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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 680 Documents
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Safety and efficacy test of a cream combination containing jujube (Ziziphus mauritiana L.) and perilla (Perilla frutescens L. Britton) leaf extracts Shaliha, Khansa Fitrah; Taurhesia, Shelly; Swandiny, Greesty Finotory
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1688

Abstract

Excessive free radicals accelerate skin degradation by causing oxidative damage to keratinocytes and fibroblasts, leading to structural protein breakdown (collagen, elastin, keratin), lipid peroxidation, and DNA damage. This process compromises skin barrier integrity, reduces elasticity, and promotes premature aging. Antioxidants play a crucial role in protecting the skin by neutralizing reactive oxygen species (ROS) and preventing lipid peroxidation. This study aimed to develop a topical cream containing jujube (Ziziphus mauritiana L.) and perilla (Perilla frutescens L. Britton) leaf extracts and evaluate its antioxidant activity and dermal safety. Extracts were obtained through kinetic maceration using 70% ethanol and formulated into oil-in-water creams at two concentration levels. The creams were assessed for physical characteristics (organoleptic properties, cream type, pH, homogeneity, spreadability, rheology, viscosity), stability under room and accelerated conditions (40°C for 4 weeks), antioxidant activity via DPPH assay, and irritation potential using albino rabbits. All formulations exhibited good physical properties, stability, and homogeneity. Irritation testing showed no erythema or edema, confirming the cream’s safety for topical application. Antioxidant testing revealed strong free radical scavenging activity, with IC50 values of 119.705 ppm (F1) and 66.938 ppm (F2). Accelerated storage slightly reduced antioxidant activity, while higher extract concentrations enhanced antioxidant effects compared to the base formulation. These findings indicate that jujube (Ziziphus mauritiana L.) and perilla (Perilla frutescens L. Britton) leaf extracts synergistically enhance antioxidant activity in a safe topical cream formulation, demonstrating potential as a natural preparation for skin protection against oxidative damage.
Smoking as a risk factor for dyslipidemia: study among type 2 diabetes mellitus patients on private hospital in Yogyakarta Patramurti, Christine; Virginia, Dita Maria
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1720

Abstract

Smoking behavior is known to be a significant factor that has adverse effects on people with type 2 diabetes (T2DM). Nicotine in cigarettes stimulate adrenoreceptors and promotes lipolysis, leading to the synthesis of free fatty acids, which in turn increase the susceptibility to dyslipidemia and the development of cardiovascular disorders. This study aimed to examine the relationship between smoking status and the occurrence of dyslipidemia in patients with T2DM in a private hospital in Yogyakarta. A total of 107 T2DM patients participated in this cross-sectional observational study. Through live interviews, we collected smoking status conducted using the Fagerström Test for Nicotine Dependence (FTND) questionnaire. The fasting blood samples taken from participants were used to analyze the lipid profiles, including triglycerides (TG), total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). The chi-square test revealed a significant association between smoking status and the risk of dyslipidemia among the participants, with χ²(2) = 13.463, p = 0.001. The findings suggest that smoking increases the risk of dyslipidemia among T2DM patients. These results highlight the importance of smoking cessation as a preventive measure to reduce metabolic complications in individuals with T2DM.
Phytochemical profile, antioxidant activity, and sun protection potential of selected Annonaceae species Djamil, Ratna; Iskandar, Maria Clarissa; Pratami, Diah Kartika
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1671

