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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 680 Documents
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The impact of medication adherence on health outcomes for patients with metabolic syndrome Setiawan, Christianus Heru; Virginia, Dita Maria; Pinaryanto, Kartono; Sari, Lisa Kurnia; Hendra, Phebe
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1378

Abstract

Cardiovascular disease is a non-communicable disease that is often associated with metabolic syndrome (MetS). MetS is a group of abnormal conditions that include hypertension, obesity, and diabetes. Patients with MetS often require multiple drugs to achieve therapeutic targets, but poor medication adherence can lead to complications. Poor medication adherence can worsen the disease and increase hospitalizations. The purpose of this study was to investigate whether medication adherence affects metabolic syndrome outcomes. This study was conducted using a cross-sectional design and purposive sampling. Our respondents were focused on patients with hypertension, diabetes mellitus, or dyslipidemia. Patients' adherence was measured using a self-made questionnaire. The study obtained data on the patient's lipid profile, HbA1c, and blood pressure (hypertension, diabetes, or dyslipidemia). The study used Spearman analysis to investigate adherence scores to lipid profile levels, HbA1c, and blood pressure. Therapeutic coverage was analyzed using a T-test. Confounding variables, such as age, HbA1c level, and blood pressure, were considered when analyzing the correlation between adherence scores and lipid profiles. The majority of patients were women or elderly, and more than 90% reported that their therapeutic needs were met. Total cholesterol and LDL-c significantly negatively correlated with adherence for patients' factor category, therapeutic regimen factor, and overall factor (p<.05). Triglyceride levels correlated significantly with adherence only to category interaction factors between patients and family/health workers. Regression analysis shows that all correlations are negative to total cholesterol, LDL, HDL, and triglyceride levels (p<.05).
Cytotoxic activity of isolate compounds from derendan (Lansium parasiticum (Osbeck) K.C. Sahni & Bennet) fruit peel Fadhli, Haiyul; Rahmayanı, Wıky; Allaya, Regina; Jumadila, Ikhsal Mukri; Fernando, Armon; Utami, Rahayu
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1309

Abstract

Derendan (Lansium parasiticum (Osbeck) K.C. Sahni & Bennet) is a plant from the Meliaceae family that grows in the tropics, especially in Sumatra (Indonesia). It was reported that this plant has antimalarial, antimutagenic, and anticancer properties. This study aims to determine the cytotoxic activity of compounds isolated from the methanol extract of Lansium parasiticum bark. Extraction using maceration method with methanol solvent. Vacuum Liquid Chromatography (KVC) with 21 different eluent ratios (n-hexane : ethyl acetate and ethyl acetate ; methanol) was utilized for the fractionation. The result was 21 fractions. The washing technique was used to purify fraction 17. The obtained compound LPR17 with a melting point of 239-241ᵒC. Based on the UV spectrum, the wavelengths of the LPR17 compound were 277.0 nm and 205.0 nm. The FT-IR spectrum shows aliphatic OH, CH, C=O, C-H, and C-C functional groups. This compound reacts positively with the Liebermann-Burchard reagent. The compound obtained is a triterpenoid group. Cytotoxic test using BSLT method. LPR17 compounds provide very strong cytotoxic activity (LC50 = 67.15 g/mL).
Cost effectiveness analysis of ceftriaxone with cefoperazon in thypoid patients at X Mataram Hospital Khairani, Sondang; Manninda, Reise; Widodo, Akhmad Fajri; Raharjo, Lalu Joko
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1585

