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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 680 Documents
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Statin prescribing pattern and the outcomes for acute coronary syndrome as primary and secondary prevention: a comprehensive review Dewi, Pramitha Esha Nirmala; Chairani, Farahdina; Himawan, Wahyu
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1604

Abstract

Cardiovascular disease is the highest rate of total burden non-communicable disease worldwide in these 5 recent years. Reducing the LDL-c level is closely related to reducing the risk of cardiovascular events recurrences among Acute Coronary Syndrome (ACS) patients. This study aims to explore the statin prescribing pattern among the ACS population and population at risk of ACS and to sum up the reported clinical outcomes, cost-effectiveness, or quality of life-related to statin utilization. The literature searching was conducted by using PubMed and Scopus databases from January 2020 to December 2021. Ten eligible studies were included, examining outcomes such as Major Adverse Cardiovascular Events (MACE), quality of life, and cost-effectiveness. Atorvastatin emerged as the most frequently prescribed statin for both primary and secondary prevention. In high-risk ACS populations, the delayed or underutilization of high-intensity statins led to suboptimal cardiovascular outcomes. Conversely, early administration, particularly within 48 hours post-event or post-PCI, significantly reduced MACE. Importantly, low to moderate intensity statin regimens showed cost-effectiveness primarily among low-risk ACS groups only when treatment was fully subsidized. In settings without government coverage, statin inaccessibility may affect the increased of recurrent events and elevated healthcare costs. The strategic use of statins—especially timely initiation and risk-based intensity selection—offers measurable benefits in reducing cardiovascular events. However, the lack of universal healthcare coverage for statin therapy in low- to middle-income settings presents a substantial barrier to cost-effective care, particularly for high-risk individuals. These findings underscore the need for policy interventions and expanded access to guideline-directed statin therapy.
Formulation of a peel-off gel mask containing mundu fruit extract (Garcinia dulcis (roxb.) kurz) for antioxidant and anti-elastase activity Ambarwati, Neneng Siti Silfi; Desmiaty, Yesi; Chandra, Amelia; Noviani, Yuslia; Triyani, Yulia; Hakim, Ratu Mayra; Amanda, Reistha Fazlia; Wahyudi, Dion
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1607

Abstract

The skin serves as a protective barrier against ultraviolet (UV) radiation. However, exposure to UV radiation can lead to various skin problems, including changes in the dermis. To prevent UV-induced damage, antioxidants and anti-elastase agents are needed to protect the skin from oxidative stress. This study aims to evaluate the antioxidant and anti-elastase activities of Mundu fruit extract (Garcinia dulcis (Roxb.) Kurz) and to formulate a peel-off gel mask using the concentrated extract. Antioxidant activity was assessed using the FRAP and ABTS methods, while anti-elastase activity was determined by measuring the release of p-nitroaniline from a substrate degraded by the elastase enzyme. The results showed that the IC50 value for antioxidant activity using the ABTS method is 29.57 ppm 0.72, and the FRAP value was 185.02 10.23 AAE/g. The anti-elastase activity showed IC50 of 82.21 ppm. Three peel-off gel mask formulations were developed, with Formula 3 (containing extract at 200 x IC50). showing the best performance. These findings suggest that the thick Mundu fruit extract, which tested positive for phenolic compounds, exhibits promising antioxidant and anti-elastase activities and is suitable for use in topical formulations.
Effectiveness of Artocarpus heterophyllus lamk. serum in eliminating dark spot in the guinea pig melasma model due to UV-a exposure Mas Tiari, Ida Ayu Dwi Putri; Mardiyanti Putri, Ni Putu Kania; Marliani, Ni Luh Setia; Sari, Ni Made Elma Agustini; Malelak, Julia Eva; Adrianta, Ketut Agus
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1639

