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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 680 Documents
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Evaluasi Penggunaan dan Biaya Obat Antihipertensi pada Pasien Hipertensi Rawat Inap di IRNA-B Rumah Sakit Umum Pusat X Periode Juli-Desember 2010 YUSI ANGGRIANI; AGUS PURWANGGANA; AHMAD SUBHAN; RIA PUSPITA WARDHANI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 2 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The appropriate use of antihypertensive have important role for the successful of hypertension therapy. The study aims were to evaluate the use of antihypertensive medicines and cost of hypertension therapy in General, Askes and Jamkesmas inpatient at IRNA-B ward in X hospital from July to December 2010 period. Design of the study were descriptive analytical and retrospectively. Inpatients with primary hypertension and concomitant disease (hypertensive heart disease with and without congestive heart failure and hypertensive renal disease with renal failure) at IRNA-B ward in X Hospital were included to the study. The results showed that the appropriateness of the selection of antihypertensive was 87.0%. Non-formulary antihypertensive medicines were 39.3%. The lowest of medicines cost of hypertension therapy was shown in Askes inpatient. There were differences in the cost of hypertension therapy among Askes with General inpatient and Askes with Jamkesmas inpatient. There was no diference drug cost therapy between General and Jamkesmas inpatient.
Isolasi Senyawa Flavonoid dari Ekstrak Metanol Daun Katuk (Sauropus androgynus (L.) Merr), Euphorbiaceae RATNA DJAMIL; SARAH ZAIDAN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Katuk (Sauropus androgyrus (L.) Merr) is one of the plants used for medicinal purposes. It has been carried out the research to isolate and to identify flavonoid compounds in the methanol extract of katuk leaves using paper chromatography and spectrophotometry ultraviolet-visible. The results demonstrated that light spectrum of uv-visible in the presence of a reagent gave an isolate NB-3 which was a compound suspected of flavonol with OH group in positions 5,7,4 ‘and o-di OH groups in the position of the A-ring (6,7 or 7,8) whrereas NB-4 isolate was suspected as flavonoids with OH groups at 5.7 and the prenil groups in position 6, methylation or glycosylation at OH group in a position 3 and o-di OH groupsin position of the a-ring (6,7 or 7,8).
Aktivitas Antimalaria dan Skrining Fitokimia Metabolit Sekunder Kayu Batang dan Kulit Akar Artocarpus Camansi Blanco (Moraceae) ALIEFMAN HAKIM; EKA JUNAIDI; BAIQ FARA DWI RANI SOFIA; YUNITA ARIAN SANI ANWAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 2 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Malarial parasite, Plasmodium, has been reported resistant to commonly used antimalarial drugs, such as chloroquin. Plants Artocarpus genus are known to have high content of flavonoids. One of interesting bioactivities of Artocarpus flavonoids is their antimalarial activity. This research is to investigate the potency of secondary metabolites in the heartwood and root bark of Artocarpus camansi Blanco as an antimalarial agent. Antimalarial activity from methanol extract of heartwood and roots bark of A. camansi were tested in vitro to Plasmodium falciparum SD7 (strain sensitive to chloroquin) and W2 (strain resistant to chloroquin) The extracts were also phytochcmically screened for compounds. The result showed that the methanol extract of heartwood and root bark of A , camansi Blanco inhibited the growth of Plasmodium falciparum 3D7 strain With IC50 values of 1.84 µg/mL and 32.13 µg/mL . respectively; While similar antimalarial activity test to Plasmodium falciparum W2 strain showed IC50 valucs of 8.11 µg/mL and 17.10 µg/mL, respectively. Phytochemical screening indicated that the heartwood and root bark of A. camansi Blanco contain flavonoids, terpenoids, and tannin, while coumarin and saponins are present only in the root bark of A. camansi Blanco.
