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YARSI Medical Journal

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Published by Universitas Yarsi

ISSN : 08541159 EISSN : 24609382 DOI : -

Core Subject : Health,

Medicine & Pharmacology

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Articles 232 Documents

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PROGRAM COMMUNITYTB CARE SEBAGAI WAHANA PENDIDIKAN KEDOKTERAN KOMUNITAS MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS YARSI Budi Susila Duarsa, Artha; Djannatun, Titiek
Jurnal Kedokteran YARSI Vol 20, No 3 (2012): SEPTEMBER - DESEMBER 2012
Publisher : Lembaga Penelitian Universitas YARSI

WHO telah mengembangkan strategi penanggulangan TB dengan strategi DOTS (Directly Observed Treatment Short-course) dan telah terbukti sebagai strategi penanggulangan yang secara ekonomis paling efektif (cost effective). Tujuan program adalahmeningkatkan keterlibatan pasien TB dan masyarakat dalam penanggulanganTB melalui peran komunitas dan UPK (UnitPelayanan Kesehatan) pemerintah dan swasta. Mahasiswa kedokteran di Fakultas Kedokteran Universitas YARSI, dalam mempelajari permasalahan TB secara komprehensif belajar untuk mengetahui dan memahami bagaimana terjadinya penularan TB di masyarakat dan faktor faktor yang menyebabkan terjadinya TB di masyarakat, mendeteksi adanya TB di masyarakat, bagaimana penderita mengakses pelayanan kesehatan yang ada dan faktor faktor yang meyebabkan penderita mengakses pelayanan kesehatan tersebut. Proses pembelajaran tersebut berada dalam kegiatan diagnosis komunitas yang masuk dalam Blok Kedokteran Komunitas di Semester 6. Pembelajaran tersebut memanfaatkan kegiatan Program Community GF ATM Round 8 YARSI TB Care yang digunakan sebagai wahana pendidikan Kedokteran Komunitas. Mahasiswa akan mengunjungi pasien TByang sedang menjalanipengobatan untuk melakukan diagnosis komunitas dengan5langkah: menentukan area permasalahan, menentukan instrumen pengumpulan data, mengumpulkan data, menganalisis data, menyusun intervensi pemecahan masalah. Mahasiswadalam melakukan diagnosis komunitas tersebut berinteraksi dengan pasien TByang sedang menjalani pengobatan, keluarga pasien, dan komunitas yang berada disekitar keluarga pasien berada. Diharapkan dengan memahami permasalahanTBsecara komprehensif, mahasiwa kedokteran akan menjadi profil dokter masa depan menurut WHO: Five Star Doctor yang mencakup: Health Care Provider, Decision Maker, Educator, Manager dan Community Leader.

PERAN PENDIDIKAN KESELAMATAN PASIEN TERHADAP PENINGKATAN PENGETAHUAN MAHASISWA KEPANITERAAN IKM FK YARSI Wijayanti, Erlina
Jurnal Kedokteran YARSI Vol 22, No 2 (2014): MEI - AGUSTUS 2014
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v22i2.304

Medication error merupakan penyebab terbanyak dari insiden keselamatan pasien di layanan primer yang sebenarnya dapat dicegah melalui pendekatan sistem. Fakultas Kedokteran Universitas YARSI bermaksud mengembangkan pendidikan Patient Safety untuk meningkatkan pengetahuan mahasiswa dan melatih mahasiswa menyelesaikan kasus insiden keselamat-an pasien. Pendidikan diberikan melalui kuliah dan simulasi kasus serta dibantu dengan media (modul, buku panduan dan video). Penelitian ini bertujuan untuk meningkatkan pengetahu-an mahasiswa terhadap materi ?Aplikasi Patient Safety dan Medication Safety dalam Praktek Kedokteran? dan untuk meng-evaluasi program pembelajaran.Penelitian ini merupakan penelitian analitik dengan mixed method dan desain kuasi eksperimental. Data kuantitatif di-dapatkan dari nilai pretes, postes, nilai diskusi, nilai presentasi dan nilai laporan. Sedangkan pengumpulan data kualitatif dengan wawancara mendalam terhadap mahasiswa. Nilai pretes dan postes dianalisis dengan Uji Wilcoxon untuk mengetahui peningkatan pengetahuan mahasiswa.Sebanyak 35 mahasiswa kepaniteraan IKM FK YARSI periode 10 Februari ? 15 Maret 2014 menjadi subyek penelitian. Hasil pembelajaran menunjukkan bahwa mahasiswa mampu mencapai target kelulusan pada kegiatan diskusi, presentasi hasil dan laporan yaitu di atas skor 55. Pengetahuan mahasiswa me-ningkat secara signifikan dilihat dari nilai pretes dan postes (p=0,000). Median meningkat dari 30 menjadi 80. Dari hasil wawancara mendalam ditemukan bahwa proses pembelajaran sudah cukup efektif sedangkan kekurangannya adalah durasi kuliah yang cukup lama (130 menit). Diharapkan ke depannya simulasi kasus dapat ditingkatkan menjadi kegiatan observasi di pelayanan kesehatan.