Abstract

Indonesia's high UV-A exposure significantly contributes to skin hyperpigmentation conditions such as melasma. This study investigated the effectiveness of Jackfruit (Artocarpus heterophyllus Lamk.) leaf serum in reducing dark spots in a guinea pig model of melasma induced by UV-A radiation. Crude extracts were prepared and purified from Jackfruit (Artocarpus heterophyllus Lamk.) leaves, then formulated into serums at 4% and 5% concentrations. These formulations underwent physical quality evaluations, including organoleptic properties, pH, homogeneity, spread ability, adhesion, and viscosity. Anti-hyperpigmentation effects were assessed using Masson Fontana staining on UV-A-exposed guinea pigs treated for 14 days. The results demonstrated a reduction in melanin content, with mean values of 17.97±1.68 (negative control), 1.17±0.28 (positive control), 3.56±2.77 (4% serum), and 2.56±1.25 (5% serum). Histological analysis showed that fibroblast proliferation and epidermal hyperplasia were significantly reduced with serum treatment. These effects are attributed to the flavonoid content in Jackfruit (Artocarpus heterophyllus Lamk.) leaves, which exhibit antioxidant and anti-melanogenesis properties. In conclusion, Jackfruit (Artocarpus heterophyllus Lamk.) leaf serum, particularly at 5% concentration, is effective in reducing melasma-related hyperpigmentation and may offer a safer alternative to synthetic treatments.
Bibliometric analysis on pharmaceutical care publications in Southeast Asia: prospective research trends Riyadi, Rahmat; Alfian, Sofa Dewi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1621

Abstract

Studies related to bibliometric analysis have been conducted globally to determine the development of pharmaceutical care. However, the prospective trends of scientific research associated with pharmaceutical care in Southeast Asia remain unclear. This study sets out to analyze and compare the results of pharmaceutical care research in Southeast Asian countries in terms of bibliometric indices. An investigation on the main electronic database Scopus was conducted for research purposes on pharmacy care in Southeast Asia until August 6, 2023. The analysis derived from the investigation included an evaluation of published document by year; lead author; country or territory, institutional affiliation, document type, subject area analysis; citation and co-citation analysis; journals that published the most articles, and the most researched topics. Microsoft Excel and VOSviewer were utilized to conduct a qualitative analysis on this dataset. This study adopted the co-authorship analysis, co-citation analysis and keyword analysis in order to gain an insight onto the research prospects and trends in pharmaceutical care. A total of 1,261 studies correlating to pharmaceutical care in Southeast Asia met the criteria for qualitative analysis. The top three countries with the highest number of publications were Malaysia, Thailand and Indonesia. Malaysia had the highest citation count (n=4670, 27.45%), followed by Thailand (n=3292, 19.35%), and Vietnam (n=3096, 18.20%). From networks of co-authorship analysis of authors, there were no collaborations found among authors in Southeast Asia. Prospective research analyzing keywords related to the theme of pharmaceutical care includes pharmacy practice, medication adherence, and qualitative research. Bibliometric analysis provides a comprehensive view of the field and status of pharmaceutical care research to develop prospective future trends and collaborations in Southeast Asia. A bibliometric analysis suggests that stronger teamwork among Southeast Asian researchers is crucial for future advancements.
Evaluation of drug services based on prescription indicators and patient care according to who at the hospital general practitioner (GP) outpatient clinic in Depok, Indonesia Syafhan, Nadia Farhanah; Risni, Hindun Wilda; Salsabila, Azzahra Fahira; Purnama Putri, Raden Jacinda Yasmin; Prasetyaningrum, Marchen
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1609

Abstract

The World Health Organization (WHO) has developed prescription and patient care indicators, accompanied by optimal benchmarks, aimed at promoting the rational and optimal medicine use. This study aims to evaluate drug services utilizing WHO prescription and patient care indicators at the hospital General Practitioner (GP) outpatient clinic. The research was conducted retrospectively for prescription indicators, consisting of 1505 prescriptions totaling 4647 medication items administered for 804 individuals between January and December 2022. Prospective data collection to evaluate patient care was conducted from April to May 2023. Evaluation of WHO prescription indicators yielded the following results: the average number of drugs prescribed per patient was 3.09 ± 2.00; the percentage of drug prescribed by generic drug names was 47.47%; the percentage of antibiotic prescriptions was 5.46%; the percentage of injectable drug prescriptions was 6.80%; and the percentage of prescriptions in accordance with the national formulary was 75.91%. The percentages of antibiotic and injectable drug prescriptions met the optimal WHO prescription values. In terms of patient care, the results showed that the average duration of a medical consultation was 12.44±8.1 minutes, the average duration of a drug dispensing was 45.65±28.8 minutes, 96.25% of the drugs were dispensed appropriately, 100% of the drugs were labeled adequately, and 78.78% of the patients were knowledgeable. Age (p=0.111) and gender (p=0.075) showed no significant correlation with patient knowledge. There was a significant relationship between education level (p=0.014) and patient knowledge. Prescription and patient care indicators are aspects of improvement to meet the optimal benchmarks according to WHO standards.
Optimization of hand sanitizer gels containing soursop (Annona muricata L.) leaf extract using simplex lattice design method Kosasih, Kosasih; Lismawati, Dita; Adinugroho, Rifael Satrio
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1717

