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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 680 Documents
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Polypharmacy and the occurrence of potential drug interactions in geriatric Covid-19 patients in Karawang General Regional Hospital, Indonesia Khairani, Sondang; Manninda, Reise; Sarah, Mutia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1662

Abstract

The management of COVID-19 treatment continues to evolve by involving various types of drugs both symptomatic and supportive therapy. COVID-19 infection with comorbid conditions in geriatric patients can have an effect on increasing drug use and the potential for drug interactions. The purpose of the study was to determine whether there is a relationship between the level of polypharmacy and the incidence of potential drug interactions at Karawang Regency Hospital for the period January to December 2021. The research method used was a cross-sectional study design. The data collected was hospital secondary data with retrospective data type and statistical analysis using Spearman Rho. The research material used was medical record data from 182 samples using the total sampling method. Based on the results of the study, it was found that as many as 108 (59.3%) patients received treatment with a total of 5-9 types of drugs. Potential drug interactions were experienced by 148 (81.3%) patients with a total of 764 events. There is a relationship between the level of polypharmacy and the potential incidence of drug interactions (r: 0.537, p: <0.001).
The association between knowledge and implementation of good compounding practice among pharmacy practitioners at community pharmacies in Central Jakarta Kurniawan, Adin Hakim; Safrina, Ulya; Yusmaniar, Yusmaniar
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1556

Abstract

Drug compounding in community pharmacy is an important process in providing drugs according to patient needs. Poor compounding practices can pose serious health and safety risks. To improve the quality of compounds used in medicinal preparations, Pharmacists need to increase their knowledge and Good Compounding Practice (GCP). This study aimed to analyze the application knowledge of pharmacists regarding GCP of non-sterile preparations in Central Jakarta Regional Pharmacies. This type of research is observational research using cross-sectional descriptive methods. Data collection was carried out using a questionnaire distributed to 82 pharmacy practitioners working in the pharmacy community and using a structured questionnaire to evaluate the level of knowledge and implementation of GCP. The data analysis technique used is chi-square. Most of the Pharmacy Practitioners had good knowledge scores (71.95%). Meanwhile, the level of implementation of GCP has a good implementation value (82.92%). Good knowledge and implementation of Good Compounding Practice is very important to maintain the integrity and safety of drugs produced in compounding practices. This must be implemented in the training and education of pharmaceutical practitioners to help maintain the quality of safe and effective drug compounding practices.
Effectiveness of nutmeg flesh extract (Myristica fragrans H) as an immunomodulator using the carbon clearance method in mice (Mus musculus) Rokhmah, Nisa Najwa; Herlina, Nina; Ananda, Syindi Yulia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1517

Abstract

Nutmeg (Myristica fragrans H) is composed of secondary metabolite compounds, among which flavonoids significantly contribute to its immunomodulatory properties. Using the carbon clearance method, this study aims to determine the efficacy of nutmeg flesh extract (NFE) as an immunomodulator. Negative control (Na-CMC 0.5%), normal control (Na-CMC 0.5%), immunostimulant positive control (Imboost® Force 0.91mg/20 g BW of mice), immunosuppressant positive control (methylprednisolone® 0.015 mg/20 g BW of mice), dose I (5 mg/20 g BW of mice), dose II (10 mg/20 g BW of mice), and dose III (20 mg/20 g BB mice) comprised the seven groups of 35 white male mice (DDY). The assessed parameters included organ index, absorbance, and the phagocytosis constant and index. The immunostimulant effect of NFE was demonstrated by the phagocytosis index values of 1.225 (indicating moderate immunostimulation), 1.512 (indicating moderate immunostimulation), and 2.202 (indicating strong immunostimulation) for NFE dose I, II, and III, respectively. The lymphoid organ index may have increased among the three NFE treatment groups, according to the results of organ index measurements. We can conclude, Nutmeg Flesh Extract (NFE) has an immunomodulatory effect in the immunostimulant category, as well as increased phagocytosis activity and lymphoid organ index.
Hand, foot, and mouth disease in children: forecasting of future research direction using bibliometric analysis Tan, Santi; Tjandrawinata, Raymond Rubianto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1563

Abstract

Since 1997, hand, foot, and mouth disease (HFMD) has become a common health problem in Southeast Asia. Various types of research have been conducted and published to handle HFMD. However, until now, many children, especially in the Asia-Pacific region, including Indonesia, still have HFMD-causing enterovirus (EV) infection. By conducting a bibliometric analysis of the literature published over the last 27 years (1997–2024), the direction of HFMD research in children can be predicted, thus research areas that have the potential and still need to be developed for future better HFMD treatment can be known. The important HFMD research topics predicted to continue to develop were identified through keyword analysis, which was subsequently mapped using a network approach. Based on this study, it can be concluded that HFMD research is predicted to lead to the development of synbiotic supplements, which can reduce HFMD severity, especially in children, by utilizing a genome-wide association study (GWAS) and machine learning.
Acute toxicity of arumanis mango leaves (Mangifera indica L.) extract against zebrafish (Danio rerio) embryos Darniwa, Adisty Virakawugi; Cahyanto, Tri; Rahayu, Ira; Ulfa, Risda Arba; Adawiyah, Ayuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1209