Abstract

Typhoid is the third most common cause of hospitalisation in Indonesia, affecting 100,000 people every year. Typhoid fever, with an average case fatality rate of 2.45% at X Mataram Hospital, was among the top 10 most common inpatient illnesses in 2019 and 2020. Antibiotics are effective in reducing typhoid infection, lowering body temperature, shortening the length of hospitalisation, and reducing mortality. The aim study to determine the cost-effectiveness of using ceftriaxone and cefoperazone antibiotics for typhoid patients at X Mataram Hospital. Method a compares two groups of antibiotics and evaluates direct costs and clinical outcomes clinic (length of stay and time free of fever). This research is using ACER's cost-effectiveness analysis. The study included 63 samples with an average direct cost of Rp 3,645,106 for cefoperazon and Rp 3,168,106 for ceftriaxone. According to the ACER analysis results, hospitalisation with ceftriaxone is more cost-effective a lower cost of Rp 704,023 and based on fever-free time, cefoperazone is more cost-effective at Rp. 1,024,094. No correlation between antibiotic effectiveness and fever-free time, no correlation between antibiotic effectiveness and length of hospitalisation (p-value >0.05).
Physical-chemical stability test on spray gel with active compound ethyl p-methoxycinnamate (Kaempferia galanga Linn.) and menthol, using combination gelling agent na cmc and copovidone Suryani, Nelly; Komala, Ismiarni; Akhsani, Luthfia Wikhdatul; Dahlizar, Sabrina; Betha, Ofa Suzanti; Rahmat, Deni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1626

Abstract

The major component of galangal rhizome (Kaempferia galanga Linn) is ethyl p-methoxycinnamate (EPMS), which amounts to 80.05%. Significant anti-inflammatory activity is exhibited by EPMS from galangal rhizome through the inhibition of carrageenan-induced mouse edema and the inhibition of IL-6 production. EPMC is recognized for various pharmacological effects, particularly its potential as a wound healing agent due to its anti-inflammatory properties. The choice of spray was made because it meets the characteristics of anti-inflammatory preparations in the wound healing process. The preparation must be moist, easily adjusted to the shape of the wound (flexible), sterile, and evenly distributed, covering the tissue, and can be easily removed from the tissue, including the wound. A spray gel dosage form was formulated with varying concentrations of the gelling agent Na CMC, F1 (0.5%), F2 (1.0%), and F3 (1.5%). Physical stability was evaluated at room temperature storage on days 0, 7, 14, and 21. Organoleptics, homogeneity, viscosity, pH, spray pattern, adhesive spread ability, centrifugation test, and cycling test were evaluated. Chemical stability evaluation was carried out using UV-Vis spectrophotometry to assess the EPMS levels in the preparation. The results of the physical evaluation showed that all formulas were stable in terms of organoleptics, homogeneity, and pH, which was in the range of 6.6–7.1; the weight per spray was uniform and relatively stable in centrifugation and cycling tests. The use of a combination of sodium carboxymethylcellulose and copovidone can produce a spray gel preparation of a good aromatic ginger (Kaempferia galanga Linn) crystal with a 1%.
Analysis for quality of senggugu plant and herbal product (Rotheca Serrata (L.) with metabolomics approach Qodriah, Rahmatul; Aziz, Zuhelmi; Damayanti, Volin; Alya, Aura Dyah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1670

Abstract

Senggugu plant (Rotheca serrata (L.) has many benefits and has the potential as a raw material for herbal medicine, so an identify in the form of an FTIR fingerprint profile is needed. The purpose of this study was to ensure the quality of simplisia and herbal product of senggugu roots and leaves by metabolomics approach. Simplisia and herbal products powder of senggugu leaves and roots were extracted with 70% ethanol solvent using ultrasonic method. The dried extracts of simplisia and herbal products were analyzed by FTIR and TLC-Densitometry. Data obtained from FTIR and TLC-Densitometry analyzed with multivariate data analysis techniques, Principal Component Analysis (PCA) to obtain fingerprint profiles. The PCA results obtained a total Principal Component value of 98,7% and showed that leaf simplisia and herbal products of senggugu leaves can cluster well, while root simplisia and herbal products of senggugu roots were at a distance from the plot. The analysis with OPLS-DA showed the same fungtional groups, which are C=H, O-H, C=C. The results of antioxidant activity testing of 70% ethanol extracts of leaves, roots, and herbal products of senggugu obtained strong antioxidant activity ability with IC50 values of 80,08; 92,12; 80,53; and 94,03 ppm.
Antihyperlipidemic activity of Marchantia paleacea herb and Zingiber officinale var. Rubrum rhizome ethanol extracts in Triton X-100-induced mice Purkon, Dicki Bakhtiar; Ningsih, Padmasari Diah Ayu Kumala; Pambudi, Fatimah Ayu Putri; Widyastiwi, Widyastiwi; Roseno, M.H.; Haerussana, Ayu Nala El Muna; Fadhlillah, Faizah Min; Trinovani, Elvi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1458