EFFECTS OF STROBILANTHES CRISPUS EXTRACT ON THE APOPTOTIC PATHWAY OF HUMAN LIVER CARCINOMA CELL LINES Endrini, Susi; Suherman, Suherman; Rahmat, Asmah; Ismail, Patimah; Taufiq-Yap, Y.H; Othman, Fauziah
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

Previous study has been shown the potential anticarcinogenic effect of Strobilanthes crispus, a plant native to countries from Madagascar to Indonesia, on human liver cancer (HepG-2) cell lines. The objective of the present study was to investigate the mechanism of anticarcinogenic effectof S.crispus extract through apoptotic pathway. Exposure of HepG-2 cells to S.crispus extract resulted in induction of apoptosis in a dose-dependent manner as measured by Fluoresence Microscopy and Confocal Laser Scanning Microscopy analysis. These findings provide important new insight into the possible molecular mechanisms of the anticancer activity of S.crispus.

PEMENDEKAN TELOMER DAN APOPTOSIS Purwaningsih, Endang
Jurnal Kedokteran YARSI Vol 22, No 2 (2014): MEI - AGUSTUS 2014
Publisher : Lembaga Penelitian Universitas YARSI

Sel normal akan mengalami kematian sel yang terprogram atau apoptosis.Apoptosis ini merupakan proses penting dalam pengaturan homeostasis normal sel, yang menghasilkan keseimbangan dalam jumlah sel jaringan tertentu melalui eliminasi sel yang rusak dan proliferasi sel. Terjadinya deregulasi apoptosis dapat menimbulkan keadaan patologis, termasuk proliferasi yang tidak terkontrol seperti dijumpai pada sel kanker atau keadaan yang berhubungan proses penuaan dan kematian sel.Penuaan atau kematian sel berhubungan dengan struktur nukleotida di ujung kromosom di dalam inti sel eukariot yang disebut telomer. Pada sel somatik normal terjadi pemendekan telomer seiring meningkatnya usia, termasuk stem cell yang dimaksudkan untuk pembaharuan sel. Sel somatik mempunyai program proses penuaan (aging). Telomer dipelihara dan dipertahankan oleh enzim telomerase. Stabilitas dan viabilitas kromosom memerlukan fungsi telomer yang baik dan stabil. Gangguan fungsi telomer dapat disebabkan oleh pemendekan telomer atau adanya mutasi protein telomer yang dapat mengakibatkan peningkatan apoptosis. Sebaliknya, apoptosis yang diakibatkan oleh adanya kerusakan DNA, dapat memicu terjadinya pemendekan telomer.

PENGARUH PEMBERIAN MINYAK IKAN TERHADAP KONSENTRASI ASAM LEMAK DAN GEJALA KLINIS MALARIA Rasyid, Haerani; Suwandi, Danny
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

The aim of the study is to find out the effects of fish oil supplementation on fatty acids concentration (Eicosapentanoat Acid and Docosahexaenoat Acid), fever attacks and Dikke Drupple (DDR) interpretation of samples. This study was designed as ?A Randomized Double Blind Pretest and Post-test Controled Group?. Samples were divided into two groups, experiment group with fish oil suplementation (8% EPA, 35 DHA) and control group (placebo) for 8 weeks. This study was conducted in a malaria endemic, Kadaila village, subdistrict of Karossa, District of Mamuju in 2003. The result of the study showed significant increased concentration of EPA and DHA of the experiment group than the control group (p 0,05). The fever attack was significantly decreased (p 0,05) in experiment group than the control group, while DDR was not significantly different (p 0,05) between two groups.

THE EFFECTS OF AEROBIC EXERCISE AND DETRAINING ON LEFT VENTRICULAR CARDIOMYOCYTE APOPTOSIS Putri, Mustika
Jurnal Kedokteran YARSI Vol 24, No 3 (2016): SEPTEMBER - DESEMBER 2016
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v24i3.276