Abstract

Arumanis is one of the cultivars of Indonesian mangoes used as a horticultural commodity. Young leaves arumanis can be used for traditional herbal medicine. Pharmacological activity of young leaf arumanis extract are known to be antidiabetic, anticancer, antibacterial, anti-inflammatory, and analgesic effects. However, it is necessary to carry out toxicity testing before young leaf arumanis extract is used in traditional herbal medicine. This study aimed to determine the LC50 value of young leaf arumanis extract and identify the hatching time of embryos, heart rate of larvae, swimming movement of larvae, and malformations in both embryos and larvae. Forty five embryos of zebrafish were exposed to several concentrations of young leaf arumanis extract at 24 h post-fertilization until 96 h post-fertilization. Percentage of embryonic death calculated using probit analysis model LC50. Hatching rate, swimming movements, and heart rate were analyzed using the IBM SPSS software version 26. The LC50 values of the young leaf arumanis extract were 42.65μg/mL at 96 hpf and also 42.65μg/mL at 72 hpf. The embryotoxic effects at high concentrations of the extract are hatching delay and decreasing heart rate. The extract also caused abnormalities in embryo morphology, including pericardial edema and tail bending.
Impact of education on anemia in pregnant women attending Bandung community health centers: knowledge, therapy adherence, hemoglobin, and iron intake Zazuli, Zulfan; Furqani, Winda Haniva; Putri, Suci Utami Ayungga
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1559

Abstract

Anemia in pregnant women poses risks to maternal and infant health. Iron supplementation therapy (IST) adherence and adequate dietary iron intake are crucial for maintaining normal hemoglobin (Hb) levels. This study investigates the impact of education on iron deficiency anemia (IDA) knowledge, IST adherence, iron intake, and Hb levels in pregnant women. A pre-post test study was conducted at Padasuka and Pagarsih Community Health Centers in Bandung. Questionnaires measuring IDA knowledge, Brief Medication Questionnaire (BMQ) for IST adherence, and Food Frequency Questionnaire (FFQ) for iron intake were utilized. This study included a total of 88 pregnant women. The majority of the participants were aged 26-35 years (55.7%), had normal BMI values (45.4%), and exhibited normal blood pressure (60.2%). Additionally, 89.8% had no history of anemia, 90.9% had no other medical history, 92% reported having a good appetite, and 97.7% did not smoke. Education significantly improved IDA knowledge (p = 0.011), IST adherence (p = 0.006), iron intake (p = 0.001), and Hb levels (p = 0.011). Strong positive correlations were found between knowledge of IDA in pregnant women and adherence to IST (r = 0.957; p<0.001), knowledge and Fe intake (r = 0.972; p<0.001), knowledge and Hb levels (r = 0.988; p<0.001), adherence to IST and Fe intake (r = 0.933; p<0.001), adherence to IST and Hb levels (r = 0.948; p<0.001), as well as Fe intake and Hb levels (r = 0.978; p<0.001). Enhanced knowledge, IST adherence, and iron intake may mitigate anemia risks in pregnant women.
Biotechnology-based therapy for stroke treatment: review Utama, Hieronimus Adiyoga Nareswara; Mariya, Sela Septima; Dumingan, Alvian; Putri, Ratih Rinendya; Sunarno, Sunarno; Malik, Amarila
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1613

Abstract

Various therapeutic agents have been used to treat stroke. However, currently there is extensive exploration of new potential therapies for stroke involving novel signaling pathways and development of therapeutic agents through biotechnological approaches. This article examines the recent advances in stroke therapy using biotechnology-based drugs. We conducted a comprehensive search using specific keywords relating to Ischemic Stroke, ATMP, Peptide, Antibody, Stem Cells, and connected topics in the databases of Medline, Scopus, Web of Science, and Pubmed. The main focus of the selection criteria was on English-language literature that explored the relationship between Ischemic Stroke, ATMP, Peptide, Antibody, Stem Cells, and related factors. This article exhibits that numerous studies are being conducted and have demonstrated the use of biotechnology-based therapeutic agents for stroke, including tissue plasminogen activators, therapeutic peptides, microRNA, monoclonal antibodies, as well as stem cells. These therapeutic agents have not only been tested on test animals but have also been commenced to be tested in clinical studies or have obtained marketing approval for use in ischemic stroke patients. In conclusion, despite the limited number of approved drugs, advancements in biotechnology are poised to make them common adjunct treatments for stroke patients, not just for managing the disease but also for its cure and regenerative effects in survivors.
Activity of hair tonic preparation combining Apium graveolens L extract, Tussilago farfara flower extract, Achillea millefolium extract, Cinchona succirubra bark extract on male New Zealand white rabbits Ardi, Maria Yedida; Faizatun, Faizatun; Desmiaty, Yesi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1615