Abstract

Excessive sun exposure can damage the skin, highlighting the need for effective natural sunscreens. This study aimed to evaluate the phytochemical profile, antioxidant activity, total phenolic content (TPC), total flavonoid content (TFC), and sun protection factor (SPF) of five Annonaceae species. Methanolic leaf extracts of Annona muricata (soursop), Annona squamosa (sugar apple), Cananga odorata (cananga), Annona reticulata (nona), and Monoon longifolium (glodokan tiang) were analyzed. Phytochemical screening was performed to identify secondary metabolites. Antioxidant activity was determined using the DPPH radical scavenging assay, while TPC and TFC were measured spectrophotometrically. SPF values were calculated using the Mansur method. Phytochemical screening confirmed the presence of flavonoids, saponins, tannins, steroids, and phenolics in all extracts, with cananga leaves additionally containing alkaloids, coumarins, and essential oils. The DPPH assay showed antioxidant activity with IC₅₀ values ranging from 12.89–228.98 ppm, classified from very strong to weak. TPC and TFC values ranged from 12.33–31.75 mg GAE/g extract and 8.83–28.19 mg QE/g extract, respectively. SPF values ranged from 19.32–35.03, indicating all extracts fall under the ultra-protection category, with soursop leaf extract exhibiting the highest SPF. This study highlights the potential of Annonaceae leaf extracts, particularly A. muricata, as promising natural antioxidant and photoprotective agents due to their high polyphenolic and flavonoid content.
Cocrystallization of curcumin–isonicotinamide with ultrasonic wave treatment to increase solubility Wicaksono, Yudi; Seva, Any You; Wisudyaningsih, Budipratiwi; Nuri, Nuri; Susanti, Devi Feby
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1497

Abstract

Curcumin is a polyphenol compound with various biological activities, but its solubility in water is very low (4-8 µg/mL). This research aims to increase the solubility of curcumin through cocrystallization with isonicotinamide coformer. Cocrystallization was carried out using solvent evaporation, which was treated with ultrasonic waves. Cocrystal characterization was carried out using light microscopy, PXRD, DSC, and FTIR. The cocrystal solid was evaluated for solubility using the shaking method, while the dissolution test was carried out in a phosphate buffer medium, pH 6.8, with type II equipment. The results show that cocrystallization with ultrasonic wave treatment produces solid cocrystals (CICoc-Ult) with different solid properties than those without ultrasonic wave treatment (CICoc). CICoc-Ult showed higher solubility and dissolution compared to initial curcumin and CICoc cocrystals. Therefore, ultrasonic wave treatment in the cocrystallization process of curcumin using the solvent evaporation method can be used as a potential strategy to overcome the problem of the solubility properties of curcumin.
The relationship between family support and compliance of chronic kidney failure patients in undergoing hemodialysis therapy at Ciamis District Hospital Lidiasari, Alda; Rahayuningsih, Nur; Nofianti, Tita
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1659

Abstract

Chronic kidney disease (CKD) is a persistent and permanent decline in kidney function, disrupting metabolism and fluid and electrolyte balance, resulting in an increase in ureum levels. This study aims to analyze the relationship between family support and compliance of CKD patients in undergoing hemodialysis therapy at Ciamis Hospital. This study is descriptive quantitative using a cross sectional approach with accidental sampling technique in January-March 2025, involving 40 inpatient respondents. Data were collected through the Familly Suppot Scale (FSS) questionnaire to measure family support variables and the Morisky Medication 8-item Adherence Scale (MMAS-8) to see hemodialysis therapy compliance. Data testing was conducted with validity, reliability, and R-Square analysis and T-test using Partial Least Squares (PLS) model. The results showed that all instruments were valid and reliable, with AVE Validity > 0.5, Cronbach Alpha and Composite Reliability > 0.7. R-Square analysis, a combination of five family support variables obtained 88.1% of patients had a high level of compliance in following hemodialysis. The T-test results show that there is a significant relationship between instrumental support, informational support, emotional support, appreciation support and self-esteem support with hemodialysis therapy adherence in CKD patients. This is the role of the family is very important in supporting the patient's adherence to hemodialysis therapy.
The antiglycation activity test of peel off mask containing gold nanoparticles synthesized from kacip fatima extract (Labisia pumilla) Ong, Putri Stephanie; Abdulah, Sutriyo; Vardhani, Afifah Kusuma
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1594