LD50 and LC50 Values of Ethanol Extracts From Herbs of Ketumpangan Air (Peperomia pellucida (L.) Kunth) INDAH DWIATMI DEWIJANTI; MARISSA ANGELINA; SRI HARTATI; BETTY ERNAWATI DEWI; LIA MEILAWATI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 2 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Ketumpangan air (Peperomia pellucida (L.) Kunth), an Indonesian wild plant, is commonly found in every Indonesian region with moist shady place. People usually consume ketumpangan air as a fresh vegetables. Empirically, ketumpangan air is consumed to treat fever, stomach disease, kidney disorders, drug abscesses, boils acne, headaches, pain in arthritic and rheumatic gout, or other external treatment. In this research, we tested the acute toxicity of ethanol extract from ketumpangan air using experimental animals mice DDY strain. We also tested the Brine Shrimp Lethality Test (BSLT) using Artemia salina Leach larva shrimp. The main aim of this reseach was to determine the LD50 and LC50 values of ethanol extract from Ketumpangan air. The results showed that the ethanol extract was categorized as ‘mild toxic’. The calculation of LD50 with Reed and Munich method showed that the LD50 value for male and female group was 15.13 g/ kg and 11.87 g/kg respectively. The BSLT result showed that the LC50 values of Ketumpangan air was 81.28 ppm.
Penetapan Parameter Mutu Ekstrak yang Memiliki Aktivitas sebagai Antioksidan dari Daun Cincau Hijau (Cyclea barbata L.Miers.) Erlindha Gangga; Rani Purwati; Yunahara Farida; Kartiningsih Kartiningsih
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.975 KB) | DOI: 10.35814/jifi.v15i2.525

Abstract

Cincau Hijau leaves (Cyclea barbata L.Miers ) has been used empirically as a medicinal plant because it contains many potential compounds such as flavonoids. Cincau Hijau leaves has been known as antioxidant activity. Determination of pharmacognosy parameters and phytochemical screening of dry leaves and extracts have been carried out as well as determination of total fl avonoids content. Fresh leaves were extracts with water and Dry leaves were macerated with 96% ethanol and were then concentrated by rotavapor to obtain viscous extracts. Free radical scavenging activity of the extracts was evaluated using DPPH method. Afterwards, determination of specifi c and non-specifi c parameters were performed. Results of phytochemical screening of powder and 50% and 96% ethanol extract showed that tall the tested samples contained alkaloid, fl avonoids, saponins, tannins, steroids/ triterpenoids, coumarin. The examination of specifi c parameter showed that the extract has a thick consistency, tawny color, bitter taste, characteristic odor. In addition, water-soluble compound and 96% ethanol extract are 46.64 and 62.13% respectively whereas ethanol-soluble compounds are 39.22 and 74.72%, respectively. While the results of nonspecifi c parameters of 50% and 96 % ethanol extract displayed total ash content of 9.69 and 9.49%, respectively, acid insoluble ash content of 0.30 and 0.16%, respectively, content of water soluble ash of 9.17 and 4.30%, respectively, loss on drying of 9.35 and 8.9%, respectively, water content of 8.45 and 7.25%, respectively. Based on heavy metal contamination, Pb concentration in 50 and 96% ethanol extract are 0.0227 and 0.0333 mg/kg, respectively whereas Cd concentration are 0.1206 and 0.0022 mg/kg, respectively and total number of CFU of 4,22 x 103 and 2,30 x 103 colonies/g, respectively while molds and yeasts number of colony of 0,48 x 102 and 8,88 x 102 colonies/g, respectively. Moreover, the total flavonoid was 0,19 %. Result of DPPH inhibition test showed that IC50 96 % ethanol extract are 83,280 ppm and water extracts are 102,01 ppm
Produksi Senyawa Kuinina dengan Fermentasi Mikroba Endofit Tanaman Cinchona pubescens Vahl. Esti Mumpuni; Herman Suryadi; Partomuan Simanjuntak
JURNAL ILMU KEFARMASIAN INDONESIA Vol 3 No 2 (2005): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This study deals with endophytic microbes, known as a potential source of secondary metabolites. The microbes (F) were isolated from Cinchona pubescens Vahl and fermented in Phoma media, observing the pH, biomass growth and secondary metabolites of alkaloids for 14 days. The result obtained showed that the pH was between 4 and 5, the biomass growth relative stable after 8 days and the production of alkaloids reached its maximum also after 8 days (32.81 mg/l).