Abstract

Numerous hair care products are currently available in the market, including shampoo, conditioner, hair mask, hair serum, and hair tonic. Unlike shampoo, hair tonic remains in contact with the scalp for a longer duration, potentially enhancing its effectiveness. Apium graveolens L (EDS) and a combination of Tussilago Farfara flowers, Achillea Millefolium L leaves, and Cinchona Succirubra L stems, marketed as ATG, are known for their hair growth-promoting properties. This study aimed to evaluate the hair growth efficacy, stability, and safety of a hair tonic formulated from EDS and ATG extracts. The prepared extract solution was applied to the shaved backs of male New Zealand rabbits, aged 4 months and weighing 2.5-3 kg, and observations were recorded on days 7, 14, 21, and 28. Parameters measured included hair length and weight. The results indicated that the F1 formulation yielded an average hair length of 9.89 mm and weight of 49.38 mg; F2, 10.36 mm and 49.5 mg; F3, 11.98 mm and 49.5 mg; F4, 17.44 mm and 60.63 mg; F5, 17.27 mm and 52.75 mg; and F6, 19.06 mm and 56.5 mg. Conclusively, the F6 formulation demonstrated the most significant results, with an average hair length of 19.06 mm and weight of 56.5 mg. The hair tonic formulation was found to be non-irritating to the skin and remained stable throughout the study.
Antioxidant and anti-elastase activity of Tampui (Baccaurea macrocarpa) and Ketapong (Terminalia badamia) barks and leaves Ariani, Lusiana; Wulandari, Endah; Desmiaty, Yesi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1393

Abstract

Elastase is a protease that is involved in the breakdown of elastin in the dermis. Likewise, free radicals can cause elastin damage. Inhibition of elastase enzyme activity and scavenging of free radicals can prevent premature aging of the skin, especially wrinkles. The current study was to investigate the antioxidant and elastase inhibition properties of the leaves and bark of the Tampui (Baccaurea macrocarpa L.) and Ketapong (Terminalia badamia L.) plants, which may be employed as an anti-aging ingredient in cosmetics and nutraceuticals. B. macrocarpa and T. badamia's leaves and bark were extracted using reflux and 96% ethanol. Anti-elastase was examined using N-succ-(Ala)3-nitroanilide as a substrate, and the DPPH reagent was used to test the antioxidants' activity. Phytochemical screening indicated the presence of flavonoids, quinone, tannins, and steroids. Antioxidant activity of B. macrocarpa leaves (BML), B. macrocarpa bark (BMB), T. badamia leaves (TBL), and T. badamia bark (TBB) had IC50 values were 15.09±0.51; 22.89±1.51; 36.43±1.94; 39.23±1.76 ppm, respectively. The anti-elastase activity of BML, BMB, TBL, and TBB had IC50 values were 48.86±2.29; 52.03±9.54; 44.42±4.53; 40.16±1.32 ppm, respectively. The ethanol extract of B. macrocarpa and T. badamia's leaves and bark exhibits anti-elastase and antioxidant action, proposing that it may be used as an anti-aging agent.
New PK/PD profile improvement following cephalosporin extended infusion : a systematic review Nurani, Melisa Rizky; Widyati, Widyati Widyati; Yasin, Nanang Munif
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1583

Abstract

Antimicrobial resistance is a global problem that is currently experienced in various countries, both developed and developing countries. The lack of discovery of new antibiotics and the increasing incidence of Multidrug–Resistant Organisms (MDROs) have sparked several efforts to optimize the administration of currently available antibiotics. Modifications in the pharmacokinetic and pharmacodynamic profiles are one of the strategies carried out, namely by extending the duration of infusion. Cephalosporins are time-dependent antibiotics; the longer they are exposed to an infusion, the more potent they are against bacteria. This is so that the drug concentration can remain above the MIC (Minimum Inhibitory Concentration) for an extended period of time throughout the infusion. In this study, articles available in Pubmed and Google Scholar from 2013-2023 using the PRISMA method related to the extension of the duration of cephalosporin infusion were evaluated. The search strategy used the keywords continuous infusion, extended infusion, prolong infusion, cefazolin, cefuroxime, ceftriaxone, ceftazidime, cefotaxime, and effectiveness. From the research results, it was found that continuous infusion was better able to achieve the desired target drug levels compared to intermittent infusion and IV bolus administration.

Page 64 of 68 | Total Record : 680

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