Abstract

Skin aging, which is influenced by intrinsic and extrinsic factors, can accelerate skin damage, with one of the main mechanisms being the glycation reaction that results in Advanced Glycation End Products (AGEs). AGEs are the result of indirect reaction between reducing sugars and amino acids, lipids, or proteins. This reaction is also known as the glycation reaction or the Maillard reaction. This research aims to develop a peel-off mask based on gold nanoparticles synthesized with Kacip Fatima extract as an anti-aging agent. Gold nanoparticles have the potential to inhibit the formation of AGEs and improve skin quality. In this study, gold nanoparticles were synthesized by the green synthesis method using Kacip Fatima extract as a reducing agent. The method used for gold characterization is by measuring the wavelength and absorbance, polydispersity index, and zeta potential value of gold nanoparticles. The method used for antiglycation is by using microplate reader, which is stored for 3 days and tested with excitation wavelength of 365 nm and emission wavelength of 415-445 nm. The characterization results showed that the gold nanoparticles had an average size of about 79.61 nm at week 0 and increased to 101.1 nm at week 9. Glycation testing revealed that masks with 20% gold nanoparticles inhibited glycation by up to 95%, higher than the concentration of 10%. This study successfully synthesized gold nanoparticles using Kacip Fatimah extract as a reducing agent, with particles ranging from 79.61 nm to 101.1 nm over 9 weeks. The nanoparticles showed antiglycation effects, with 10% nanoparticles inhibiting glycation by 78%, suggesting potential for environmentally friendly cosmetic applications like peel-off masks.
An analysis of the unified theory of acceptance and use of technology (UTAUT) to the adoption of electronic medical records in hospital settings Ghozali, Muhammad Thesa; Rassyifa, Aloina Jean; Faradiba, Faradiba; Damanik, Ferina Septiani; Sari, Seftika; Satibi, Satibi; Fortwengel, Gerhard
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1693

Abstract

Electronic Medical Records (EMRs) are increasingly recognized as vital tools for enhancing the efficiency, accuracy, and quality of healthcare delivery. Despite regulatory mandates in Indonesia, the adoption of EMRs remains uneven, particularly in rural healthcare settings. This study applied the Unified Theory of Acceptance and apply of Technology (UTAUT) to investigate the behavioral intention of healthcare professionals working in private hospitals to use electronic medical records. A quantitative, cross-sectional design was implemented involving 90 participants selected through purposive sampling in an Indonesian hospital. The study's data were gathered between October 2024 and January 2025 using a validated 18-item UTAUT-based questionnaire. Data analysis was conducted with SPSS and SmartPLS software. Results indicated that all four UTAUT construct – Performance Expectancy (β = 0.200, p = 0.016), Effort Expectancy (β = 0.353, p < 0.001), Social Influence (β = 0.291, p < 0.001), and Facilitating Conditions (β = 0.262, p = 0.008 – had statistically significant positive effects on Behavioral Intention. The model demonstrated moderate explanatory power (R² = 0.655) and strong predictive relevance (Q² = 0.512). These results validate the UTAUT model's suitability in this context and provide practical insights for strengthening EMR implementation strategies. Future research should consider longitudinal approaches and multi-site comparisons to enhance generalizability and policy relevance.
Green synthesis of silver nanoparticles using Pluchea (Pluchea indica (L.)) leaf extract and antibacterial activity against Staphylococcus aureus and Propionibacterium acnes Ratnasari, Devi; Kasasiah, Ahsanal; Sulastri, Sulastri; Aida, Fitri
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1648