Apoptosis can occur in several pathological heart conditions. Physical exercise, particularly aerobic exercise may reduce apoptosis on cardiomyocytes. Detraining can restore adaptation after exercise. This study aimed to see the effect of aerobic exercise and detraining on left ventricular cardiomyocyte apoptosis using caspase-3 as the parameter.This was an in vivo experimental study on Wistar rats Rattus Novergicus. Rats divided to 8 groups: 4 sedentary control groups: 4-week (C4), 8-week (C4D), 12-week (C12), 16-week control (C12D), and 4 aerobic exercise treatment groups: 4-week (A4) and 12-week (A12), and 4 12-week post aerobic exercise treatment followed by 4 weeks detraining (A4D, A12D). Caspase-3 protein in rat left ventricular tissue was identified by immunohistochemistry staining. Data were analized with ANOVA test using SPSS proggramme version 20.Data analysis showed an increase percentage of caspase-3 expression on post-aerobic exercise (A), be compared with conntrol group (C) (A4 65,3%±2,54 vs K4 6,4%±1,78, p 0,001; A12 41,8%±3,21 vs K12 5,7%±0,88, p 0,001; A4D 66,6%±1,89 vs K4D 8,6%±3,60, p 0,001; A12D 45,1%±1,50 vs K12D 7,4%±2,06, p 0,001). Percentage of caspase-3 expression was not different on post-aerobc exercise (A), be compare with detraining group (A4D 66,6%±1,89% vs A4 65,4%±2,54, p=0,484; A12D 45,1%±1,50 vs A12 41,8%±3,21, p=0,063). Percentage of caspase-3 expression on post 4-week aerobic exercise group was higher than post12-week aerobic exercise (A4 65,4%±2,54 vs A12 41,8%±3,21, p 0,001).In conclusion, the aerobic exercise protocol used in this study, was not found to decrease left ventricular cardiomyocyte apoptosis. Detraining did not increase left ventricular cardiomyocyte apoptosis.

PREVALENSI DEFISIENSI GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) PADA ANAK SEKOLAH DASAR YANG TINGGAL DI DAERAH ENDEMIS MALARIA DI SULAWESI UTARA S.B Tuda, Josef; J. Kepel, Billy; Nakatsu, Masami; Matsuoka, Hiroyuki
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

Deficiency of glucose-6-phosphate dehydrogenase (G6PD) is the most common enzyme disorder in the world with a very high incidence in the tropics and sub-tropics as a result of malaria selection. North Sulawesi is a part of Indonesian archipelago where malaria has been endemic. This study was aimed to examine the prevalence of G6PD deficiency in the region. An observational cross sectional study was conducted on primary school students belong to different ethnic groups. The purposive sampling method was used to select 442 study subjects, age 5-9 years. The G6PDdeficiency screening test was carried out using G6PD-assay kit. The prevalences of G6PDdeficiency male students were 0% in the Minahasans, 7,4%-12,0% in the Sangihenese, and 4,0%10,3% in the Bolaang Mongondownese. The results suggest that the highest prevalence of G6PD deficiency was in the Sangihe ethnic group. Further molecular analysis would be beneficial to study the genetic relationship of those populations with other neighboring population.

PURIFIKASI PARSIAL DAN KARAKTERISASI B-GALACTOSIDASE DARI LACTOBACILLUS PLANTARUM STRAIN D-210 Nunu Prihantini, Nur; Khusniati, Tatik; Bintang, Maria; Choliq, Abdul; Sulistiani, Sulistiani
Jurnal Kedokteran YARSI Vol 21, No 1 (2013): JANUARI - APRIL 2013
Publisher : Lembaga Penelitian Universitas YARSI

Pemurnian parsial dan karakterisasi B-galaktosidase dari Lactobacillus plantarum strain D-210 belum dilaporkan. L. plantarum strain D-210 ditemukan sebagai bakteri penghasil B-galaktosidase sebagian dimurnikan dengan dialisis. Hasil penelitian menunjukkan bahwa aktivitas optimum dalam 24 jam dengan dan total protein adalah 0,454 mg/ml pada pH 6.5 aktivitas enzim 252,341 U/ml, dan suhu 45°C dengan aktivitas 0,582 U/ ml. Total aktivitas B-galaktosidase L.plantarum strain D-210 adalah 138,396 U dan endapan dengan amonium sulfat dicapai pada 40% - 50% dengan aktivitas total 87,030 U. Setelah dialisis, aktivitas total adalah 50,420 U. Penghambat B-galaktosidase adalah Hg dan Cu dengan aktivitas relatif adalah 56,82% dan 1,04%, sedangkan aktivator adalah Mg, Mn, Ca, Co, Zn. Vmaks dari enzim adalah 0.093 µmol/menit dan KM enzim B-galaktosidase L. plantarum adalah 0,491 mM. Berdasarkan karakteristik B-galaktosidase, dapat disimpulkan bahwa L. plantarum strain D-210 adalah bakteri baik dan unggul yang dapat memproduksi B-galaktosidase. Studi lebih lanjut diperlukan untuk mengeksplorasi kemungkinan menggunakan bakteri ini dalam pengolahan susu pada bayi dengan intoleransi laktosa.Partial purification and characterization of Lactobacillus plantarum strain D-210 B-galactosidase has not been reported yet. L. plantarum strain D-210 known as bacteria producing B-galactosidase was partially purified by membrane dialysis. The results showed that optimum activity in 24 hour with total protein yield 0.454 mg/ml at pH 6.5 the enzyme activity was 252.341 U/ml, and at 45°C the activity was 0.582 U/ml. The total activity of B-galactosidase L.plantarum strain D-210 was 138.396 U and precipitated by sulphate ammonium at 40%-50% with total activity was 87.030 U. Following dialysis, the total activity was 50.420 U. The inhibitors of B-galactosidase were Hg and Cu with relative enzyme activities of 56.82% and 1.04% respectively, while the activators were Mg,Mn,Ca,Co,Zn. Vmax of the enzyme was 0.093 µmol/min and KM was 0.491 mM. Based on the characteristics of the enzyme, it can be concluded that L. plantarum strain D-210 was a good B-galactosidase producing bacteria. Further studies are required to explore the possibility of using this bacteria in milk processing for lactose intolerance babies.