Abstract

Non-communicable diseases cause 71% of deaths in the world, one of which is caused by dyslipidemia. Dyslipidemia has been established as a cause of various non-communicable diseases such as obesity and heart disease. This study aims to determine the antihyperlipidemic activity of the ethanol extract of the liverworts of Marchantia paleacea (EEMP) and the rhizome of Zingiber officinale var. rubrum (EEZOR) on male mice induced by Triton X-100. Grouping the number of test animals per group based on the Federer formula. Triton X-100 is used as an inducer of hyperlipidemic given intraperitoneally at a dose of 140 mg/kg body weight. Total cholesterol levels were measured by the colorimetric enzymatic method (CHOD-PAP) using a UV-Vis clinic photometer. Results from ethanol extract of the herb liverwort Marchantia paleacea (EEMP) and red ginger rhizomes Zingiber officinale var. Rubrum (EEZOR) can respectively reduce total hypercholesterol levels in male mice induced by Triton X-100 whose data were analyzed using the One-Way Anova test. The results of optimal dose of EEMP 200 mg/kg bw had the highest percentage of antihyperlipidemic activity and effectiveness (%) and also had a significant reduction in total cholesterol levels compared to the negative control group (p<0.05). While the results for the optimal dose of EEZOR 1000 mg/kg bw with the highest percentage of activity and effectiveness (%) and having a significant decrease compared to the negative control group (p <0.05). In conclusion, these findings suggest that both extracts have potential as natural antihyperlipidemic agents that can be further explored in the management of hyperlipidemic (dyslipidemic) and related non-communicable diseases.
Antibacterial effects of Andrographis paniculata extract, Curcuma domestica extract, chloramphenicol and their combinations on the growth of Salmonella typhi bacteria Rahmadi, Agus; Elya, Berna; Suryadi, Herman; Prasetio, Nisrina Putri; Kamaruzzaman, Mohd Amir
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1677

Abstract

Typhoid fever caused by Salmonella typhi remains a serious health threat. Although standard treatment with antibiotics such as chloramphenicol has helped reduce mortality rates, bacterial resistance to this antibiotic is increasing. New treatment approaches are urgently needed, including combining antibiotics with natural compounds from medicinal plants, such as Andrographis paniculata and Curcuma domestica. This study aimed to compare the antibacterial effects of A. paniculata extract, C. domestica extract, chloramphenicol, and their combinations on the growth of S. typhi. This in vitro experimental study used the disc diffusion method to evaluate antibacterial activity. Antibacterial activity tests were performed against S. typhi using discs soaked in 70% ethanol extract solutions of A. paniculata and C. domestica, chloramphenicol, and their combinations. Inhibition zones were measured after incubation for 24 hours at 37°C. Chloramphenicol showed the strongest antibacterial activity with a mean inhibition zone of 28.33 ± 0.58 mm. Single extracts of A. paniculata and C. domestica had relatively weak antibacterial activity (inhibition zones of 9.67 ± 1.15 mm and 9.83 ± 0.29 mm) and there was no significant difference between them (p>0.05). Combinations of extracts with chloramphenicol showed increased antibacterial activity compared to single extracts (inhibition zones of 23.17 ± 1.26 mm for A. paniculata + chloramphenicol and 21.00 ± 2.65 mm for C. domestica + chloramphenicol) and there were significant differences between combinations and single extracts (p<0.05), but still lower than single chloramphenicol and statistically significant (p<0.05). Although combining medicinal plant extracts with chloramphenicol increased antibacterial activity compared to single extracts, it did not exceed single chloramphenicol.
Literature review: treatment design to overcome anticancer drug resistance Udin, Baha; Yusransyah, Yusransyah; Stiani, Sofi Nurmay; Rizkiana, Muhammad Dinta
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1573