Analisa Kualitatif dan Kuantitatif Teofilin dan Metabolitnya dalam Darah Tikus yang Diinduksi Bunga Kubis (Brassica oleracea var Botrytis L.) ENDAH SRI SUNARSIH; LUKMAN HAKIM; SUMANTRI SUMANTRI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 2 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

(Isolation of Lutein from Kenikir Flowers (Tagetes erecta L.) and Identification by Fourier Transformed Infra Red and Liquid Chromatography Mass Spectrometry) KUSMIATI KUSMIATI; SWASONO R TAMAT; TRIA AJENG ILMIARTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Lutein merupakan karotenoid golongan xantofil yang digunakan untuk pewarna alami dan bersifat antioksidan yang mampu mencegah berbagai penyakit termasuk kanker. Senyawa ini ditemukan dalam jumlah besar pada bunga kenikir (Tagetes erecta L.). Penelitian ini bertujuan untuk mengisolasi dan mengidentifikasi lutein dari bunga kenikir jenis lokal. Serbuk kering bunga kenikir dimaserasi dengan n-heksan, kemudian maserat didigesti dengan isopropanol dan disaponifikasi menggunakan larutan NaOH 50% hingga terbentuk semisolid. Selanjutnya, dilarutkan dengan air hingga terbentuk endapan halus dan disentrifus. Residu yang dihasilkan difraksinasi dengan kromatografi kolom silika gel dengan fase gerak n-heksan-kloroform-aseton (6:2:2) secara isokratik menghasilkan fraksi 3 dan 4 yang mempunyai nilai Rf pada KLT mirip dengan lutein BP (0,39-0,40). Identifikasi dengan spektrofotometri cahaya tampak menunjukkan panjang gelombang serapan maksimum pada 447 nm, dengan spektrofotometri FT-IR menunjukkan adanya gugus fungsi C–H tekuk, C–H ulur, C = C, serta –OH. Analisis KCKT dengan kolom C18 dan eluen metanol-diklorometan-asetonitril (67,5 : 22,5 : 10 v/v) menunjukkan waktu retensi sama dengan lutein BP (3,48-3,53 menit), dan analisis KG-SM menunjukkan berat molekul 568 serta fragmentasi sama dengan lutein BP. Penelitian menyimpulkan bahwa lutein dapat diisolasi dari bunga kenikir dengan rendemen sebesar 5,26% dan lutein kasar sebanyak 32,23%.
Penggunaan Obat Herbal pada Pasien Kanker Serviks MAKSUM RADJI; HENDRI ALDRAT; YAHDIANA HARAHAP; COSPHIADI IRAWAN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Herbal medicines have widely been used to treat many type of diseases despite the advance of standard or conventional therapy. In fact, many people in Indonesia use medicinal plant as their customary part of life. Therefore, it is necessary to further explore the use of herbal medicines through modern perception. ln this study we would like to know the frequency and species of herbal medicines used among cervical cancer patients in National Cancer Hospital Dharmais, Jakarta, Indonesia and also to assess the relationship between age, education, jobs, stage of cancer, and payment status of the patients. The results were 61,8% patients used herbal medicines. The herbal medicines used most were mahkota dewa (Phaleria macrocarpa Scheetf Boerl.) 35.3%, temu putih (Curcuma zedoaria Rosc.) 32.4%, and buah merah (Pandanus conoideus Lam) 17,6%. There was a significant relationship (p=0,039) between the use of herbal medicines and stage of cancer but no relationship between age, education, occupation, income and payment status with the use of herbal medicines.
Aktivitas Isolat Actinomycetes dari Rumput Laut (Eucheuma cottonii) sebagai Penghasil Antibiotik terhadap Staphylococcus aureus dan Escherichia coli NANIK SULISTYANI; ACHMAD NURYADIN AKBAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 1 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Actinomycetes are microbial group of the most widely produced bioactive compound as antibiotics.This study was intended to isolate Actinomycetes from seaweed Eucheuma cottonii and to identify the activity of isolated Actinomycetes as antibiotic producer against Staphylococcus aureus and Escherichia coli. Furthermore, the research was aimed to know the spots on thin-layer chromatography(TLC) which has antibacterial activity against S. aureus and E. coli. Isolation of Actinomycetes from E. cottonii was carried out with a spread plate method. The activity test of Actinomycetes as antibiotic producer against S. aureus and E. coli was performed by cup plate method. TLC bioautography was done with stationary phaseof silica gel GF254 and mobile phase of n-hexane : ethylacetate (2:3). The results showed that RL 6 and RL 12 isolate produced antibiotic against S. aureus and E. coli.The TLC bioautography result of ethyl acetate extracts of RL 6 and RL 12 cultures against S. aureus and E. coli showed a inhibition zone at Rf 0.05 and 0.22, respectively.

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