebagai Prebiotik Pemacu Pertumbuhan Lactobacillus plantarum Secara In Vitro MIN RAHMINIWATI; SAEPUDIN RAHMATULLAH; IRMANIDA BATUBARA; SUMINAR S. ACHMADI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Turmeric contains curcumin which has antibacterial and anti-inflammatory activities. In addition, turmeric contain also carbohydrates that has potency as a prebiotic agent. Research on turmeric extract that was obtained by maceration in variety of solvent, temperatures and time have been carried out to get the most potent prebiotic extract of turmeric to stimulate L. plantarum growth. Maceration with water at 28oC for 1 hour resulted in extract which can enhance the growth of L. plantarum approximately is higher than controls at a concentration of 1 ppm. L. plantarum growth rate increases with increasing concentration of extract. Sugars content of oligosaccharide in the extract were stakiosa, sucrose and lactose of 3014, 164, and 82 ppm respectively. It is concluded that oligosaccharide in turmeric extract is potential as prebiotic agent to increase L. plantarum growth.
Sintesis Senyawa N-(2-Klorobenzoil)-N’-Fenilurea dan Uji Aktivitas Anti Kanker Terhadap Sel HeLa Bambang Tri Purwanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.562 KB) | DOI: 10.35814/jifi.v16i2.548

Abstract

Research in the search for cancer drug compounds continue to be developed given the lack of specific anticancer compounds. Some urea derived compounds are also continuously being developed in search of potent anticancer compounds with minimal side effects. In relation to the above, we want to develop an urea derivative of N-phenylurea compound which will be reacted with benzoyl chloride derivative that is 2-chlorobenzoyl chloride so that N-(2-chlorobenzoyl) -N'phenylurea will be obtained. Synthesis of N- (2-chlorobenzoyl) -N'phenylurea was done by modified Schotten-Baumman method, then purity test was performed with thin layer chromatography using 3 different solvents. The next step is structural characterization using UV and IR spectrophotometry method, then 1H-NMR and MS spectrometry, so that the structure of N- (2-chlorobenzoyl) -N'phenylurea will be obtained. An anticancer activity test is performed on HeLa cells using MTT assay method and IC50 value will be obtained. Compounds that have been successfully synthesized are compound of N- (2-chlorobenzoyl) -N'phenylurea, with yield of 80.47% in the form of white needle crystal. The purity test of the N- (2-chlorobenzoyl) -N'phenylurea compound was performed by thin layer chromatography with 3 different solvents (hexan: ethyl acetate: methanol = 2: 3: 1; Hexan: acetone = 4: 2; Hexan: ethylacetate = 4: 2) a single stain is obtained which is different from the Rf value compared to the N-phenylurea origin compound. The Melting Point of the compound is 149oC so it is seen that the compound has been formed and different from the origin compound of N-phenylurea. The anticancer activity test after performed with MTT assay method using HeLa cells line, has an IC50 2100 mg / ml or 8,52 mM for the N- (2-chlorobenzoyl) -N'phenylurea and higher than hydroxy urea as standard compound which has the activity as 7537 mg / ml or 99,10 mM. Conclusion: N- (2-chlorobenzoyl) -N'phenylurea compound has been successfully synthesized and can be further developed as an anticancer compound. Keywords: Synthesis; N-(2-chlorobenzoyl)-N'phenylurea; anticancer activity; HeLa cells.
Penyakit Kaki, Tangan, dan Mulut dan Pengobatannya Ilma Nugrahani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 1 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Information related to cause, spreading, prevention, and symptomatic treatment of Handfoot-and-mouth disease (HFMD) has been compiled. It is a viral illness with a distinct clinical presentation of oral and distal extremity lesions characteristic. Most commonly, the etiologic agent are coxsackieviruses, members of Picornaviridae family, namely coxcackievirus A16 or enterovirus 71. The drugs used to symptomatic care are anesthetic agent, antipyretic, analgesic, antihistamine, antacid, and antiseptic agent.

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