Abstract

One of the main causes of death in the world today is cancer. Chemotherapy is one treatment that cancer patients may utilize. Anticancer medication resistance, which might forecast a rise in treatment failure rates among cancer patients, poses a challenge to the current use of anticancer treatments. Numerous investigators have studied potential approaches to combat anti-cancer medication resistance. The purpose of this literature review is to provide information on treatment planning that can be applied to counteract anti-cancer medication resistance. Cancer is one of the leading causes of death in the modern world. One therapeutic option available to cancer patients is chemotherapy. The current usage of anticancer medicines is challenged by anticancer medication resistance, which may predict an increase in treatment failure rates among cancer patients. Many researchers have looked into possible strategies to fight drug resistance to anti-cancer medications. This review of the literature aims to give information on treatment planning that can be used to combat drug resistance to anti-cancer medications.
The effectiveness of butterfly pea hydrogel film (Clitoria Ternatea) with chitosan and poly-vinyl-alcohol based as diabetic wound healing Wicita, Prisca Safriani; Daud, Rizka Puji Astuti; Sapiun, Zulfiayu; Yahya, Cindy; Wantaa, Nurunnisa; Mohamad, Fihrina; Imran, Arlan K.; Hartati, Hartati; Husain, Fadli
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1483

Abstract

Butterfly pea possesses antioxidant activities with IC50 470 μg/ml of wound healing acceleration quality. Hydrogel for diabetic wound healing due to its physical characteristic that binds water, aside from its qualities that wets the surface and bio-compatibility in the body. This study aimed to identify effectivity test of hydrogel film preparation with butterfly pea (clitoria ternatea l.) Water extract for diabetic wound healing, employing true experimental method which involves 12 rats divided into 4 groups. The control group was treated without the Hydrogel (HET) or HET0 on hyperglycemic rats, HET1 (2%), HET2 (5%), and HET3 (7.5%). The findings revealed wounds treated with HET0 was healed in 9 days with 11.13 mm of diameter (100%), HET1 was healed in 6 days with 15.22 mm of diameter (100%), HET2 that was healed in 4 days with 11.29 mm of diameter (100%), and HET3 that was healed in 8 days with 9.05 mm of diameter (100%). It was concluded that the effectivity test revealed that the best formula is HET2 (5%) healed in 4 days with 11.29 mm of diameter in 100%.
The effect of technology implementation in providing drug information on consumer satisfaction in Jakarta, Indonesia Noviani, Lusy; rachmawati, Putriana; Octavioni, Octavioni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1598

Abstract

The provision of drug information (PDI) is a crucial factor influencing consumer behavior and ensuring appropriate drug use, thereby achieving therapeutic goals. With advancements in technology, digital platforms such as tele-counseling, WhatsApp, and social media are increasingly being used for PDI. However, challenges such as unclear communication, incomplete information, and delayed responses remain, which may affect consumer satisfaction. This study aims to assess consumer satisfaction with PDI through the implementation of a pharmacy application, using the End User Computing Satisfaction (EUCS) model, which evaluates information content, accuracy, format, ease of use, and timeliness. The research employed an associative, cross-sectional design and involved 250 consumers at Atma Jaya Pharmacy. Data were collected via a Likert-scale-based questionnaire, with responses analyzed to determine satisfaction levels in each EUCS dimension. Results showed that consumer satisfaction was consistently high across all dimensions, with the average satisfaction scores being 89.10% for information content, 90.19% for accuracy, 87.25% for format, 85.33% for ease of use, and 86.78% for timeliness. In conclusion, the use of technology in PDI significantly enhances consumer satisfaction, offering more accessible, accurate, and timely drug information. This study highlights the importance of optimizing technological tools in pharmaceutical services to improve user experience and satisfaction.

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