Abstract

Soursop (Annona muricata L.) is a plant whose leaf extract contains alkaloids, flavonoids, saponins, and tannins and can be antibacterial. Based on the compounds it contains, soursop leaf extract can be an active substance in hand sanitizer gel preparations. This study aims to determine the characteristics of the resulting hand sanitizer gel and the optimum concentration of the base combination that can produce a qualified hand sanitizer gel. This study used a Simplex Lattice Design experimental method with two factors (carbomer 940 and HPMC). Three hand sanitizer gels were prepared, with a ratio of carbomer 940: HPMC for F1 (1%:0%), F2 (0.5%:0.5%), and F3 (0%:1%). Tests conducted on hand sanitizer gel preparations included organoleptic, homogeneity, spreadability, adhesion, pH, and viscosity. The results of physical properties tests (spreadability, adhesion, and viscosity) were analyzed using Design Expert 11. The results showed that carbomer 940 and HPMC could increase viscosity and adhesion but could decrease spreadability. Ethanol extract of soursop leaves (Annona muricata L.) could be formulated and optimized into hand sanitizer gels. The optimum formula contained carbomer 940 0% and HPMC 1%, obtained in Formula 3 with a desirability value of 0.986.
Natural deep eutectic solvents (NaDES) improves extraction and antioxidant activity of stem bark of Garcinia cowa Roxb. Fahleni, Fahleni; Mun'im, Abdul; Saputri, Fadlina Chany; Surini, Silvia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1722

Abstract

Garcinia cowa Roxb. ex DC. is a plant belonging to the Clusiaceae family, and commonly dicovered in Southeast and South Asia. This study aimed to assess the efficiency of eight natural deep eutectic solvents (NaDES) in extracting total xanthones and phenolic compounds from the stem bark using ultrasound-assisted extraction as there is limited research on the use of NaDES in this plant extraction process. The study also examined their antioxidant properties. The NaDES were synthesized with choline chloride and betaine as hydrogen-bond acceptors, accompanied by various acids, alcohols, and glucose as hydrogen-bond donors. In comparison, ethanol was used as standard solvent. The NaDES exhibited higher densities than water, ranging from 1.059 to 1.244 g/cm³, with density increasing according to the number of hydroxyl groups present in the constituents. The total phenolic content (TPC) varied from 22.82 to 28.73 mg GAE/g extract, with NaDES1 (a combination of choline chloride, 1,2-propanediol, and water in a ratio of 1:3:1) showing the highest TPC at 28.73±0.18 mg GAE/g extract. It also exhibited significant antioxidant activities, as demonstrated by DPPH (28.98±0.03 µg/mL) and FRAP assays (43.66±1.51 mmol trolox/g dw). A significant negative correlation was observed between total xanthone, total phenolic content, and IC50 values. These findings suggest that NaDES, particularly NaDES1, have considerable advantages in extracting phenolic compounds and xanthones from G. cowa stem bark, resulting in enhanced antioxidant properties.This highlights the potential of NaDES as eco-friendly and effective solvents for the extraction of bioactive compounds from plant materials.
Analysis of pharmaceutical service improvement based IPA (Importance Performance Analysis) at pharmacy Kimia Farma Ijen, Malang Nurmawati, Dian; Priyono, Tridoso Sapto Agus; Siswidiasari, Arifani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1646