PENGARUH KEKERUHAN AIR TERHADAP EFEKTIFITAS BACILLUS THURINGIENSIS H-14 Darwin, Akhid
Jurnal Kedokteran YARSI Vol 13, No 1 (2005): JANUARI - APRIL 2005
Publisher : Lembaga Penelitian Universitas YARSI

Bacillus thuringiensis H-14 (Bt H-14) usually controled the larvae of Aedes, Culex, and Anopheles. Turbidity could be caused by organic and inorganic substances suspended in water which might disturb the disinfection process. The aim of this study was to know the effectivity of the turbidity and the duration of the exposure in terms of the number of dead of the third instar Anopheles sundaicus larvae. The results showed different effectivity of B. thuringiensis H-14 in terms of the turbidity level and the duration of the exposure after six and twelve hours with the probability value p 0.05. Doses of 0.5 ? 1.0 L/Ha at the turbidity levels of 30 untill 227 Nephelometric Turbidity Units (NTU) at six hours exposure then the number of dead larvae was less than 50 %, while the number of dead larvae was more than 50 % at twelve hours exposure. Effective doses of the B. thuringiensis H-14 after the exposure of twelve hours were 0.5 L/Ha at the level of turbidity of 30 NTU, 0.6 L/Ha at 40 NTU, 0,7 L/Ha at 46 NTU, and 0.9 L/Ha at 189 NTU respectively, while a dose of 1.0 L/Ha was not effective at 227 NTU with a number of dead larvae less than 50 %. It was suggested to determine the turbidity of water before the application of B. thuringiensis H-14 in order to obtain the exact and effective dose of the B. thuringiensis H-14 tested

DETEKSI INTERLEUKIN-10 (IL-10) PADA MICE BALB/C YANG DIINFEKSI DENGAN VIRUS DENGUE: TELAAH PATOGENESIS ANTARA TEORI INFEKSI SEKUNDER DAN VIRULENSI Yusuf, Iwang; Konthen, P.G.; A. Rantam, Fedik
Jurnal Kedokteran YARSI Vol 13, No 1 (2005): JANUARI - APRIL 2005
Publisher : Lembaga Penelitian Universitas YARSI

Since the pathogenesis/immunopathogenesis of vasculopathy plasma leakage in DHF/ DSS was not clearly understood, this study was conducted. Considering the equilibrium between pro and anti inflammatory cytokine in homeostatic process in inflammation, this study was aimed to; first, detect the increase of secretion of IL-10 of immune responses of Mice Balb/c that were challenged with dengue virus serotype Den-1 Den-3. Second, compare the secretion of IL-10 of immune responses of Mice Balb/c that were challenged with dengue viruses in primary infection, secondary monospecific infection and secondary heterologous infection. This study was experimental laboratory, with randomised pretest-posttest with spread control group design. Balb/C mice were used as animal laboratory models. The dengue viruses Den-1 Den-3 that used in this study were isolated from dengue suspected patients and the viruses were innoculated and bred in BHK 21 clone 13 cell line, before they were injected to the models. Serum samples were collected from blood by centrifuging the blood for 10 minutes at 1000 rpm. The data of this experiment were obtained by applying the serum samples in Murine IL-10 Elisa Kit product of Diaclone Research France. In primary infection, significant increase of IL-10 mean titer in experimental group challenged with dengue viruses Den-1 was obtained (p=0.03) compared with the control group. Conversely the experimental group challenged with dengue viruses Den-3 showed no significant increase of mean titer (p=0.127). In the secondary infection, group treated with dengue Viruses Den-1 showed decrease of mean titer of IL-10 (p=0.034 p=0.003). Meanwhile, group treated with dengue Viruses Den-3 showed no significant different compared to primary infection group (p=0.571 p=0.359). The results of the study, support both virulence theory and the secondary heterologous dengue infection theory.

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