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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 680 Documents
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Spray-gel formulations of Cantigi extract and Cantigi extract-loaded gelatin nanoparticles as antioxidant Kosasih, Kosasih; Alifiya, Nesshi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1586

Abstract

Spray-gel formulations may contain natural antioxidants like plant extracts. They can reduce free radicals and prevent premature aging. This research aims to study spray-gel formulations using Cantigi extracts and Cantigi extract-loaded gelatin nanoparticles as antioxidants. Extract preparation used the maceration method concentrated by a rotavapor and characterized for specific and nonspecific parameters. Antioxidant activity analysis of extract, nanoparticles, and formulations used the DPPH method. Gelatin nanoparticle synthesis was done using the nanoprecipitation method and then characterized for particle size, polydispersity index, zeta potential, entrapment efficiency, aldimine linkage formation, and morphology. Two spray-gel formulations were manufactured (F1 contained the extract, and F2 contained the nanoparticles) and evaluated for one month for organoleptics, homogeneity, viscosity, flow properties, spray pattern, pH, and antioxidant activity tests. The extract and nanoparticles meet all parameters. The antioxidant activities (IC50) are Cantigi extract of 17.4 ppm, gelatin nanoparticles of 33.6 ppm, F1 of 60.6 ppm, and F2 of 99.5 ppm. After the stability study, the spray-gel formulation characteristics were: Organoleptics, homogeneity, homogeneity, and viscosity complied (F1 and F2); flow property showed plastic thixotrophy properties (F1 and F2); spray pattern showed best at 20 cm distance (F1 and F2); pH complied (F1 and F2); and IC50 of F1 was 63.0 ppm while F2 was 103.3 ppm. Conclusions were that the spray-gel formulations (F1 and F2) complied with the standards and were stable during the storage time. However, F1 has more potent antioxidant activity than the F2.
Association of side effects to medication adherence of antiepileptic drug use in epileptic patients Ernawati, Iin; Wyono, Oktaviani Putri; Yunitasari, Fitria Dewi; Pradani, Erwindy Yastika; Islamiyah, Wardah Rahmatul
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1269

Abstract

Epilepsy is a chronic neurological disorder with symptoms characterized by seizures, arising spontaneously with brief episodes with the main symptom of decreased or loss of consciousness. This study aims to examine the effect of side effects of medication adherence to antiepileptic drug use in epilepsy patients. This research is an observational study that was analyzed using quantitative descriptive methods in Neurology patients at the Airlangga University Hospital from March until May 2022. Side effects were measured using the LAEP (Liverpool Adverse Effects Profile) questionnaire and adherence was measured using a pill count. Results showed that the influence of side effects on medication adherence (pill count method) to antiepileptic drugs using linear regression, it is known that the P-value is 0.501. There is no significant relationship between the category of side effects and medication adherence to antiepileptic drugs. Another factor that influences compliance with medication use is the appearance of seizures. Based on the results of this study, it is known that the greater the frequency of seizures, the more likely patients are to be non-compliant (P-value 0.006). To increase adherence, it is necessary to pay attention to other factors such as knowledge, economy, and type of therapy in epilepsy patients so that therapeutic outcomes can be achieved.
Powder drink of Permesia americana Mill. Seed with adding Zingiber officinale Rosc. Var Rubrum and Stevia rebaudiana L. to enhance Cardiovascular health Agustin, Arum Dwi; Purwasih, Ratih
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1438

Abstract

In today’s modern era many people consume unhealthy foods, which can lead to decreased immunity. One way to increase immunity is by consuming functional drinks from Avocado seeds and red ginger, which is contain flavonoid compounds. This study aims to determine antioxidant activity in functional drinks of avocado seeds by adding red ginger and stevia. The method used in this research is a quantitative analysis using the UV-Vis Spectrophotometer instrument at a wavelength of 418 nm for F1, F2 and F3 were brown, had a characteristic smell of spices, and had a distinctive taste. The pH test results were 6.243 ± 0.025, 6.167 ± 0.045, and 6.089 ± 0.005 respectively. The raw material and functional drinks positively contain flavonoids. Flavonoid content in F1, F2, and F3 were 12.214 ± 0.009428%, 12.419 ± 0.009428%, and 12.624 ± 0.009428% respectively. Antioxidant test results for functional drinks showed an IC50 value of F1 and F2 were 118.30 ± 1.57 ppm and 105.88 ± 1.11 ppm, which is categorized as moderate levels of antioxidants, and F3 was 88.09 ± 1.62 ppm, which is categorized as strong levels of antioxidants.
Formulation and test of mosquito repellent lotion from the extract of kecombrang (Etlingera elatior (Jack)) and beluntas (Pluchea indica) leaves extract Taurhesia, Shelly; Endah, Endah; Basuki, Witono; Djamil, Ratna
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1521