Abstract

Pharmaceutical services are direct and responsible services to patients related to pharmacy to achieve real results and improve patients' quality of life. This study aims to analyze the improvement of pharmaceutical services at the Kimia Farma 36 Ijen Pharmacy using the IPA (Importance Performance Analysis) method. The method used is descriptive research with a quantitative approach through questionnaire instruments. The SERVQUAL (Service Quality) model was used to measure the pharmaceutical service questionnaire. Sampling by the Accidental sampling technique. Questionnaires were distributed to patients or families of patients who redeem prescriptions at the Pharmacy in February 2023. The questionnaire refers to the research of Parasuraman, A., Zeithaml, V. A., & Berry adapted to the research context in the pharmacy. The dimensions are empathy, reliability, responsiveness, assurance, and tangibility, which are divided into importance and performance. The IPA method will analyze performance as the X axis and Importance as the Y. The results show that the service aspects require urgent improvement to improve service quality and patient satisfaction. Aspects that need to be improved include product completeness, the physical appearance of the pharmacy building, cleanliness, comfort, and neatness of the pharmacy, as well as the appearance and service of pharmacy officers. Overall, the results of this analysis provide clear guidance on the priorities for improvements that need to be made at Pharmacy Kimia Farma 36 Ijen.
Andrographis paniculata Burm. F. in-silico analysis compounds that function as an insulin sensitizer therapy for type 2 diabetes via peroxisome proliferator activated gamma receptors (pparγ) receptor activator Pristiyantoro, Pristiyantoro; Siswandono, Siswandono; Mumpuni, Esti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1651

Abstract

Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, requires safer PPARγ-targeting therapies to overcome the limitations of current thiazolidinediones (e.g., hepatotoxicity of pioglitazone). Andrographis paniculata, a traditional medicinal plant, contains bioactive flavonoids with putative insulin-sensitizing effects, although their PPARγ binding mechanisms remain unexplored. This study conducted in silico screening of eight A. paniculata compounds against PPARγ (PDB:5Y2O) using: (1) molecular docking (Molegro Virtual Docker 2013.6.0.0) to calculate binding affinities (MolDock/Rerank scores) and hydrogen bond interactions; (2) physicochemical profiling (ChemDraw Ultra 22.2/Chem3D Ultra 22.2) for drug-likeness parameters; and (3) ADMET prediction (pkCSM) for pharmacokinetic and toxicity assessment, with pioglitazone as the positive control. The results showed that 5,4'-dihydroxy-7,8,2',3'-tetramethoxyflavone exhibited near-native binding (MolDock: -111.653 vs pioglitazone -137.994) with optimal ligand-receptor stabilization through strong hydrogen bonds (-7.840 kcal/mol) with Ser289, His323, and Tyr473, as well as hydrophobic interactions with Phe282 and Leu330. This compound also demonstrated better aqueous solubility (-3.404 vs -4.309 log mol/L; p<0.05) and a favorable safety profile (non-hepatotoxic, AMES-negative) despite lower Caco-2 permeability (0.141×10⁻⁶ cm/s). This study identifies 5,4'-dihydroxy-7,8,2',3'-tetramethoxyflavone as a lead PPARγ agonist from A. paniculata with enhanced safety and drug-like properties. The HBond score of -7.840 suggests improved target specificity compared to pioglitazone. In vitro validation of glucose uptake modulation is recommended to confirm its therapeutic potential.
Adverse events among pulmonary drug-resistant tuberculosis patients in Banten, Indonesia Restinia, Mita; Siddiqa, Alyya; Sari, Wulan Purnama
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1704

Abstract

Drug-resistant Tuberculosis (DR-TB) treatment requires an extended duration, making adverse events (AEs) a common concern. This study aimed to assess the frequency of AEs, time to events, and their association with treatment outcomes among DR- pulmonary TB patients. A retrospective cohort study was conducted on patients aged >18 years at one of public hospitals at Tangerang, Banten, Indonesia, from March 2021 to May 2023. Bivariate analysis was used to analyze the association between AEs and treatment outcomes. Among 53 patients included in the study, all experienced at least one AEs. Number of AEs mean ± SD; 9.724±4.86. Mild AEs were reported in 100% of patients, while 75.5% experienced moderate AEs, and 81.1% experienced severe AEs. The most common AEs included nausea (90.6%), anemia (73.6%), vomiting (62.3%), decreased appetite (60.4%), and joint pain (60.4%). The AEs were frequently reported during intensive phase (4-6 months). AEs have association with treatment outcome (P<0.05). The frequency of AE among DR-TB patients was high. Early detection and effective management of AEs are essential to improving treatment outcomes for DR-TB patients.

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