Abstract

Nanotechnology is widely used in the biomedical purpose as a drug delivery system, cancer, and tumor biomarkers. Currently, metals are most used as precursor agents to form nanoparticles such as silver, gold, iron, zinc, and metal oxides. Acne is one of the skin problems caused by the growth of S. aureus and P. acnes bacteria. Treatment of acne using inappropriate antibiotics can lead to resistance. Silver nanoparticles are known to have the ability to kill pathogenic microorganisms. Pluchea leaf extract contains flavonoid, polyphenol, and tannin compounds that can work as natural bioreductors in the formation of silver nanoparticles while inhibiting bacterial growth. This study aims to synthesize silver nanoparticles using Pluchea leaf extract and testing antibacterial activity against Staphylococcus aureus and Propionibacterium acnes. Extraction of Pluchea leaves was carried out using the infusion method with the water solvent. The synthesis of silver nanoparticles was used a shaker incubator at a speed of 150 rpm and a temperature of 37 ºC for 48 hours. Characterization of silver nanoparticles using uv-vis spectrophotometry, particle size analyzer (PSA), zeta potential analyzer, and FESEM-EDX. Antibacterial activity test using microdilution method. The characterization results of silver nanoparticles showed a particle size of 20.50 nm, a zeta potential of -38.6 mV, and a spherical morphological shape. Silver nanoparticles have antibacterial activity against S. aureus and P. acnes with a Minimum Inhibitory Concentration (MIC) value of 62.5 ppm and Minimum Bactericidal Concentration (MBC) value >250 ppm.
Enhancing capsaicin solubility in lidocaine-based therapeutic deep eutectic solvents (THEDES): a COSMO-RS predictive study Asma, Nur; Alwi, Ratna Surya; Ramadon, Delly; Mun’im, Abdul
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1665

Abstract

Capsaicin, a potent analgesic, suffers from poor aqueous solubility and low bioavailability. Therapeutic deep eutectic solvents (THEDES) have emerged as a promising platform to enhance the solubility of poorly soluble drugs. This study employed the conductor-like screening model for real solvents (COSMO-RS) for the in-silico screening of capsaicin solubility in 34 lidocaine-based THEDES, comprising 10 hydrogen bond acceptors (HBAs) and 26 hydrogen bond donors (HBDs) at 1:1 and 1:2 molar ratios. The σ-profiles and σ-potentials of the components were analysed to understand the intermolecular interactions governing solubility. Our predictions revealed a remarkable solubility range from below 1 g/L to over 437 g/L. The betaine-lidocaine (1:1) system was identified as the optimal solvent, achieving a capsaicin solubility of 437.47 g/L at 333.15 K, attributed to betaine's zwitterionic nature facilitating multifaceted hydrogen-bonding. Small polyols like ethylene glycol also performed excellently. A consistent enhancement in solubility was observed in HBD-rich (1:2) compositions and with increasing temperature. Molecular interaction analysis confirmed a robust network of conventional and non-conventional hydrogen bonds within the optimal betaine-lidocaine-capsaicin system. This work demonstrates the power of COSMO-RS as a rational design tool for formulating high-loading THEDES-based drug delivery systems, with betaine-lidocaine emerging as a top candidate for advanced capsaicin topical formulations.
Formulation of facial liquid soap wıth 4-(Dimethylamino) chalcone and virgin coconut oil as antibacterial agents against acne-causing bacteria Wulandari, Putri; Mumpuni, Esti; Mulatsari, Esti; Kartiningsih, Kartiningsih
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1653

Abstract

Acne vulgaris is a multifactorial skin disorder commonly associated with infections caused by Staphylococcus epidermidis and Cutibacterium acnes. This study aimed to develop and evaluate an antibacterial facial liquid soap containing 4-(Dimethylamino) chalcone and virgin coconut oil (VCO). The synthesized chalcone, a flavonoid derivative obtained through the Claisen–Schmidt condensation reaction, was characterized using TLC, melting point analysis, UV-Vis spectrophotometry, and LC-MS/MS. Formulations containing 1.25% and 2.5% chalcone combined with 40% VCO were prepared and tested. Antibacterial activity was evaluated using the agar diffusion method, while physical properties were assessed through organoleptic observation, homogeneity, foaming ability, pH measurement, stability testing, and skin irritation tests. The 1.25% chalcone formulation demonstrated strong antibacterial activity, producing inhibition zones of 19.40±0.39 mm against C. acnes and 18.97±0.45 mm against S. epidermidis. All formulations were stable, homogeneous, and non-irritating. These findings indicate a synergistic antibacterial effect between chalcone and VCO, supporting their potential use as natural active ingredients in anti-acne facial soap formulations.

Page 68 of 68 | Total Record : 680

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