Abstract

Dengue fever is an infectious disease which is transmitted by Aedes aegypti mosquitoes and commonly occurs in Indonesia. The use of natural ingredients for mosquito repellent is becoming a trend. Kecombrang (Etlingera elatior (Jack)) is known as a medicinal plant which contains alkaloids, saponins, tannins, phenolics, flavonoids, triterpenoids, steroids, and glycosides. Beluntas (Pluchea indica) contains tannins, alkaloids, flavonoids, phenols, saponins and essential oils. This study aims to develop mosquito repellent lotion using combined leaf extracts of E. elatior and P. indica at different ratios (1:1; 1:2; 2:1). The materials used in this study were E. elatior and P. indica leaves, Aedes aegypti mosquitoes, 96% ethanol, stearic acid, triethanolamine, white oil, methyl paraben, cetyl alcohol, and distilled water. The repellent activity is tested using a standard method of WHO, comparing control group and treatment group, repeating for four times, then the protection level was calculated. The three formulas of lotion fulfilled both physical and chemical requirements and had a repellent activity of above 80%. The formulae of F3, a lotion containing both E. elatior and P. indica leaf extracts of 2:1, gave the highest protection of 88.1%.
Analisis Manajemen Penyimpanan Sediaan Vaksin COVID-19 di Instalasi Farmasi RSUD S. K. Lerik Kota Kupang Sarifudin, Barbara Azalya; Lette, Arman Rifat; Kulla, Selviana Take
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1439

Abstract

The COVID-19 pandemic poses a vast morbidity and mortality burden and disrupts communities and economies globally, including Indonesia. Vaccination is an essential prevention. Vaccine storage must be maintained to preserve its potency and safety. This study determined the suitability of the storage and COVID-19 vaccine preparations at the Pharmacy Installation of RSUD S. K. Lerik Kupang City, based on the 2020 Good Drug Distribution Method (Cara Distribusi Obat yang Baik or CDOB) standard and the 2021 Ministry of Health regarding Technical Instructions for Vaccination Implementation in Combating the Corona Virus Disease 2019 (COVID-19) Pandemic. This study used a qualitative, non-experimental observational method, data collection, structured interviews, and documentation. The storage management assessment for the COVID-19 vaccine is carried out using Zuhroh's checklist tool. The results show that the COVID-19 vaccine storage system at the RSUD S. K. Lerik needs development to follow CDOB 2020 and Kepmenkes 2021 rules fully. Indicators results that are below the standard: training and evaluation, the unavailability of a hygiene schedule, air ventilation, Vaccine Vial Monitor (VVM) images, expiration places, quarantine places, destruction of damaged vaccines, weekly and monthly recording maintenance, and also unavailability of replacement equipment during the implementation, repair, maintenance, and calibration of equipment.
Hydrating serum made of potassium azeloyl diglycinate with CMC-Na variations as a gelling agent on physical-chemical and safety tests Rohmani, Sholichah; Aditya, Shafira Nur; Husna, Hanna Miftahul; Ermawati, Dian Eka; Utami, Diyah Tri
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1257

Abstract

Potassium azeloyl diglycinate is an ingredient for moisturizing the skin. In this research, potassium-azeloyl-diglycinate was formulated into a gel-based hydrating serum. A good serum gel can be identified by its physicochemical properties and stability, which are determined by the composition of the ingredients used, one of which is CMC-Na, which is used as a gelling agent. The aim of this research was to test the effect of CMC-Na concentrations (1%, 1.25%, and 1.5%) on the physicochemical stability of serum and to find a formulation with the best stability by testing the water content and safety. The evaluation results show that increasing the concentration of CMC-Na has an impact on increasing viscosity, pH, and adhesion, thereby providing a different gel consistency in each formula and reducing its spreadability. The best formulation is Formula-2, which is then tested for water content on respondents. The research results show that this formula has the ability to hydrate the skin, as seen from an increase in oil content of 8.39% and an increase in water content of 8.86%. Initial acute dermal toxicity test results show that the serum is safe to use on the skin and does not cause side effects or toxicity reactions.
Red pomegranate (Punica granatum L.) peel extract mud mask formulation and tyrosinase-inhibition activity test Faizatun, Faizatun; Alfianita, Alfianita; Nafisa, Safira
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1600

Abstract

The peel of red pomegranates (Punica granatum L.) contains gallic acid and ellagic acid, which inhibit tyrosinase, an enzyme that aids melanin formation. This study aimed to determine how variations in the concentration of kaolin base affected the evaluation outcomes of mud mask formulations containing P. granatum fruit peel extract. P. granatum fruit peel extract was used in 3 formulas with variations in the kaolin base concentration of 19.5%, 22.5%, and 26.3%. The three formulations were subsequently evaluated through a series of procedures, which included organoleptic, homogeneity, spreadability, viscosity, pH measurements, and drying time. The enzyme-linked immunosorbent assay (ELISA) method was employed to determine the inhibitory activity of the tyrosinase enzyme. Formula 2 gives the best results with the characteristics of having a distinctive odor and thick brownish-green color, homogeneous preparation, spreadability of 20.5863 cm2, a viscosity of 16040 cPs; pH of 5.86, and drying time of 16.67 minutes. Inhibition of the tyrosinase enzyme by kojic acid, extracts, and preparations resulted in respective IC50 values of 31.64 μg/mL, 155.49 μg/mL, and 276.15 μg/mL. The results of the viscosity test, pH test, and mask drying time were significantly different as the concentration of the kaolin base varied (p<0.05).
Effect of solvent polarity on secondary metabolite content and α-glucosidase enzyme IC50 of Dendrophthoe pentandra (L). Miq leaves extract Subandrate, Subandrate; Sinulingga, Sadakata; Adma, Annes Claudia; Monanda, M. Dias Athallah; Fatmawati, Fatmawati; Safyudin, Safyudin; Oswari, Liniyanti D
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1363

Abstract

Cherry mistletoe (Dendrophthoe pentandra (L). Miq) have an inhibitory effect on the α-glucosidase enzyme, but research related to solvent optimization to find active compound is unclear. Secondary metabolites that can be identified depend on the level of solvent polarity. This study aims to determine the effect of solvent polarity on the secondary metabolite content and the α-glucosidase enzyme by using the polar and nonpolar fractions of the ethyl acetate extract of cherry mistletoe leaves. Cherry mistletoe leaves were extracted using ethyl acetate and were followed by a liquid-liquid fractionation. The polar fraction used ethanol and ethyl acetate as solvents, whereas the nonpolar fraction used n-hexane and ethyl acetate as solvents. Secondary metabolites present in polar fractions were alkaloids, flavonoids, steroids, tannins, and terpenoids, whereas those present in nonpolar fractions were flavonoids and steroids. The IC50 value of the polar fraction (54.8 ppm) was lower than that of the nonpolar fraction (192.0 ppm). The polar fraction of the ethyl acetate extract of cherry mistletoe leaves could inhibit the α-glucosidase enzyme and, therefore, is classified as active. On the other hand, the nonpolar fraction of the ethyl acetate extract of cherry mistletoe leaves could not inhibit the α-glucosidase enzyme and, therefore, is classified as inactive in general.
Optimation of meniran (Phyllanthus niruri L.) leaf extract using natural deed eutectic solvent basis choline cloride–glycol on antioxidant Handayani, Marybet Tri Retno; Yulianita, Yulianita; Lohitasari, Bina; P, Rieke Fitria
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1561

Abstract

Phyllanthus niruri L. has many benefits because it is known that meniran leaves contain secondary metabolites in the form of alkaloids, flavonoids, tannins, saponins and phenolics. The content of phenol compounds which are constituent compounds for antioxidant activity. This research was conducted to determine the combination of Natural Deep Eutectic Solvents (NADES) which can produce extracts with strong antioxidant activity. The preliminary stage determines the best combination of NADES with choline chloride as the Hydrogen Bond Acceptor and the type of sugar as the Hydrogen Bond Donor. The NADES screening obtained the best combination of choline chloride: glycerol, then the optimization stage was carried out using the RSM method with a Central Composite Design. Three variables used were temperature (25°, 40°, 60°C), time (10, 30, 60 minutes) and the ratio of NADES usage (50%, 70% and 90%). Antioxidant activity was determined with the value of in Meniran extract with positive control of vitamin C. The best NADES combination was choline chloride–glycerol (1:1) with an value of 18.039 ppm. Optimization with variations in temperature time and ratio variables obtained optimal conditions at temperature of 60°C with an extraction time of 44 minutes and ratio of 90% NADES obtained values ​​of 8.040 ppm and positive control of vitamin C obtained values ​​of 4.307 ppm. The best results for antioxidant activity are at a temperature of 60°C gives an value of 8.050 ppm was obtained and the average is 8.075 ppm.
Development of web-based application of medicine management dashboard for pharmacists in primary health care using a user-centered design: evidence from Indonesia Faradiba, Faradiba; Satibi, Satibi; Lazuardi, Lutfan; Ivanawati, Anselma
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1574

Abstract

Although the minimum standard of pharmaceutical services at the primary health centres (PHCs) has been determined, the quality of drug management at PHCs is not optimal. There is no information system in PHC to help pharmacists monitor drug management performance. This study aims to describe the systematic development of such an application. A descriptive study with a case study approach was conducted, consisting of three stages: user needs analysis, model and prototype development, and prototype evaluation. The first stage in the user-centred design method is through focus group discussion and observation. There were 13 institutions involved in the needs analysis and 9 institutions in the evaluation stage by purposive sampling. The institutions are health centres and offices in Yogyakarta from September 2021 to April 2022. Data were analysed using descriptive qualitative and quantitative methods. The research resulted in a prototype web application, PharmD, which functions as a drug management performance dashboard for pharmacists at PHCs.

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